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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Reservoir architecture patterns of sandy gravel braided distributary channel A case study of Triassic Upper Karamay Formation,Xinjiang oilfield显示文摘The purpose of this study was to discuss shape,scale and superimposed types of sandy gravel bodies in sandy-gravel braided distributary channel.Lithofacies analysis,hierarchy bounding surface analysis and subsurface dense well pattern combining with outcrops method were used to examine reservoir architecture patterns of sandy gravel braided distributary channel based on cores,well logging,and outcrops data,and the reservoir architecture patterns of sandy gravel braided distributary channels in different grades have been established.The study shows:(1)The main reservoir architecture elements for sandy gravel braided channel delta are distributary channel and overbank sand,while reservoir flow barrier elements are interchannel and lacustrine mudstone.(2)The compound sand bodies in the sandy gravel braided delta distributary channel take on three shapes:sheet-like distributary channel sand body,interweave strip distributary channel sand body,single strip distributary channel sand body.(3)Identification marks of single distributary channel include:elevation of sand body top,lateral overlaying,“thick-thin-thick”feature of sand bodies,interchannel mudstone and overbank sand between distributary channels and the differences in well log curve shape of sand bodies.(4)Nine lithofacies types were distinguished in distributary channel unit interior,different channel units have different lithofacies association sequence. | Senlin Yin Zhangming Hu Xiang Ren Xiaojun Wu Yanhui Chen Lijun Zheng Zhibin Jiang | 2016 | Petroleum2016，2，2： | 2 |
| 3 | Cbln1和Cbln4在结构上相似但与GluD2相互作用显著不同显示文摘文章简介本研究以参与突触形成的Cbln家族为研究对象。Cbln家族包含4个成员,其中Cbln1通过在突触间隙中结合Nrxn蛋白和δ-谷氨酸受体参与突触形成;然而,尽管Cbln4与Cbln1有高达74%的序列等同性,文献报道Cbln4不能结合Nrxn蛋白和δ-谷氨酸受体,而是DCC的配体。 | 钟琛 Jinlong Shen Huibing Zhang Guangyi Li Senlin Shen Fang Wang Kuan Hu Longxing Cao Yongning He 丁建平 | 2018 | 科学新闻2018，0，4： | 0 |
| 4 | CNOOC Acquires Oversea Assets Successfully显示文摘在去年以后, CNOOC 正在期望外面为美国买精力公司 Unocal Corplost 到 V 形臂章公司,它在今年的开始再进行了十字路口边阶的财产获得。在 2006 年 1 月 9 日, CNOOC 有限公司签署了一个权威的协议,尼日利亚 SouthAtlantic 石油(SAPETRO ) 限制了获得工作的 45 % 对的兴趣一近海在为 22680 亿美元现金的尼日利亚的油发展中许可证 OML 130。购买将被在的 CNOOC 有限公司的内部大写的资源资助, 17.5 亿美元将支付买的 SAPETRO,并且留下的现金将被用来支付早操作费用。 | Hu Senlin | 2006 | China Oil & Gas2006，13，1： | 0 |
| 5 | Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study显示文摘Thoracic aortic dissection(TAD)without familial clustering or syndromic features is known as sporadic TAD(STAD).So far,the genetic basis of STAD remains unknown.Whole exome sequencing was performed in 223 STAD patients and 414 healthy controls from the Chinese Han population(N=637).After population structure and genetic relationship and ancestry analyses,we used the optimal sequence kernel association test to identify the candidate genes or variants of STAD.We found that COL3A1 was significantly relevant to STAD(P=7.35×10^(−6))after 10000 times permutation test(P=2.49×10^(−3)).Moreover,another independent cohort,including 423 cases and 734 non-STAD subjects(N=1157),replicated our results(P=0.021).Further bioinformatics analysis showed that COL3A1 was highly expressed in dissected aortic tissues,and its expression was related to the extracellular matrix(ECM)pathway.Our study identified a profile of known heritable TAD genes in the Chinese STAD population and found that COL3A1 could increase the risk of STAD through the ECM pathway.We wanted to expand the knowledge of the genetic basis and pathology of STAD,which may further help in providing better genetic counseling to the patients. | Yanghui Chen Yang Sun Zongzhe Li Chenze Li Lei Xiao Jiaqi Dai Shiyang Li Hao Liu Dong Hu Dongyang Wu Senlin Hu Bo Yu Peng Chen Ping Xu Wei Kong Dao Wen Wang | 2021 | Frontiers of Medicine2021，15，3： | 0 |
| 6 | Application and Thinking of Right Species for Right Land in Urban Plant Landscaping显示文摘With the acceleration of eco-garden city construction,tree resources have been increasingly applied in landscape construction.Combining with the authors' work experience,plant landscaping cases in domestic and foreign cities,this paper analyzed the concept of right species for right land and problems in plant landscaping,and took specific cases to explore the application of right species for right land,in order to provide references for the reasonable utilization of indigenous tree resources. | DING Senlin HU Weifeng GENG Shijun CAI Ping | 2016 | Journal of Landscape Research2016，8，4： | 0 |
| 7 | Pore-pressure and stress-coupled creep behavior in deep coal:Insights from real-time NMR analysis显示文摘Understanding the variations in microscopic pore-fracture structures(MPFS) during coal creep under pore pressure and stress coupling is crucial for coal mining and effective gas treatment. In this manuscript, a triaxial creep test on deep coal at various pore pressures using a test system that combines in-situ mechanical loading with real-time nuclear magnetic resonance(NMR) detection was conducted.Full-scale quantitative characterization, online real-time detection, and visualization of MPFS during coal creep influenced by pore pressure and stress coupling were performed using NMR and NMR imaging(NMRI) techniques. The results revealed that seepage pores and microfractures(SPM) undergo the most significant changes during coal creep, with creep failure gradually expanding from dense primary pore fractures. Pore pressure presence promotes MPFS development primarily by inhibiting SPM compression and encouraging adsorption pores(AP) to evolve into SPM. Coal enters the accelerated creep stage earlier at lower stress levels, resulting in more pronounced creep deformation. The connection between the micro and macro values was established, demonstrating that increased porosity at different pore pressures leads to a negative exponential decay of the viscosity coefficient. The Newton dashpot in the ideal viscoplastic body and the Burgers model was improved using NMR experimental results, and a creep model that considers pore pressure and stress coupling using variable-order fractional operators was developed. The model’s reasonableness was confirmed using creep experimental data. The damagestate adjustment factors ω and β were identified through a parameter sensitivity analysis to characterize the effect of pore pressure and stress coupling on the creep damage characteristics(size and degree of difficulty) of coal. | Wenhao Jia Hongwei Zhou Senlin Xie Yimeng Wang Xinfeng Hu Lei Zhang | 2024 | International Journal of Mining Science and Technology2024，34，1： | 0 |
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