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| 1 | Synthesis of novel nanomaterials and their application in efficient removal of radionuclides显示文摘With the development of nuclear energy, large amounts of radionuclides are inevitably released into the natural environment. It is necessary to eliminate radionuclides from wastewater for the protection of environment. Nanomaterials have been considered as the potential candidates for the effective and selective removal of radionuclides from aqueous solutions under complicated conditions because of their high specific surface area, large amounts of binding sites, abundant functional groups, pore-size controllable and easily surface modification. This review mainly summarized the recent studies for the synthesis, fabrication and surface modification of novel nanomaterials and their applications in the efficient elimination and solidification of radionuclides,and discussed the interaction mechanisms from batch experiments, spectroscopy analysis and theoretical calculations. The sorption capacities with other materials, advantages and disadvantages of different nanomaterials are compared, and at last the perspective of the novel nanomaterials is summarized. | Xiangxue Wang Long Chen Lin Wang Qiaohui Fan Duoqiang Pan Jiaxing Li Fangting Chi Yi Xie Shujun Yu Chengliang Xiao Feng Luo Jun Wang Xiaolin Wang Changlun Chen Wangsuo Wu Weiqun Shi Shuao Wang Xiangke Wang | 2019 | Science China Chemistry2019，62，8： | 20 |
| 2 | A pre-generated matrix-based method for real-time robotic drilling chatter monitoring显示文摘Currently, due to the detrimental effects on surface finish and machining system, chatter has been one crucial factor restricting robotic drilling operations, which improve both quality and efficiency of aviation manufacturing. Based on the matrix notch filter and fast wavelet packet decomposition, this paper presents a novel pre-generated matrix-based real-time chatter monitoring method for robotic drilling. Taking vibration characteristics of robotic drilling into account, the matrix notch filter is designed to eliminate the interference of spindle-related components on the measured vibration signal. Then, the fast wavelet packet decomposition is presented to decompose the filtered signal into several equidistant frequency bands, and the energy of each sub-band is obtained. Finally, the energy entropy which characterizes inhomogeneity of energy distribution is utilized as the feature to recognize chatter on-line, and the effectiveness of the presented algorithm is validated by extensive experimental data. The results show that the proposed algorithm can effectively detect chatter before it is fully developed. Moreover, since both filtering and decomposition of signal are implemented by the pre-generated matrices, calculation for an energy entropy of vibration signal with 512 samples takes only about 0.690 ms. Consequently, the proposed method achieves real-time chatter monitoring for robotic drilling, which is essential for subsequent chatter suppression. | Jianfeng TAO Chengjin QIN Dengyu XIAO Haotian SHI Chengliang LIU | 2019 | Chinese Journal of Aeronautics2019，32，12： | 9 |
| 3 | Graphitic carbon nitride/biochar composite synthesized by a facile ball-milling method for the adsorption and photocatalytic degradation of enrofloxacin显示文摘In order to enhance the removal performance of graphitic carbon nitride(g-C_(3)N_(4)) on organic pollutant, a simultaneous process of adsorption and photocatalysis was achieved via the compounding of biochar and g-C_(3)N_(4). In this study, g-C_(3)N_(4) was obtained by a condensation reaction of melamine at 550 °C. Then the g-C_(3)N_(4)/biochar composites were synthesized by ball milling biochar and g-C_(3)N_(4) together, which was considered as a simple, economical, and green strategy. The characterization of resulting g-C_(3)N_(4)/biochar suggested that biochar and g-C_(3)N_(4) achieved effective linkage. The adsorption and photocatalytic performance of the composites were evaluated with enrofloxacin(EFA) as a model pollutant. The result showed that all the g-C_(3)N_(4)/biochar composites displayed higher adsorption and photocatalytic performance to EFA than that of pure g-C_(3)N_(4). The 50% g-C_(3)N_(4)/biochar performed best and removed 45.2% and 81.1% of EFA(10 mg/L) under darkness and light with a dosage of 1 mg/mL, while g-C_(3)N_(4) were 19.0% and 27.3%, respectively. Besides, 50% g-C_(3)N_(4)/biochar showed the highest total organic carbon(TOC) removal efficiency(65.9%). Radical trapping experiments suggested that superoxide radical( ·O_(2)^(-)) and hole(h~+) were the main active species in the photocatalytic process. After 4 cycles, the composite still exhibited activity for catalytic removal of EFA. | Yao Xiao Honghong Lyu Chengliang Yang Beibei Zhao Lan Wang Jingchun Tang | 2021 | Journal of Environmental Sciences2021，33，5： | 8 |
