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| 1 | Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes显示文摘Superparamagnetic iron oxide (SPIO) nanoparticles are effective contrast agents for enhancement of magnetic resonance imaging at the tissue, cellular or even molecular levels. High quality SPIO nanoparticles can be synthesized in the organic phase but need to be transferred into water before any biomedical applications. In this study, amphiphilic poly(ε-caprolactone) grafted dextran (Dex-g-PCL) was used as carriers for particle encapsulation and stabilization in the aqueous phase. Multiple SPIO nanoparticles were self-assembled together with the help of Dex-g-PCL during phase transfer from chloroform to water, and diameters of Dex-g-PCL/SPIO nanocomposites were (64 ± 22) nm through dynamic light scattering measurement. These nanocomposites were superparamagnetic at 300 K with saturated magnetization of 88 emu/g Fe. In the magnetic field of 1.5 T, Dex-g-PCL/SPIO nanocomposites had a T2 relaxivity of 363 Fe mL·mol-1·s-1. This unique nanocomposite brought significant mouse liver contrast with signal intensity changes of -60% at 5 min after intravenous administration. However, uptake of Dex-g-PCL/SPIO nanocomposites in liver reticuloendothelial cells (Kupffer cells) did not immediately happen at shorter time points (<4 h) as verified by histology studies, and it was evident that more iron staining would be located in Kupffer cells 24 h after contrast agent administration. After 24 h and 10 d, the signal intensities (SI) gradually recovered, and SI changes were -44% and -31%, respectively. From our observation, the time window for enhanced-MRI could last at least 12 days and totally recovered after 16 days. This novel sensitive MRI contrast agent may find potential applications in discovering small liver lesions such as early tumor diagnosis. | WANG QiaoYing SU HongYing XIA ChunChao SUN JiaYu LIU Chen WANG ZhiYong GONG QiYong SONG Bin GAO FaBao AI Hua GU ZhongWei | 2009 | Chinese Science Bulletin2009，54，17： | 5 |
| 2 | Hydrophilic/underwater superoleophobic graphene oxide membrane intercalated by TiO2 nanotubes for oil/water separation显示文摘 | Zhichao Wu Chang Zhang Kaiming Peng Qiaoying Wang Zhiwei Wang | 2018 | Frontiers of Environmental Science & Engineering2018，12，3： | 5 |
| 3 | Coriander Genomics Database:a genomic,transcriptomic,and metabolic database for coriander显示文摘Coriander(Coriandrum sativum L.),also known as cilantro,is a globally important vegetable and spice crop.Its genome and that of carrot are models for studying the evolution of the Apiaceae family.Here,we developed the Coriander Genomics Database(CGDB,http://cgdb.bio2db.com/)to collect,store,and integrate the genomic,transcriptomic,metabolic,functional annotation,and repeat sequence data of coriander and carrot to serve as a central online platform for Apiaceae and other related plants.Using these data sets in the CGDB,we intriguingly found that seven transcription factor(TF)families showed significantly greater numbers of members in the coriander genome than in the carrot genome.The highest ratio of the numbers of MADS TFs between coriander and carrot reached 3.15,followed by those for tubby protein(TUB)and heat shock factors.As a demonstration of CGDB applications,we identified 17 TUB family genes and conducted systematic comparative and evolutionary analyses.RNA-seq data deposited in the CGDB also suggest dose compensation effects of gene expression in coriander.CGDB allows bulk downloading,significance searches,genome browser analyses,and BLAST searches for comparisons between coriander and other plants regarding genomics,gene families,gene collinearity,gene expression,and the metabolome.A detailed user manual and contact information are also available to provide support to the scientific research community and address scientific questions.CGDB will be continuously updated,and new data will be integrated for comparative and functional genomic analysis in Apiaceae and other related plants. | Xiaoming Song Fulei Nie Wei Chen Xiao Ma Ke Gong Qihang Yang Jinpeng Wang Nan Li Pengchuan Sun Qiaoying Pei Tong Yu Jingjing Hu Xinyu Li Tong Wu Shuyan Feng Xiu-Qing Li Xiyin Wang | 2020 | Horticulture Research2020，7，1： | 4 |
