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| 1 | Genome-Wide Analysis of Histone Modifications: H3K4me2, H3K4me3, H3K9ac, and H3K27ac in Oryza sativa L. Japonica显示文摘当以前的研究证明了 histone 修正能由调整基因抄写影响工厂生长和开发时,在这些修正和基因表示之间的关系的知识仍然是有限的。这研究使用了高产量的定序跟随的染色质 immunoprecipitation (ChIP-Seq ) ,到调查四 histone 修正的染色体宽的分发:H3K4 (H3K4me2 和 H3K4me3 ) 和在 Oryza sativa L 的 H3K9 和 H3K27 (H3K9ac 和 H3K27ac ) 的 acylation 的 di 和 trimethylation。装饰用的梨树。由分析出版 DNase-Seq 数据,这研究探索了 DNase 过分敏感(DH ) 沿着米饭染色体的地点。histone 标记主要在通用区域出现了并且在基因的抄写开始地点(TSS ) 附近被充实。这分析证明四 histone 修正和 DH 地点都与活跃抄写被联系。而且,四 histone 修正与答应被用来在米饭基因注解预言失踪的基因的特征的抄本 regionsa 是高度并发的。预言被试验性地证实二的抄写预言了失踪的基因进一步验证。而且,顺序主题分析被构造以便识别 DH 地点和许多通常认为的抄写因素绑定地点。 | Zhou Du Hui Li Qiang Wei Xin Zhao Chunchao Wang Qilin Zhu Xin Yi Wenying Xua X. Shirley Liu Weiwei Jin Zhen Su | 2013 | Molecular Plant2013，6，5： | 8 |
| 2 | Infl uence of structural parameters on dynamic characteristics and wind-induced buffeting responses of a super-long-span cable-stayed bridge显示文摘A 3D finite element(FE) model for the Sutong cable-stayed bridge(SCB) is established based on ANSYS. The dynamic characteristics of the bridge are analyzed using a subspace iteration method. Based on recorded wind data, the measured spectra expression is presented using the nonlinear least-squares regression method. Turbulent winds at the bridge site are simulated based on the spectral representation method and the FFT technique. The influence of some key structural parameters and measures on the dynamic characteristics of the bridge are investigated. These parameters include dead load intensity, as well as vertical, lateral and torsional stiffness of the steel box girder. In addition, the influence of elastic stiffness of the connection device employed between the towers and the girder on the vibration mode of the steel box girder is investigated. The analysis shows that all of the vertical, lateral and torsional buffeting displacement responses reduce gradually as the dead load intensity increases. The dynamic characteristics and the structural buffeting displacement response of the SCB are only slightly affected by the vertical and torsional stiffness of the steel box girder, and the lateral and torsional buffeting displacement responses reduce gradually as the lateral stiffness increases. These results provide a reference for dynamic analysis and design of super-long-span cable-stayed bridges. | Wang Hao Chen Chunchao Xing Chenxi Li Aiqun | 2014 | Earthquake Engineering and Engineering Vibration2014，13，3： | 5 |
| 3 | The landscape of gene-CDS-haplotype diversity in rice:Properties,population organization,footprints of domestication and breeding,and implications for genetic improvement显示文摘Polymorphisms within gene coding regions represent the most important part of the overall genetic diversity of rice.We characterized the gene-coding sequence-haplotype(gcHap)diversity of 45963 rice genes in 3010 rice accessions.With an average of 226±390 gcHaps per gene in rice populations,rice genes could be classified into three main categories:12865 conserved genes,10254 subspecific differentiating genes,and 22844 remaining genes.We found that 39218 rice genes carry>255179 major gcHaps of potential functional importance.Most(87.5%)of the detected gcHaps were specific to subspecies or populations.The inferred proto-ancestors of local landrace populations reconstructed from conserved predominant(ancient)gcHaps correlated strongly with wild rice accessions from the same geographic regions,supporting a multiorigin(domestication)model of Oryza sativa.Past breeding efforts generally increased the gcHap diversity of modern varieties and'caused significant frequency shifts in predominant gcHaps of 14266 genes due to independent selection in the two subspecies.Low frequencies of“favorable”gcHaps at most known genes related to rice yield in modern varieties suggest huge potential