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| 1 | Mechanism of the December 2015 Catastrophic Landslide at the Shenzhen Landfill and Controlling Geotechnical Risks of Urbanization显示文摘 | Yueping Yin Bin Li Wenpei Wang Liangtong Zhan Qiang Xue Yang Gao Nan Zhang Hongqi Chen Tiankui Liu Aiguo Li | 2016 | Engineering2016，2，2： | 64 |
| 2 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 3 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 4 | Exosome-encapsulated miR-505 from ox-LDL-treated vascular endothelial cells aggravates atherosclerosis by inducing NET formation显示文摘Neutrophil extracellular traps(NETs)play an important role in the pathological process of atherosclerosis(AS).This study aims to evaluate whether exosomes from oxidized low-density lipoprotein(ox-LDL)-treated vascular endothelial cells(VECs)aggravate AS by inducing NET formation.Exosomes from the peripheral blood of healthy donors and AS patients(namely NC-EXO and AS-EXO,respectively)and exosomes from human umbilical vein endothelial cells(HUVECs)treated without or with ox-LDL(namely normal EXO and ox-LDL-EXO,respectively)were isolated,identified,and co-cultured with neutrophils from peripheral blood of healthy donors.NET formation was evaluated by immunofluorescence staining and determining the content of cell-free DNA and myeloperoxidase-DNA complex.Dual-luciferase reporter assay,chromatin immunoprecipitation assay,quantitative reverse transcription polymerase chain reaction,and western blot analysis were performed to explore the underlying mechanisms.We found that AS-EXO and ox-LDLEXO in duced NET release from n eutrophils.Meeh a nistically,ox-LDL treatment in HUVECs might activate the NF-κB pathway,which transcriptionally activates miR-505,and then the exosome-encapsulated high miR-505 expression targeted and inhibited SIRT3 in neutrophils,thereby inducing reactive oxygen species(ROS)level increase and NET release by neutrophils.Further in vivo experiments showed that ox-LDLEXO accelerated AS progression in AS mice.In summary,exosome-encapsulated miR-505 from ox-LDLtreated VECs aggravates AS by inducing NET formation. | Li Chen Liqun Hu Qing Li Jian Ma Hongqi Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 11 |
| 5 | Mesenchymal stem cell-derived exosomal miR-21a-5p promotes M2 macrophage polarization and reduces macrophage infiltration to attenuate atherosclerosis显示文摘Atherosclerosis(AS)is the main pathological basis for ischemic cardiovascular and cerebrovascular diseases.Mesenchymal stem cell(MSC)-derived exosomes have the potential to alleviate AS,while the underlying mechanism remains unclear.Here,we aimed to investigate the mechanism of MSC-derived exosomes in AS.The AS mouse model was prepared by feeding ApoE–/–mice with high-fat diet.AS mice were administered with MSC-derived exosomes,and the atherosclerotic plaque area was analyzed by Oil Red O staining.Mouse RAW264.7 macrophages were incubated with MSC-derived exosomes.The macrophage infiltration,macrophage proportion,and cell migration were estimated by immunohistochemistry,flow cytometry,or Transwell assay.The relationship between miR-21a-5p and kruppel-like factor 6(KLF6)or extracellular signal-regulated protein kinases 2(ERK2)was verified by luciferase reporter assay.We found that MSC-derived exosomes promoted M2 polarization of macrophages and reduced plaque area and macrophage infiltration in AS mice.miR-21a-5p overexpression caused an increase of M2 macrophages in RAW264.7 cells and led to a decrease in migration of RAW264.7 cells.Moreover,both KLF6 and ERK2 are the targets of miR-21a-5p.MSC-derived exosomes containing miR-21a-5p promoted M2 polarization of RAW264.7 cells by suppressing KLF6 expression.MSC-derived exosomes containing miR-21a-5p inhibited migration of RAW264.7 cells through inhibiting the ERK1/2 signaling pathway.In conclusion,MSC-derived exosomes containing miR-21a-5p promote macrophage polarization and reduce macrophage infiltration by targeting KLF6 and ERK1/2 signaling pathways,thereby attenuating the development of AS.Thus,MSC-derived exosomes may be a promising treatment for AS. | Jian Ma Li Chen Xiang Zhu Qing Li Liqun Hu Hongqi Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 7 |
