|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biostratigraphy and geography of the Ordovician-Silurian Lungmachi black shales in South China显示文摘Based on the new material of seven Ordovician-Silurian boundary sections investigated recently, together with previously published data, we analyze the temporal and spatial distributions of the Lungmachi black shales, a key petroleum source bed widely distributed in South China. The Lungmachi black shales range in age from the Normalograptus persculptus Biozone of the uppermost Ordovician to the Spirograptus guerichi Biozone of the lower Telychian, and ten graptolite biozones can be recognized within this unit. The basal and upper contacts of the Lungmachi black shales are diachronous. The basal contact ranges from the N. persculptus to the C. cyphus biozones, a span of five graptolite biozones over two stages. The upper contact ranges from the D. pectinatus-M. argenteus Biozone to the Spirograptus guerichi Biozone, which spans four graptolite biozones over two stages. The Yichang Uplift resulted in the formation of the Hunan-Hubei Submarine High in the border area of Hubei, Hunan, and Chongqing. This is supported by a break in sedimentation in this area spanning all or part of the Hirnantian, and in many areas extending into the underlying Katian and overlying Rhuddanian. Comparison of the distribution of the Katian to Rhuddanian strata in this area indicates a growth and subsequent reduction in area of the Hunan-Hubei Submarine High particularly in the Hirnantian to early Rhuddanian. This may partly represent the influence of the process of formation and melting of ice sheet in Ordovician South Pole and consequent sea level change. | FAN JunXuan Michael J MELCHIN CHEN Xu WANG Yi ZHANG YuanDong CHEN Qing CHI ZhaoLi CHEN Feng | 2011 | Science China Earth Sciences2011，54，12： | 24 |
| 2 | Synthesis of novel nanomaterials and their application in efficient removal of radionuclides显示文摘With the development of nuclear energy, large amounts of radionuclides are inevitably released into the natural environment. It is necessary to eliminate radionuclides from wastewater for the protection of environment. Nanomaterials have been considered as the potential candidates for the effective and selective removal of radionuclides from aqueous solutions under complicated conditions because of their high specific surface area, large amounts of binding sites, abundant functional groups, pore-size controllable and easily surface modification. This review mainly summarized the recent studies for the synthesis, fabrication and surface modification of novel nanomaterials and their applications in the efficient elimination and solidification of radionuclides,and discussed the interaction mechanisms from batch experiments, spectroscopy analysis and theoretical calculations. The sorption capacities with other materials, advantages and disadvantages of different nanomaterials are compared, and at last the perspective of the novel nanomaterials is summarized. | Xiangxue Wang Long Chen Lin Wang Qiaohui Fan Duoqiang Pan Jiaxing Li Fangting Chi Yi Xie Shujun Yu Chengliang Xiao Feng Luo Jun Wang Xiaolin Wang Changlun Chen Wangsuo Wu Weiqun Shi Shuao Wang Xiangke Wang | 2019 | Science China Chemistry2019，62，8： | 20 |
