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| 1 | Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury显示文摘We report the generation of human ESC-derived,expandable hepatic organoids(hEHOs)using our newly established method with wholly defined(serum-free,feeder free)media.The hEHOs stably maintain phenotypic features of bipotential liver stem/progenitor cells that can differentiate into functional hepatocytes or cholangiocytes.The hEHOs can expand for 20 passages enabling large scale expansion to cell numbers requisite for industry or clinical programs.The cells from hEHOs display remarkable repopulation capacity in injured livers of FRG mice following transplantation,and they differentiate in vivo into mature hepatocytes.If implanted into the epididymal fat pads of immune-deficient mice,they do not generate non-hepatic lineages and have no tendency to form teratomas.We further develop a derivative model by incorporating human fetal liver mesenchymal cells(hFLMCs)into the hEHOs,referred to as hFLMC/hEHO,which can model alcoholic liver disease-associated pathophysiologic changes,including oxidative stress generation,steatosis,inflammatory mediators release and fibrosis,under ethanol treatment.Our work demonstrates that the hEHOs have considerable potential to be a novel,ex vivo pathophysiological model for studying alcoholic liver disease as well as a promising cellular source for treating human liver diseases. | Shuyong Wang Xuan Wang Zuolong Tan Yuxin Su Juan Liu Mingyang Chang Fang Yan Jie Chen Tao Chen Chuanjiang Li Jie Hu Yunfang Wang | 2019 | Cell Research2019，29，12： | 20 |
| 2 | Three-dimensional finite-time cooperative guidance for multiple missiles without radial velocity measurements显示文摘In order to simultaneously attack a target with impact angle constraint in threedimensional(3-D) space, a novel distributed cooperative guidance law for multiple missiles under directed communication topologies is proposed without radial velocity measurements. First, based on missiles-target 3-D relative motion equations, the multiple missiles cooperative guidance model with impact angle constraint is constructed. Then, in Line-of-Sight(LOS) direction, based on multiagent system cooperative control theory, one guidance law with directed topologies is designed with strict proof, which can guarantee finite time consensus of multiple missiles' impact times. Next, in elevation direction and azimuth direction of LOS, based on homogeneous system stability theory and integral sliding mode control theory, two guidance laws are proposed respectively with strict proof, which can guarantee LOS angles converge to desired values and LOS angular rates converge to zero in finite time. Finally, the effectiveness of the designed cooperative guidance law is demonstrated through simulation results. | Teng LYU Chuanjiang LI Yanning GUO Guangfu MA | 2019 | Chinese Journal of Aeronautics2019，32，5： | 14 |
| 3 | Effects of fumaric acid supplementation on methane production and rumen fermentation in goats fed diets varying in forage and concentrate particle size显示文摘Background: In rumen fermentation, fumaric acid(FA) could competitively utilize hydrogen with methanogenesis to enhance propionate production and suppress methane emission, but both effects were diet-dependent. This study aimed to explore the effects of FA supplementation on methanogenesis and rumen fermentation in goats fed diets varying in forage and concentrate particle size.Methods: Four rumen-cannulated goats were used in a 4 × 4 Latin square design with a 2 × 2 factorial arrangement of treatments: low or high ratio of forage particle size: concentrate particle size(Fps:Cps), without or with FA supplementation(24 g/d). Fps:Cps was higher in the diet with chopped alfalfa hay plus ground corn than in that with ground alfalfa hay plus crushed corn.Results: Both increasing dietary Fps:Cps and FA supplementation shifted ruminal volatile fatty acid(VFA) patterns toward more propionate and less acetate in goats. An interaction between dietary Fps:Cps and FA supplementation was observed for the ratio of acetate to propionate(A:P), which was more predominant when FA was supplemented in the low-Fps:Cps diet. Methane production was reduced by FA, and the reduction was larger in the low-Fps:Cps diet(31.72%) than in the high-Fps:Cps diet(17.91%). Fumaric acid decreased ruminal total VFA concentration and