| 6 | Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics显示文摘Colorectal cancer(CRC), a malignant tumor worldwide consists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. Collectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for colon cancer immunotherapy. | Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo Cheng Xianjia Qi Yuxian Shen Qiang Xu Hongqi Chen Dijun Chen Yang Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 5 |
| 7 | Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells显示文摘 | Nengquan Sheng Li Yan Weiqiang You Gewen Tan Jianfeng Gong Hongqi Chen Yi Yang Landian Hu Zhigang Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 4 |
| 8 | MULTI-PARAMETER TIKHONOV REGULARIZATION FOR LINEAR ILL-POSED OPERATOR EQUATIONS显示文摘我们考虑解决线性提出病的操作员方程。基于多尺度的分解解决方案空格,我们为解决方程建议多参数规则化。我们为多参数规则化答案建立弱、强壮的集中定理。基于特徵函数分解,特别地,我们为与最佳的错误界限给一个规则化答案的多参数开发后验选择策略。多参数的几种实际选择被建议。我们也介绍数字实验示威外面在单个参数规则化上的经产妇米规则化的性能。 | Zhongying Chen Yao Lu Yuesheng Xu Hongqi Yang | 2008 | Journal of Computational Mathematics2008，26，1： | 4 |
| 9 | BURST-LDA: A NEW TOPIC MODEL FOR DETECTING BURSTY TOPICS FROM STREAM TEXT显示文摘Topic models such as Latent Dirichlet Allocation(LDA) have been successfully applied to many text mining tasks for extracting topics embedded in corpora. However, existing topic models generally cannot discover bursty topics that experience a sudden increase during a period of time. In this paper, we propose a new topic model named Burst-LDA, which simultaneously discovers topics and reveals their burstiness through explicitly modeling each topic's burst states with a first order Markov chain and using the chain to generate the topic proportion of documents in a Logistic Normal fashion. A Gibbs sampling algorithm is developed for the posterior inference of the proposed model. Experimental results on a news data set show our model can efficiently discover bursty topics, outperforming the state-of-the-art method. | Qi Xiang Huang Yu Chen Ziyan Liu Xiaoyan Tian Jing Huang Tinglei Wang Hongqi | 2014 | Journal of Electronics(China)2014，31，6： | 3 |
| 10 | A Text Similarity Measurement Based on Semantic Fingerprint of Characteristic Phrases显示文摘Text similarity measurements are the basis for measuring the degree of matching between two or more texts. Traditional large-scale similarity detection methods based on a digital fingerprint have the advantage of high detection speed, which are only suitable for accurate detection. We propose a method of Chinese text similarity measurement based on feature phrase semantics.Natural language processing(NLP) technology is used to pre-process text and extract the keywords by the Term frequency-Inverse document frequency(TF-IDF) model and further screen out the feature words. We get the exact meaning of a word and semantic similarities between words and a How Net semantic dictionary. We substitute concepts to get the feature phrases and generate a semantic fingerprint and calculate similarity. The experimental results indicate that the method proposed is superior in similarity detection in terms of its accuracy rate,recall rate, and F-value to the traditional and digital fingerprinting method. | PANG Shanchen YAO Jiamin LIU Ting ZHAO Hua CHEN Hongqi | 2020 | Chinese Journal of Electronics2020，29，2： | 3 |
| 11 | Tribological properties of M0S_(2) coating for ultra-long wear-life and low coefficient of friction combined with additive g-C3N4 in air显示文摘The solid lubricant M0S_(2) demonstrates excellent lubricating properties,but it spontaneously oxidizes and absorbs moisture in air,and thus results in poor wear resistance and short wear-life.In this study,the additive g-C_(3)N_(4)(CN)was successfully combined with M0S_(2) via hydrothermal synthesis as a solid lubricant for the first time.Meanwhile,a low friction coefficient(COF,y=0.031)and ultra-long wear-life of CN/M0S_(2) compared to pure M0S_(2) in air were demonstrated.The functional groups and good crystallinity of the lubricant material were characterized via Fourier transform infrared(FTIR)spectroscopy and X-ray diffraction(XRD).The formed valence states in CN/M0S_(2) were analyzed via X-ray