| 4 | Comprehe nsive an alysis of SSRs and database construction using all complete gene-cod ing sequences in major horticultural and represe ntative plants显示文摘Simple sequence repeats(SSRs)are one of the most important genetic markers and widely exist in most species.Here,we identified 249,822 SSRs from 3,951,919 genes in 112 plants.Then,we conducted a comprehensive analysis of these SSRs and constructed a plant SSR database(PSSRD).Interestingly,more SSRs were found in lower plants than in higher plants,showing that lower plants needed to adapt to early extreme environments.Four specific enriched functional terms in the lower plant Chlam^tdomonas reinhardtii were detected when it was compared with seven other higher plants.In addition,Guanylate_cyc existed in more genes of lower plants than of higher plants.In our PSSRD,we constructed an interactive plotting function in the chart interface,and users can easily view the detailed information of SSRs.All SSR information,including sequences,primers,and annotations,can be downloaded from our database.Moreover,we developed Web SSR Finder and Batch SSR Finder tools,which can be easily used for identifying SSRs.Our database was developed using PHP,HTML,J avaScript,and MySQL,which are freely available at http://www.pssrd.info/.We conducted an analysis of the Myb gene families and flowering genes as two applications of the PSSRD.Further analysis indicated that whole-genome duplication and whole-genome triplication played a major role in the expansion of the Myb gene families.These SSR markers in our database will greatly facilitate comparative genomics and functional genomics studies in the future. | Xiaoming Song Qihang Yang Yun Bai Ke Gong Tong Wu Tong Yu Qiaoying Pei Weike Duan Zhinan Huang Zhiyuan Wang Zhuo Liu Xi Kang Wei Zhao Xiao Ma | 2021 | Horticulture Research2021，8，1： | 2 |
| 5 | Comparative analysis of the TCP gene family in celery,coriander and carrot(family Apiaceae)显示文摘Apiaceae is one of the most important families in Apiales and includes many economically important vegetables and medicinal plants.The TEOSINTE BRANCHED 1/CYCLOIDEA/PROLIFERATING CELL FACTOR 1/2(TCP)gene family plays an important role in regulating plant growth and development,but it has not been widely studied in Apiaceae.In the present study,we identified 215 TCP family genes in six species of plant,of which 122 genes were present in three Apiaceae including 29 in celery(Apium graveolens),43 in coriander(Coriandrum sativum),and 50 in carrot(Daucus carota).Whole-genome duplication likely contributed to TCP gene family expansion in Apiaceae.There were more paralogs in carrot than in coriander and celery,which was attributable to the greater number of tandem and proximal duplicated genes on chromosome 1.Nine microRNAs were found to regulate 20 TCP genes in the three Apiaceae species,with miR-319 having the most target genes.Several TCP genes showed high expression in the root,petiole and leaf of celery and coriander.These results provide a basis for comparative and functional genomic analyses of TCP genes in Apiaceae and other plants. | Qiaoying Pei Nan Li Yun Bai Tong Wu Qihang Yang Tong Yu Zhiyuan Wang Zhuo Liu Qiang Li Hao Lin Xiaoming Song | 2021 | Vegetable Research2021，1，1： | 2 |
| 6 | Influence of casting speed variation during unsteady continuous casting on non-metallic inclusions in IF steel slabs显示文摘 | Zhang Qiaoying Wang Litao Wang Xinhua | 2006 | ISI J International2006，27，10： | 1 |
