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| 1 | Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals显示文摘尽管 myocyte 房间移植研究为心肌的梗塞建议了一个有希望的治疗学的潜力,到为心肌的修理的临床的治疗的发展的一个主要障碍是与为移植获得相对同类的室的 myocytes 联系的困难。人的胚胎的干细胞(hESCs ) 是 cardiomyocytes 的有希望的来源。这里,我们报导发信号的 retinoid 在 hESCs 的心脏的区别期间调整 atrial 对室的 myocytes 的命运说明。我们发现少量和 pan-retinoic 酸受体对手 BMS-189453 (RAi ) 显著地增加了 hESCs 的心脏的区别效率。为了调查 retinoid,工作,我们把对待 Noggin+RAi 的文化与对待 Noggin+RA 的文化作比较。我们的结果证明室特定的基因 IRX-4 的表示层次极端地在对待 Noggin+RAi 的文化被提高。MLC-2V,另一个室特定的标记,在对待 Noggin+RAi 的文化,然而并非在对待 Noggin+RA 的文化的 cardiomyocytes 在 cardiomyocytes 的多数被表示。流动 cytometry 分析和 electrophysiological 研究与 64.7 | Qiangzhe Zhang Junjie Jiang Pengcheng Han Qi Yuan Jing Zhang Xiaoqian Zhang Yanyan Xu Henghua Cao Qingzhang Meng Li Chen Tian Tian Xin Wang Pu Li Jurgen Hescheler Guangju Ji Yue Ma | 2011 | Cell Research2011，21，4： | 10 |
| 2 | Rational design of novel ultra-small amorphous Fe_(2)O_(3)nanodots/graphene heterostructures for all-solid-state asymmetric supercapacitors显示文摘Constructing graphene-based heterostructures with large interfacial area is an efficient approach to enhance the electrochemical performance of supercapacitors but remains great challenges in their synthesis.Herein,a novel ultra-small amorphous Fe_(2)O_(3)nanodots/graphene heterostructure(a-Fe_(2)O_(3)NDs/RGO)aerogel was facilely synthesized via excessive metal-ion-induced self-assembly and subsequent calcination route using Prussian blue/graphene oxide(PB/GO)composite aerogel as precursors.The deliberately designed a-Fe_(2)O_(3)NDs/RGO heterostructure offers a highly interconnected porous conductive network,large heterostructure interfacial area,and plenty of accessible active sites,greatly facilitating the electron transfer,electrolyte diffusion,and pseudocapacitive reactions.The obtained a-Fe_(2)O_(3)NDs/RGO aerogel could be used as flexible free-standing electrodes after mechanical compression,which exhibited a significantly enhanced specific capacitance of 347.4 F·g^(-1)at 1 A·g^(-1),extraordinary rate capability of 184 F·g^(-1)at 10 A·g^(-1),and decent cycling stability.With the as-prepared a-Fe_(2)O_(3)NDs/RGO as negative electrodes and the Co_(3)O_(4)NDs/RGO as positive electrodes,an all-solid-state asymmetric supercapacitor(a-Fe_(2)O_(3)NDs/RGO//Co_(3)O_(4)NDs/RGO asymmetric supercapacitor(ASC))was assembled,which delivered a high specific capacitance of 69.1 F·g^(-1)at 1 A·g^(-1)and an impressive energy density of 21.6 W·h·k·g^(-1)at 750 W·k·g^(-1),as well as good cycling stability with a capacity retention of 94.3%after 5,000 cycles.This work provides a promising avenue to design high-performance graphene-based composite electrodes and profound inspiration for developing advanced flexible energy-storage devices. | Chenxiao Wu Zhifang Zhang Zhonghui Chen Zuimin Jiang Huiyu Li Haijing Cao Yongsheng Liu Yanyan Zhu Zebo Fang Xiangrong Yu | 2021 | Nano Research2021，14，4： | 6 |
| 3 | Cyclospora cayetanensis infections among diarrheal outpatients in Shanghai: a retrospective case study显示文摘Cyclospora cayetanensis 是引起世界范围的地方性、流行的人的腹泻的 foodborne 和水运的病原体。关于 C 的一些流行病学的研究。在中国的 cayetanensis 感染被进行了。在 2013 期间, 291 个凳子标本的一个总数在城市的上海在一所医院与腹泻从病人被收集。C。, cayetanensis 没被传统的显微镜学在任何凳子标本检测五个凳子标本(1.72% , 5/291 ) 由 PCR 是积极的。分子的技术证实的这些积极盒子都在成年的组(吝啬的年龄 27.8 年;2.94% , 5/170 ) 与水的腹泻。显著感染发生在 5 月和 7 月的雨季。顺序和 C 的部分 18S rRNA 基因的种系发生的分析。cayetanensis 孤立这个寄生虫的显示出的 intra 种类差异。第一次,这研究显示出那 C。cayetanensis 是在有在上海的腹泻的门诊病人的病原体,在底层的虽然。然而,在这些病人的这个寄生虫的传播动力学仍然保持不明确。 | Yanyan Jiang Zhongying Yuan Guoqing Zang Dan Li Ying Wang Yi Zhang Hua Liu Jianping Cao Yujuan Shen | 2018 | Frontiers of Medicine2018，12，1： | 5 |
