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| 1 | Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing显示文摘A patch with the capability of avoiding wound infection and promoting tissue remolding is of great value for wound healing.In this paper,we develop a biomass chitosan microneedle array(CSMNA)patch integrated with smart responsive drug delivery for promoting wound healing.Chitosan possesses many outstanding features such as the natural antibacterial property and has been widely utilized for wound healing.Besides,the microstructure of microneedles enables the effective delivery of loaded drugs into the target area and avoids the excessive adhesion between the skin and the patch.Also,vascular endothelial growth factor(VEGF)is encapsulated in the micropores of CSMNA by temperature sensitive hydrogel.Therefore,the smart release of the drugs can be controllably realized via the temperature rising induced by the inflammation response at the site of wounds.It is demonstrated that the biomass CSMNA patch can promote inflammatory inhibition,collagen deposition,angiogenesis,and tissue regeneration during the wound closure.Thus,this versatile CSMNA patch is potentially valuable for wound healing in clinical applications. | Junjie Chi Xiaoxuan Zhang Canwen Chen Changmin Shao Yuanjin Zhao Yongan Wang | 2020 | Bioactive Materials2020，5，2： | 25 |
| 2 | Responsive and self-healing structural color supramolecular hydrogel patch for diabetic wound treatment显示文摘The treatment of diabetic wounds remains a great challenge for medical community.Here,we present a novel structural color supramolecular hydrogel patch for diabetic wound treatment.This hydrogel patch was created by using N-acryloyl glycinamide(NAGA)and 1-vinyl-1,2,4-triazole(VTZ)mixed supramolecular hydrogel as the inverse opal scaffold,and temperature responsive poly(N-isopropylacrylamide)(PNIPAM)hydrogel loaded with vascular endothelial cell growth factor(VEGF)as a filler.Supramolecular hydrogel renders hydrogel patch with superior mechanical properties,in which NAGA and VTZ also provide self-healing and antibacterial properties,respectively.Besides,as the existence of PNIPAM,the hydrogel patch was endowed with thermal-responsiveness property,which could release actives in response to temperature stimulus.Given these excellent performances,we have demonstrated that the supramolecular hydrogel patch could significantly enhance the wound healing process in diabetes rats by downregulating the expression of inflammatory factors,promoting collagen deposition and angiogenesis.Attractively,due to responsive optical property of inverse opal scaffold,the hydrogel patch could display color-sensing behavior that was suitable for the wound monitoring and management as well as guidance of clinical treatment.These distinctive features indicate that the presented hydrogel patches have huge potential values in biomedical fields. | Canwen Chen Yu Wang Han Zhang Hui Zhang Weiliang Dong Weijian Sun Yuanjin Zhao | 2022 | Bioactive Materials2022，7，9： | 2 |
| 3 | Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1α/VP16 Hybrid Transcription Factor显示文摘 | Karen A. Vincent Kou-Gi Shyu Yuxia Luo Meredith Magner Rene A. Tio Canwen Jiang Mark A. Goldberg Geoffrey Y. Akita Richard J. Gregory Jeffrey M. Isner | 2000 | Circulation: Journal of the American Heart Association2000，，18： | 1 |
| 4 | The developing condition analysis of semiconductor laser frequency stabilization technology显示文摘The frequency stability of free-running semiconductor lasers is influenced by several factors, such as driving current and external operating environment. The frequency stabilization of laser has become an international research hotspot in recent years. This paper reviews active frequency stabilization technologies of laser diodes and elaborates their principles. Based on differences of frequency discrimination curves, these active frequency stabilization technologies are classified into three major types, which are harmonic frequency stabilization,Pound-Drever-Hall(PDH) technology and curve subtraction frequency stabilization. Further, merits and demerits of each technology are compared from aspects of frequency stability and structure complexity. Finally, prospects of frequency stabilization technologies of semiconductor lasers are discussed in detail. Combining several of these methods are future trends, especially the combination of frequency stabilization of F–P cavity. And PID electronic control for optimizing the servo system is generally added in the methods mentioned above. | Yijun Yao Canwen Zou Haiyang Yu Jinjin Guo Yaming Li Jianguo Liu | 2018 | Journal of Semiconductors2018，39，11： | 1 |
