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| 1 | 前列腺癌骨转移患者的临床特征和预后因素显示文摘本文为了研究前列腺癌骨转移患者的临床特征及相关预后因素。研究搜集1997--2009年间诊治的115例前列腺癌骨转移患者进行回顾性分析。对患者年龄、诊断原发灶时Gleason评分、诊断原发灶时临床分期、是否内分泌治疗、是否行去势术、原发灶是否放疗、骨转移灶数目、骨转移时PSA和ALP水平、有无周围器官侵犯、有无区域和非区域淋巴结转移、是否伴骨旁软组织侵犯及其他脏器转移进行单因素和多因素预后分析。生存率计算运用Kaplan.Meier法,单因素分析采用Logrank法,多因素分析采用Cox回归模型。结果发现随访率为100%,1、3、5年随访例数分别为103、79、55例。1、3、5年生存率分别为89.1%、60.9%、49.8%,中位生存期为48.5个月。单因素分析结果显示患者年龄(Z2=7.18,P=0.028)、诊断原发灶时Gleason评分(x2=8.58,P=0.014)、诊断原发灶时临床分期(x2=10.62,P=0.014)、骨转移灶数目(x2=6.87,P=0.009)、骨转移时ALP水平(2=8.95,P=0.011)、有无周围器官侵犯(x2=9.03,P=0.003)和有无非区域淋巴结转移(Z2=12.45,P=0.000)的生存率有差异,余各项无差异。Cox模型多因素分析显示骨转移时ALP水平(x2=4.077,P=0.020)、诊断原发灶时Gleason评分(x2=4.573,P=0.044)和是否有非区域淋巴结转移(x2=3.934,P=0.030)是影响预后的因素。骨转移时碱性磷酸酶水平、诊断原发灶时Glason评分和非区域淋巴结转移是独立预测因素,这些预后因素将有助于我们确定适当的放射治疗分割方式和治疗剂量。 | Jian He Zhao-Chong Zeng Ping Yang Bing Chen We Jiang Shi-Suo Du | 2012 | Asian Journal of Andrology2012，14，3： | 16 |
| 2 | Induction of cytotoxic T lymphocyte respones in vivo after immunotherapy with dendritic cells in patients with nasopharyngeal carcinoma显示文摘The aim of the present study was to determine the efficacy of immunotherapy with dendritic cells to elicit EBV-specific CTL-immunity in advanced cases of EBV-positive patients with nasopharyngeal carcinoma (NPC) and to determine the safety and toxicity of this preparation. Nine cases of histologically confirmed patients with NPC undergoing treatment with radiological therapy were enrolled in this study. Dendritic cells, generated in vitro from blood monocytes of patients were cultured and matured with cytokines and then infected with recombinant adenovirus vaccine containing EBV-latent membrane protein-2 (Ad-LMP2). On 9 days' cultivation of cells, the matured DCs were harvested, irradiated with Co and then injected intradermally to patients with NPC. The injections were performed 3 times totally. After immunization, the CTL responses were assayed by means of cytotoxicity and epitope-specific IFN-γproduction. The results of this trial showed that all patients could tolerate this kind of treatment without any side effect, during which marked increase of LMP2-specific CTL-responses could be demonstrated in 5 patients of this group. And the level of IgA/VCA antibody decreased in 8 of 9 patients, thus accounting for a better prognosis for these patients. All patients will be followed up for another one year. At least, the present work shows that intradermal vaccination with autologous DCs infected with recombinant Ad-LMP2 adenovirus is a safe procedure in NPC patients, in which this procedure can enhance the LMP2-specific CTL responses in patients. These data are encouraging to develop more effective vaccine strategies for the treatment of nasopharyngeal carcinoma. | JIAN MIN ZUO LING ZHOU ZHI JIAN CHEN DE RUI LI QI WANG JIONG YU CHEN ZHAN WANG SI-IU QING WE YI ZENG | 2006 | Journal of Microbiology and Immunology2006，4，1： | 7 |
| 3 | Estimates of Tuberculosis Mortality Rates in China Using the Disease Surveillance Point System,2004-2010显示文摘Objective To understand the current status and trends of tuberculosis mortality rates in China.Methods In 2010,161 National Disease Surveillance Points representing all 31 mainland provinces,municipalities,and autonomous regions of China collected tuberculosis mortality surveillance data,including age,sex,region,and type of tuberculosis(all,pulmonary,and extra-pulmonary).The mortality rates of the three types of tuberculosis were compared between 2004 and 2010.Results In 2010,the mortality rates due to all tuberculosis,pulmonary tuberculosis,and extra-pulmonary tuberculosis were 4.69(95% Cl 4.54-4.84),4.38(4.23-4.52),and 0.31(0.27-0.35) per 100 000 population,respectively.Mortality rates due to all tuberculosis and pulmonary tuberculosis were higher in males,the elderly,and those living in