photoelectron spectroscopy(XPS).The characterized results of the scanning electron microscopy(SEM)and high-resolution transmission electron microscopy(HRTEM)show the morphology and interior crystal phase structure of CN/M0S_(2).From the cross-section analysis,the presence of iron oxide nanoparticles lubricating film is synergistic with CN/M0S_(2) film during the friction process,resulting in its ultra-long wear-life.In particular,the friction mechanism of interlayer sliding friction combined with energy storage friction was analyzed and proposed. | Yupeng ZHANG Panpan LI Li JI Xiaohong LIU Hongqi WAN Lei CHEN Hongxuan LI Zhiiiang JIN | 2021 | Friction2021，9，4： | 3 |
| 12 | In situ TEM observation of magnetization-enhanced dislocation emission and motion for 60Fe40Ni alloy显示文摘TENSILE test for pure iron in the magnetic field with the intensity of 2 400 A/m indicated thatthe lower yield stress was decreased and the upper yield point disappeared in the magneticfield. This seems to show that magnetization can reduce the resistance of dislocation mo-tion. Up to now, however, direct proof of magnetization-enhanced dislocation emission andmotion is lacking. | LI Hongqi, WANG Yanbin, CHEN Qizhi CHU WuyangDepartment of Materials Physics, University of Science and Technology Beijing, Beijing 100083, China | 1997 | Chinese Science Bulletin1997，42，24： | 3 |
| 13 | Identification of the Quaternary low gas-saturation reservoirs in the Sanhu area of the Qaidam Basin,China显示文摘低煤气浸透的水库是煤气的忍受其煤气的浸透是不到 47% 的间隔。他们是普通的在在 Qaidam 盆的 Sanhu 区域第四级。由于复杂开始机制和特殊地质的特征,低煤气浸透的水库的记载的曲线被歧义和差异描绘,也就是没有重要木头反应特征。因此,在学习区域识别低煤气浸透的水库是特别地困难的。另外,传统的方法象在岩性学,电的性质,忍受性质的物理性质和气体之中使用关系那样,以及他们的阀值价值,不能有效地识别低 gassaturation 水库。解决这个问题,我们采用决定树,支持向量机器和建立低煤气浸透的水库的一个预兆的模型的不平的集合方法,它能够分类多维、模糊的数据的一个团。根据学习过程和学习结果的可理解性的透明性,预兆的模型被吸收实际水库特征也修订。实际应用显示预兆的模型在在学习区域识别低煤气浸透的水库是有效的。 | Li Xiongyan Li Hongqi Zhou Jinyu He Xu Chen Yihan Yu Hongyan | 2011 | Petroleum Science2011，8，1： | 2 |
| 14 | Representing Model Uncertainty by Multi-Stochastic Physics Approaches in the GRAPES Ensemble显示文摘To represent model uncertainties more comprehensively,a stochastically perturbed parameterization(SPP)scheme consisting of temporally and spatially varying perturbations of 18 parameters in the microphysics,convection,boundary layer,and surface layer parameterization schemes,as well as the stochastically perturbed parameterization tendencies(SPPT)scheme,and the stochastic kinetic energy backscatter(SKEB)scheme,is applied in the Global and Regional Assimilation and Prediction Enhanced System-Regional Ensemble Prediction System(GRAPES-REPS)to evaluate and compare the general performance of various combinations of multiple stochastic physics schemes.Six experiments are performed for a summer month(1-30 June 2015)over China and multiple verification metrics are used.The results show that:(1)All stochastic experiments outperform the control(CTL)experiment,and all combinations of stochastic parameterization schemes perform better than the single SPP scheme,indicating that stochastic methods can effectively improve the forecast skill,and combinations of multiple stochastic parameterization schemes can better represent model uncertainties;(2)The combination of all three stochastic physics schemes(SPP,SPPT,and SKEB)outperforms any other combination of two schemes in precipitation forecasting and surface and upper-air verification to better represent the model uncertainties and improve the forecast skill;(3)Combining SKEB with SPP and/or SPPT results in a notable increase in the spread and reduction in outliers for the upper-air wind speed.SKEB directly perturbs the wind field and therefore its addition will greatly impact the upper-air wind-speed fields,and it contributes most to the improvement in spread and outliers for wind;(4)The introduction of SPP has a positive added value,and does not lead to large changes in the evolution of the kinetic energy(KE)spectrum at any wavelength;(5)The introduction of SPPT and SKEB would cause a 5%-10%and 30%-80%change in the KE of mesoscale systems,and all three stochastic schemes(SPP,SPPT,and SKEB)mainly affect the KE of mesoscale systems.This study indicates the potential of combining multiple stochastic physics schemes and lays a foundation for the future development and design of regional and global ensembles. | Zhizhen XU Jing CHEN Zheng JIN Hongqi LI Fajing CHEN | 2020 | Advances in Atmospheric Sciences2020，37，4： | 2 |
