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| 1 | A photothermal reservoir for highly efficient solar steam generation without bulk water显示文摘A solid photothermal reservoir is designed to implement solar-steam generation in the absence of bulk water.The photothermal reservoir is composed of a water absorbing core encapsulated by a photothermal reduced graphene oxide based aerogel sheet which absorbs light and converts it into heat thus evaporating the stored water.The photothermal reservoir is able to store 6.5 times its own weight in water,which is sufficient for one day solar evaporation,thus no external water supplement is required.During solar-steam generation,since no bulk water is involved,the photothermal reservoir minimizes heat conduction loss,and maximizes both of the exposed evaporation surface area and net energy gain from the environment,leading to an energy efficiency beyond the theoretical limit.An extremely high water evaporation rate of 4.0 kg m-2 h-1(normalized to projection area)is achieved in laboratory studies over a cylinder photothermal reservoir with a diameter of 5.2 cm and a height of 15 cm under 1.0 sun irradiation.Practical evaluation of the photothermal reservoir outdoors as part of a desalination device demonstrates a similar evaporation rate where the salinity of the clean water produced is lower than 24 ppb.Thus the photothermal reservoir shows great potential for real world applications in portable solarthermal desalination. | Xuan Wu Ting Gao Chenhui Han Jingsan Xu Gary Owens Haolan Xu | 2019 | Science Bulletin2019，64，21： | 9 |
| 2 | IL-17-triggered downregulation of miR-497 results in high HIF-1α expression and consequent IL-1β and IL-6 production by astrocytes in EAE mice显示文摘Interleukin 17(IL-17)is increasingly recognized as a key factor that contributes to the pathogenesis of multiple sclerosis(MS)and its experimental mouse autoimmune encephalomyelitis(EAE)model.However,the roles and regulatory mechanisms of IL-17-induced pro-inflammatory cytokine production in EAE mice remain largely unclear.In this study,the expression of IL-17,hypoxia inducible factor-1α(HIF-1α),IL-1β,IL-6 and microRNA-497(miR-497),as well as their intrinsic associations,was investigated using EAE model mice and cultured astrocytes exposed to IL-17 in vitro.We observed markedly increased production of IL-17,HIF-1α,IL-1βand IL-6 in the brain tissues of EAE mice,while the expression and secretion of HIF-1α,IL-1βand IL-6 were also significantly increased when cultured primary astrocytes from mice were stimulated with IL-17.Meanwhile,the expression of miR-497 was downregulated both in vivo and in vitro.Subsequent in vitro experiments revealed that IL-17 induced the production of IL-1βand IL-6 in astrocytes through the upregulation of HIF-1αas a transcriptional factor,indicating that IL-17-mediated downregulation of miR-497 enhanced HIF-1αexpression.Furthermore,astrocytespecific knockdown of IL-17RA and HIF-1αor astrocyte-specific overexpression of miR-497 by infection with different lentiviral vectors containing an astrocyte-specific promotor markedly decreased IL-1βand IL-6 production in brain tissues and alleviated the pathological changes and score of EAE mice.Collectively,these findings indicate that decreased miR-497 expression is responsible for IL-17-triggered high HIF-1αexpression and consequent IL-1βand IL-6 production by astrocytes in EAE mice. | Kai Shan Rongrong Pang Chenhui Zhao Xiaomei Liu Wenxing Gao Jing Zhang Dan Zhao Yingwei Wang Wen Qiu | 2017 | Cellular & Molecular Immunology2017，14，11： | 5 |
| 3 | Flexible bioelectronics for physiological signals sensing and disease treatment显示文摘Flexible bioelectronics,including wearable and implantable electronics,have revolutionized the way of human-machine interaction due to the fact that they can provide natural and seamless interactions with humans and keep stable and durable at strained states.As sensor elements or biomimetic actuators,flexible bioelectronics can dynamically sense and monitor physiological signals,reveal real-time physical health information and provide timely precise stimulations or treatments.Thus,the flexible bioelectronics are playing increasingly important roles in human-health monitoring and disease treatment,which will significantly change the future of healthcare as well as our relationships with electronics.This review summarizes recent major progress in the development of flexible substrates or encapsulation materials,sensors,circuits and energy-autonomous powers toward digital healthcare monitoring,emphasizing its role in biomedical applications in vivo and problems in practical applications.A future perspective into the challenges and opportunities in emerging flexible bioelectronics designs for the next-generation healthcare monitoring systems is also presented. | Guang Yao Chenhui Yin Qian Wang Tianyao Zhang Sihong Chen Chang Lu Kangning Zhao Weina Xu Taisong Pan Min Gao Yuan Lin | 2020 | Journal of Materiomics2020，6，2： | 2 |
