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| 1 | Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells显示文摘Diffuse intrinsic pontine glioma(DIPG) is the main cause of brain tumor-related death among children.Until now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical strategy for preclinical cancer research is to find out the molecular differences between tumor tissue and para-tumor normal tissue, in order to identify potential therapeutic targets. Unfortunately, it is impossible to obtain normal tissue for DIPG because of the vital functions of the pons.Here we report the human fetal hindbrain-derived neural progenitor cells(pontine progenitor cells, PPCs) as normal control cells for DIPG. The PPCs not only harbored similar cell biological and molecular signatures as DIPG glioma stem cells, but also had the potential to be immortalized by the DIPG-specific mutation H3 K27 M in vitro. These findings provide researchers with a candidate normal control and a potential medicine carrier for preclinical research on DIPG. | Yu Sun Cheng Xu Changcun Pan Xin Chen Yibo Geng Yuliang Wu Peng Zhang Wenhao Wu Yu Wang Deling Li Zhen Wu Junting Zhang Qiaoran Xi Liwei Zhang | 2019 | Neuroscience Bulletin2019，35，2： | 2 |
| 2 | Akt1/protein Kinase Bα is Involved in Gastric Cancer Progression and Cell Proliferation显示文摘 | Zheyi Han Kaichun Wu Huiqin Shen Chunying Li Shuang Han Liu Hong Yongquan Shi Na Liu Changcun Guo Yan Xue Taidong Qiao Daiming Fan | 2008 | Digestive Diseases and Sciences2008，，7： | 1 |
| 3 | An SO(3) picture for quantum searching 显示文摘 | LONG Guilu TU Changcun LI Yansong | 2001 | J Phys A: Math Gen2001，34，： | 1 |
| 4 | Involvement of MGr1-Ag/37LRP in the vincristine-induced HIF-1 expression in gastric cancer cells显示文摘 | Lili Liu Xiaoxuan Ning Li Sun Yongquan Shi Shuang Han Changcun Guo Yu Chen Shiren Sun Fang Yin Kaichun Wu Daiming Fan | 2007 | Molecular and Cellular Biochemistry2007，，： | 1 |
| 5 | Vegetation and Community Changes of Elm (Ulmus pumila) Woodlands in Northeastern China in 1983-2011显示文摘Elm (Ulmus pumila), widely distributed in the north temperate zone, contributes to a special savanna-like woodland in typical grassland region in the northeastern China. This woodland performs a variety of ecological functions and environmental significance, such as decreasing soil erosion, stabilizing sand dunes, preserving species diversity. However, in the last approximate 30 years, the species composition, productivity and distribution area of elm woodland has decreased severely. A series of studies have been carried out to find out whether the climate changes or human disturbances caused the degradation of elm woodland and how these factors affected elm woodland. In this study, undisturbed, plowing and grazing elm woodland were investigated in 1983 and 2011 by using Point-Centered Quarter method. The relationship between vegetation changes and environmental factors was analyzed by Bray-Curtis ordination. The results show that in 2011, species diversity and understory productivity of undisturbed elm woodland decrease slightly compared to those of undisturbed elm woodland in 1983. However, nearly 60% of the species is lost in the plowing and grazing elm woodland relative to the species undisturbed elm woodland in 1983. Interestingly, plowing stimulates the growth of elm and certain understory species through furrowing soil and accelerating soil nutrient turnover rate. Grazing disturbance not only leads to species loss and productivity decrease, but also induces changes in elm growth (small, short and twisted). The mean age of the elm was 29±2 yr in undisturbed and plowing elm woodland, while only 15 yr in the grazing elm woodland. The results of Bray-Curtis ordination analysis show that all sample stands clustered to three groups: Group I including the undisturbed sample stands of 83UE (undisturbed elm woodland in 1983) and 11UE (undisturbed elm woodland in 2011); Group II including sample stands of PE (elm woodland disturbed by plowing); Group III including samples stands of GE (elm woodland disturbed by grazing). The results indicate that the long time disturbance of the plowing and grazing have converted elm woodland to different community types. Climate change is not the primary reason causing the degradation of elm woodland, but plowing and grazing disturbance. Both plowing and grazing decrease the vegetation composition and species diversity. Grazing further decreases vegetation productivity and inhibits the growth of elm tree. Therefore, we suggest that reasonable plowing and exclusive grazing would be favorable for future regeneration of degraded elm woodland. | LIU Li WANG He LIN Changcun WANG Deli | 2013 | Chinese Geographical Science2013，23，3： | 1 |
