|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | BUD2,encoding an S-adenosylmethionine decarboxylase,is required for Arabidopsis growth and development显示文摘Polyamines 在在植物,而是他们的准确角色调整各种各样的发展过程被含有并且他们怎么管理这些过程尚待逃犯。我们这里报导浓密的 Arabidopsis 和矮子异种, bud2,哪个从编码 S-adenosylmethionine decarboxylases (SAMDC ) 的小基因家庭的一个成员的完全的删除的结果为在 polyamine 简历的不可缺少的中介的形成必要合成小径。bud2 植物在开花期,根,和叶柄扩大了脉管的系统,并且 polyamines 的改变的动态平衡。bud2 和 samdc1 的双异种,另一个 SAMDC 成员的击倒的异种,是胚胎致命,证明 SAMDC 为植物胚胎开始是必要的。我们的结果建议 polyamines 为更高的植物的正常生长和发展被要求。 | Chunmin Ge Xia Cui Yonghong Wang Yuxin Hu Zhiming Fu Dongfen Zhang Zhukuan Cheng Jiayang Li | 2006 | Cell Research2006，16，5： | 14 |
| 2 | The BUD2 mutation affects plant architecture through altering cytokinin and auxin responses in Arabidopsis显示文摘植物生长素和细胞激动素的比率在由支持或镇压调整天线建筑学起一个关键作用腋的芽长出。我们以前鉴别了显示的 Arabidopsis 变异的 bud2 改变了根和射击建筑学,它源于 S-adenosylmethionine decarboxylase 的 loss-of-function 4 (SAMDC4 ) 。在这研究,我们证明 BUD2 能被植物生长素导致,并且正式就职依赖于植物生长素发信号。BUD2 的变化导致弱敏到植物生长素和超敏性到细胞激动素,它被胼胝正式就职试金证实。我们的学习建议 polyamines 可以在通过影响细胞激动素和敏感的动态平衡到植物生长素和细胞激动素调整植物建筑学起他们的作用。 | Xia Cui Chunmin Ge Renxiao Wang Huanzhong Wang Weiqi Chen Zhiming Fu Xiangning Jiang Jiayang Li Yonghong Wang | 2010 | Cell Research2010，20，5： | 12 |
| 3 | m^6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2显示文摘N6-methyladenosine (m6A),catalyzed by the methyltransferase complex consisting of Mettl3 and Mettl14,is the most abundant RNA modification in mRNAs and participates in diverse biological processes. However,the roles and precise mechanisms of m6A modification in regulating neuronal development and adult neurogenesis remain unclear. Here,we examined the function of Mettl3,the key component of the complex,in neuronal development and adult neurogenesis of mice. We found that the depletion of Mettl3 significantly reduced m6A levels in adult neural stem cells (aNSCs) and inhibited the proliferation of aNSCs. Mettl3 depletion not only inhibited neu-ronal development and skewed the differentiation of aNSCs more toward glial lineage,but also affected the morphological maturation of newborn neurons in the adult brain. m6A immunoprecip-itation combined with deep sequencing (MeRIP-seq) revealed that m6A was predominantly enriched in transcripts related to neurogenesis and neuronal development. Mechanistically,m6A was present on the transcripts of histone methyltransferase Ezh2,and its reduction upon Mettl3 knockdown decreased both Ezh2 protein expression and consequent H3K27me3 levels. The defects of neurogenesis and neuronal development induced by Mettl3 depletion could be rescued by Ezh2 overexpression. Collectively,our results uncover a crosstalk between RNA and histone modifica-tions and indicate that Mettl3-mediated m6A modification plays an important role in regulating neurogenesis and neuronal development through modulating Ezh2. | Junchen Chen Yi-Chang Zhang Chunmin Huang Hui Shen Baofa Sun Xuejun Cheng Yu-Jie Zhang Yun-Gui Yang Qiang Shu Ying Yang Xuekun Li | 2019 | Genomics, Proteomics & Bioinformatics2019，17，2： | 12 |
| 4 | A Transgenic Study on Affecting Potato Tuber Yield by Expressing the Rice Sucrose Transporter Genes OsSUT5Z and OsSUT2M显示文摘在许多植物,蔗糖 transporters 为从来源和进口的两个蔗糖出口是必要的进水池,显示功能在吸收划分。为了调查蔗糖 transporters 是否能改进淀粉的收益,种,土豆植物(茄属 tuberosum L。cv。 | Aijun Sun Yan Dai Xinsheng Zhang Chunmin Li Kun Meng Honglin Xu Xiaoli Wei Guifang Xiao Pieter B.F, Ouwerkerk Mei Wang Zhen Zhu | 2011 | Journal of Integrative Plant Biology2011，53，7： | 9 |
| 5 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 6 | Effect of boronizing temperature and time on microstructure and abrasion wear resistance of Cr12Mn2V2 high chromium cast iron显示文摘 | Chunmin Li Baoluo Shen Guijiang Li Chao Yang | 2008 | Surface & Coatings Technology2008，，24： | 1 |
| 7 | Mine safety information technology in the framework of Digital Mine显示文摘 | LI Chunmin ZHANG Xin LIU Xin | 2012 | Safety Science2012，50，4： | 1 |