| 4 | A polymer electrolyte with a thermally induced interfacial ion-blocking function enables safety-enhanced lithium metal batteries显示文摘Lithium metal batteries(LMBs)have recently been revitalized as one of the most promising electrochemical energy storage systems,owing to the ultrahigh specific capacity(3860 mAh g^(-1))and ultralow potential(-3.04 V vs.standard hydrogen electrode)of lithium metal anodes.However,safety hazards originating from lithium dendrite growth and pulverization during cycling and thermal stimulation present significant challenges to the practical application of LMBs.To address this issue,we have developed an in situ polymer electrolyte with thermally induced interfacial ion-blocking ability.We demonstrate that the repolymerization and deposition of residual vinylene carbonate in the as-prepared electrolyte under thermal abuse predominantly results in thermally induced ion blocking at the solid electrolyte interface,thus achieving superior LMB safety.The developed polymer electrolyte also yields superior cyclability in LMBs.This design philosophy provides a good paradigm for improving the safety of LMBs. | Huanrui Zhang Lang Huang Hantao Xu Xiaohu Zhang Zhou Chen Chenhui Gao Chenglong Lu Zhi Liu Meifang Jiang Guanglei Cui | 2022 | eScience2022，2，2： | 1 |
| 5 | PVdF-HFP-Based Gel Polymer Electrolyte with Semi-Interpenetrating Networks For Dendrite-Free Lithium Metal Battery显示文摘The safety issues and lower energy density of the lithium metal batteries are the two main challenges that hinder their applications in the fields of electric vehicles and portable devices.In this work,the semi-interpenetrated polyvinylidene fluoride-hexafluoropropylene(PVdF-HFP)-based gel polymer electrolyte was synthesized through UV-curing method by employing the ethoxylated trimethylolpropane triacrylate(ETPTA)monomer.The semi-interpenetrating networks formed by polymerization of ETPTA and the high liquid absorption rate of the PVdF-HFP impart the as-prepared electrolyte with a high room temperature ionic conductivity of 3.17×10-3 s cm^(-1)and a high mechanical strength of 3.46 MPa.LiFePO4 was selected as cathode materials,and the active material loading of the cathode is about 4.2 mg cm-2.The electrolyte shows superior long-term cycling properties(127 mAh g^(-1)after 200 cycles at 0.5 C),excellent rate performance(113 mAh g^(-1)at1 C,80 mAh g^(-1)at 2 C,and the discharge capacity of 135 mAh g^(-1)can be restored when the rate goes back to 0.1 C)as well as good ability to inhibit the growth of lithium dendrite(about 150 h).The facile synthesis strategy and great electrochemical performance of the electrolyte make it a potential candidate for lithium metal batteries. | Lu Liu Xiaodong Wang Chenhui Yang Peng Han Lei Zhang Li Gao Zirui Wu Bingxin Liu Ruiping Liu | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，3： | 1 |
| 6 | Transient temperature field a-nalysis of a brake in a non-axisymmetric three-dimensionalmodel 显示文摘 | Gao Chenhui Lin Xiezhao | 2002 | Materials Processing Technology2002，129，23： | 1 |
| 7 | A novel degradable injectable HLC-HPA hydrogel with antiinflammatory activity for biomedical materials:Preparation,characterization,in vivo and in vitro evaluation显示文摘In situ injectable hydrogels,which have great potential in tissue engineering,are characterized by simple preparation,minimal invasiveness and adaptation to complex shapes.However,injectable hydrogels have higher requirements for biocompatibility and safety due to their use in vivo implantation.Therefore,in this study,a human-like collagen(HLC)-based in situ gel-forming injectable HLC-HPA hydrogel was synthesized by combining the amino group of HLC with the carboxyl group of HPA activated using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride(EDC)and N-hydroxysuccinimide(NHS),followed by crosslinking by horseradish peroxidase(HRP)and H_2O_2,and used as scaffold material for tissue engineering.The hydrogel stiffness,gel time and biodegradation rate could be easily and independently adjusted by varying the H_2O_2 and HRP concentrations.Scanning electron microscope(SEM)clarified the homogeneous porous and interconnected internal structures of the hydrogel.In vitro cell viability and in vivo degradation experiments confirmed that the HLC-HPA hydrogel had good biodegradability and excellent biocompatibility.Interestingly,in cultured macrophages,the HLC-HPA hydrogel showed anti-inflammatory activity by reducing the amount of the pro-inflammatory cytokines tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)and increasing the secretion of the anti-inflammatory cytokine interleukin-10(IL-10)induced by lipopolysaccharide(LPS).Meanwhile,in animal experiments,HLC-HPA hydrogels exhibit excellent biocompatibility and have properties of hemostasis and reduction of inflammatory response.Therefore,the HLC-HPA hydrogel prepared in this study has great potential for development for use in the biomedical field. | GAO Shang QU LinLin ZHU ChenHui OUYANG PingKai FAN DaiDi | 2020 | Science China(Technological Sciences)2020，63，11： | 1 |