| 4 | Design criteria for tetradentate phenanthroline-derived heterocyclic ligands to separate Am(Ⅲ) from Eu(Ⅲ)显示文摘To design novel phenanthroline-derived soft ligands for selectively separating minor actinides from lanthanides, four tetradentate phenanthroline-derived heterocyclic ligands(BTPhen, BPyPhen, BPzPhen, and BBizPhen) were constructed and their complexation behaviors with Am(ⅡI) and Eu(ⅡI) were systematically investigated by density functional theory(DFT) coupled with relativistic small-core pseudopotential. In all the 1:1-type species, the metal ion is in the center of the cavity and coordinates with two nitrogen atoms(N1 and N1′) of the phenanthroline skeleton and the other two nitrogen atoms(N2 and N2′) of the auxiliary groups. The bond lengths of Am–N are comparable to or even shorter than those of Eu–N bonds because the ionic radii of Am(ⅡI) are larger than those of Eu(ⅡI). Additionally, the negative ΔΔGAm/Eu value for the reaction of [M(H2O)4-(NO3)3] + L → ML(NO3)3 + 4H2 O indicates that the complexation reaction of Am(ⅡI) is more energetically favorable than that of Eu(ⅡI); this can be considered as an important design criterion to screen phenanthroline-derived ligands for MA(ⅡI) extraction. According to this criterion, the selectivity of tetradentate phenanthroline-derived ligands for separating Am(ⅡI) over Eu(ⅡI) follows the order of BTPhen > BBizPhen > BPyPhen > BPzPhen. | XIAO ChengLiang WU QunYan WANG CongZhi ZHAO YuLiang CHAI ZhiFang SHI WeiQun | 2014 | Science China Chemistry2014，57，11： | 1 |
| 5 | HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19显示文摘Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)is a major pathological feature of Coronavirus Disease 2019(COVID-19)and a crucial determinant in COVID-19 prognosis.Understanding the mechanism underlying the SARS-CoV-2-induced cytokine storm is critical for COVID-19 control.Here,we identify that SARS-CoV-2 ORF3a and host hypoxia-inducible factor-1α(HIF-1α)play key roles in the virus infection and pro-inflammatory responses. | Mingfu Tian Weiyong Liu Xiang Li Peiyi Zhao Muhammad Adnan Shereen Chengliang Zhu Shanyu Huang Siyu Liu Xiao Yu Miaomiao Yue Pan Pan Wenbiao Wang Yongkui Li Xulin Chen Kailang Wu Zhen Luo Qiwei Zhang Jianguo Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 6 | Chromatographic separation of cesium by a macroporous silica - based supramolecular recognition agent impregnated material显示文摘 | Anyun Zhang Chengliang Xiao Wenjing Xue | 2009 | Separation and Purification Technology2009，66，： | 1 |
| 7 | A new method for evaluating the quality of single sperm by detecting reactive oxygen species显示文摘Sperm damage caused by reactive oxygen species(ROS) is one of the main causes of male infertility.Therefore, the level of ROS in sperm is an important indicator for the diagnosis and prognosis of male infertility. Herein, we constructed a single sperm ROS detection method(SSRDM) with an optical microprobe fabricated via focused ion beam process. The micro-probe is used to separately excite fluorescence in the sperm and the area around the sperm after ROS staining, and the difference in fluorescence values can reflect the level of ROS in the sperm. We collected 102 semen samples and 72 of them were divided into asthenozoospermia and non-asthenozoospermia groups. SSRDM and flow cytometry were used to detect the ROS levels of the two groups. The results of SSRDM showed that the ROS levels of asthenozoospermia group were higher than that of non-asthenozoospermia group(P = 0.002), while the results of flow cytometry indicated no difference(P = 0.152). In terms of ROS levels, compared with flow cytometry, SSRDM has a stronger ability to distinguish between those two groups, providing a reliable basis for assessment of sperm quality. Another 30 semen samples were used to investigate temperature and temporal variability of SSRDM to ensure the stability and accuracy of this method. Overall, we have developed a method that can quantitatively detect fluorescent substances in sperm at the single-cell level supplying evidence for diagnosis and prognosis of male infertility. | Hao Hu Bei Yan Wei Zhang Wenbo Yan Liquan Liu Xiaofeng Tang Kejun Dong Longjie Li Xianjin Xiao Chengliang Xiong | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 8 | Chromate separation by selective crystallization显示文摘A new paradigm to remove toxic chromate anions from aqueous solution by crystallization of chromatewater clusters with imine-linked guanidinium cationic ligands is introduced.The guanidium-based cationic ligand was easily prepared through the imine condensation of an alde hyde and aminoguanidine hydrochloride.The cationic imine-linked guanidinium liga nd(BBIG-CI)showed a high re moval capacity(292.5 mg/g)in the solutions.Rapid decontamination of chromate anions from the wastewater by this cationic ligand was resulted from an instantaneous crystallization.The produced guanidium chromate salts have an extremely low solubility(Ksp,BBIG=8.19×10^9).Such superior removal performance of these mate rials was attributed to the cha rge-assisted hydrogen bonding between the cationic ligand and chromate-water hydrate anions,which was revealed by the single-crystal X-ray diffraction analysis and density functional theory(DFT)calculations.In addition,the succes s ful recove ry of the guanidium-based ligand makes it more attractive for real-world applications. | Xijian Chen Xing Dai Rongzhen Xie Jie Li Afshin Khayambashi Lei Xu Chuang Yang Nannan Shen Yaxing Wang Linwei He Yugang Zhang Chengliang Xiao Zhifang Chai Shuao Wanga | 2020 | Chinese Chemical Letters2020，31，7： | 0 |