| 6 | Research Article Core/hybrid-shell structures boost thermoelectric performance of flexible inorganic/organic nanowire films显示文摘Interface control in inorganic/organic composites has always been regarded as one of the effective means to optimize their thermoelectric(TE)performance,and the past few years have witnessed its development,including carrier-energy filtering and phonon scattering.However,the energy barrier created by the band alignment at the composite interface depends on the Fermi level difference between the organic and inorganic components,which is difficult to be controlled by the common means.Herein,a core/hybrid-shell strategy aiming for efficient interface control is proposed to tune the energy barrier of the inorganic/organic core/shell nanowire interface.The Fermi level of hybrid-shell can be effectively controlled by separating the charge carriers compared to the single-shell composites.The energy barrier of the core/hybrid-shell interface is tuned to an appropriate position,and the energy filtering effect is utilized,resulting in a substantial improvement in power factor and reduction in thermal conductivity for the prepared core/hybrid-shell composites with good air-stability and flexibility.Moreover,both the flexible p type and p-n type TE devices based on the prepared core/hybrid-shell films yield excellent output properties with the maximum power densities of 41 and 45μW·cm^(−2)at a temperature difference of ca.30 K,respectively.This study provides a novel strategy to improve the TE performance of the inorganic/organic composites,displaying great potential for low-power wearable electronics. | Changcun Li Xiaoqi Lan Peipei Liu Jingkun Xu Qinglin Jiang Congcong Liu Cheng Liu Fengxing Jiang | 2023 | Nano Research2023，16，4： | 1 |
| 7 | Recent progress in the synthesis of novel two-dimensional van der Waals materials显示文摘The last decade has witnessed the significant progress of physical fundamental research and great success of practical application in two-dimensional(2D)van der Waals(vdW)materials since the discovery of graphene in 2004.To date,vdW materials is still a vibrant and fast-expanding field,where tremendous reports have been published covering topics from cutting-edge quantum technology to urgent green energy,and so on.Here,we briefly review the emerging hot physical topics and intriguing materials,such as 2D topological materials,piezoelectric materials,ferroelectric materials,magnetic materials and twistronic heterostructures.Then,various vdW material synthetic strategies are discussed in detail,concerning the growth mechanisms,preparation conditions and typical examples.Finally,prospects and further opportunities in the booming field of 2D materials are addressed. | Renji Bian Changcun Li Qing Liu Guiming Cao Qundong Fu Peng Meng Jiadong Zhou Fucai Liu Zheng Liu | 2022 | National Science Review2022，9，5： | 0 |
| 8 | Flexible Au micro-array electrode with atomic-scale Au thin film for enhanced ethanol oxidation reaction显示文摘The catalysis of Au thin film could be improved by fabrication of array structures in large area.In this work,nanoimprint lithography has been developed tofabricate flexible Au micro-array(MA)electrodes with~100%coverage.Advanced electron microscopy characterisations have directly visualised the atomic-scale three-dimensional(3D)nanostructures with a maximum depth of 6 atomic layers.In-situ observation unveils the crystal growth in the form of twinning.High double layer capacitance brings about large number of active sites on the Au thin film and has a logarithmic relationship with mesh grade.Electrochemistry testing shows that the Au MAs perform much better ethanol oxidation reaction than the planar sample;MAs with higher mesh grade have a greater active site utilisation ratio(ASUR),which is important to build electrochemical double layer for efficient charge transfer.Further improvement on ASUR is expected for greater electrocatalytic performance and potential application in direct ethanol fuel cell. | Xun Cao Dongdong Peng Cao Wu Yongmin He Chaojiang Li Bowei Zhang Changcun Han Junsheng Wu Zheng Liu Yizhong Huang | 2021 | Nano Research2021，14，1： | 0 |
| 9 | New Discovery of Neocalamites from the Upper Triassic Daheba Formation in West Qinling, Northwest China显示文摘Objective Neocalamites is a common plant fossil from the Triassic to the Middle Jurassic. Neocalamites fossils are commonly found in coal-bearing sedimentary rocks of Rhaetian stage from South China and the Yanchang Group from North China(Mei and Liu, 2017). Moreover, the fossils also distribute in the Late Triassic such as the Babaoshan Group in Dulan and Darigemole Group in Gangcha of Qinghai Province, the Haojiagou Formation in Turpan and the Taliqike Formation in Kuche of Xinjiang.Besides,Neocalamites fossils are also found in the Early and Middle Jurassic strata of North China. | LI Zuochen PEI Xianzhi WEI Liyong GUO Junfeng XIAO Liang LI Ruibao PEI Lei ZHAO Wenchuan WANG Meng CHEN Youxin LIU Chengjun ZHAO Shaowei GAO Feng SHAO Jiakun Qin Li ZHAO Changcun ZHANG Zhen | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 0 |
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