| 8 | DOCK2 regulates antifungal immunity by regulating RAC GTPase activity显示文摘Fungal infections cause~1.5 million deaths each year worldwide,and the mortality rate of disseminated candidiasis currently exceeds that of breast cancer and malaria.The major reasons for the high mortality of candidiasis are the limited number of antifungal drugs and the emergence of drug-resistant species.Therefore,a better understanding of antifungal host defense mechanisms is crucial for the development of effective preventive and therapeutic strategies.Here,we report that DOCK2(dedicator of cytokinesis 2)promotes indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.DOCK2-deficient macrophages exhibit decreased RAC GTPase(Rac family small GTPase)activation and ROS(reactive oxygen species)production,which in turn attenuates the killing of intracellular fungi and the activation of downstream signaling pathways.Mechanistically,after fungal stimulation,activated SYK(spleen-associated tyrosine kinase)phosphorylates DOCK2 at tyrosine 985 and 1405,which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling activation.Importantly,nanoparticle-mediated delivery of in vitro transcribed(IVT)Rac1 mRNA promotes the activity of Rac1 and helps to eliminate fungal infection in vivo.Taken together,this study not only identifies a critical role of DOCK2 in antifungal immunity via regulation of RAC GTPase activity but also provides proof of concept for the treatment of invasive fungal infections by using IVT mRNA. | Xiaojian Ma Xi Tan Bingbing Yu Wanwei Sun Heping Wang Huijun Hu Yanyun Du Ruirui He Ru Gao Qianwen Peng Zhihui Cui Ting Pan Xiong Feng Junhan Wang Chengqi Xu Bin Zhu Wei Liu Chenhui Wang | 2022 | Cellular & Molecular Immunology2022，19，5： | 1 |
| 9 | A common variant in AAK1 reduces risk of noise-induced hearing loss显示文摘Noise-induced hearing loss(NIHL)is one of the most common types of hearing loss and contributes to significant morbidity worldwide,as well as being the major cause of age-related hearing loss and tinnitus.The World Health Organization(WHO)estimates that 10%of the world's population is exposed to sound levels that could potentially cause NIHL[1].It has been widely accepted that NIHL is a multifactorial genetic disorder with estimated heritability of 36%to 40%[2].Ideally,identification of the modifying genetic variants would help protect individuals at high risk of NIHL.For decades,many geneticists have searched for genes that either predispose or protect from NIHL.Howeve r,the majority of genetic studies for NIHL were conducted in independent known candidate genes[3]. | Qixuan Wang Xueling Wang Tao Yang Lu Yang Huihui Liu Yihang Zheng Guixian Jiang Hongchao Liu Chenhui Huang Juan Chen Zhentao Wang Zhaoyan Wang Wei Zhao Jiannan Lin Xuejie Zhang Junbo Shi Kun Han Xingyu Le Yan Ren Yun Li Yingying Hong Wentao Shi Dongqi Cui Minfei Qian Jun Xu Xiaofei Zheng Yunge Gao Chen Li James Lin Zhiwu Huang Hao Wu | 2023 | National Science Review2023，10，7： | 0 |
| 10 | Linguistic Characteristics of Mandarin-Speaking Huntington’s Disease Patients显示文摘Objective Linguistic problem is common in Huntington’s disease(HD)patients.It has been studied before in native speakers of alphabetic languages,such as English.As a hieroglyphic language,Chinese differs from alphabetic languages in terms of phonology,morphology,semantics and syntax.We aimed to investigate the linguistic characteristics of manifest HD in native speakers of Mandarin.Meanwhile,we expected to explore the linguistic differences associated with cortical or subcortical pathology.Methods Five HD patients and five Alzheimer’s disease(AD)patients matched in age,gender,disease course and educational level were enrolled.All the participants were Mandarin native speakers.All finished history inquiry,physical examination,basic test,genetic test and neuropsychological assessment.Language evaluation was performed by Aphasia Battery of Chinese.Results HD patients had a mean disease course of 5.4±2.97(range,2-10)years.They showed a linguistic disorder close to transcortical motor aphasia.They exhibited prominent phonological impairment,as well as slight semantic and syntactic abnormality.Tonic errors were found in speech.Character structural errors and substitutions were detected in writing.In comparison,AD patients showed a more severe linguistic impairment,characterized by global aphasia with more semantic errors.Conclusion Mandarin-speaking HD patients have a transcortical motor aphasia-like disturbance with prominent phonological impairment,whereas AD patients have a more severe global aphasia with salient semantic impairment. | Liling Dong Caiyan Liu Chenhui Mao Shanshan Chu Jie Li Xinying Huang Jing Gao | 2020 | Chinese Medical Sciences Journal2020，35，3： | 0 |
