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| 1 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 2 | Correlations Between Single Nucleotide Polymorphisms,Cognitive Dysfunction,and Postmortem Brain Pathology in Alzheimer's Disease Among Han Chinese显示文摘In this study, the distribution of five Alzheimer's disease(AD)-related single nucleotide polymorphisms(SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs,clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College(CAMS/PUMC) Human Brain Bank.APOE ?4(OR = 4.482, P = 0.004), the RS2305421 GG genotype(adjusted OR = 4.397, P = 0.015), and the RS10498633 GT genotype(adjusted OR = 2.375,P = 0.028) were associated with a higher score on the ABC(Ab plaque score, Braak NFT stage, and CERAD neuritic plaque score) dementia scale. These results advance our understanding of the pathogenesis of AD,the relationship between pathological diagnosis and clinical diagnosis, and the SNPs in the Han population for future research. | Qian Yang Kang Chen Hanlin Zhang Wanying Zhang Changlin Gong Qing Zhang Pan Liu Tianyi Sun Yuanyuan Xu Xiaojing Qian Wenying Qiu Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 5 |
| 3 | KINETICS OF GOLD LEACHING FROM SULFIDE GOLD CONCENTRATES WITH THIOSULFATE SOLUTION显示文摘The reaction process for leaching gold from sulfide gold concentrates containing copperwith ammonia-ammonium thiosulfate solution containing copper(Ⅱ)can be divided into initialstage and later stage of reaction.Initial stage of reaction is controlled by interface reaction.Lat-er stage of reaction is controlled by diffusion process of reaction through solid products layer.Whole leaching process is under the control of corrosion reaction of pyrite bearing gold.Actionof ammonium sulfate in the system is probably as follows:(1)NH4+ and NH3 forms a buffer so-lution;(2)SO42-ion inhibites the oxidation and decomposition of S2O32-ion.Cu2+ion in thesystem acts as an oxidant and oxygen makes the Cu2-regenerate. | Gong,Qian Hu,Jiexue Cao,Changlin Institute of Chemical Metallurgy,Academia Sinica,Beijing 100080,China | 1993 | 中国有色金属学会会刊:英文版1993，3，4： | 3 |
| 4 | OXIDATION OF GALENA IN AMMONIUM CARBONATE SOLUTION AND APPLIED REACTOR显示文摘OXIDATIONOFGALENAINAMMONIUMCARBONATESOLUTIONANDAPPLIEDREACTOR￥Gong,Qian;Gong,Yajun;Cao,Changlin;Lu,Keyuan(InstituteofChemical... | Gong, Qian Gong, Yajun Cao, Changlin Lu, Keyuan(Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing 100080) | 1995 | 中国有色金属学会会刊:英文版1995，5，3： | 2 |
| 5 | Distribution characteristics and source tracing of petroleum hydrocarbons in the northeastern South China Sea显示文摘In recent years,oil spills caused by human activities have occurred frequently,and the resultant oil pollution has received extensive attention worldwide.In this paper,a total of 50 water samples were collected from the northeastern part of the South China Sea,and total petroleum hydrocarbons(TPHs)and n-alkane content in the samples were analyzed by gas chromatography-flame ionization detector(GC-FID)technology.The petroleum hydrocarbon characteristic indices,such as carbon predominance index(CPI)and terrigenous/aquatic ratio(TAR),were calculated to trace the source of petroleum hydrocarbons.The measured value of TPHs ranged from 121.31-603.02μg/L.For surface waters,the TPHs in the no rthern coastal waters and the central waters were higher than that in the far shore.For ve rtical waters,the TPHs sharply decreased at first,and then increased slowly and finally reached a steady state.The n-alkanes in the water samples were concentrated in C10-C38,and they were mainly from terrestrial higher plant.The waters in the near shore,mid-layer and deep sea showed a strong reducing terrestrial characteristic,while the surface waters in the open sea showed an obvious oxidizing endogenous characteristic. | Shengying Gong Wenhu Liu Yazhuo Li Jibiao Zhang Changlin Chen Jie Fu | 2020 | Chinese Chemical Letters2020，31，10： | 1 |
| 6 | Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response显示文摘FANCM/FAAP24 heterodimer 在保护房间免受象 interstrand 交叉连接那样的复杂 DNA 损害的伤害有不同功能。这些功能依靠 FANCM/FAAP24 的生物化学的活动认出并且绑在损坏 DNA 或阻止的复制叉。然而,这建筑群的 DNA 有约束力的活动清楚地没被定义。我们调查了 FAAP24 怎么由获得人的 FAAP24 的 N 终端和 C 终端解决方案结构贡献 FANCM/FAAP24 建筑群的交往 DNA 函数。FAAP24 结构当模特儿显示 FAAP24 可以向搁浅单人赛的 DNA (ssDNA ) 拥有一种高亲密关系。在 vitro 并且在 vivo 各种各样的 FAAP24 变化测试验证了从结构的分析导出的这预言。我们发现 DNA 有约束力并且尽管两个要求 C 终端(HhH )2 领域, FAAP24 的交往 FANCM 功能能被 segregation-of-function 变化区分。这些结果证明在 DNA 的 FAAP24 的双角色对 crosslinking 损害损坏反应,通过经由它的 ssDNA 有约束力的活动的 FANCM/FAAP24 heterodimer 和其它的形成的在优化检查点激活要求了。 | Yucai Wang Xiao Han Fangming Wu Justin W Leung Megan G Lowery Huong Do Junjie Chen Chaowei Shi Changlin Tian Lei Li Weimin Gong | 2013 | Cell Research2013，23，10： | 1 |