| 7 | A hybrid membrane process for simultaneous thickening and digestion of waste activated sludge显示文摘A hybrid membrane process for simultaneous sludge thickening and digestion(MSTD)was studied.During one cycle(15 d)of operation under a hydraulic retention time of 1 d,the concentration of mixed liquor suspended solids(MLSS)continuously increased from about 4 g·L^(–1)to 34 g·L^(–1),and the mixed liquor volatile suspended solids(MLVSS)increased from about 3 g·L^(–1)to over 22 g·L^(–1).About 42%of the MLVSS and 39%of the MLSS reduction were achieved.The thickening and digestion effects in the MSTD were further analyzed based on a mass balance analysis.Test results showed that biopolymers and cations of biomass were gradually released to the bulk solution during the process.It was also found that the capillary suction time,colloidal chemical oxygen demand,soluble microbial products,viscosity,and MLSS had significant positive correlations with the membrane fouling rate,whereas extracellular polymeric substances,polysaccharides,and proteins extracted from biomass had negative impacts on membrane fouling. | Zhiwei WANG Qiaoying WANG Zhichao WU Xinhua WANG | 2010 | Frontiers of Environmental Science & Engineering2010，4，3： | 1 |
| 8 | Influence ofcasting speed variation during unsteady continuous castingon non-metallic inclusions in IF steel slabs 显示文摘 | Zhang Qiaoying Wang Litao Wang Xinhua | 2006 | ISU Int2006，46，10： | 1 |
| 9 | A framework for basic administrative metadata in digital libraries显示文摘Administrative metadata means the expansion of the metadata research to the administrative level of resource development.Based on the basic administrative sections in the information resource lifecycle(IRL),the framework for basic administrative metadata(FBAM)is helpful in constructing open interoperable platforms for acquisition,processing and services of information resources in digital libraries.It facilitates the seamless communication,the cooperative construction and management,and the sharing of digital resources.The formulation of FBAM follows the principles of modularity and openness that promote interoperability in resource management.It also adopts the structured methodology of information system design,with which the FBAM data model is developed in conformity withand PREMIS.The capabilities of FBAM are driven by a metadata repository with administrative information that is contained in FBAM records. | ZHENG Qiaoying WANG Shaoping | 2008 | Chinese Journal of Library and Information Science2008，，1： | 1 |
| 10 | Sorption mechanisms of perfluorinated compounds on carbon nanotubes显示文摘 | Shubo Deng Qiaoying Zhang Yao Nie Haoran Wei Bin Wang Jun Huang Gang Yu Baoshan Xing | 2012 | Environmental Pollution2012，，： | 1 |
| 11 | Influence ofcasting speed variation during unsteady continuous castingon non-metallic inclusions in IF steel slabs 显示文摘 | Zhang Qiaoying Wang Litao Wang Xinhua | 2006 | ISU Int?2006，46，10： | 1 |
| 12 | Bioinspired therapeutic platform based on extracellular vesicles for prevention of arterial wall remodeling in hypertension显示文摘Arterial stiffness due to the vessel remodeling is closely linked to raised blood pressure,and its physiopathologic mechanism is still not fully understood.We here aimed to explore whether extracellular vesicle(EV)mediated intercellular communication between endothelium and smooth muscle cell contribute to the blood vessel remodeling under hypertension.We here revealed that the arterial endothelial cells robustly secreted EV,which in turn could be circulated and/or directly taken up by the subendothelial smooth muscle cells(SMC).Under hypertension,the EV secretion increased and the miRNA profile changed significantly mainly due to the raised mechanical force and subsequent enhanced reactive oxygen species generation.Among the miRNA cargos in the EV,miR-320d/423-5p were found increased most significantly.In vivo delivery of miR-320d/423-5p mimics via engineered EV increased their expression in arterial vessels,recapitulating the phenotype in hypertension.In contrast,therapeutic delivery of miR-320d/423-5p inhibitors via engineered EV alleviated the phenotype in spontaneous hypertension rat model.Together,we have found that the injured endothelium due to the raised mechanical force in hypertension contributes to the arterial wall remodeling via the secreted EV.Our study has not only provided novel insights on the mechanism of hypertension associated blood vessel wall remodeling,but also shed light on therapeutic intervention of hypertension associated vascular diseases. | Chen Wang Changyang Xing Zhelong Li Yunnan Liu Qiaoying Li Yixiao Wang Jiao Hu Lijun Yuan Guodong Yang | 2022 | Bioactive Materials2022，7，2： | 1 |