for rice improvement by mining and pyramiding of favorable gcHaps.The gcHap data were demonstrated to have greater power than SNPs for the detection of causal genes that affect complex traits.The rice gcHap diversity dataset generated in this study would facilitate rice basic research and improvement in the future. | Fan Zhang Chunchao Wang Min Li Yanru Cui Yingyao Shi Zhichao Wu Zhiqiang Hu Wensheng Wang Jianlong Xu Zhikang Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 4 | Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes显示文摘Superparamagnetic iron oxide (SPIO) nanoparticles are effective contrast agents for enhancement of magnetic resonance imaging at the tissue, cellular or even molecular levels. High quality SPIO nanoparticles can be synthesized in the organic phase but need to be transferred into water before any biomedical applications. In this study, amphiphilic poly(ε-caprolactone) grafted dextran (Dex-g-PCL) was used as carriers for particle encapsulation and stabilization in the aqueous phase. Multiple SPIO nanoparticles were self-assembled together with the help of Dex-g-PCL during phase transfer from chloroform to water, and diameters of Dex-g-PCL/SPIO nanocomposites were (64 ± 22) nm through dynamic light scattering measurement. These nanocomposites were superparamagnetic at 300 K with saturated magnetization of 88 emu/g Fe. In the magnetic field of 1.5 T, Dex-g-PCL/SPIO nanocomposites had a T2 relaxivity of 363 Fe mL·mol-1·s-1. This unique nanocomposite brought significant mouse liver contrast with signal intensity changes of -60% at 5 min after intravenous administration. However, uptake of Dex-g-PCL/SPIO nanocomposites in liver reticuloendothelial cells (Kupffer cells) did not immediately happen at shorter time points (<4 h) as verified by histology studies, and it was evident that more iron staining would be located in Kupffer cells 24 h after contrast agent administration. After 24 h and 10 d, the signal intensities (SI) gradually recovered, and SI changes were -44% and -31%, respectively. From our observation, the time window for enhanced-MRI could last at least 12 days and totally recovered after 16 days. This novel sensitive MRI contrast agent may find potential applications in discovering small liver lesions such as early tumor diagnosis. | WANG QiaoYing SU HongYing XIA ChunChao SUN JiaYu LIU Chen WANG ZhiYong GONG QiYong SONG Bin GAO FaBao AI Hua GU ZhongWei | 2009 | Chinese Science Bulletin2009，54，17： | 5 |
| 5 | Near-infrared fluorescent amphiphilic polycation wrapped magnetite nanoparticles as multimodality probes显示文摘Construction of multifunctional/multimodality nanoparticles for cancer diagnosis and therapy has become an attractive area of investigation. In this report, we designed a multimodality nanoprobe for cell labeling, and can be detectable by both magnetic resonance and near infrared (NIR) fluorescence imaging. Multiple hydrophobic superparamagnetic iron oxide (SPIO) nanocrystals are self-assembled into nanocomposites in water phase with the help of partially alkylated hyperbranched polycation, polyethylenimine (PEI), which already conjugated with the indocyanine dye Cy5.5 and can be used for cell imaging under NIR fluorescence imaging. The amphiphilic PEI/SPIO nanocomposites have a strong T 2 relaxivity. The iron uptake process in MCF-7/Adr displays a time dependent behavior. Confocal laser scanning microscopy reveals that the nanoprobes are internalized into the cytoplasm of MCF-7/Adr after 24 h labeling. Both MR and NIR fluorescence imaging showed strong image contrast against unlabeled cells. Under a clinical MRI scanner, labeled cells in gelatin phantom present much darker images than controlled ones. The T2 relaxation rate of the labeled cells is 98.2 s 1 , significantly higher than that of the control ones of 2.3 s 1 . This study provides an important alternative to label MCF-7/Adr at