| 3 | Tissue clearing of both hard and soft tissue organs with the PEGASOS method显示文摘织物空地技术由转织物在 3 尺寸(3-D ) 启用不透明的机关和纸巾的可视化透明。当前的组织空地方法被能与每个单个协议被清除的纸巾的有限类型限制,它不可避免地导致了存在在整个身体或身体部分成像以内盲点。包括骨头和牙齿的难纸巾仍然是要清除的最困难的机关。另外,内长的荧光的损失为基于溶剂的空地方法仍然是一颗主要担心。这里,我们发展了聚乙烯乙二醇(木钉) 联系了溶剂系统(PEGASOS ) ,它将近显示了纸巾的所有类型透明、保存的内长的荧光。骨头和牙齿能被转在变清以后将近不可见。PEGASOS 方法转了透明的整个成年老鼠身体,我们对一个成年老鼠头骨头,牙齿,大脑,肌肉,和其它填写了的图象有能力没有盲目区域的纸巾。难织物透明性使我们能重建在 3-D 的未经触动的上颚,牙齿,腿节,或膝关节。另外,我们在长距离上在亚 cellular 分辨率并且到踪迹个人神经原和轴突管理了未经触动的鼠标大脑到图象。我们也通过 vertebrae 直接设想了背面的根中心。最后,我们在长骨头的髓空间以内在 3-D 揭示了神经网络的分发模式。这些结果建议 PEGASOS 方法是为一般生物医学的研究的一个有用工具。 | Dian Jing Shiwen Zhang Wenjing Luo Xiaofei Gao Yi Men Chi Ma Xiaohua Liu Yating Yi Abhijit Bugde Bo O. Zhou Zhihe Zhao Quan Yuan Jian Q. Feng Liang Gao Woo-Ping Ge Hu Zhao | 2018 | Cell Research2018，28，8： | 18 |
| 4 | Prognostic factors for late mortality after liver transplantation for benign end-stage liver disease显示文摘背景正在增加在研究在这些 patients.However 的早死亡上集中了的肝 transplantation.Many 以后熬过超过一年的病人的数字,影响长期的幸存的因素不是充分, understood.This 学习试图评估预言长期的幸存的预示的因素并且为改进为良性的结束阶段肝 diseases.Methods | ZHANG Ying-cai ZHANG Qi LI Hua ZHANG Jian WANG Gen-shu XU Chi YI Shu-hong YI Hui-min CAI Chang-jie LU Min-qiang YANG Yang CHEN Gui-hua | 2011 | Chinese Medical Journal2011，，24： | 13 |
| 5 | Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong显示文摘瞄准:用香港汉语调查流行和胃肠的基质肿瘤(大意) 的临床的模式,并且估计发病率的 CD117 的介绍的影响。方法:从 Yan Chai 医院的病理的部门的数据库, 47 个病人,在这研究与到 2003 年 12 月的从 1995 年 9 月的大意被包括。十大意在 CD117 的介绍前被诊断。临床的特征,肿瘤特征,和治疗被分析。预言肿瘤的因素联系了死亡或复发与比例的危险建模的考克斯一起被学习。结果:病人包括了 26 男性和 21 女性,与 66.6 年的吝啬的年龄(SD 13.1,范围 29-87 年) 。大意的估计的流行每 100,000 个人是 13.4-15.6,与每 100,000 个人的 1.68-1.96 的年度发生。在 CD117 的介绍前后的大意的年度发生每 100,000 个人是 1.1 并且 2.1 每 100,000 个人分别地。胃(34 个病人, 72.3%) 是为肿瘤的最普通的地点,由小肠列在后面(8 个病人, 17.0%) ,食管(2 个病人, 4.3%) ,网膜(2 个病人, 4.3%) 并且冒号(1 个病人, 2.1%) 。31 个病人(66%) 有完全的肿瘤切除术。十一从 16 死亡(23%) 是肿瘤相关的。中部的生存时间是 26 瞬间。五年的幸存率是 61.3% 。与肿瘤相关的死亡或复发联系的重要因素是不完全的切除术,肿瘤尺寸 5 厘米以上,侵略到转移的邻近的机关或存在。结论:在香港的大意的发生在美国比得上那,但是在芬兰比那降低。大意的真发生能在 CD117 的介绍前被低估。不完全的切除术,肿瘤尺寸 5 厘米以上,到转移的邻近的机关或存在的侵略是预言肿瘤相关的死亡或复发的因素。 | Kam Hoi Chan Chun Wing Chan Wai Hung Chow Wai Keung Kwan Chi Kwan Kong Ka Fung Mak Miu Yi Leung Lin Kiu Lau | 2006 | World Journal of Gastroenterology2006，12，14： | 12 |
| 6 | Synthesis and Properties of High Performance Functional Polyimides Containing Rigid Nonplanar Conjugated Fluorene Moieties显示文摘A diamine(WuFDA) containing vertical rigid non-planar conjugated fluorene moiety and low polarizability group(C―F)was designed and synthesized through three steps of reactions(halogenated reaction, Suzuki coupling reaction, and reduction reaction).Four kinds of high performance functional polyimides(WuFPI-6 F, WuFPI-BP, WuFPI-BT, and