| 4 | Co-Co304@carbon core-shells derived from metal-organic framework nanocrystals as efficient hydrogenevolution catalysts显示文摘Controllable pyrolysis of metal-organic frameworks (MOFs) in confined spacesis a promising strategy for the design and development of advanced functionalmaterials. In this study, Co-C0304@carbon composites were synthesized viapyrolysis of a Co-MOFs@glucose polymer (Co-MOFs@GP) followed by partialoxidation of Co nanoparticles (NPs). The pyrolysis of Co-MOFs@GP generated acore-shell structure composed of carbon shells and Co NPs. The controlled partialoxidation of Co NPs formed Co-Co304 heterojunctions confined in carbon shells.Compared with Co-MOFs@GP and Co@carbon-n (Co@C-n), Co-C0304@carbon-n(Co-Co304@C-n) exhibited higher catalytic activity during NaBH4 hydrolysis.Co-C0304@C-II provided a maximum specific H2 generation rate of5,360 mL.min-l.gco-1 at room temperature due to synergistic interactionsbetween Co and C0304 NPs. The Co NPs also endowed Co-C0304@C-n with theferromagnetism needed to complete the magnetic momentum transfer process. | Yanyan Liu Guosheng Han Xiaoyu Zhang Congcong Xing Chenxia Du Huaqiang Cao Baojun Li | 2017 | Nano Research2017，10，9： | 5 |
| 5 | An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair显示文摘Acute myocardial infarction(AMI)remains a dominant origin of morbidity,mortality and disability worldwide.Increases in reactive oxygen species(ROS)are key contributor to excessive cardiac injury after AMI.Here we developed an immobilized enzyme with Superoxide Dismutase(SOD)activity cross-link with Zr-based metal-organic framework(ZrMOF)(SOD-ZrMOF)for mitigate ROS-caused injury.In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility.By efficiently scavenging ROS and suppressing oxidative stress,SOD-ZrMOF can protect the function of mitochondria,reduce cell death and alleviate inflammation.More excitingly,long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area,protect cardiac function,promote angiogenesis and inhibit pathological myocardial remodeling.Therefore,SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI. | Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang | 2022 | Bioactive Materials2022，7，4： | 4 |
| 6 | Characteristics and runoff volume of the Yangtze River paleo-valley at Nanjing reach in the Last Glacial Maximum显示文摘在 No.1, No.3 和 No.4 南京长江桥附近切入山谷的长江的地层学的剖面图与各自的讨厌的人日期和文件一起被建立。由四把钻的样品的 14C 年龄分析,核心接近 No.4 桥(被造) ,我们能发现 paleo 山谷的时间范围在在深度的 LGM 是过时的 ? 60 m 到 ? 南京附近的 90 m。深切入山谷的隧道是狭窄的,河迅速流动了,这也被显示。部分并且深深地介绍的古老的长江深隧道在 No.1 桥附近切入特征。根据以前的出版物,许多研究在长江的主要 paleo 隧道上被做了,但是很少结果在分泌物评价上被完成了。在这篇论文,早期的速度和 LGM 的平均速度被计算与,等等以河形状,沉积谷物尺寸和序列接近 No.3 和 No.1 桥。而且,在长江的南京活动范围的分泌物在 LGM 期间被估计了根据分泌物的关系在 12,00016,000 m3/s 附近,流动和剖面图的速度。 | CAO Guangjie WANG Jian WANG Lingjun LI Yanyan | 2010 | Journal of Geographical Sciences2010，20，3： | 4 |
| 7 | A targeted sequencing approach to find novel pathogenic genes associated with sporadic aortic dissection显示文摘Aortic dissection(AD) is a heterogeneous genetic disease of the aorta with high mortality and poor prognosis. However, only few genetic causes of AD have been explored till date. After conducting a broad literature review focused on identifying potential pathogenic pathways, we designed a panel containing 152 AD-associated genes to conduct massively parallel targeted nextgeneration sequencing of 702 sporadic aortic dissection patients and 163 matched healthy controls. After validation by Sanger sequencing, we identified 21 definitely pathogenic and 635 likely pathogenic variants in 61.25%(430/702) of patients. In these patients, 34.88%(150/430) harbored more than one variant that was either definitely or likely to be pathogenic. Among the candidate genes, we identified 546 likely pathogenic variants in 47.72%(335/702) of patients. Importantly, we identified 94 lossof-function(LOF) variants in 45 genes in AD patients, but only five LOF variants in the controls(P=1.34×10^(-4)). With a burden test, we highlighted RNF213 as an important new gene for AD pathogenesis. We also performed transcriptome sequencing of human aorta tissues to evaluate the expression levels of these newly identified genes. Our study has compiled a comprehensive genetic map of sporadic AD in the Han Chinese population. We believe it will facilitate risk predicting and genetic diagnosis of this severe disease in the future. | Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang | 2018 | Science China(Life Sciences)2018，61，12： | 4 |
