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| 1 | Targeted gene disruption by use of a group 11 intron (targetron) vector in Clostridium acetobutylicum显示文摘 | Lijun Shao Shiyuan Hu Yi Yang Yang Gu Jun Chen Yunliu Yang Weihong Jiang ShengYang | 2007 | Cell Research2007，17，11： | 23 |
| 2 | Methane and nitrous oxide concentration and emission flux of Yangtze Delta plain river net显示文摘Methane (CH4) and nitrous oxide (N2O) saturation concentration and gas-water interface emission flux in surface water of the Yangtze Delta plain river net were investigated in summer at representative sites including the upper reaches of the Huangpu River and the rivers in the Chongming Island. The results show that the CH4 concentration in river water ranged from 0.30±0.03 to 6.66±0.14 μmol.L-1, and N2O concentration ranged from 13.8±2.33 to 435±116 nmol.L-1. River surface water had a very high satura- tion level of CH4 (from 468±49.0% to 11560±235%) and that of N2O (from 175±29.5% to 4914±1304%). Dissolved oxygen (DO) was the primary factor controlling the CH4 concentration in water. N2O concentration had significant negative correlation with salinity and a significant positive correlation with nitrate (NO3-), nitrite (NO2-), chemical oxygen demand (CODcr) concentration and pH of river water. CH4 and N2O of river water were brought about mainly by methanogenesis and denitrification in river bottom sediment that diffused through sediment-water interface into the water body and then into atmosphere through the gas-water interface. The emission flux of CH4 and N2O at river gas-water interface reached 778±59.8 and 236±63.6 μmol.m-2.h-1, respectively in summer. The river net was a potential source of atmospheric CH4 and N2O because of eutrophication of the water body. | WANG DongQi CHEN ZhenLou SUN WeiWei HU BeiBei XU ShiYuan | 2009 | Science China Chemistry2009，52，5： | 19 |
| 3 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 4 | Walnut-inspired microsized porous silicon/graphene core-shell composites for high-performance lithium-ion battery anodes显示文摘 | Wei Zhai Qing Ai Lina Chen Shiyuan Wei Deping Li Lin Zhang Pengchao Si Jinkui Feng Lijie Ci | 2017 | Nano Research2017，10，12： | 12 |
| 5 | Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study显示文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations. | Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye | 2019 | Cancer Biology & Medicine2019，16，1： | 7 |
| 6 | The variation of sediments organic carbon content in Chongming east tidal flat during Scirpus mariqueter growing stage显示文摘The investigations on the organic carbon (OC) of core sediments were carried out in Chongming easttidalflat(CM ) during Scirpus mariqueter growing stage (from Aprilto December 2004)in Yangtze Estuary.The Yangtze Riverannually transports a runoffdischarge of30,000 m3/s, carrying about480 million tons ofsediments to the estuarine and coastalarea,which formed a great OC pool.In the sampling spots,seven quadratsof50 cm × 50 cm and five sedimentscoresof20 cm deep (40 cm deep in December)were randomly established in orderto collectvegetations and core sediments samples during the low tide each month except November.After pretreatment,the core sediments were sieved and theirOC contents were measured according to the potassium dichromate method. The results show that the higher surface sediment OC content in summer comes from allochthonous terrigenous particle settlements on the Chongming eastmiddle tidalflatS.mariqueter zone.In autumn and winter,the decomposing of the defoliated S.mariqueter increases the surface sediments OC content.Settling velocity,sedimenttemperature and S.mariquetergrowth are the main factorsthatcan controlthe sedimentcarbon content.Summeristhe 'carbon losing'period ofthe tidal flatsediments,while from September,itchanges into the 'carbon accumulating' period ofsediment OC poolbecause ofthe decomposing ofdead S.mariquetercommunity in the sediments.From this alternation of'carbon losing'period and 'carbon accumulating'period,weconcludethatcarbon in the OC pool of the middle tidalflatS.mariqueter zone sediments mainly comes from the atmospheric carbon rooted by S.mariqueterphotosynthesis. | CHEN Hua WANG Dongqi CHEN Zhenlou WANG Jun XU Shiyuan | 2005 | Journal of Geographical Sciences2005，15，4： | 5 |