| 7 | LEACHING GOLD BY LOW CONCENTRATION THIOSULFATE SOLUTION显示文摘The effects of the concentrations of thiosulfate,copper and ammonia on the extraction of gold from sulfide gold concentrate have been studied.The results show that it is possible to reduce thiosulfate concentration.More than 95%of the gold could be extracted by a 0.2 mol/L thiosulfate leaching solution in two hours under suitable conditions.Therefore,the process of washing the residue was simplified,and the consumption and loss of thiosulfate carried by the washing residue were reduced. | Cao Changlin Hu Jiexue Gong Qian | 1992 | Transactions of Nonferrous Metals Society of China1992，2，4： | 0 |
| 8 | Allosteric conformational changes of G proteins upon its interaction with membrane and GPCR显示文摘Current resolved structures of GPCRs and G protein complexes provided important insights into G protein activation. However, the binding or dissociation of GPCRs with G protein is instantaneous and highly dynamic in the intracellular environment. The conformational dynamic of G protein still needs to be addressed. In this study, we applied ^(19)F solution NMR spectroscopy to monitor the conformational changes of G protein upon interact with detergent mimicking membrane and receptor. Our results show that there are two states equilibria in the G_(α)in apo states. The interaction of G_(α)with detergents will accelerate this conformational transformation and induce a state that tends to bind to GPCRs. Finally, the G_(α)proteins presented a fully activation state when they coupled to GPCRs. | Longmei Li Jin Zhang Wenjing Sun Weimin Gong Changlin Tian Pan Shi Chaowei Shi | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
| 9 | A direct spino-cortical circuit bypassing the thalamus modulates nociception显示文摘Nociceptive signals are usually transmitted to layer 4 neurons in somatosensory cortex via the spinothalamic-thalamocortical pathway.The layer 5 corticospinal neurons in sensorimotor cortex are reported to receive the output of neurons in superficial layers;and their descending axons innervate the spinal cord to regulate basic sensorimotor functions.Here,we show that a subset of layer 5 neurons receives spinal inputs through a direct spino-cortical circuit bypassing the thalamus,and thus define these neurons as spino-cortical recipient neurons(SCRNs).Morphological studies revealed that the branches from spinal ascending axons formed a kind of disciform structure with the descending axons from SCRNs in the basilar pontine nucleus(BPN).Electron microscopy and calcium imaging further confirmed that the axon terminals from spinal ascending neurons and SCRNs made functional synaptic contacts in the BPN,linking the ascending sensory pathway to the descending motor control pathway.Furthermore,behavioral tests indicated that the spino-cortical connection in the BPN was involved in nociceptive responses.In vivo calcium imaging showed that SCRNs responded to peripheral noxious stimuli faster than neighboring layer 4 cortical neurons in awake mice.Manipulating activities of SCRNs could modulate nociceptive behaviors.Therefore,this direct spino-cortical circuit represents a noncanonical pathway,allowing a fast sensory-motor transition of the brain in response to noxious stimuli. | Bing Cai Dan Wu Hong Xie Yan Chen Huadong Wang Sen Jin Yuran Song Anan Li Shiqi Huang Sashuang Wang Yingjin Lu Lan Bao Fuqiang Xu Hui Gong Changlin Li Xu Zhang | 2023 | Cell Research2023，33，10： | 0 |
| 10 | Recent advances in chemical protein synthesis:method developments and biological applications显示文摘The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and versatility.Chemical protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image proteins.This review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic methods.Furthermore,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse proteins.Recent applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further discussed.Together,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis. | Suwei Dong Ji-Shen Zheng Yiming Li Huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun Guo Chunmao He Honggang Hu Xuechen Li Yanmei Li Zigang Li Man Pan Shan Tang Changlin Tian Ping Wang Bian Wu Chuanliu Wu Junfeng Zhao Lei Liu | 2024 | Science China Chemistry2024，67，4： | 0 |
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