increased ruminal p H. No difference was found in ruminal DM degradation of concentrate or alfalfa hay by dietary Fps:Cps or FA. Goats presented a lower ruminal methanogen abundance with FA supplementation and a higher B. fibrisolvens abundance with high dietary Fps:Cps.Conclusions: Adjusting dietary Fps:Cps is an alternative dietary model for studying diet-dependent effects without changing dietary chemical composition. Fumaric acid supplementation in the low-Fps:Cps diet showed greater responses in methane mitigation and propionate increase. | Zongjun Li Nannan Liu Yangchun Cao Chunjia Jin Fei Li Chuanjiang Cai Junhu Yao | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 8 |
| 4 | Backstepping-based distributed coordinated tracking formultiple uncertain Euler-Lagrange systems显示文摘Based on the idea of backstepping design, distributed coordinated tracking problems under directed topology are discussed for multiple Euler-Lagrange(EL) systems. The dynamic leader case is considered. First, with the parameter-linearity property, a distributed coordinated adaptive control scheme is proposed for EL systems in the presence of parametric uncertainties.Then, subject to nonlinear uncertainties and external disturbances,an improved adaptive control algorithm is developed by using neural-network(NN) approximation of nonlinear functions. Both proposed algorithms can make tracking errors for each follower ultimately bounded. The closed-loop systems are investigated by using the combination of graph theory, Lyapunov theory, and Barbalat Lemma. Numerical examples and comparisons with other methods are provided to show the effectiveness of the proposed control strategies. | yanchao sun wenjia wang guangfu ma zhuo li chuanjiang li | 2016 | Journal of Systems Engineering and Electronics2016，27，5： | 4 |
| 5 | Nonlinear dynamics and station-keeping control of a rotating tethered satellite system in halo orbits显示文摘The dynamics of a rotating tethered satellite system(TSS) in the vicinity of libration points are highly nonlinear and inherently unstable.In order to fulfll the station-keep control of the rotating TSS along halo orbits,a nonlinear output tracking control scheme based on the h–D technique is proposed.Compared with the popular time-variant linear quadratic regulator(LQR) controller,this approach overcomes some limitations such as on-line computations of the algebraic Riccati equation.Besides,the obtained nonlinear suboptimal controller is in a closed form and easy to implement.Numerical simulations show that the TTS trajectories track the periodic reference orbit with low energy consumption in the presence of both tether and initial injection errors.The axis of rotation can keep pointing to an inertial specifc object to fulfll an observation mission.In addition,the thrusts required by the controller are in an acceptable range and can be implemented through some low-thrust propulsion devices. | Liu Gang Huang Jing Ma Guangfu Li Chuanjiang | 2013 | Chinese Journal of Aeronautics2013，26，5： | 3 |
| 6 | Determination of insecticide monosultap residues in tomato and soil by capillary gas chromatography with flame photometric detection 显示文摘 | TAO Chuanjiang HU Jiye LI Jianzhong | 2007 | Can J Anal Sci Spect2007，52，5： | 1 |
| 7 | Evaluation of pesticide residues in fruits and vegetables from Xiamen, China显示文摘 | Chen Chen Yongzhong Qian Qiong Chen Chuanjiang Tao Chuanyong Li Yun Li | 2011 | Food Control2011，，： | 1 |
| 8 | Risk assessment of chlorpyrifos on rice and cabbage in China显示文摘 | Chen Chen Yongzhong Qian Xianjin Liu Chuanjiang Tao Ying Liang Yun Li | 2011 | Regulatory Toxicology and Pharmacology2011，，1： | 1 |
| 9 | Formalized abstract Component Object Mode显示文摘 | MIAO HUAIKOU YU CHUANJIANG LI LIA | 2000 | IEEE Technology of Object-Oriented Languages and System2000，，4： | 1 |
| 10 | Multi-residue Determination of 41 Insecticides in Garlic by Gas Chromatography and Ion Trap Mass Spectrometry Using the Selective Ion Storage Technique 显示文摘 | Ma Xiaodong Li Chongjiu Tao Chuanjiang | 2001 | Rapid Commun Mass Spectrom2001，，15： | 1 |
| 11 | Free weight exercises recognition based on dynamic time warping of acceleration data 显示文摘 | Li Chuanjiang Fei Minrui Hu Huosheng | 2013 | Communications in Computer and Information Science2013，355，9： | 1 |
| 12 | Risk assessment of chlorpyrifos on rice and cabbage in China显示文摘 | Chen Chen Yongzhong Qian Xianjin Liu Chuanjiang Tao Ying Liang Yun Li | 2011 | Regulatory Toxicology and Pharmacology2011，，1： | 1 |