| 8 | Antifogging properties and mechanism of micron structure in Ephemera pictiventris McLachlan compound eyes显示文摘An antifogging function surface with simple structure and suitable for large-area production was found inspired by Ephemera pictiventris McLachlan compound eyes.The compound eyes structure,antifogging properties and mechanism were studied by anti-fog test,dyeing test and scanning electron microscopy,and so forth.Then,3D model of the sample was established,and the antifogging mechanism was explained by the Cassie model.Results showed that the compound eyes are composed of hundreds of micron size ommatidia arranged in curved array form,and this structure shows excellent antifogging function.This research may provide new ideas for design of simple structure and micron size antifogging function surface.This work is also expected to be applied to antifogging function surface of astronaut helmets and medical endoscopes,and so forth. | Zhiwu Han Huiying Guan Yanyan Cao Shichao Niu Luquan Ren | 2014 | Chinese Science Bulletin2014，59，17： | 4 |
| 9 | Variants of genes encoding collagens and matrix metalloproteinase system increased the risk of aortic dissection显示文摘Aortic dissection(AD) is a devastating,heterogeneous condition of aorta.The homeostasis between collagens and matrix metalloproteases(MMPs)/tissue inhibitors of MMPs(TIMPs) system in the extracellular matrix plays an important role for structure and functions of aorta.However,our knowledge on association between variants of genes in this system and pathogenesis of AD is very limited.We analyzed all yet known coding human genes of collagens(45 genes),MMPs/TIMPs(27genes) in 702 sporadic AD patients and in 163 matched healthy controls,by using massively targeted next-generation and Sanger sequencing.To define the pathogenesis of potential disease-causing candidate genes,we performed transcriptome sequencing and pedigree co-segregation analysis in some genes and generated Col5a2 knockout rats.We identified 257 pathogenic or likely pathogenic variants which involved 88.89%(64/72) genes in collagens-MMPs/TIMPs system and accounted for 31.05%(218/702) sporadic AD patients.In them,84.86%patients(185/218) carried one variant,12.84%two variants and 2.30%more than two variants.Importantly,we identified 52 novel probably pathogenic loss-of-function(LOF) variants(20 nonsense,16 frameshift,14 splice sites,one stop-loss,one initiation codon) in 11.06%(50/452) AD patients,which were absent in 163controls(P=2.5×10^(-5)).Transcriptome sequencing revealed that identified variants induced dyshomeostasis in expression of collagens-TIMPs/MMPs systems.The Col5α2^(-/-) rats manifested growth retardation and aortic dysplasia.Our study provides a first comprehensive map of genetic alterations in collagens-MMPs/TIMPs system in sporadic AD patients and suggests that variants of these genes contribute largely to AD pathogenesis. | Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Chenze Li Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang | 2017 | Science China(Life Sciences)2017，60，1： | 4 |
| 10 | A new megastigmane from fresh roots of Rehmannia glutinosa显示文摘A new megastigmane,rehmamegastigmane(1),together with eighteen known compounds lariciresinol(2),lariciresinol-4′-O-β-D-glucopyranoside(3),hierochin D(4),yemuoside YM1(5),darendoside B(6),decaffeoylacteoside(7),jionoside B1(8),catalpol(9),ajugol(10),6-O-vanilloylajugol(11),6-O-E-feruloylajugol(12),rehmapicroside(13),rehmapicrogenin(14),3-methoxy-2,6,6-trimethylcyclohexane-1-enecarboxylic acid(15),vanillic acid(16),hydroferulic acid(17),threo-1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol(18),p-hydroxyphenylethyl alcohol(19)was isolated from the fresh roots of Rehmannia glutinosa.Compounds 2–6 and 16–18 were isolated from this plant for the first time. | Weisheng Feng Yanyan Lv Xiaoke Zheng Yanli Zhang Yangang Cao Yuanyuan Pei | 2013 | Acta Pharmaceutica Sinica B2013，3，5： | 4 |