| 9 | Common problems in the TCM intellectualized development and strategies for its sustainable development显示文摘 | SONG Chengliang XIAO Yukun | 2017 | International English Education Research2017，，6： | 0 |
| 10 | Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell显示文摘Hematopoietic stem cell(HSC) transplantation is the only curative therapy for many diseases.HSCs from umbilical cord blood(UCB) source have many advantages over from bone marrow.However,limited HSC dose in a single CB unit restrict its widespread use.Over the past two decades,ex vivo HSC expansion with small molecules has been an effective approach for obtaining adequate HSCs.Till now,several small-molecule compounds have entered the phase Ⅰ/Ⅱ trials,showing safe and favorable pharmacological profiles.As HSC expansion has become a hot topic over recent years,many newly identified small molecules along with novel biological mechanisms for HSC expansion would help solve this challenging issue.Here,we will give an overview of HSC biology,discovery and medicinal chemistry development of small molecules,natural products targeting for HSC expansion,and their recent clinical progresses,as well as potential protein targets for HSC expansion. | Jiaxing Li Xiao Wang Jiayu Ding Yasheng Zhu Wenjian Min Wenbing Kuang Kai Yuan Chengliang Sun Peng Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 0 |
| 11 | Bispecific antibodies in cancer therapy:Target selection and regulatory requirements显示文摘In recent years,the development of bispecific antibodies(bsAbs)has been rapid,with many new structures and target combinations being created.The boom in bsAbs has led to the successive issuance of industry guidance for their development in the US and China.However,there is a high degree of similarity in target selection,which could affect the development of diversity in bsAbs.This review presents a classification of various bsAbs for cancer therapy based on structure and target selection and examines the advantages of bsAbs over monoclonal antibodies(mAbs).Through database research,we have identified the preferences of available bsAbs combinations,suggesting rational target selection options and warning of potential wastage of medical resources.We have also compared the US and Chinese guidelines for bsAbs in order to provide a reference for their development. | Yanze Sun Xinmiao Yu Xiao Wang Kai Yuan Gefei Wang Lingrong Hu Guoyu Zhang Wenli Pei Liping Wang Chengliang Sun Peng Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 12 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 13 | Temperature-responsive alkaline aqueous biphasic system for radioactive wastewater treatment显示文摘The treatment of anionic ^(99)TcO_(4)^(-)in the waste tank with high alkalinity is still very challenging.In this work,a new temperature-responsive alkaline aqueous biphasic system(ABS)based on(tri-n–butyl)-ntetradecyl phosphonium chloride(P_(44414)Cl)was developed to remove radioactive ^(99)TcO_(4)^(-).The phase transition mechanism was studied by cloud point titration,small-angel X-ray scattering,dynamic light scattering,and molecular dynamic simulations.As the Na OH concentration or temperature increased,the P_(44414)^(+)micelle could grow and aggregate.This micelle showed a particularly high affinity toward ReO_(4)^(-)/^(99)TcO_(4)^(-)compared to other competing anions and could directly extract more than 98.6%of ^(99)TcO_(4)^(-)from simulated radioactive tank waste supernatant.Furthermore,the loaded ^(99)TcO_(4)^(-)could be easily stripped by using concentrated nitric acid rather than metal salt-based reductants.This work clearly demonstrates that the alkaline ABS is a promising separation system for solving the technetium problem in the alkaline waste tank. | Chuanying Liu Jianhui Lan Qibin Yan Zhipeng Wang Chao Xu Weiqun Shi Chengliang Xiao | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