optimized low dosages with high efficiency, and may be useful to label other biologically important cells and track their behaviors in vivo. | WANG Dan SU HongYing LIU yanHong WU ChangQiang XIA ChunChao SUN JiaYu GAO FaBao GONG QiYong SONG Bin AI Hua | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 6 | Comparative analysis of metabolite changes in two contrasting rice genotypes in response to low-nitrogen stress显示文摘Identification of metabolites responsible for tolerance to low nitrogen availability(low-N)will aid in the genetic improvement of rice yield under nitrogen deficiency.In this study,a backcross introgression line(G9)and its recurrent parent Shuhui 527(SH527),which show differential responses to low-N stress,were used to identify metabolites associated with lowN tolerance in rice.Differences in metabolite contents in the leaves of G9 and SH527 at three growth stages under low-N stress were assessed by gas chromatography–mass spectrometry.Many metabolites,including amino acids and derivatives,were highly enriched in G9 compared with SH527 under the control condition,suggesting that the two genotypes had basal metabolite differences.Low-N stress induced genotype-specific as well as growth stagedependent metabolite changes.Metabolites induced specifically in G9 that were involved in glycolysis and tricarboxylic acid metabolism were enriched at the tillering and grain filling stages,and metabolites involved in nitrogen and proline metabolism were enriched at the booting stage.Enrichment of pyroglutamate,glutamate,2-oxoglutarate,sorbose,glycerate-2-P,and phosphoenolpyruvic acid in G9 suggests that these metabolites could be involved in low-N stress tolerance.The results presented here provide valuable information for further elucidation of the molecular mechanisms of low-N tolerance in crops. | Xiuqin Zhao Wensheng Wang Ziyan Xie Yongming Gao Chunchao Wang Muhammed Mahbubur Rashid Mohammad Rafiqul Islam Binying Fu Zhikang Li | 2018 | The Crop Journal2018，6，5： | 2 |
| 7 | Identification of quantitative trait loci associated with resistance to Xanthomonas oryzae pv. oryzae pathotypes prevalent in South China显示文摘Bacterial blight(BB), which is caused by Xanthomonas oryzae pv. oryzae(Xoo), is an important rice disease responsible for significant yield losses. In the rice-growing regions of South China where BB outbreaks are common, the resistance of cultivars with BB resistance genes Xa4 and Xa21 has been lost because of rapid changes in the Xoo population structure and virulence. In this study, 421 diverse rice accessions were evaluated regarding their resistance to two Xoo strains, namely GD1358(C5) and IV, which are prevalent pathotypes in South China and overcame the resistance of Xa4 and Xa21, respectively. Using the 4.8 mio filtered SNP dataset, we conducted a genome-wide association study, which identified 13 loci associated with BB resistance, including eight new quantitative trait loci(QTL) and five QTL harboring known BB resistance genes: Xa3/Xa26, xa5, Xa35(t), Xa36(t), Xa40, Xa43(t), and xa44(t). Intriguingly, a steep peak was detected on chromosomes 5 and 11. Six QTL including three new ones, were distributed on chromosome 11, whereas a new QTL q BB5.1 and a known QTL were detected on chromosome 5. Haplotype analyses indicated that the LOC;s05 g01610(Os PRAF2) gene within the q BB5.1 region, which encodes a PRAF protein, is associated with BB resistance. Furthermore, Os PRAF2 knockout lines generated using the CRISPR-Cpf1 system were significantly more resistant to Xoo strains than the wild-type plants. Our results provide researchers and breeders with useful information regarding QTL and gene resources,which may be relevant for developing new BB-resistant rice cultivars. | Jialing Lu Quanlin Li Chunchao Wang Mingming Wang Dan Zeng Fan Zhang Wenxue Zhai Yongli Zhou | 2022 | The Crop Journal2022，10，2： | 1 |