western and rural areas.From 2004 to 2010,the mortality rates due to all tuberculosis and pulmonary tuberculosis decreased by 36.02% and 37.70%,respectively,with an average annual rate of decline of 7.20% and 7.61%,respectively.Conclusion Mortality rates due to tuberculosis have declined rapidly in China.The target of reducing the 1990 mortality rate by 50% by 2015 has already been achieved.However,the tuberculosis control program should pay more attention to high-risk groups,including the elderly and those living in underdeveloped areas. | ZHANG Hui HUANG Fei CHEN We DU Xin ZHOU Mai Geng HU Jia WANG Li Xia | 2012 | Biomedical and Environmental Sciences2012，25，4： | 7 |
| 4 | Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata显示文摘调查水的效果可溶乙醇的 降水部分( AC-1 )和从 Antrodia camphorata 的碱的抽取等电位的 降水部分( AC-2 )( Polyporaceae , Aphyllophorales )在 lipopolysaccharide ( LPS )上在 mousemacrophages.Methods 的 -in-duced 基因激活: AC-1 和 AC-2 部分被准备,并且他们 导致LPS 的 geneexpression 上的效果被西方的弄污和 RT-PCR.Results 监视:我们的结果显示了那 AC-2 ,( 50-200 mg/L ) butnot AC-1 dose-dependently | Yen-ying WE Chin-chu CHEN Chamg-cherng CHYAU Sin-yi CHUNG Yi-wen LIU | 2007 | Acta Pharmacologica Sinica2007，28，2： | 5 |
| 5 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | 2013 (9881)2013，，9881： | 2 |
| 6 | Video Sequence-Based Iris Recognition Inspired by Human Cognition Manner显示文摘 | Yuanning Liu | 2014 | Journal of Bionic Engineering2014，11，3： | 2 |
| 7 | Blunt splenic injury: Operation versus angiographic embolization显示文摘 | Wahl WE Ahms KS Chen S | 2004 | Surgery2004，136，89： | 1 |
| 8 | Wild-type-like viral replication potential of human immunodeficiency virus type 1 envelope mutants lacking palmitoylation signals显示文摘 | Chan WE Lin HH Chen SS | 2005 | J Virol2005，79，13： | 1 |
| 9 | Increased atrial and brain natriuretic peptides in adults with cyanotic: congenital heart disease 显示文摘 | Hopkins WE Chen Z Fukagawa NK | 2004 | Circulation2004，109，23： | 1 |
| 10 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 11 | Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor显示文摘 | Chen Y Nakanishi K | 2000 | Kidney Int2000，57，1： | 1 |
| 12 | A meta-analysis of epidemiological studies in depression of older people in the People,s Republic of China显示文摘 | Chen R Copeland JR We L | 1999 | Int J Geriatr Psychiaty1999，14，10： | 1 |
| 13 | Optimization of blood oxygenation level-dependent sensitivity in magnetic resonance imaging using intermolecular double-quantum coherence显示文摘 | Zhong JH Chen Z Kwok WE | 2002 | J Magn Reson Imaging2002，16，6： | 1 |
| 14 | Overexpression ofβIII-tubulin and survivin associated with drug resistance to docetaxel-based chemotherapy in advanced gastric Cancer显示文摘 | Zheng WE Chen H Yuan SF | | 0，，02： | 1 |
| 15 | The viscosity reduction of nano-keggin-K3PMo1204oin catalytic aquathermolysis of heavy oil显示文摘 | CHEN Y WANG Y LU J WE C | 2009 | Fuel2009，88，8： | 1 |
| 16 | Increased atrial and brain natriuretic peptides in adults with cyanotic congestive heart disease:enhanced understanding of the relationship between hypoxia and natriuretic peptide secretion显示文摘 | Hopkins WE Chen Z Fukagawa NK | 2004 | Circulation2004，109，： | 1 |
| 17 | Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis 显示文摘 | Chen J Tan KP Ward WE | 2003 | Exp Biol Med2003，228，8： | 1 |
| 18 | Brain abscess and necrotic brain tumors: discrimination with proton MR spectroscopy and diffusion-weighted imaging显示文摘 | Lai PH Ho JT Chen WE | 2002 | AJNR Am J Neuroradiol2002，23，： | 1 |
| 19 | Transforming growth factor-β1 connective tissue growth factor axis in the kidney显示文摘 | QI WE CHEN XM PORONNIK P | 2008 | Int J Biochem Cell Biol2008，40，1： | 1 |
| 20 | Characteristics of Carbon Nitride Films Prepared by Magnetic Filtered Plasma Stream显示文摘 | WE A X CHEN D H KE N | 1998 | Thin Solid Films1998，323，： | 1 |
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