| 5 | Cardiovascular protection by estrogen-a calcium antagnist effect?显示文摘 | Peper C Giuseppe MC Canwen J | 1993 | Lancet1993，341，： | 1 |
| 6 | Cardiovascular protection by oestrogen - a calicium amagnist effect? 显示文摘 | Petter C Giuseppe MC Canwen J | 1993 | Lancet1993，341，： | 1 |
| 7 | Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia-Inducible Factor 1显示文摘 | Louis X. Liu Hsienwie Lu Yuxia Luo Taro Date Adam J. Belanger Karen A. Vincent Geoffrey Y. Akita Mark Goldberg Seng H. Cheng Richard J. Gregory Canwen Jiang | 2002 | Biochemical and Biophysical Research Communications2002，，4： | 1 |
| 8 | Development of amulti-channel readout electronics verification system for MWDC detectors显示文摘Background The Multi-Wire Drift Chamber(MWDC)is among the significant detectors for CSR External Target Experiment(CEE).We require the MWDC detector’s front-end readout circuits to have a high integration,high count rate,and big dynamic range in order to measure the tracks of fore-angle products.Purpose In this paper,MWDC readout electronics verification system is shown,which is based on the front-end amplifier chip and Switched Capacitor Array(SCA)chip independently established by the project team.Results In the dynamic input range of 14 fC–950 fC,the readout electronics’energy measurement linearity is greater than 1%.The test results with MWDC illustrate that with a 55Fe source an energy resolution of 22.4%was acquired,and with cosmic rays the residual error is less than 400um. | Jiapeng Xu Canwen Liu Tianlei Pu Wei Liu Junwei Yan Zhi Qin Feng Li Zhi Deng Yi Qian Jie Kong | 2022 | Radiation Detection Technology and Methods2022，6，3： | 0 |
| 9 | Antioxidant defense mechanisms and fatty acid catabolism in Red-billed Leiothrix(Leiothrix lutea)exposed to high temperatures显示文摘Extreme hot weather is occurring more frequently due to global warming,posing a significant threat to species survival.Birds in particular are more likely to overheat in hot weather because they have a higher body temperature.This study used a heat stress model to investigate the antioxidant defense mechanisms and changes in fatty acid catabolism in Red-billed Leiothrix(Leiothrix lutea)to gain an understanding of how birds adapt to high temperatures.The birds were divided into five groups:a control group(30℃for 0 days),1 D group(40℃for 1 day),3 D group(40℃for 3 days),14 D group(40℃for 14 days)and recovery group(40℃for 14 days,then 30℃for 14 days).Our results indicated that when Red-billed Leiothrix are subjected to heat stress,malondialdehyde(MDA)content in the liver significantly increased,as did the enzyme activities of catalase(CAT),glutathione-SH-peroxidase(GSH-PX)and total antioxidant capacity(T-AOC)in the liver.Furthermore,there was a significant increase in heat shock protein 70(HSP70)expression in the liver,while avian uncoupling protein(avUCP)expression in muscle was significantly reduced.Additionally,there was a significant reduction in fatty acid catabolism enzyme activity such as 3-hydroxyacyl-CoAdehydrogenase(HOAD)activity in the heart,and carnitine palmitoyl transferase 1(CPT-1)and citrate synthase(CS)activity in the heart and liver.Furthermore,fatty acid translocase(FAT/CD36)in the heart,heart-type fatty acid binding protein(H-FABP)and fatty acid binding protein(FABP-pm)in the liver and heart were also significantly decreased.These changes reverted after treatment,but not to the same level as the control group.Our results indicated that when Red-billed Leiothrix are exposed to heat stress their internal antioxidant defense system is activated to counteract the damage caused by high temperatures.However,even with high antioxidant levels,prolonged high temperature exposure still caused some degree of oxidative damage possibly requiring a longer recovery time.Additionally,Red-billed Leiothrix may be able to resist heat stress by reducing fatty acid transport and catabolism. | Ruiping Xu Canwen Yu Liyao Mao Mengchen Jiang Luyao Gao Ming Li Jinsong Liu | 2022 | Avian Research2022，13，1： | 0 |
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