|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China显示文摘The dengue virus(DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope(E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype Ⅰ strains, including 8genotype Ⅰ and 9 genotype V strains. Additionally, 6 genotype Ⅰ strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype Ⅰ strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype Ⅴ strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou. | Geng Li Pan Pan Qiuyan He Xiujuan Kong Kailang Wu Wei Zhang Yuntao Liu Huiting Huang Jianbo Liu Zhongde Zhang De Wu Xiaoping Lai Xiaohong Liu Jianguo Wu | 2017 | Virologica Sinica2017，32，1： | 7 |
| 2 | Swansea criteria score in acute fatty liver of pregnancy显示文摘To the Editor:Acute fatty liver of pregnancy(AFLP)is an uncommon but potentially fatal disease unique to pregnancy that typically occurs in the third trimester and is one of the leading causes of maternal mortality in critically ill patients.^([1])The Swansea diagnostic criteria have been widely used in the diagnosis of AFLP worldwide since their proposal.The Swansea criteria include clinical symptoms and laboratory tests,imaging,and pathological examination results. | Jianbo Tan Fei Hou Haofeng Xiong Lin Pu Pan Xiang Chuansheng Li | 2022 | Chinese Medical Journal2022，，7： | 2 |
| 3 | ADMETNet:The knowledge base of pharmacokinetics and toxicology network显示文摘A good drug or drug candidate should not only interact with its target molecule effectively and specifically,but also be absorbed into the body,distributed to the right location,metabolized into right compounds,and eliminated out of the body in proper manner.The processes of drug getting into and out of the body involve Absorption,Distribution,Metabolism,and Excretion(ADME),which | Quan Xu Ke Liu Xingming Lin Yangmei Qin Linshan Chen Jiao Cheng Mindong Zhong Qiushun He Yinbo Li Tingwu Wang Jianbo Pan Menglu Peng Lixia Yao Zhiliang Ji | 2017 | Journal of Genetics and Genomics2017，44，5： | 2 |
| 4 | Differential SW16.1 allelic effects and genetic backgrounds contributed to increased seed weight after soybean domestication显示文摘Although seed weight has increased following domestication from wild soybean(Glycine soja) to cultivated soybean(Glycine max), the genetic basis underlying this change is unclear. Using mapping populations derived from chromosome segment substitution lines of wild soybean, we identified SW16.1 as the causative gene underlying a major quantitative trait locus controlling seed weight.SW16.1 encodes a nucleus-localized LIM domaincontaining protein. Importantly, the GsSW16.1 allele from wild soybean accession N24852 had a negative effect on seed weight, whereas the GmSW16.1 allele from cultivar NN1138-2 had a positive effect. Gene expression network analysis,reverse-transcription quantitative polymerase chain reaction, and promoter-luciferase reporter transient expression assays suggested that SW16.1 regulates the transcription of MT4, a positive regulator of seed weight. The natural variations in SW16.1 and other known seed weight genes were analyzed in soybean germplasm. The SW16.1 polymorphism was associated with seed weight in 247 soybean accessions, showing much higher frequency of positive-effect alleles in cultivated soybean than in wild soybean. Interestingly,gene allele matrix analysis of the known seed weight genes revealed that G. max has lost 38.5%of the G. soja alleles and that most of the lost alleles had negative effects on seed weight. Our results suggest that eliminating negative alleles from G. soja led to a higher frequency of positive alleles and changed genetic backgrounds in G. max,which contributed to larger seeds in cultivated soybean after domestication from wild soybean.Our findings provide new insights regarding soybean domestication and should assist current soybean breeding programs. | Xianlian Chen Cheng Liu Pengfei Guo Xiaoshuai Hao Yongpeng Pan Kai Zhang Wusheng Liu Lizhi Zhao Wei Luo Jianbo He Yanzhu Su Ting Jin Fenfen Jiang Si Wang Fangdong Liu Rongzhou Xie Changgen Zhen Wei Han Guangnan Xing Wubin Wang Shancen Zhao Yan Li Junyi Gai | 2023 | Journal of Integrative Plant Biology2023，65，7： | 1 |