| 8 | Hypoglyccmic activity of fermented mushroom of Coprinus comatus rich in vanadium 显示文摘 | HAN Chunchao YUAN Junhua WANG Yingzi | 2006 | Journal of Trace Elements in Medicine and Biology2006，20，： | 1 |
| 9 | The effect of neighbor distance of magnetic nanoparticle clusters on magnetic resonance relaxation properties显示文摘Superparamagnetic iron oxide(SPIO) nanoparticle clusters are one unique form which can enhance magnetic relaxivity and improve the magnetic resonance imaging contrast at the same iron concentration, comparing to single SPIO nanoparticles. Controlling of cluster size and other structural parameters have drawn great interests in this field to further improve their magnetic properties. In this study, we investigated how the interparticle distance(also known as neighbor distance) of SPIO nanocrystals within clusters affect their magnetic relaxation behaviors.To adjust the neighbor distance, different amount of cholesterol(CHO) was chosen as model spacers embedded into SPIO nanocluster systems with the help of amphiphilic diblock copolymer poly(ethylene glyco)-polyester. Smallangle X-ray scattering was applied to quantify the neighbor distance of SPIO clusters. The results demonstrated that the averaged SPIO nanocrystal neighbor distance of nanoclusters increased with higher amount of added CHO.Moreover, these SPIO nanocrystal clusters had the prominent magnetic relaxation properties. Simultaneously, controlling of SPIO nanocrystal neighbor distance can regulate the saturation magnetization(Ms) and magnetic resonance(MR) T2 relaxation of the aggregation, and ultimately obtain better MR contrast effects with decreased neighbor distance. | Dan Wang Bingbing Lin Taipeng Shen Jun Wu Chunchao Xia Bin Song Hua Ai | 2016 | Science Bulletin2016，61，13： | 1 |
| 10 | Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging显示文摘 | Jian Lu Shuli Ma Jiayu Sun Chunchao Xia Chen Liu Zhiyong Wang Xuna Zhao Fabao Gao Qiyong Gong Bin Song Xintao Shuai Hua Ai Zhongwei Gu | 2009 | Biomaterials2009，，15： | 1 |
| 11 | Effect of Kushen(Radix Sophorae flavescentis) extract on laryngeal neoplasm Hep2 cells显示文摘OBJECTIVE:To evaluate the effect of fermented extract of Kushen(Radix Sophorae Flavescentis) or non-fermented ESF on laryngeal neoplasms Hep2 cells.METHODS:Use 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay to explore the effect of fermented ESF and non-fermented ESF on Hep2 cells,and detect the mRNA and protein expression level of Bcl-2,Bax and Caspase-3 with reverse transcription polymerase chain reaction(RT-PCR) andWestern blot.RESULTS:Both fermented ESF and non-fermented ESF could inhibit laryngeal neoplasm's Hep2 cells,but and the cells did not response to the dilution 1:320 of fermented ESF,nor to the 1:1280 dilution of non-fermented ESF.As time progressed,the dilution 1:80 of fermented ESF and 1:320 dilution of non-fermented ESF could significantly reduce Bcl-2 mRNA and protein expression and down-regulate Caspase-3 mRNA and protein expression.Bax mRNA and protein were not expressed in Hep2 cells.CONCLUSIONS:Both fermented ESF and non-fermented ESF could inhibit the proliferation of Hep2 cells,and the effect of non-fermented ESF was significantly better than that of the fermented. | Yingzi Wang Chunchao Han Xinsheng Fang Xinyuan Shi Ailing Feng Kuibang He Shenghai Zhang Xiuyu Sun | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 1 |