| 11 | Kinetics of Catalyzed Thermal Degradation of Polylactide and Its Application as Sacrificial Templates显示文摘Polylactide(PLA)is an outstanding sacrificial template material for the manufacture of microchannels in a thermosetting matrix.However,the initial thermal degradation temperature of pure PLA is relatively high(about 280℃),which limits its use as a sacrificial template.In this report,we found that TBD,an organic base catalyst,can significantly reduce the thermal degradation temperature of PLA.TBD has higher catalytic activity for the thermal degradation of PLA compared with Tin(II)oxalate(Sn(Oxa)),one catalyst reported in the literature.Moreover,the gaseous products catalyzed by TBD for PLA thermal degradation are mainly lactide,and the formation temperature of the monomer is lower and the yield is higher,which may have potential value for PLA recycling.A combined catalyst,S8T2,was composed of 80%low activity catalyst Sn(Oxa)and 20%high activity catalyst TBD,which can catalyze the rapid degradation of PLA without greatly damaging the mechanical properties of PLA.PLA-S8T2 sacrificial fibers can form high-precision one-dimensional microchannels in the epoxy resin matrix,and 3D-printed PLA-S8T2 sacrificial templates can be used to form three-dimensional microchannels in a thermosetting matrix by vaporization of sacrificial components process(VaSC).These features highlight the great potential of PLA-S8T2 as sacrificial template material for the preparation of the complicated microchannels in the thermosetting matrix. | Li Feng Chenhui Cui Zhen Li Mengyuan Zhang Shenghui Gao Qiang Zhang Youshen Wu Zhishen Ge Yilong Cheng Yanfeng Zhang | 2022 | Chinese Journal of Chemistry2022，40，23： | 0 |
| 12 | Tuning coordination environment of iron ions to ensure ultra-high pseudocapacitive capability in iron oxide显示文摘The mechanism governing the pseudocapacitive lithium storage behavior is one of the most critical unsolved issues in conversion-type anodes for lithium-ion batteries.In this work,we,for the first time,demonstrate that the pseudocapacitive capability of iron oxide-based anodes is closely associated with the electronic structures of iron ions.As proof of concept,the introduction of amorphization,nitrogen doping,oxygen vacancies reduces the coordination of iron ions and contributes significantly to the pseudocapacitive lithium storage capability of iron oxide,reaching up to 96%of the specific capacity at 1 mV·s^(−1).Due to the significantly modulated coordination environment,the 3d electrons of Fe(II)are delocalized with increased spin state and the energy band gap is narrowed,accompanied by an upshift of Fermi energy.The redox activity and carrier mobility of iron oxides are substantially increased,which substantially enhance the exchange current density and thereby improve the pseudocapacitive capability of iron oxide. | Wubin Du Chenhui Yan Mingxi Gao Jian Chen Panyu Gao Xuebin Yu Yinzhu Jiang Wenping Sun Yongfeng Liu Mingxia Gao Shibo Xi Hongge Pan | 2023 | Nano Research2023，16，5： | 0 |
| 13 | External Incentive Mechanism Research on Knowledge Cooperation-Sharing in the Chinese Creative Industry Cluster显示文摘The creative industry is a knowledge-based industry,but it is difficult and complex to create knowledge for enterprises.The principle of cooperationsharing posits that companies’limited resources prohibit them from gaining a competitive advantage in all business areas.Therefore,cooperation-sharing can help businesses overcome this hurdle.Cooperation-sharing expedites economic development,breaks the barrier of independent knowledge creation,and enhances resource utilization.However,the effectiveness and stability of knowledge cooperation-sharing are key problems facing governments and other regulators.This study can help regulators promote honesty in enterprise cooperation-sharing.Based on the hypothesis of bounded rationality,the evolutionary game theory was used to construct the“Enterprises–Informal Institutions–Government”tripartite game matrix.Next,based on this game matrix,a simulation analysis method was used to analyze the effects of external incentives on the stability of evolutionary strategies.The analysis shows that the strategic choice of the“Enterprises–Informal Institutions–Government”tripartite game could be affected by the initial state strategy choices of the other two players,but more influential were the cost and external incentive levels of the game players.The results indicate that the government and informal institutions should regulate enterprises with a rational external incentive mechanism that boosts the enterprises’incentive to cooperate honestly.Thus,an effective external incentive mechanism can significantly improve the probability of enterprises behaving honestly in cooperation-sharing and promote the development of the creative industry. | Changchun Gao Shiyu Liu Chenhui Yu Peng Guo | 2021 | Computer Systems Science & Engineering2021，38，9： | 0 |
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