| 5 | Fabrication of large-area uniform carbon nanotube foams as near-critical-density targets for laser–plasma experiments显示文摘Carbon nanotube foams(CNFs)have been successfully used as near-critical-density targets in the laser-driven acceleration of high-energy ions and electrons.Here we report the recent advances in the fabrication technique of such targets.With the further developed floating catalyst chemical vapor deposition(FCCVD)method,large-area(>25 cm^(2))and highly uniform CNFs are successfully deposited on nanometer-thin metal or plastic foils as double-layer targets.The density and thickness of the CNF can be controlled in the range of 1−13 mg/cm^(3)and 10−200µm,respectively,by varying the synthesis parameters.The dependence of the target properties on the synthesis parameters and the details of the target characterization methods are presented for the first time. | Pengjie Wang Guijun Qi Zhuo Pan Defeng Kong Yinren Shou Jianbo Liu Zhengxuan Cao Zhusong Mei Shirui Xu Zhipeng Liu Shiyou Chen Ying Gao Jiarui Zhao Wenjun Ma | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 6 | Tailoring MgH_(2) for hydrogen storage through nanoengineering and catalysis显示文摘Hydrogen energy has been recognized as “Ultimate Power Source” in the 21st century, which could be the best solution to the looming energy crisis and climate degeneration in the near future. Due to its high safety, low price, abundant resources and decent hydrogen storage density, magnesium based solid-state hydrogen storage materials are becoming the leading candidate for onboard hydrogen storage. However,the high operation temperature and slow reaction rate of MgH_(2), as a result of the large formation enthalpy and high reaction activation energy,respectively, are the first and most difficult problems we need to face and overcome to realize its industrialization. Herein, a state-of-the-art review on tailoring the stable thermodynamics and sluggish kinetics of hydrogen storage in MgH_(2), particularly through nanoengnieering and catalysis is presented, aiming to provide references and solutions for its promotion and application. Promising methods to overcome the challenges faced by MgH_(2)/Mg, such as bidirectional catalysts and nanoconfinement with in-situ catalysis are compared and the required improvements are discussed to stimulate further discussions and ideas in the rational design of MgH_(2)/Mg systems with ability for hydrogen release/uptake at lower temperatures and cycle stability in the near future. | Zhao Ding Yuting Li Hang Yang Yangfan Lu Jun Tan Jianbo Li Qian Li Yu'an Chen Leon L.Shaw Fusheng Pan | 2022 | Journal of Magnesium and Alloys2022，10，11： | 1 |
| 7 | Effect of Zener–Hollomon Parameter on High-Temperature Deformation Behaviors of Mg–6Zn–1.5Y–0.5Ce–0.4Zr Alloy显示文摘High-temperature compressive deformation behaviors of Mg–6Zn–1.5Y–0.5Ce–0.4Zr alloy were investigated at temperatures and strain rates ranging from 523 to 673 K and from 0.001 to 1 s~(-1),respectively.The studied alloy was mainly composed ofα-Mg,Mg_(3)Zn_(6)Y(I phase),Mg–Zn–Ce and Mg_(3)Zn_(3)Y_(2)(W phase).The constitutive equation of Mg alloy was obtained,and the apparent activation energy(Q)was determined as 200.44 k J/mol,indicating that rare earth phase increases the difficulty of deformation.The work hardening involves three stages:(1)linear hardening stage;(2)strain hardening stage;and(3)softening and steady-state stage.During these three stages,the dislocation aggregation and tangling,dynamic recovery and recrystallization occur sequentially.To characterize the dynamic recrystallization(DRX)volume fraction,the DRX kinetics was investigated using the Avrami-type equation.The deformation mechanism of magnesium alloy under different Zener–Hollomon parameter(Z)value conditions was also studied.At high Z values and intermediate conditions,dislocations rapidly generate and pile up in the alloy.Recrystallization is hardly seen at this time.At low Z condition,the DRX occurs in the alloy. | Bo Wu Jianbo Li Lizi Liu Xianhua Chen Jun Tan Jiangfeng Song Muhammad Rashad Fusheng Pan | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，5： | 1 |
| 8 | Long-Term Temperature Variability and Risk of Dyslipidemia Among Middle-Aged and Elderly Adults:A Prospective Cohort Study-China,2011-2018显示文摘Summary What is already known about this topic?Long-term temperature variability(TV)has been examined to be associated with cardiovascular disease(CVD).TV-related dyslipidemia helps us understand the mechanism of how climate change affects CVD.What is added by this report?Based on the China Health and Retirement Longitudinal Study(CHARLS)from 2011 to 2018,this study estimated the long-term effect of TV on dyslipidemia in middle-aged and elderly adults. | Jianbo Jin Yuxin Wang Zhihu Xu Ru Cao Hanbin Zhang Qiang Zeng Xiaochuan Pan Jing Huang Guoxing Li | 2022 | China CDC weekly2022，4，26： | 1 |
| 9 | Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures显示文摘 | Guoyin Kai Hui Xu Congcong Zhou Pan Liao Jianbo Xiao Xiuqin Luo Lijia You Lin Zhang | 2011 | Metabolic Engineering2011，，3： | 1 |
| 10 | PaGenBase: a pat- tern gene database for the global and dynamic understanding ofgene function显示文摘 | Pan Jianbo Hu Shichang Shi Dan | 2013 | PLoS ONE2013，8，80： | 1 |