WuFPI-PM) were thus prepared by the condensation polymerization of WuFDA with four commercial dianhydride 6 FDA, BPDA, BTDA, and PMDA, respectively. The polyimides exhibited low dielectric constant, excellent thermal stability, outstanding solubility, good film-forming property, and mechanical properties. The dielectric constants of the polyimides were in the range of 2.28-2.88(f = 10~4 Hz). The 5% weight-loss temperatures(Td 5%)in nitrogen were in the range of 555-584 °C, and the glass transition temperatures(T_g) were in the range of 408-448 °C. The weight loss of WuFPI-BP maintaining at 450 and 500 °C for half an hour was only 0.33% and 1.26%, respectively. All the WuFPIs could be dissolved in almost all organic solvents, even chloroform. The tensile strength and tensile modulus of these films were in the ranges of 78.6-85.7 MPa and 3.1-3.2 GPa, respectively. In addition, the polyimides displayed light color with special fluorescent and resistive switching(ON-OFF) characteristics; the maximum fluorescence emission was observed at 422-424 nm in NMP solution and at 470-548 nm in film state. The memory devices with the configuration of indium tin oxide/WuFPIs/aluminum(ITO/WuFPIs/Al) exhibited distinct volatile memory characteristics of static random access memory(SRAM), with an ON/OFF current ratio of 10~5-10~6. These functional polyimides showed attractive potential applications in the field of high performance flexible polymer photoelectronic devices or polymer memory devices. | Yi-Wu Liu Li-Shuang Tang Lun-Jun Qu Si-Wei Liu Zhen-Guo Chi Yi Zhang Jia-Rui Xu | 2019 | Chinese Journal of Polymer Science2019，37，4： | 10 |
| 7 | Hepatic artery complications after orthotopic liver transplantation: interventional treatment or retransplantation?显示文摘背景为在 orthotopic 肝移植(OLT ) 以后的肝的动脉复杂并发症的主要治疗学的治疗包括 thrombolysis,经皮的 transluminal angioplasty, stent 放置,和肝移植。在 OLT 以后的肝的动脉复杂并发症的预后与类型有关不仅,程度,并且预定而且仔细与选择联系了并且治疗学的方法预定。然而,没有关于这些复杂并发症的治疗的意见的一致。这研究的目的是在 25 个病人的临床的数据与肝的动脉血栓(帽子) 和肝的动脉狭窄诊断了的 OLT.Methods 以后为肝的动脉复杂并发症决定最佳的治疗() 在 2003 年 10 月和 2007 年 3 月之间回顾地被考察。治疗包括了包含 thrombolysis,经皮的 transluminal angioplasty 和 stent 放置的肝移植和干预。在有帽子的五个病人之中的结果, 3 与 thrombolysis 被对待。一个人恢复了,一个人在 thrombolysis 以后死了,因为周期性的帽子,另一一个在移植以后死于多器官失败。留下 2 个病人经历了成功的移植并且在那以后幸存。在介绍与的 12 个病人之中手术后地在 1 个月以内有, 2 个病人由于不可逆的肝失败和另外一个经历了移植 10 个病人与干预被对待。肝功能没能在 3 个病人改善,因为 ischemic 胆管炎,移植在 stent 放置以后在 4 个病人被执行。在经历肝移植的 6 个病人之中,二分别地死于 intracranial 出血和感染。介绍与的八个病人手术后地在 1 个月以后有, 5 个病人与 interventional 管理被对待并且在 stent 以后恢复了放置。在另外一个之中, 3 个病人介绍了与, 2 病人的肝功能是稳定的,一个病人由于 ischemic 胆汁管 lesion.Conclusions 收到了迟了的肝移植个性化的治疗学的政体应该在在 OLT 以后对待肝的动脉复杂并发症被采用根据手术后的时期,打字并且 ischemic 胆汁管损害是否存在。肝移植是为有肝的动脉血栓的病人的最好的治疗。Interventional 治疗没有不可逆的肝失败,近来有或胆汁管局部缺血是适当的,而移植被推荐为早。 | YANG Yang LI Hua FU Bin-sheng ZHANG Qi ZHANG Ying-cai LU Ming-qiang CAI Chang-jie XU Chi WANG Gen-shu YI Shu-hong ZHANG Jian ZHANG Jun-feng YI Hui-min JIANG Nan JIANG Hua ZHU Kang-shun JIANG Zai-bo SHAN Hong CHEN Gui-hua | 2008 | Chinese Medical Journal2008，，20： | 9 |