| 12 | Discovery and genetic characterization of intestinal metaplasia in the Helicobacter felis-infected mouse model of gastric cancer显示文摘Gastric adenocarcinoma(GA)remains a leading cause of cancer-related deaths in the world [1].Of the different types of GA,intestinal-type GA is especially a major world-wide concern not only because this type of GA accounts for a large proportion of the global incidences but also because it is believed to be acquired,and thus possibly preventable.In particular,Helicobacter pylori-induced chronic inflammation is suggested to lead to the transformation of normal gastric mucosa to chronic gastritis,gastric atrophy,intestinal metaplasia(IM),dysplasia,and finally intestinal-type GA,as first proposed by Correa [2].Thus,IM tissue,characterized by the presence of cells resembling those derived from the intestine-specific lineage such as goblet cells that are not present in the normal stomach,is considered to be a critical precancerous tissue en route to GA [3].Furthermore,the transition to IM is believed to be the ‘point of no return’since the IM tissue does not revert back to normal gastric tissue after the eradication of H.pylori [4].However,the precise details of the IM tissue that are critical to the subsequent development of GA are not presently understood. | Jiangrong Chen Chunchao Zhu Chaojie Wang Xiaodan Zhang Jian Ni Daniel M.Czajkowsky Bingya Liu Yan Guo | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 1 |
| 13 | Kinetic analysis and modeling of maize straw hydrochar combustion using a multi-Gaussian-distributed activation energy model显示文摘Combustion kinetics of the hydrochar was investigated using a multi-Gaussian-distributed activation energy model(DAEM)to ex-pand the knowledge on the combustion mechanisms.The results demonstrated that the kinetic parameters calculated by the multi-Gaussian-DAEM accurately represented the experimental conversion rate curves.Overall,the feedstock combustion could be divided into four stages:the decomposition of hemicellulose,cellulose,lignin,and char combustion.The hydrochar combustion could in turn be divided into three stages:the combustion of cellulose,lignin,and char.The mean activation energy ranges obtained for the cellulose,lignin,and char were 273.7-292.8,315.1-334.5,and 354.4-370 kJ/mol,respectively,with the standard deviations of 2.1-23.1,9.5-27.4,and 12.1-22.9 kJ/mol,re-spectively.The cellulose and lignin contents first increased and then decreased with increasing hydrothermal carbonization(HTC)temperature,while the mass fraction of char gradually increased. | Chunmei Yu Shan Ren Guangwei Wang Junjun Xu Haipeng Teng Tao Li Chunchao Huang Chuan Wang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，3： | 1 |
| 14 | What Role Does the Political Environment Play in Economic Development? --A Case Study of Fujian Province显示文摘政治环境导致的无常影响投资风险,并且因此影响投资决定,它与经济开发有一种靠近的关系。这份报纸用紧张的关系的案例研究调查政治不稳定性的经济费用到对面 -- 在中国的海峡。我们使用一个合成控制方法更好为这案例研究的 counterfactual 分析建模。关系越过的强烈状况 -- 海峡在福建的经济发展有大影响省。福建省是在到台湾的最近的最靠近的省并且也为台湾的直接投资拥有最大的优先的政策。这研究的实验结果表明在 2001-2008 福建期间,省在 GDP 平均年度损失人均是 682.54 元。换句话说,在福建人均的 GDP 衰退了大约 12.1% 每年由合成控制方法与同样人均的 GDP 相比在这个时期期间计算了。 | Jingwen Yu Chunchao Wang | 2012 | Frontiers of Economics in China-Selected Publications from Chinese Universities2012，7，4： | 0 |
| 15 | Multiple rapid-responsive probes for hypochlorite detection based on dioxetane luminophore derivatives显示文摘In recent years,various methods for detecting exogenous and endogenous hypochlorite have been studied,considering its essential role as a biomolecule.However,the existing technologies still pose obstacles such as their invasiveness,high costs,and complicated operation.In the current study,we developed a glow-type chemiluminescent probe,hypochlorite chemiluminescence probe(HCCL)-1,based on the scaffold of Schaap's 1,2-dioxetane luminophores.To better explore the physiological and pathological functions of hypochlorite,we modified the luminophore scaffold of HCCL-1 to develop several probes,including HCCL-2,HCCL-3,and HCCL-4,which amplify the response signal of hypochlorite.By comparing the luminescent intensities of the four probes using the IVIS®system,we determined that HCCL-2 with a limit of detection of 0.166 mM has enhanced sensitivity and selectivity for tracking hypochlorite both in vitro and in vivo. | Yingai Sun Yuqi Gao Chunchao Tang Gaopan Dong Pei Zhao Dunquan Peng Tiantian Wang Lupei Du Minyong Li | 2022 | Journal of Pharmaceutical Analysis2022，12，3： | 0 |