| 11 | A case of lethal hemolytic anemia associated with severe pneumonia caused by Mycoplasma pneumoniae显示文摘To the editor:A 31-year-old previous healthy male patient was admitted to the hospital with fever (Tmax 41℃) and non-productive cough for seven days and dyspnea for three days.On day 4 after disease onset,his chest X-ray showed right upper lung small opacity and left lung large opacity (Figure 1A).The patient has been administrated levofloxacin for two days before he came into our hospital. | Gu Li Chen Xiukai Li Huiqiao Qu Jiuxin Miao Miao Zhou Fei Zhu Yanyan Wang Xu Wang Chunlei Liu Yingmei Li Wenxiong Cao Bin | 2014 | Chinese Medical Journal2014，，21： | 3 |
| 12 | Intestinal Protozoan Infections in Patients with Diarrhea—Shanghai Municipality,Zhenjiang City,and Danyang City,China,2011–2015 and 2019–2021显示文摘Summary What is already known about this topic?Intestinal protozoa are common pathogens of diarrhea globally.However,the etiology of diarrhea due to intestinal protozoan infections in China is not known.What is added by this report?Based on active syndromic surveillance in Shanghai,Zhenjiang,and Danyang during 2011–2015 and 2019–2021,89(1.67%)patients were infected with intestinal protozoa(Cryptosporidium spp.,Giardia duodenalis,Enterocytozoon bieneusi,and Cyclospora cayetanensis),and positivity rates statistically differed by region and age.What are the implications for public health practice?This was the most comprehensive data collection in investigating parasitic diarrheal diseases in humans.Identification of these protozoa in diarrhea will provide new perspectives for detecting hidden etiological agents of diarrhea as early as possible. | Yanyan Jiang Zhongying Yuan Hua Liu Jianhai Yin Yuan Qin Xiaofeng Jiang Jie Xu Jianping Cao Yujuan Shen | 2022 | China CDC weekly2022，4，8： | 2 |
| 13 | Electrochemical noise study on 2024-T3 Aluminum alloy corrosion in simulated acid rain under cyclic wet–dry condition显示文摘 | Yanyan Shi Zhao Zhang Jingxin Su Fahe Cao Jianqing Zhang | 2006 | Electrochimica Acta2006，，23： | 2 |
| 14 | Biocompatible chitosan/polyethylene glycol/multi-walled carbon nanotube composite scaffolds for neural tissue engineering显示文摘Carbon nanotube(CNT)composite materials are very attractive for use in neural tissue engineering and biosensor coatings.CNT scaffolds are excellent mimics of extracellular matrix due to their hydrophilicity,viscosity,and biocompatibility.CNTs can also impart conductivity to other insulating materials improve mechanical stability guide neuronal cell behavior and trigger axon regeneration.The performance of chitosan(CS)/polyethylene glycol(PEG)composite scaffolds could be optimized by introducing multi-walled CNTs(MWCNTs).CS/PEG/CNT composite scaffolds with CNT content of 1%,3%,and 5%(1%=0.01 g/mL)were prepared by freeze-drying.Their physical and chemical properties and biocompatibility were evaluated.Scanning electron microscopy(SEM)showed that the composite scaffolds had a highly connected porous structure.Transmission electron microscope(TEM)and Raman spectroscopy proved that the CNTs were well dispersed in the CS/PEG matrix and combined with the CS/PEG nanofiber bundles.MWCNTs enhanced the elastic modulus of the scaffold.The porosity of the scaffolds ranged from 83%to 96%.They reached a stable water swelling state within 24 h,and swelling decreased with increasing MWCNT concentration.The electrical conductivity and cell adhesion rate of the scaffolds increased with increasing MWCNT content.Immunofluorescence showed that rat pheochromocytoma(PC12)cells grown in the scaffolds had characteristics similar to nerve cells.We measured changes in the expression of nerve cell markers by quantitative real-time polymerase chain reaction(qRT-PCR),and found that PC12 cells cultured in the scaffolds expressed growth-associated protein 43(GAP43),nerve growth factor receptor(NGFR),and class IIIβ-tubulin(TUBB3)proteins.Preliminary research showed that the prepared CS/PEG/CNT scaffold has good biocompatibility and can be further applied to neural tissue engineering research. | Shengbo SANG Rong CHENG Yanyan CAO Yayun YAN Zhizhong SHEN Yajing ZHAO Yanqing HAN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，1： | 2 |