| 13 | Hepatopro- teetive effects of phloridzin on hepatic fibrosis induced by carbon tetraehloride against oxidative stress-triggered damage and fibrosis in rats显示文摘 | DENG Gaigai WANG Junzhi ZHANG Qiaoying | 2012 | Biol Pharm Bull2012，35，7： | 1 |
| 14 | Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides显示文摘 | Jing Wang Li Wang Meixing Li Qiaoying Jin Shouliang Dong | 2011 | Peptides2011，，5： | 1 |
| 15 | Effective control of membrane fouling by filamentous bacteria in a submerged membrane bioreactor 显示文摘 | Zhiwei Wang Pan Wang Qiaoying Wang | 2010 | Chemical Engineering Journal2010，158，3： | 1 |
| 16 | Biomimetic synthesis and characterization of carbon nanofiber/ hydroxyapatite composite scaffolds 显示文摘 | Meiyu Wu Qiaoying Wang Xinqing Liu | 2013 | Carbon2013，，51： | 1 |
| 17 | Disintegration and acidification of MBR sludge under alkaline conditions 显示文摘 | Yu Hongguang Wang Zhiwei Wang Qiaoying | 2013 | Chemical Engineering Journal2013，231，9： | 1 |
| 18 | Influence of Casting Speed Variation During Unsteady Continuous Casting on Non-Metallic Inclusions in IF Steel Slabs显示文摘 | Zhang Qiaoying Wang Litao Wang Xinhua | 2006 | ISIJ International2006，46，10： | 1 |
| 19 | Practical and modular construction of benzo[c]phenanthridine compounds显示文摘Here,we describe a general and modular strategy for the rapid assembly of benzo[c]phenanthridine(BCP)derivatives using homogeneous gold catalysis.Notably,in contrast to traditional methods based on the specially preformed substrates that have an inherent preference for the formation of this class of compounds with limited flexibility,this protocol is achieved via a selectively intramolecular cascade of a diazo-tethered alkyne and subsequently an intermolecular cyclization with a nitrile to facilitate the successive C–N and C–C bonds formation.This methodology uses readily available nitriles as the nitrogen source to deliver the products in good yield with excellent functional group compatibility.A preliminary anti-tumor activity study of these generated products exhibits high anticancer potency against five tumor cell lines,including He La,Mel624,SW-480,8505C,LAN-1.Besides,we report a catalyst-controlled intermolecular cycloaddition/intramolecular insertion of the substrate with a fulvene to provide fused polycarbocycles containing a seven-membered ring. | Cheng Zhang Qian Chen Lei Wang Qiaoying Sun Yangyang Yang Matthias Rudolph Frank Rominger A.Stephen K.Hashmi | 2022 | Science China Chemistry2022，65，7： | 0 |
| 20 | Generation ofαGal-enhanced bifunctional tumor vaccine显示文摘Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high mortality.In this study,we demonstrated a novel vaccine targeting HCC and tumor neovascular endothelial cells by fusing recombinant MHCC97H cells expressing porcine a-1,3-galactose epitopes(a Gal)and endorphin extracellular domains(END)with dendritic cells(DCs)from healthy volunteers.END^(+)/Gal^(+)-MHCC97H/DC fusion cells induced cytotoxic T lymphocytes(CTLs)and secretion of interferon-gamma(IFN-γ).CTLs targeted cells expressing a Gal and END and tumor angiogenesis.The fused cell vaccine can effectively inhibit tumor growth and prolong the survival time of human hepatoma mice,indicating the high clinical potential of this new cell based vaccine. | Jian He Yu Huo Zhikun Zhang Yiqun Luo Xiuli Liu Qiaoying Chen Pan Wu Wei Shi Tao Wu Chao Tang Huixue Wang Lan Li Xiyu Liu Yong Huang Yongxiang Zhao Lu Gan Bing Wang Liping Zhong | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 0 |
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