| 8 | 3D thermomechanically coupled FEM analysis of large disk rolling process and trial production显示文摘 | Qinghua Li Zhanchao Ma Taiying Liu Fuguo Li Zhijian Wei Chunmin Su | 2014 | 2014 (1-4)2014，，1： | 1 |
| 9 | Preliminary investigation of seeding mesenchymal stem cells on biodegradable scaffolds for vascular tissue engineering in vitro显示文摘 | Li Chunmin Wang Zhonggao Gu Yongquan | 2009 | ASAIO J2009，55，6： | 1 |
| 10 | TGF-β1-induced expression of Id-1 is associated with tumor progression in gastric cancer显示文摘 | Huiying Ma Ye Wei Yongmei Leng Shichao Li Lingling Gao Heng Hu Long Chen Fei Wang Honglei Xiao Chouwen Zhu Chunmin Liang | 2014 | Medical Oncology2014，，7： | 1 |
| 11 | Protective roles of Asperosaponin VI,a triterpenesaponin isolated from Dipsacus asper Wall on acutemyocardial infarction in rats 显示文摘 | Li Chunmin Liu Zhifeng Tian Jingwen | 2010 | European Journal ofPharmacology2010，627，： | 1 |
| 12 | A novel in vitro prognostic model of bladder cancer based on urine-derived living tumor cells显示文摘Bladder cancer(BLCA)remains a difficult malignancy to manage because of its high recurrence,intense follow-up,and invasive diagnostic and treatment techniques.Immune checkpoint inhibitors(ICIs)have forged a new direction for the treatment of BLCA,but it is currently challenging to predict whether an individual patient will be sensitive to ICIs.We collected 43 urine/tumor samples from BLCA patients for primary bladder cancer cells(BCCs)culturing using our previously reported BCC culture platform.We used flow cytometry(FCM)to measure the expression levels of Programmed Death-Ligand 1(PD-L1)on BCCs before and after interferon-gamma(IFN-γ)treatment and found that PD-L1 expression and the sensitivities to IFN-γvaried among patients.RNA-sequencing,western blotting,and programmed death-1(PD-1)binding assays confirmed that the BCC FCM-based PD-L1 detection platform(BC-PD-L1)was reliable and was not hindered by the glycosylation of PD-L1.In the subsequent retrospective study,we found that IFN-γ-stimulated PD-L1(sPD-L1)expression on BCCs detected by BC-PD-L1 could predict the prognosis of BLCA patients.Importantly,the prognostic value was similar or even better in urine-derived BC-PD-L1(UBC-PD-L1).Transcriptome analysis showed that BCCs with high sPD-L1 tended to enrich genes associated with the collagen-containing extracellular matrix,cell–cell adhesion,and positive regulation of the immune system.In addition,the UBC-PD-L1 also exhibited predictive value for ICI response in BLCA patients.In conclusion,as a novel personalized urine-detection method,UBC-PD-L1 may provide a rapid,accurate,and non-invasive tool for monitoring tumor progression,predicting therapeutic responses,and helping improve BLCA clinical treatment in future. | Jiaqi Wang Jiying Zhu Junchi Hu Ziruoyu Wang Xiaobo Wang Jianbo Pan Yiwei Chu Zengxia Li Wei Jiang Chunmin Liang Jun Hou Jianming Guo Yongjun Dang Shuai Jiang | 2023 | Genes & Diseases2023，10，6： | 0 |
| 13 | CBX4 deletion promotes tumorigenesis under Kras^(G12D) background by inducing genomic instability显示文摘Chromobox protein homolog 4(CBX4)is a component of the Polycomb group(PcG)multiprotein Polycomb repressive complexes 1(PRC1),which is participated in several processes including growth,senescence,immunity,and tissue repair.CBX4 has been shown to have diverse,even opposite functions in different types of tissue and malignancy in previous studies. | Fangzhen Chen Wulei Hou Xiangtian Yu Jing Wu Zhengda Li Jietian Xu Zimu Deng Gaobin Chen Bo Liu Xiaoxing Yin Wei Yu Lei Zhang Guoliang Xu Hongbin Ji Chunmin Liang Zuoyun Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 14 | Multiband camouflage design with thermal management显示文摘Although the effective“stealth”of space vehicles is important,current camouflage designs are inadequate in meeting all application requirements.Here,a multilayer wavelength-selective emitter is demonstrated.It can realize visible light and dual-band mid-infrared camouflage with thermal control management in two application scenarios,with