| 14 | Peptides-modified polystyrene-based polymers as high-performance substrates for the growth and propagation of human embryonic stem cells显示文摘As human stem cells with the special pluripotency play important roles in the innovative drug discovery and regenerative medicine,development of extracellular matrix(ECM)mimetics or functional materials that can support stem cell growth and propagation is of high significance.Despite numerous efforts spent,one major limitation restricting the wide applications of stem cells to the clinical translation is the lack of efficient strategies for low cost and large-scale stem cell production under xeno-free culture conditions.Herein,we reported a new strategy with peptides-modified polystyrene-based polymers coated onto the surface of coverslips for the growth and reproduction of human embryonic stem cells(h ESCs).The modified peptides are the active parts of proteins which has been shown to contribute to the pluripotent stem cell attachment or proliferation.The peptides were linked to the glass coverslips coated by the polymer materials via chemical crosslinking,and the composite substrates successfully maintain the longterm growth of HUES-7,H7 and DF699.Our study shows that the coating of polystyrene-derived polymer modified by our developed peptides is a good matrix for long-term growth and reproduction of stem cells.This polystyrene-derived polymer substrate can be produced in large scale and stored for a long time.The most important thing is that it can support the growth of undifferentiated human pluripotent stem cells(h PSCs)for more than ten passages,which could provide a new and relatively easy way to amplify h ESCs in vitro. | Fen Yang Da Zhang Quanming Zhou Mengchu Li Chengliang Xie Shaoyun Li Xuan Wang Wei Wang Ying Guo Qicai Xiao Yong Wang Liqian Gao | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 15 | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents显示文摘Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1)have emerged as one of the most promising immune checkpoint targets for cancer immunotherapy.Despite the inherent advantages of small-molecule inhibitors over antibodies,the discovery of small-molecule inhibitors has fallen behind that of antibody drugs.Based on docking studies between small molecule inhibitor and PD-L1 protein,changing the chemical linker of inhibitor from a flexible chain to an aromatic ring may improve its binding capacity to PD-L1 protein,which was not reported before.A series of novel phthalimide derivatives from structure-based rational design was synthesized.P39 was identified as the best inhibitor with promising activity,which not only inhibited PD-1/PD-L1 interaction(IC_(50)=8.9 nmol/L),but also enhanced killing efficacy of immune cells on cancer cells.Co-crystal data demonstrated that P39 induced the dimerization of PD-L1 proteins,thereby blocking the binding of PD-1/PD-L1.Moreover,P39 exhibited a favorable safety profile with a LD_(50)>5000 mg/kg and showed significant in vivo antitumor activity through promoting CD8^(+)T cell activation.All these data suggest that P39 acts as a promising small chemical inhibitor against the PD-1/PD-L1 axis and has the potential to improve the immunotherapy efficacy of T-cells. | Chengliang Sun Yao Cheng Xiaojia Liu Gefei Wang Wenjian Min Xiao Wang Kai Yuan Yi Hou Jiaxing Li Haolin Zhang Haojie Dong Liping Wang Chenguang Lou Yanze Sun Xinmiao Yu Hongbin Deng Yibei Xiao Peng Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 0 |
| 16 | A one-pot process based on P_(44414)Cl-HCl aqueous biphasic system for recovering rare earth elements from NdFeB permanent magnet显示文摘Recovering critical metals from secondary resources have attracted great interest recently.In this work,a green one-pot leaching-extraction process based on tributyl(tetradecyl)phosphonium chloride (P_(44414)Cl)aqueous biphasic system (ABS) was developed to efficiently recover rare earth elements (REEs) from Nd Fe B permanent magnet.The reaction process,phase separation mechanism,and operation conditions were thoroughly investigated.It is found that the P_(44414)Cl-HCl ABS showed strong extraction ability towards Fe (>99%) whereas only a few REEs (<10%) were extracted,leading to extremely high separation selectivity between Fe and REEs.The characterization results showed that the coordination differences of Fe and Nd in HCl were the main driving forces for such highly selective separation.The phase diagram of P_(44414)Cl-Nd Cl_(3)ABS indicated that the salting-out effect of Nd Cl_(3)was stronger than common chlorides.Due to the hydrophobic property of P_(44414)[Fe Cl_(4)]and salting-out effect of Nd Cl_(3),the P_(44414)Cl could directly form ABS at room temperature after dissolving practical roasted Nd Fe B samples without any other operations and reagents.REEs and Fe could be mutually separated in just one step.Compared with traditional liquid-liquid extraction or ABS separation,this recovery process is green and facile and shows great application prospects in the field of rare-earth recovery. | Chuanying Liu Qibin Yan Xingwang Zhang Lecheng Lei Chengliang Xiao | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
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