| 7 | Preparation and Tribological Properties of Lanthanum-doped Muscovite Composite Particles as Lubricant Additives in Lithium Grease显示文摘Lanthanum-doped muscovite(MC) composite particles(hereinafter abbreviated as La-MC) were prepared by the mechanical solid-state-chemistry-reaction method, followed by surface modification with oleic acid. The microstructure of materials was characterized by SEM, XRD, EDS and FTIR. Furthermore, the friction-reduction and anti-wear properties of MC and La-MC as lubricant additives in lithium grease were evaluated using a four-ball friction and wear tester. The results showed that La(OH)_3 nanoparticles were coated on the surface of muscovite. Both MC and La-MC can effectively improve the friction-reduction and anti-wear properties of lithium grease and La-MC presents better tribological properties than MC. The excellent tribological properties of La-MC can be attributed to the formation of the adsorbed La-MC film and the chemical reaction film mainly composed of Fe_2O_3 and SiO_2 on the worn surface, as well as the catalysis of lanthanum element during the friction process. | Du Pengfei Chen Guoxu Song Shiyuan Zhao Litao Wu Jiang Cheng Peng Yang Xiao | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，2： | 4 |
| 8 | Miniature Fluorescence Microscopy for Imaging Brain Activity in Freely-Behaving Animals显示文摘An ultimate goal of neuroscience is to decipher the principles underlying neuronal information processing at the molecular,cellular,circuit,and system levels.The advent of miniature fluorescence microscopy has furthered the quest by visualizing brain activities and structural dynamics in animals engaged in self-determined behaviors.In this brief review,we summarize recent advances in miniature fluorescence microscopy for neuroscience,focusing mostly on two mainstream solutions-miniature single-photon microscopy,and miniature two-photon microscopy.We discuss their technical advantages and limitations as well as unmet challenges for future improvement.Examples of preliminary applications are also presented to reflect on a new trend of brain imaging in experimental paradigms involving body movements,long and complex protocols,and even disease progression and aging. | Shiyuan Chen Ziehen Wang Dong Zhang Aiming Wang Liangyi Chen Heping Cheng Runlong Wu | 2020 | Neuroscience Bulletin2020，36，10： | 2 |
| 9 | EVchain: An Anonymous Blockchain-Based System for Charging–Connected Electric Vehicles显示文摘Purchases of electric vehicles have been increasing in recent years. These vehicles differ from traditional fossil-fuel-based vehicles especially in the time consumed to keep them running. Electric-Vehicle-charging Service Providers(EVSPs) must arrange reasonable charging times for users in advance. Most EVSP services are based on third-party platforms, but reliance on third-party platforms creates a lack of security, leaving users vulnerable to attacks and user-privacy leakages. In this paper, we propose an anonymous blockchain-based system for charging-connected electric vehicles that eliminates third-party platforms through blockchain technology and the establishment of a multi-party security system between electric vehicles and EVSPs. In our proposed system, digital certificates are obtained by completing distributed Public Key Infrastructure(distributed-PKI) identity registration,with the user registration kept separate from the verification process, which eliminates dependence on the EVSP for information security. In the verification process, we adopt smart contracts to solve problems associated with centralized verification and opaque services. Furthermore, we utilize zero-knowledge proof and ring-signature superposition to realize completely anonymous verification, which ensures undeniability and unforgeability with no detriment to anonymity. The evaluation results show that the user anonymity, information authenticity, and system security of our system fulfill the necessary requirements. | Shiyuan Xu Xue Chen Yunhua He | 2021 | Tsinghua Science and Technology2021，26，6： | 2 |