| 8 | The active principle region of Buyang Huanwu decoction induced differentiation of bone marrow-derived mesenchymal stem cells into neural-like cells Superior effects over original formula of Buyang Huanwu decoction显示文摘The present study induced in vitro-cultured passage 4 bone marrow-derived mesenchymal stem cells to differentiate into neural-like cells with a mixture of alkaloid, polysaccharide, aglycone, glycoside, essential oils, and effective components of Buyang Huanwu decoction (active principle region of decoction for invigorating yang for recuperation). After 28 days, nestin and neuron-specific enolase were expressed in the cytoplasm. Reverse transcription-PCR and western blot analyses showed that nestin and neuron-specific enolase mRNA and protein expression was greater in the active principle region group compared with the original formula group. Results demonstrated that the active principle region of Buyang Huanwu decoction induced greater differentiation of rat bone marrow-derived mesenchymal stem cells into neural-like cells in vitro than the original Buyang Huanwu decoction formula. | Jinghui Zheng Yi Wan Jianhuai Chi Dekai Shen Tingting Wu Weimin Li Pengcheng Du | 2012 | Neural Regeneration Research2012，7，4： | 9 |
| 9 | Regulating Effects of Novel CpG Chitosan-nanoparticles on Immune Responses of Mice to Porcine Paratyphoid Vaccines显示文摘Objective To study the regulating effects of a novel CpG oligodeoxynuleotide and the synergistic effect of chitosan-nanoparticles (CNP) with CpG on immune responses of mice, which were used to develop a novel immunoadjuvant to boost immune response to conventional vaccines. Methods A novel CpG ODN containing 11 CpG motifs was synthesized and its bioactivities to stimulate the proliferation of lymphocytes of pig in vitro were detected. Then it was entrapped with CNP prepared in our laboratory by the method of ionic cross linkage, and immunized Kunming mice were co-inoculated with paratyphoid vaccine. The peripheral blood was collected weekly from the tail vein of inoculated mice to detect the contents of IgG, IgA, IgM, and specific antibody against salmonella as well as the levels of interleukin-2 (IL2), IL-4, and IL-6 by SABC-ELISA assay. The numbers of leucocytes, monocytes, granuloytes, and lymphocytes were calculated separately using the routine method. The experimental mice were orally challenged with virulent salmonella 35 days after inoculation. Results This CpG ODN could remarkably provoke the proliferation of lymphocytes of pig in vitro in contrast with the control (P<0.05). Compared with those of the control, immunoglobulins, including IgG, IgA, IgM, and specific antibodies to paratyphoid vaccine, increased significantly in sera from the CpG or CpG-CNP-vaccinated mice (P<0.05). IL-2, IL-4, and IL-6 increased remarkably in sera from immunized mice (P<0.05). The leucocytes, monocytes, granuloytes, and lymphocytes of the mice immunized with CpG or CpG-CNP were also increased in