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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Isolation and culture of hepatic stellate cells from mouse liver显示文摘肝的星形的房间(HSC ) 是在肝以内的主要细胞外的生产矩阵的房间并且有众多的 vitalfunctions。为 HSC 的隔离和文化的一个柔韧的协议是重要的因为房间 functionsand 的进一步的调查在肝疾病联系了机制。鼠标肝的卷比老鼠肝的小得多,哪个对更困难的 makesit 比老鼠 HSC 孤立鼠标 HSC (mHSCs ) 。目前,孤立 mHSCs 仍然是挑战 becausethere 不是有效、柔韧的方法孤立并且文化这些房间。在现在的学习, C57BL/6J 老鼠是有包含 liposome 的 dichloromethylene diphosphate (CL2MDP ) 的 intravenouslyinjected 有选择地从 theliver 消除 Kupffer 房间。老鼠肝然后在 situ 被酒,并且 mHSCs 与一种优化密度坡度 centrifugation 技术被孤立。在磷酸盐缓冲区答案(PBS )-liposome 组, mHSCs 的收益是(1. | Wenj u Chang Mengxuan Yang Lujun Song Kuntang Shen Hongshan Wang Xiaodong Gao Min Li Weixin Niu Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 6 |
| 3 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 4 | Numerical treatment of diffusion coefficient at interfaces显示文摘 | Chang K C Payne U J | 1992 | Numerical Heat Transfer:Part A1992，21，： | 1 |
| 5 | Safety and accuracy of bedside external ventricular drain placement 显示文摘 | Kakarla U K Kim L J Chang S W | 2008 | Neurosurgery2008，63，11： | 1 |
| 6 | Molecular mechanism underlying the suppression of lipid oxidation during endotoxemia 显示文摘 | Maitra U Chang S Singh N | 2009 | Mol Immu- nol2009，47，23： | 1 |
| 7 | poly(lactic acid) nanocomposites: Comparison of their properties with montmorillonite and synthetic mica (Ⅱ) 显示文摘 | CHANG J H AN Y U CHO D H | 2003 | Polymer2003，44，13： | 1 |
| 8 | Ganoderiol F,a ganoderma triterpene,induces senescence in hepatoma HepG2 cells显示文摘 | CHANG U M LI C H LIN L I | 2006 | Life Sci2006，79，12： | 1 |
| 9 | Akt decreases lymphocyte apoptosis and improves survival in sepsis显示文摘 | Bommhardt U Chang KC Swanson PE | 2004 | J Immunol2004，172，12： | 1 |
| 10 | Poly(butylene terephthalate)/organo clay nanocomposites prepared by in-situ interlayer polymerization and its fiber (Ⅱ)显示文摘 | Chang J H Ana Y U Kim S J | 2003 | Polymer2003，44，19： | 1 |
| 11 | Efficient Video Indexing Scheme for Content-based Retrieval显示文摘 | Chang Hyun-sung Sull S Lee S U | 1999 | IEEE Transactions on Circuits and Systems for Video Technology1999，9，8： | 1 |
| 12 | Evolution of the felinesubgroup parvoviruses and the control of canine host range in vivo 显示文摘 | Tmyen U Gruenberg A Chang S F | 1995 | J Virol1995，69，： | 1 |
| 13 | The disulfidefolding pathway of human epidermal growth factor 显示文摘 | Chang JY Schindler P Ramseier U Lai PH | 1995 | J BiolChem1995，270，16： | 1 |
| 14 | Additional pain relieving effect of in- traoperative periarticular injections after simultaneous bilateral TKA: a randomized, controlled study显示文摘 | Koh U Kang YG Chang CB | 2010 | Knee Surg Sports Traumatol Ar- throsc2010，18，7： | 1 |
| 15 | Efficient video indexing scheme for content-based retrieval 显示文摘 | Chang H S Sull S Lee S U | 1999 | IEEE Trans on Circuits and Systems for Video Technology1999，9，8： | 1 |
| 16 | Intracranial meningeal hemangiopericytoma:the role of radiotherapy:report of 29 cases and review of the literature显示文摘 | Soyuer S Chang EL Selek U | 2004 | Cancer2004，100，7： | 1 |
| 17 | Face recognition robust to left/right shadows facial symmetry显示文摘 | Song Y J Kim Y G Chang U D | 2006 | Pattern Recognition2006，39，： | 1 |
| 18 | The influence of polyvinyl alcohol(PVA)characteristics on the physical stability of encapsulated immobilization media for advanced wastewater treatment显示文摘 | Chang I S Kim C I Nam B U | 2005 | Process Biochemistry2005，40，9： | 1 |
| 19 | Low-dose endotoxin induces inflammation by selectively removing nuclear receptors and activa- ting CCAAT/enhancer-binding protein 8 显示文摘 | Maitra U Gan L Chang S | 2011 | J Immunol2011，186，7： | 1 |
| 20 | Cooling precipitation and strengthening study in powder metallurgy superalloy Rene88DT显示文摘 | MAO Jian CHANG Keh-minn YANG Wan-hong Furrer D U Ray K Vaze S P Furrer D U | 2002 | Materials Science and Engineering: A2002，332，12： | 1 |
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