better effect and stronger radiation cooling capability,which can significantly improve the stealth and survivability of space vehicles in different environments.The selective emitter demonstrated in this paper has the advantages of simple structure,scalability,and ease of large-area fabrication,and has made a major breakthrough in driving multiband stealth technology from simulation research to physical verification and even practical application. | LEHONG HUANG HAOCHUAN LI ZHIGUO LI WENBO ZHANG CAIWEN MA CHUNMIN ZHANG YUXUAN WEI LIANG ZHOU XUN LI ZHIYUAN CHENG XIAOHUI GUO SHIPING GUO | 2023 | Photonics Research2023，11，5： | 0 |
| 15 | XCO_2 satellite retrieval experiments in short-wave and infrared spectra with SCIATRAN model for Sahara Desert显示文摘The spectra of O_2 A-band(0.76 μm) and CO_2 near-infrared emissions(1.6 μm) are simulated by the SCIATRAN radiative transfer model(V3.1.23), and compared with those observed by GOSAT-FTS(Greenhouse gases Observing SATellite-Fourier Transform Spectrometer). Systematic deviations between the observed and simulated spectra are found to exist,especially for the O_2 A-band. The discrepancies are characterized by their mean differences averaged over the observed spectral ranges. A correction is applied to the observed GOSAT-FTS L1B(V141.141) spectra by scaling the spectral intensity measured by TANSO-FTS(Thermal and Near infrared Sensor for carbon Observation Fourier Transform Spectrometer) onboard GOSAT.The average columnar CO_2 concentrations(XCO_2) are retrieved from the observed and the corrected GOSAT-FTS spectra by using the SCIATRAN inversion algorithm. Compared with the GOSAT-FTS L2 XCO_2 data products retrieved from the observed spectra of GOSAT-FTS, the SCIATRAN retrievals from the corrected spectra show a much better agreement, with the relative error less than 1%. But the results of GOSAT TANSO-FTS(V161.160) show smaller residuals than GOSAT TANSO-FTS(V141.141) without mean residual correction. The results indicate that the mean residual correction would increase the precision of XCO_2 retrieval for spectra with systematic deviations. | LI YanFen ZHANG ChunMin DAI HaiShan ZHANG XingYing ZHANG Peng | 2016 | Science China Earth Sciences2016，59，11： | 0 |
| 16 | Clinical study of traditional Chinese medicine fumigation in the treatment of allergic rhinitis显示文摘Objective:To study the clinical effect of traditional Chinese medicine fumigation on treating allergic rhinitis.Methods:80 cases of patients with allergic rhinitis in our hospital from August 2020 to August 2021 were selected and then randomly divided into two groups.In this research,the combination of montelukast sodium tablets and cetirizine was used in the control group.Traditional Chinese medicine fumigation was given in addition to oral medication in the treatment group.Results:The total effective rate of the clinical treatment in the treatment group was higher than that in the control group,and the difference was statistically significant(p<.05).It took less time to relieve nasal itching,runny nose,nasal congestion,and sneezing in the treatment group than in the control group,and the difference was statistically significant(p<.05).Besides,the symptoms were much more relieved in the treatment group than in the control group,and the difference was statistically significant.Conclusions:Traditional Chinese medicine fumigation shows a remarkable clinical effect on the treatment of allergic rhinitis,and it is worthy of clinical application. | Li Wang Chunmin Li Baoying Wang | 2022 | Discussion of Clinical Cases2022，9，3： | 0 |
| 17 | 非核糖体多肽Surugamide生物合成途径中青霉素结合蛋白类多肽环化酶和水解酶研究显示文摘文章简介非核糖体肽生物合成由非核糖体多肽合酶(NRPS)多功能域大蛋白负责完成,其肽链的环化和释放由NRPS蛋白C末端释放功能域负责。然而该释放功能域并没有在非核糖体多肽Surugamide(SGM)生物合成NRPS蛋白中找到,SGM的NRPS负责合成的产物为环八肽SGM-A^E和链十肽SGM-F。通过基因缺失突变,我们确认了surE基因为SGM合成所必须。 | 周永军 Xiao Lin Chunmin Xu Yaoyao Shen Shu-Ping Wang Hongze Liao Lei Li 邓海 林厚文 | 2020 | 科学新闻2020，，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员