number (P<0.05). After the challenge, these immunity values were elevated in the mice vaccinated with CpG or CpG-CNP. The immunized mice all survived, while the control mice fell ill with evident lesions with diffuse hemorrhage in stomach, small intestine, and peritoneum. Conclusions CpG ODN entrapped with CNP is a promising effective immunoadjuvant for vaccination, which promotes humoral and cellular immune responses, enhances immunity and resistance against salmonella by co-administration with paratyphoid vaccine. | MAN-LIANG FU SAN-CHENG YING MEI WU HUI LI KAI-YUAN WU YI YANG HUAN ZHANG CHI CHENG ZE-ZHOU WANG XIU-YING WANG XUE-BING LV YI-ZHENG ZHANG RONG GAO | 2006 | Biomedical and Environmental Sciences2006，19，4： | 8 |
| 10 | Immunomodulatory therapy of cytomegalovirus pneumonia after liver transplantation显示文摘在那里的背景在对 cytomegalovirus (CMV ) 的研究一直在增加兴趣在肝移植(副) 以后的肺病。这研究被承担在 LT.Methods 以后调查 CMV 肺病的 immunomodulatory 治疗有在到 2005 年 11 月的从 2003 年 10 月的副以后的 CMV 肺病的六个病人回顾地被分析。他们根据临床的表明,胸 X 光检查调查结果和病原的变化被诊断并且给主要包括 immunomodulation 治疗和抗病毒的药的全面治疗。在 CMV 肺病的早阶段,抑制免疫力的代理人的剂量被减少或停止,相反由 immunoenhancement 治疗代替了。在从 CMV 肺病的恢复时期期间,抑制免疫力的代理人的剂量再被给或提高,并且 immunoenhancement 治疗是病人的 ceased.The 肝功能在这个系列在 treatment.Results 期间仔细被监视,五个病人被熬过,一个人死了。在治疗期间正常的仍然是的六个病人的肝功能,和尖锐拒绝的没有事件拿了 place.Conclusions 穷人免疫是在在 CMV 肺病的早舞台的副以后的 CMV 肺病的病原的基础,病人的免疫应该被提高,并且在从 CMV 肺病的恢复时期期间, immunosuppresants shoud 再被给,但是 immunoenhancement 治疗停止。个性化的 immunomodulatory 治疗对在副以后的 CMV 肺病的治疗必要。 | WANG Gen-shu CHEN Gui-hua LU Min-qiang YANG Yang CAI Chang-jie YI Hui-min LI Hua XU Chi YI Shu-hong | 2006 | Chinese Medical Journal2006，，17： | 8 |
| 11 | Early liver retransplantation versus late liver retransplantation: analysis of a single-center experience显示文摘背景 Orthotopic 肝移植(re-OLT ) 是为肝接枝的不可逆的失败的唯一的有效治疗。早、迟了的接枝失败让路给应该独立被讨论的二个不同临床的条件。这研究被设计比较早、迟了的 re-OLT 因为有差的接枝的病人在我们的中心在主要移植以后工作并且在 re-OLT.Methods 总结我们的临床的经验在我们到2007年2月的从2004年1月的中心的 31 re-OLTs 的临床的数据回顾地被分析,近来与 17 个盒子与早 re-OLT 和第二个组的 14 个盒子由第一个组组成胆汁的道复杂并发症是的 re-OLT.Results 为早 re-OLT (57.1%)的主要指示并且迟了另外的普通指示是在在迟了的 re-OLT 的主要疾病的早 re-OLT 和复发的脉管的复杂并发症。没有重要差别关于在操作,冷局部缺血时间,起作用的持续时间,和 perioperative 死亡期间流血的体积在这些组之间被发现;除了结束阶段肝疾病的模型(吞没) 分数。结果在迟了的 re-OLT 为在早 re-OLT 和 9 个病人的 7 个病人是致命的。二死亡由于在早 re-OLT 的严重败血相关的疾病由于有 3 死亡的多重机关失败,并且 4 死亡在迟了的 re-OLT 由于 hepatocellular 癌(HCC ) 的复发由于有 3 死亡的严重败血相关的疾病。分别地,在 re-OLT 以后的和 2 年的保险统计的幸存率为在早 re-OLT 的病人是 55.2% 和 36.9% ,并且 65.1% 和 52% 分别地,为在迟了的 re-OLT 的病人。没有重要差别关于在二 groups.Conclusions 之间的幸存率被发现类似的临床的结果能在早、迟了的 re-OLT 被完成。预定的合适的指示和最佳的操作,足够的外科手术前的准备,富有经验的外科的过程,和有效 perioperative 反感染策略在 re-OLT 以后贡献病人的全面幸存率的改进。 | CHEN Gui-hua FU Bin-sheng YANG Yang CAI Chang-jie LU Min-qiang LI Hua WANG Gen-shu YI Shu-hong XU Chi ZHANG Jun-feng ZHANG Tong WANG Guo-ying | 2008 | Chinese Medical Journal2008，，20： | 7 |