| 16 | Stress-Activated Protein Kinase OsSAPK7 Regulates Salt- Stress Tolerance by Modulating Diverse Stress-Defensive Responses in Rice显示文摘Soil salinity is an environmental threat limiting rice productivity.Identification of salinity tolerance genes and exploitation of their mechanisms in plants are vital for crop breeding.In this study,the function of stress-activated protein kinase 7(OsSAPK7),a SnRK2 family member,was characterized in response to salt stress in rice.Compared with variety 9804,OsSAPK7-overexpression plants had a greater survival rate,increased chlorophyll and proline contents,and superoxide dismutase and catalase activities at the seedling stage under salt-stress conditio ns,as well as decreased sodium potassium ratio(Na+/K+)and malondialdehyde contents.After salt stress,the OsSAPK7 knockout plants had lower survival rates,in creased Na^K*ratios and malomdiadehyde contents,and decreased physiological parameters compared with 9804.These changes in transgenic lines suggested that OsSAPK7 increased the salt tolerance of rice by modulating ion homeostasis,redox reactions and photosynthesis.The results of RNA-Seq indicated that genes involved in redox-dependent signaling pathway,photosynthesis and zeatin synthesis pathways were significantly down-regulated in the OsSAPK7 knockout line compared with 9804 un der salt-stress conditio n,which con firmed that OsSAPK7 positively regulated salt tolera nee by modulating diverse stress-defe nsive resp on ses in rice.These findings provided novel in sights for the genetic improvement of rice and for understanding the regulatory mechanisms of salt-stress toleranee. | ZENG Dan WANG Chunchao XIE Junpin ZHANG Fan LU Jialing SHI Xiaorong SHI Yingyao ZHOU Yongli | 2021 | Rice science2021，28，6： | 0 |
| 17 | Slow light between two absorbing resonance in asymmetry double quantum dots显示文摘We demonstrate the slow light in double quantum dots (QDs) resonance dispersion material in theory. The slow factor, absorption, and bandwidth are greatly influenced by the energy difference of the two resonance energy. The bandwidth of this system is up to 60 GHz. The 20 ps input signal pulse is delayed by 180 ps (group index of approximately 55) relative to free-space propagation with little broadening in 1 mm dispersion material for the optical communication wavelength. The signal pulse delay can be tuned by the pump pulse. | YU ChunChao WANG Tao | 2013 | Chinese Science Bulletin2013，58，20： | 0 |
| 18 | Characterization of endogenous nucleic acids that bind to NgAgo in Natronobacterium gregoryi sp2 cells显示文摘As nucleic acid-guided endonucleases,some prokaryotic Argonautes have been used as programmable nucleases.Natronobacterium gregoryi Argonaute(NgAgo)has also been proposed for gene editing,but this remains very controversial.Until now,the endogenous nucleic acids that bind to NgAgo in Natronobacterium gregoryi sp2(N.gregoryi sp2)have not been characterized.We expressed the conserved PIWI domain of NgAgo and used it to induce anti-PIWI antibody.We also cultured the N.gregoryi sp2 strain and performed immunoprecipitation,chromatin immunoprecipitation(ChIP),and RNA immunoprecipitation(RIP)assays.The nucleic acids that endogenously bound NgAgo in N.gregoryi sp2 cells were sequenced and analyzed.The results showed that NgAgo endogenously bound RNA rather than DNA.NgAgo-associated RNAs were mainly transcripts of genes that encoded tRNA,transcriptional regulators,RNA polymerases,and RNA-binding proteins.NgAgo mainly binds to the transcripts inside genes or in their upstream sequences.Interestingly,the top enriched motif of peaks was the same as that of miR-1289,suggesting that NgAgo may regulate gene expression post-transcriptionally.GO enrichment analysis showed that the peak-associated genes were enriched in transmembrane transport processes.These results revealed that NgAgo binds RNA and may function in post-transcriptional regulation in vivo. | LIXU JIANG LIN NING CHUNCHAO PU ZIXIN WANG BIFANG HE JIAN HUANG | 2022 | BIOCELL2022，46，2： | 0 |