| 15 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 16 | Mesenchymal stem cells loaded on 3D-printed gradient poly(e-caprolactone)/methacrylated alginate composite scaffolds for cartilage tissue engineering显示文摘Cartilage has limited self-repair ability due to its avascular,alymphatic and aneural features.The combination of three-dimensional(3D)printing and tissue engineering provides an up-and-coming approach to address this issue.Here,we designed and fabricated a tri-layered(superficial layer(SL),middle layer(ML)and deep layer(DL))stratified scaffold,inspired by the architecture of collagen fibers in native cartilage tissue.The scaffold was composed of 3D printed depth-dependent gradient poly(e-caprolactone)(PCL)impregnated with methacrylated alginate(ALMA),and its morphological analysis and mechanical properties were tested.To prove the feasibility of the composite scaffolds for cartilage regeneration,the viability,proliferation,collagen deposition and chondrogenic differentiation of embedded rat bone marrow mesenchymal stem cells(BMSCs)in the scaffolds were assessed by Live/dead assay,CCK-8,DNA content,cell morphology,immunofluorescence and real-time reverse transcription polymerase chain reaction.BMSCs-loaded gradient PCL/ALMA scaffolds showed excellent cell survival,cell proliferation,cell morphology,collagen II deposition and hopeful chondrogenic differentiation compared with three individual-layer scaffolds.Hence,our study demonstrates the potential use of the gradient PCL/ALMA construct for enhanced cartilage tissue engineering. | Yanyan Cao Peng Cheng Shengbo Sang Chuan Xiang Yang An Xiaochun Wei Zhizhong Shen Yixia Zhang Pengcui Li | 2021 | Regenerative Biomaterials2021，8，3： | 2 |
| 17 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 18 | Determination of ifenprodil by LC–MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers显示文摘This paper reports the development and validation of an assay for ifenprodil based on liquid chromatography–tandem mass spectrometry(LC–MS/MS)and its application to a pharmacokinetic study involving single and multiple intravenous infusions to healthy Chinese volunteers.After sample preparation of plasma by liquid–liquid extraction with ethyl acetate,the analyte and internal standard,urapidil,were separated by reversed phase chromatography in a run time of 4 min and detected by positive ion electrospray ionization followed by multiple reaction monitoring of the precursor-to-product ion transitions at m/z 326.2-308.1 for ifenprodil and m/z 388.4-205.3 for IS.The assay was linear in the concentration range 0.2–50.0 ng/mL with recovery 476.4%.In the pharmacokinetic study of single intravenous infusions of 5,10 and 15 mg ifenprodil,peak plasma concentrations and areas under the plasma concentration–time curve were both linearly related to dose.In the pharmacokinetic study of multiple once daily intravenous infusions of 10 mg ifenprodil for 7 days,pharmacokinetic parameters were similar to those after the single dose showing that ifenprodil does not accumulate on repeated administration. | Jing Yang Chengtao Lu Wei Song Jiankang Li Yi Ding Yanrong Zhu Jinyi Cao Likun Ding Yanyan Jia Aidong Wen | 2013 | Acta Pharmaceutica Sinica B2013，3，3： | 2 |
| 19 | Antidiabetes and Anti-Obesity Activity of Lagerstroemia speciosa显示文摘 | Guy Klein Jaekyung Kim Klaus Himmeldirk Yanyan Cao Xiaozhuo Chen | 2007 | Evidence-Based Complementary and Alternative Medicine2007，，4： | 1 |
| 20 | CpG ODN107 potentiates radiosensitivity of human glioma cells via TLR9-mediated NF-κB activation and NO production显示文摘 | Xiaoli Li Dan Liu Xin Liu Weiwei Jiang Weiying Zhou Wei Yan Yanyan Cen Bin Li Guanqun Cao Guofu Ding Xueli Pang Jianguo Sun Jiang Zheng Hong Zhou | 2012 | Tumor Biology2012，，5： | 1 |
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