| 12 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 13 | A Facile Strategy for Non-fluorinated Intrinsic Low-k and Low-loss Dielectric Polymers: Valid Exploitation of Secondary Relaxation Behaviors显示文摘High-performance low-k and low-loss circuit materials are urgently needed in the field of microelectronics due to the upcoming FifthGeneration Mobile Communications Technology(5 G Technology).Herein,a facile design strategy for non-fluorinated intrinsic low-k and low-loss polyimides is reported by fully considering the secondary relaxation behaviors of the polymer chains.A new amorphous non-fluorinated polymer(TmBPPA)with a k value of 2.23 and a loss tangent lower than 3.94×10^-3 at 104 Hz has been designed and synthesized,which to the best of our knowledge is the lowest value amongst the non-fluorinated and non-porous polymers reported in literature.Meanwhile,TmBPPA exhibits excellent overall properties,such as excellent thermostability,good mechanical properties,low moisture absorption,and high bonding strength.As high-performance flexible circuit materials,all these characteristics are highly expected to meet the present and future demands for high density,high speed,and high frequency electronic circuit used in 5 G wireless networks. | Chao Qian Zhen-Guo Fan Wei-Wen Zheng Run-Xin Bei Tian-Wen Zhu Si-Wei Liu Zhen-Guo Chi Matthew P.Aldred Xu-Dong Chen Yi Zhang Jia-Rui Xu | 2020 | Chinese Journal of Polymer Science2020，38，3： | 7 |
| 14 | Prevalence and Risk Factors of Atrial Fibrillation in Chinese Elderly: Results from the Chinese Longitudinal Healthy Longevity Survey显示文摘 | Choy-Lye Chei Prassanna Raman Chi Keong Chino Zhao-Xue Yin Xiao-Ming Shi Yi Zeng David B Matchar | 2015 | Chinese Medical Journal2015，，18： | 7 |
| 15 | 青年型开角型青光眼的中国家系的新型Myocilin基因突变显示文摘目的:探讨某中国家系青年型开角型青光眼(JOAG)的致病基因。
方法:在一个青光眼家系中,三代人中患JOAG或高眼压。我们筛查了6位家族成员Myocilin(MYOC)和 optineurin(OPTN)的突变和apolipoprotein E的多态性,2位患有JOAG,2位患有高眼压,2位无症状。正常对照组包括200位与本家系无关联的受试者。用编码野生型或变异性 MYOC 互补 DNA 的表达载体转染cos-7细胞系。细胞内或分泌的MYOC蛋白用Western法进行检测。 | Bao Jian Fan Dexter Y. L Leung Dan Yi Wang Stéphane Vincent Raymond Pancy O. S. Tam Dennis S. C. Lam Chi Pui Pang 王婷(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 5 |
| 16 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 17 | Loading-free supramolecular organic framework drug delivery systems(sof-DDSs) for doxorubicin:normal plasm and multidrug resistant cancer cell-adaptive delivery and release显示文摘Four water-soluble porous supramolecular organic framework drug delivery systems(sof-DDSs) have been used to adsorb doxorubicin(DOX) in water at physiological pH of 7.4,which is driven exclusively by hydrophobicity.The resulting complexes DOX@SOFs are formed instantaneously upon dissolving the components in water.The drug-adsorbed sof-DDSs can undergo plasm circulation with important maintenance of the drug and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells.DOX is released readily in the cancer cells due to the protonation of its amino group in the acidic medium of cancer cells.In vitro and in vivo experiments reveal that the delivery of SOF-a-d remarkably improve the cytotoxicity of DOX for the MCF-7/Adr cells and tumors,leading to 13-19-fold reduction of the 1C_(50)values as compared with that of DOX.This new sof-DDSs strategy omits the indispensable loading process required by most of reported nano-scaled carriers for neutral hydrophobic chemotherapeutic agents,and thus should be highly valuable for future development of low-cost delivery systems. | Chi Yao Jia Tian Hui Wang Dan-Wei Zhang Yi Liu Fan Zhang Zhan-Ting Li | 2017 | Chinese Chemical Letters2017，28，4： | 5 |