| 11 | PaGeFinder: quantitative identification of spatiotemporal pattern genes显示文摘 | Pan Jianbo Hu Shichang Wang Hao | 2012 | Bioinformatics2012，28，11： | 1 |
| 12 | Identification of two glycerophosphodiester phosphodiesterase genes in maize leaf phosphorus remobilization显示文摘Phosphate deficiency is one of the leading causes of crop productivity loss.Phospholipid degradation liberates phosphate to cope with phosphate deficiency.Glycerophosphodiester phosphodiesterases(GPX-PDEs)hydrolyse the intermediate products of phospholipid catabolism glycerophosphodiesters into glycerol-3-phosphate,a precursor of phosphate.However,the function of GPX-PDEs in phosphate remobilization in maize remains unclear.In the present study,we characterized two phosphate deficiency-inducible GPX-PDE genes,ZmGPX-PDE1 and ZmGPX-PDE5,in maize leaves.ZmGPX-PDE1 and ZmGPX-PDE5 were transcriptionally regulated by ZmPHR1,a well-described phosphate starvation-responsive transcription factor of the MYB family.Complementation of the yeast GPX-PDE mutant gde1Δindicated that ZmGPX-PDE1 and ZmGPX-PDE5 functioned as GPX-PDEs,suggesting their roles in phosphate recycling from glycerophosphodiesters.In vitro enzyme assays showed that ZmGPX-PDE1 and ZmGPX-PDE5 catalysed glycerophosphodiester degradation with different substrate preferences for glycerophosphoinositol and glycerophosphocholine,respectively.ZmGPX-PDE1 was upregulated during leaf senescence,and more remarkably,loss of ZmGPXPDE1 inmaize compromised the remobilization of phosphorus fromsenescing leaves to young leaves,resulting in a stay-green phenotype under phosphate starvation.These results suggest that ZmGPX-PDE1 catalyses the degradation of glycerophosphodiesters in maize,promoting phosphate recycling from senescing leaves to new leaves.This mechanism is crucial for improving phosphorus utilization efficiency in crops. | Jingxin Wang Wenbo Pan Alexiy Nikiforov William King Wanting Hong Weiwei Li Yang Han Jana Patton-Vogt Jianbo Shen Lingyun Cheng | 2021 | The Crop Journal2021，9，1： | 1 |
| 13 | Raman spectra of carbon nanotubes and nanofibers prepared by ethanol flames显示文摘 | Liu Yueli Pan Chunxu Wang Jianbo | 2004 | J Mater Sci2004，39，： | 1 |
| 14 | Tumor suppressor gene Oxidored-nitro domain-containing protein 1 regulates nasopharyngeal cancer cell autophagy, metabolism, and apoptosis in vitro显示文摘 | Wenjuan Li Xiaoling Li Wei Wan Mei Yi Yanhong Zhou Pan Zheng Wei Xiong Jianbo Yang Shuping Peng James B. McCarthy Bo Xiang Guiyuan Li | 2013 | International Journal of Biochemistry and Cell Biology2013，，： | 1 |
| 15 | A novel in vitro prognostic model of bladder cancer based on urine-derived living tumor cells显示文摘Bladder cancer(BLCA)remains a difficult malignancy to manage because of its high recurrence,intense follow-up,and invasive diagnostic and treatment techniques.Immune checkpoint inhibitors(ICIs)have forged a new direction for the treatment of BLCA,but it is currently challenging to predict whether an individual patient will be sensitive to ICIs.We collected 43 urine/tumor samples from BLCA patients for primary bladder cancer cells(BCCs)culturing using our previously reported BCC culture platform.We used flow cytometry(FCM)to measure the expression levels of Programmed Death-Ligand 1(PD-L1)on BCCs before and after interferon-gamma(IFN-γ)treatment and found that PD-L1 expression and the sensitivities to IFN-γvaried among patients.RNA-sequencing,western blotting,and programmed death-1(PD-1)binding assays confirmed that the BCC FCM-based PD-L1 detection platform(BC-PD-L1)was reliable and was not hindered by the glycosylation of PD-L1.In the subsequent retrospective study,we found that IFN-γ-stimulated PD-L1(sPD-L1)expression on BCCs detected by BC-PD-L1 could predict the prognosis of BLCA patients.Importantly,the prognostic value was similar or even better in urine-derived BC-PD-L1(UBC-PD-L1).Transcriptome analysis showed that BCCs with high sPD-L1 tended to enrich genes associated with the collagen-containing extracellular matrix,cell–cell adhesion,and positive regulation of the immune system.In addition,the UBC-PD-L1 also exhibited predictive value for ICI response in BLCA patients.In conclusion,as a novel personalized urine-detection method,UBC-PD-L1 may provide a rapid,accurate,and non-invasive tool for monitoring tumor progression,predicting therapeutic responses,and helping improve BLCA clinical treatment in future. | Jiaqi Wang Jiying Zhu Junchi Hu Ziruoyu Wang Xiaobo Wang Jianbo Pan Yiwei Chu Zengxia Li Wei Jiang Chunmin Liang Jun Hou Jianming Guo Yongjun Dang Shuai Jiang | 2023 | Genes & Diseases2023，10，6： | 0 |