| 15 | Recent progress in solar physics made during the program of 2008 August 1st solar total eclipse显示文摘The development of solar physics is presented from the program of 2008 total eclipse in China,including the presentations in the international workshop in this period and some observational results of the solar eclipse. | ZHANG HongQi ZHANG Mei LIN Jun CHEN PengFei FANG Cheng | 2010 | Chinese Science Bulletin2010，55，27： | 2 |
| 16 | Fault Diagnosis for Service Composition by Spiking Neural P Systems with Colored Spikes显示文摘A variety of web services have emerged with the rapid development of the Internet. These services are often of a single function. The value-added services can be achieved by combing with multiple services. The processing speed and stability of existing methods in service composition were not very well and seldom consider the fault diagnosis and handling methods for the service, which results in a greater probability of the service composition failure at run time. We use spiking neural P systems with colored spikes to model the fault of available service, component, and connector in the service composition. The proposed model can be used to locate a fault and handle it correctly when the service combination fails, the advantage of efficiency and stability of proposed method has been proved by comparing with the method of Petri net. | PANG Shanchen WANG Min QIAO Sibo WANG Xun CHEN Hongqi | 2019 | Chinese Journal of Electronics2019，28，5： | 2 |
| 17 | Nitrogen-doped Carbon Nanospheres-Modified Graphitic Carbon Nitride with Outstanding Photocatalytic Activity显示文摘Metals and metal oxides are widely used as photo/electro-catalysts for environmental remediation.However,there are many issues related to these metal-based catalysts for practical applications,such as high cost and detrimental environmental impact due to metal leaching.Carbon-based catalysts have the potential to overcome these limitations.In this study,monodisperse nitrogen-doped carbon nanospheres(NCs)were synthesized and loaded onto graphitic carbon nitride(g-C3N4,GCN)via a facile hydrothermal method for photocatalytic removal of sulfachloropyridazine(SCP).The prepared metal-free GCN-NC exhibited remarkably enhanced efficiency in SCP degradation.The nitrogen content in NC critically influences the physicochemical properties and performances of the resultant hybrids.The optimum nitrogen doping concentration was identified at 6.0 wt%.The SCP removal rates can be improved by a factor of 4.7 and 3.2,under UV and visible lights,by the GCN-NC composite due to the enhanced charge mobility and visible light harvesting.The mechanism of the improved photocatalytic performance and band structure alternation were further investigated by density functional theory(DFT)calculations.The DFT results confirm the high capability of the GCN-NC hybrids to activate the electron–hole pairs by reducing the band gap energy and efficiently separating electron/hole pairs.Superoxide and hydroxyl radicals are subsequently produced,leading to the efficient SCP removal. | Qiaoran Liu Hao Tian Zhenghua Dai Hongqi Sun Jian Liu Zhimin Ao Shaobin Wang Chen Han Shaomin Liu | 2020 | Nano-Micro Letters2020，12，2： | 2 |
| 18 | Quantitative determination of proteins at nanogram levels by the Resonmance light scatting technique with macromolecules nanoparticle of PS-AA 显示文摘 | Wang Leyu Chen Hongqi Xia Tingting | 2004 | Spectrochimica Acta Part A2004，60，： | 1 |
| 19 | Preparation of Cu-Ni bimetallic nanoparticles surface-capped with dodecanethiol and their tribological properties as lubricant additive显示文摘 | Lei Chen Haiyan Xu Haixia Cui Huidi Zhou Hongqi Wan Jianmin Chen | 2017 | Particuology2017，15，5： | 1 |
| 20 | Earnings Management and Resource Allocation: Evidence From China's Accounting Based Regulation of Rights Issue显示文摘 | Yuan Hongqi | 2004 | The Accounting Review2004，79，3： | 1 |
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