| 18 | Prophylaxis of hepatitis B recurrence in post-liver transplantation patients with lamivudine-resistant YMDD mutant显示文摘大多数经常使用了的背景为肝炎 B 的移植以后的复发的治疗病毒(HBV ) 感染是 lamivudine,但是这药由于 YMDD 与高抵抗率被联系变异。在初步的报告, adefovir dipivoxil (副词) 被显示了对 HBV 的 lamivudine 抵抗的紧张举办活动。然而,在在肝移植(副) 以后的 HBV 感染的治疗的临床的经验仍然不是完全清楚的。这研究被瞄准从2004年3月与在 LT.Methods 前变异的 YMDD 在病人评估副词正肝炎 B 免疫球蛋白( HBIG )的预防功效到2006年3月,有长期的肝炎 B 的 16 个病人把lamivudine抵抗的 YMDD 异种在肝移植以前检测了并且对接枝再感染作为预防在副以后与副词正另外的肌内的 HBIG 接受了治疗。为肝功能,浆液 HBsAg, anti-HBs (HBIG ) , HBeAg, anti-HBc, anti-HBe, HBV-DNA,和 creatinine 的测试是估计的肝前或肝以后的 transplantation.Results 肝以后的移植是的这些病人的中部的后续 19.4 个月。十五个病人幸存,一个病人死于 hepatocellular 癌(HCC ) 的复发。有重要差别(10.98% 对 2.26% , P0.05 ) 处于在有在有 HBV-DNA 的 106 copies/ml 和那些上的 HBV-DNA 的病人之间的 YMDD 变异的率不到 106 copies/ml。十五个病人(93.8%)在 4 个星期有无法发现的 HBV-DNA 并且 1 (6.3%)在在副以后的 6 个月,没有肝炎 B 复发被 HBsAg 的坚持的测试检测, HBeAg ,并且 HBV-DNA 和与副词联系的浆液 creatinine 水平的没有增加在任何与肌内的 HBIG 相结合的 patients.Conclusion 副词被观察能有效地在副以后与从 HBV 复发变异的移植前 YMDD 阻止病人。 | ZHANG Qi CAI Chang-jie LU Ming-qiang LI Xi JIANG Nan JIANG Hua XU Chi LI Hua WANG Gen-shu YI Shu-hong ZHANG Jian ZHANG Jun-feng YI Hui-min ZHANG Ying-cai CHEN Gui-hua | 2007 | Chinese Medical Journal2007，，16： | 5 |
| 19 | In situ-prepared homogeneous supramolecular organic framework drug delivery systems(sof-DDSs):Overcoming cancer multidrug resistance and controlled release显示文摘Water-soluble three-dimensional porous supramolecular organic frameworks(SOFs) have been demonstrated as a new generation of homogeneous polycationic platforms for anti-cancer drug delivery.The new SOF drug delivery systems(sof-DDSs) can adsorb dianionic pemetrexed(PMX),a clinically used chemotherapeutic agent instantaneously upon dissolving in water,which is driven by both electrostatic attraction and hydrophobicity.The in situ-prepared PMX@SOFs are highly stable and can avoid important release of the drug during plasm circulation and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells to enter the cancer cells.Acidic microenvironment of cancer cells promotes the release of the drug in cancer cells.Both in vitro and in vivo studies have revealed that sofDDSs considerably improve the treatment efficacy of PMX,leading to 6-12-fold reduction of the IC50 values,as compared with that of PMX alone.The new drug delivery strategy omits the loading process required by most of reported nanoparticle-based delivery systems and thus holds promise for future development of low-cost drug delivery | Jia Tian Chi Yao Wen-Lin Yang Lei Zhang Dan-Wei Zhang Hui Wang Fan Zhang Yi Liu Zhan-Ting Li | 2017 | Chinese Chemical Letters2017，28，4： | 4 |