| 13 | Finite-time attitude tracking control for spacecraft without angular velocity measurements显示文摘The output feedback control for spacecraft attitude tracking system is investigated in this study. It is assumed that angular velocity measurements are not available for feedback control.A technique named adding power integrator(API) is adopted to estimate the pseudo-angular-velocity. Then we design a finite-time attitude control law, which only utilizes the relative attitude information. The stability analyses of the feedback system are proved as well, which shows the attitude tracking errors will converge into a region of zero even the external disturbances exist. The simulation results illustrate the high precision and robust attitude control performance of the proposed control strategy. | Li Yuan Guangfu Ma Chuanjiang Li Boyan Jiang | 2017 | Journal of Systems Engineering and Electronics2017，28，6： | 1 |
| 14 | DNA Barcoding of Catfish: Species Authentication and Phylogenetic Assessment 显示文摘 | Li Lian Wong Eric Peatman Jianguo Lu Huseyin Kucuktas Shunping He Chuanjiang Zhou | 2011 | PLoS ONE2011，6，17： | 1 |
| 15 | Tensor diffusion level set method for infrared targets contours extraction显示文摘 | Li Meng He Chuanjiang Zhan Yi | 2012 | Infrared Physics & Technology2012，55，1： | 1 |
| 16 | Multi-residue Determination of 41 Insectides in Garlic by Gas Chromatography and Ion Trap Mass Spectrometry Using the Selective Ion Storage Technique 显示文摘 | Ma Xiaodong Li Chongjiu Tao Chuanjiang Insecticides | 2001 | Rapid Commun Mass Spectrom2001，15，： | 1 |
| 17 | Adaptive regularized level set method for weak boundary object segmentation 显示文摘 | Li Meng He Chuanjiang Zhan Yi | 2012 | Mathematical Problems in Engineering2012，，5： | 1 |
| 18 | Data-driven unsupervised anomaly detection and recovery of unmanned aerial vehicle flight data based on spatiotemporal correlation显示文摘Anomaly detection is crucial to the flight safety and maintenance of unmanned aerial vehicles(UAVs)and has attracted extensive attention from scholars.Knowledge-based approaches rely on prior knowledge,while model-based approaches are challenging for constructing accurate and complex physical models of unmanned aerial systems(UASs).Although data-driven methods do not require extensive prior knowledge and accurate physical UAS models,they often lack parameter selection and are limited by the cost of labeling anomalous data.Furthermore,flight data with random noise pose a significant challenge for anomaly detection.This work proposes a spatiotemporal correlation based on long short-term memory and autoencoder(STCLSTM-AE)neural network data-driven method for unsupervised anomaly detection and recovery of UAV flight data.First,UAV flight data are preprocessed by combining the Savitzky-Golay filter data processing technique to mitigate the effect of noise in the original historical flight data on the model.Correlation-based feature subset selection is subsequently performed to reduce the reliance on expert knowledge.Then,the extracted features are used as the input of the designed LSTM-AE model to achieve the anomaly detection and recovery of UAV flight data in an unsupervised manner.Finally,the method's effectiveness is validated on real UAV flight data. | YANG Lei LI ShaoBo LI ChuanJiang ZHU CaiChao ZHANG AnSi LIANG GuoQiang | 2023 | Science China(Technological Sciences)2023，66，5： | 0 |
| 19 | 天路历程显示文摘Shandong Province has a mountain so sacred, it is to the Chinese what Mount Sinou is to the Jews. 山东省有座圣山泰山,对中国人来说,它就如同西奈山对犹太人一般神圣。 | Ju Chuanjiang Li Anna Zhao Ruixue 张慧妍(译注) 梦竹(校) | 2010 | 英语世界2010，，5： | 0 |
| 20 | Occurrence Regularity and Green Prevention and Control Technology of Bradysia odoriphaga in Shandong Province显示文摘The occurrence regularity,damage characteristics and difficulties in prevention and control of Bradysia odoriphaga in Shandong Province were elaborated,and effective,economic,no residue,simple and feasible green prevention and control technology were put forward,in order to better guide the Chinese chive production.The study would also promote benign development of Chinese chive industry in Shandong Province. | Li Zhaoxia Xu Nianfang Zang Chuanjiang Song Jiping Wang Zhenbao Fu Zaiqiu | 2019 | Plant Diseases and Pests2019，10，4： | 0 |
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