| 19 | Comparative microRNA profiling reveals microRNAs involved in rice resistant response to bacterial blight显示文摘Bacterial blight(BB), which is caused by Xanthomonas oryzae pv. oryzae(Xoo), is one of the most destructive bacterial diseases of rice(Oryza sativa L.). During plant defense responses, micro RNAs(mi RNAs) play important roles in regulating disease resistance. However, the functions of mi RNAs in the interaction between rice and Xoo remain relatively uncharacterized. In this study, we compared the mi RNA profiles of the BB resistant rice introgression line F329 and its susceptible recurrent parent Huang-Hua-Zhan(HHZ) at multiple time points after inoculation with Xoo. A total of 538 known and 312 novel mi RNAs were identified, among which only 17 and 26 were responsive to Xoo infection in F329 and HHZ, respectively. Compared with the expression levels in HHZ, 37 up-regulated and 53 down-regulated mi RNAs were detected in F329. The predicted target genes for the mi RNAs differentially expressed between F329 and HHZ were revealed to be associated with flavonoid synthesis, the reactive oxygen species regulatory pathway, plant hormone signal transduction, defense responses, and growth and development.Additionally, the patterns of interactions between osa-mi R390-3 p, novel_mi R_104, novel_mi R_238,osa-mi R166 k-5 p, osa-mi R529 b, and osa-mi R167 h-3 p and their target genes were further validated by quantitative real-time PCR. Furthermore, we overexpressed osa-mi R167 h-3 p in transgenic plants and proved that this mi RNA positively regulates the resistance of rice to BB. These results provide novel information regarding the mi RNA-based molecular mechanisms underlying the disease resistance of rice. The data presented herein may be useful for engineering rice BB resistance via mi RNAs. | Jialing Lu Chunchao Wang Fan Zhang Dan Zeng Yongli Zhou | 2021 | The Crop Journal2021，9，4： | 0 |
| 20 | Oncometabolic surgery:Emergence and legitimacy for investigation显示文摘Studies on morbid obesity have shown remarkable improvement of diabetes in patients who have undergone bariatric operations.It was subsequently shown that these operations induce diabetes remission independent of the resultant weight loss;as a result,surgeons began to investigate whether operations for gastric cancer(GC)could have the same beneficial effect on diabetes as bariatric operations.It was then shown in multiple reports that followed that certain operations for GC were able to improve or even cure type 2 diabetes mellitus(T2 DM)in GC patients.This finding gave rise to the concept of'oncometabolic surgery',in which a patient diagnosed with both GC and T2 DM undergo a single operation with the purpose of treating both diseases.With the increasing incidence of T2 DM,oncometabolic surgery has the potential to improve the quality of life and even extend survival of many GC patients.However,because the GC patient population and the bariatric patient population are wildly different and because different GC operations have different properties,the effect of oncometabolic surgery must be carefully assessed and engineered in order to maximize benefit and avoid harm.This manuscript aims to summarize the findings made so far in the field of oncometabolic surgery and to provide an outlook regarding the possibility of oncometabolic surgery being incorporated into standard clinical practice. | Won Jun Kim Yeongkeun Kwon Chang Min Lee Seung Hyun Lim Yong Li Junjiang Wang Weixian Hu Jiabin Zheng Gang Zhao Chunchao Zhu Wei Wang Wenjun Xiong Quan Wang Mingjie Xia Sungsoo Park | 2020 | Chinese Journal of Cancer Research2020，32，2： | 0 |
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