| 20 | The effect of Fe-Mn minerals and seawater interface and enrich-ment mechanism of ore-forming elements of polymetallic crusts and nodules from the South China Sea显示文摘Ferromanganese crusts and nodules are important submarine mineral resources that contain various metal elements with significant economic value. In this study, polymetallic crusts and nodules obtained from the South China Sea(SCS) were determined by using X-ray power diffraction(XRD), Raman spectroscopy(RS), Fourier transform infrared spectroscopy(FTIR), and X-ray photoelectron spectroscopy(XPS) to systematically investigate and analyze the mineralogical and spectral characteristics of the Fe-Mn minerals. XRD measurements revealed that the SCS polymetallic crusts and nodules were composed of vernadite, quartz, and plagioclase. The nodules also contained todorokite. The Fe-phase minerals of the SCS crusts and nodules were composed of amorphous Fe oxide/hydroxide, and the Mn-and Fe-phases minerals exhibited relatively poor degrees of crystallization. FTIR results showed that the Fe-Mn minerals in the crusts and nodules included a large number of surface hydroxyl groups. These surface hydroxyl groups contained protons that could provide reactive sites for complexation of ore-forming elements in seawater. XPS results indicated that the surfaces of the Fe-Mn minerals mainly contained Fe, Mn, and O. Fe was present in the trivalent oxidation state, while Mn, which may contain several bivalent oxidation state, was present in the tetravalent and trivalent oxidation states. The SCS polymetallic crusts and nodules were compared with Pacific seamount crusts, and results showed that the surface hydroxyl(-OH) groups of the SCS crusts and nodules numbered more than the lattice oxygen(O^(2-)). But the lattice oxygen of Pacific seamount crusts numbered more than the surface hydroxyl groups. This characteristic indicated that the degree of crystallization of Fe-Mn minerals from the Pacific Ocean was higher than that of minerals from the South China Sea. Comprehensive studies showed that ore-forming elements in the interface between seawater and the Fe-Mn minerals in the submarine ferromanganese crusts and nodules employed the following enrichment mechanisms:(1) the metal ion complexed with the surface hydroxyl of Fe-Mn minerals to form hydroxyl complexes, which were connected by coordination bonds or stable inner-sphere complexes that exchanged protons on the mineral surfaces;(2) the charged surfaces of the minerals and metal cations formed outer-sphere complexes, which made up the electrostatic double layer, through electrostatic adsorption; and(3) the metal cations isomorphously exchanged the Mn and Fe ions of the mineral lattice structure. | GUAN Yao SUN Xiaoming IANG Xiaodong SA Rina ZHOU Li HUANG Yi LIU Yating LI Xiaojie LU Rongfei WANG Chi | 2017 | Acta Oceanologica Sinica2017，36，6： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员