| 10 | A comparative study of health risk of potentially toxic metals in urban and suburban road dust in the most populated city of China显示文摘 | Guitao Shi Zhenlou Chen Chunjuan Bi Li Wang Jiyan Teng Yuansheng Li Shiyuan Xu | 2010 | Atmospheric Environment2010，，3： | 2 |
| 11 | Advanced Mueller matrix ellipsometry:Instrumentation and emerging applications显示文摘Mueller matrix ellipsometry(MME)provides the 4×4 Mueller matrix of a sample under test,which determines how the state of polarization is changed as light interacts with the sample.Due to the redundant information contained in the Mueller matrix,MME has gained more and more extensive applications in the characterization of surfaces,interfaces,thin films,and nanostructures.In addition,the instrumentation of MME has also achieved great developments since its advent in the 1970 s.In this paper,we will first review the basic principle as well as the common system layouts of MME for the full Mueller matrix measurement.Then,the basic procedure of ellipsometry data analysis is reviewed.After that,some new developments in MME in our lab for different applications are introduced,including the broadband MME,the high-resolution imaging MME,and the high-speed MME.Some emerging applications of the developed MMEs are also presented.Conclusions and perspectives of the advanced ellipsometry are finally drawn and discussed. | CHEN XiuGuo GU HongGang LIU JiaMin CHEN Chao LIU ShiYuan | 2022 | Science China(Technological Sciences)2022，65，9： | 2 |
| 12 | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy显示文摘Polyetheretherketone(PEEK)has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance.However,its biological inertness,poor osteoinduction,and weak antibacterial activity make the clinical applications in a dilemma.Inspired by the mussel adhesion mechanism,here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins(Mfps)-mimic peptide with clickable azido terminal.The peptide enables mussel-like adhesion on PEEK biomaterial surfaces,leaving azido groups for the further steps of biofunctionalizations.In this study,antimicrobial peptide(AMP)and osteogenic growth peptide(OGP)were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair.Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios,an optimal PEEK surface was finally obtained in this research,which could long-term inhibit bacterial growth,stabilize bone homeostasis and facilitate interfacial bone regeneration.In a word,this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants,in particular,achieving rational integration of multiple biofunctions to match clinical requirements. | Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng | 2022 | Bioactive Materials2022，7，2： | 2 |
| 13 | Core-shell latex containing fluorinated polymer rich in shell 显示文摘 | Shiyuan Chen Yanjun Chen | 2002 | J Appl Polymer Sci2002，85，6： | 1 |
| 14 | Electrospun chitosan-graft-poly,(-caprolactone)/poly,(-caprolactone) cationic nanofibrous mats as potential scaffolds for skin tissue engineering显示文摘 | Honglin Chen Jin Huang Jiahui Yu Shiyuan Liu Ping Gu | | 0，，： | 1 |
| 15 | Potentiallytoxic metal contamination of urban soils and roadside dust inShanghai,China显示文摘 | SHI Guitao? CHEN Zhenlou XU Shiyuan | 2008 | Environmental Pollution2008，156，2： | 1 |
| 16 | Preparation and Tribological Properties of Cu-doped Muscovite Composite Particles as Lubricant Additive显示文摘 | DU Pengfei CHEN Guoxu SONG Shiyuan ZHU Dachuan WU Jiang CHEN Peng CHEN Hanlin | 2017 | Chemical Research in Chinese Universities2017，33，3： | 1 |
| 17 | Core -shell latex containing fluorinated polymer rich in shell 显示文摘 | Cheng Shiyuan Chen Yanjun Chen ZhengGuo | 2002 | Journal of Applied Polymer Science2002，85，： | 1 |
| 18 | Estimation of the convergence order of rigorous coupled-wave analysis for OCD metrology显示文摘 | Ma Yuan Liu Shiyuan Chen Xiuguo | | 0，，： | 1 |
| 19 | Polymer Nanoeomposite Containing CdS-ZnS Core-Shell Particles: Optical Properties and Morphology显示文摘 | Lu Shiyuan Wu Meiling Chen Linlung | 2003 | Journal of Applied Physics2003，93，： | 1 |
| 20 | Ammonium acetate en- hances solvent production by Clostridium acetobutylicum E A 2018 using cassava as a fermentation medium显示文摘 | Gu Yang Hu Shiyuan Chen Jun | 2009 | J Ind Microbiol Bio- techno12009，36，9： | 1 |
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