| 16 | Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells显示文摘Prostate cancer(PCa)is the second most prevalent malignancy in males across the world.A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for PCa.Herein,we establish 35 Chinese PCa primary cell models to capture specific characteristics among PCa patients,including gene mutations,mRNA/protein/surface protein distributions,and pharmaceutical responses.The multi-omics analyses identify Anterior Gradient 2(AGR2)as a pre-operative prognostic biomarker in PCa.Through the drug library screening,we describe crizotinib as a selective compound for malignant PCa primary cells.We further perform the pharmacoproteome analysis and identify 14,372 significant protein-drug correlations.Surprisingly,the diminished AGR2 enhances the inhibition activity of crizotinib via ALK/c-MET-AKT axis activation which is validated by PC3 and xenograft model.Our integrated multi-omics approach yields a comprehensive understanding of PCa biomarkers and pharmacological responses,allowing for more precise diagnosis and therapies. | Ziruoyu Wang Yanan Li Wensi Zhao Shuai Jiang Yuqi Huang Jun Hou Xuelu Zhang Zhaoyu Zhai Chen Yang Jiaqi Wang Jiying Zhu Jianbo Pan Wei Jiang Zengxia Li Mingliang Ye Minjia Tan Haowen Jiang Yongjun Dang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 17 | Genome-wide association with transcriptomics reveals a shade-tolerance gene network in soybean显示文摘Shade tolerance is essential for soybeans in inter/relay cropping systems.A genome-wide association study(GWAS)integrated with transcriptome sequencing was performed to identify genes and construct a genetic network governing the trait in a set of recombinant inbred lines derived from two soybean parents with contrasting shade tolerance.An improved GWAS procedure,restricted two-stage multi-locus genome-wide association study based on gene/allele sequence markers(GASM-RTM-GWAS),identified 140 genes and their alleles associated with shade-tolerance index(STI),146 with relative pith cell length(RCL),and nine with both.Annotation of these genes by biological categories allowed the construction of a protein–protein interaction network by 187 genes,of which half were differentially expressed under shading and non-shading conditions as well as at different growth stages.From the identified genes,three ones jointly identified for both traits by both GWAS and transcriptome and two genes with maximum links were chosen as beginners for entrance into the network.Altogether,both STI and RCL gene systems worked for shade-tolerance with genes interacted each other,this confirmed that shadetolerance is regulated by more than single group of interacted genes,involving multiple biological functions as a gene network. | Yanzhu Su Xiaoshuai Hao Weiying Zeng Zhenguang Lai Yongpeng Pan Can Wang Pengfei Guo Zhipeng Zhang Jianbo He Guangnan Xing Wubin Wang Jiaoping Zhang Zudong Sun Junyi Gai | 2024 | The Crop Journal2024，12，1： | 0 |
| 18 | Zn^(2+) loading as a critical contributor to the circ_0008553-mediated oxidative stress and inflammation in response to PM_(2.5) exposures显示文摘Inflammation is a major adverse outcome induced by inhaled particulate matter with a diameter of≤2.5μm(PM_(2.5)),and a critical trigger ofmost PM_(2.5) exposure-associated diseases.However,the key molecular events regulating the PM_(2.5)-induced airway inflammation are yet to be elucidated.Considering the critical role of circular RNAs(circRNAs)in regulating inflammation,we predicted 11 circRNAs that may be involved in the PM_(2.5)-induced airway inflammation using three previously reportedmiRNAs through the starBasewebsite.A novel circRNA circ_0008553 was identified to be responsible for the PM_(2.5)-activated inflammatory response in human bronchial epithelial cells(16HBE)via inducing oxidative stress.Using a combinatorial model PM_(2.5) library,we found that the synergistic effect of the insoluble core and loaded Zn^(2+)ions at environmentally relevant concentrations was the major contributor to the upregulation of circ_0008553 and subsequent induction of oxidative stress and inflammation in response to PM2.5 exposures.Our findings provided new insight into the intervention of PM_(2.5)-induced adverse outcomes. | Jingzhou Wang Jianbo Jia Dujia Wang Xiujiao Pan Haiyan Xiong Chengjun Li Yiguo Jiang Bing Yan | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
| 19 | Construction of Meteorological Observation Quality Management System for Basic Observation Business显示文摘A set of closed-loop normative standards of PDCA(planning-implementing-checking-improvement) of the quality management system is applied to promote the standardization, normalization and institutionalization of grass-roots meteorological observations, further improve the service availability and timely rate of data, and improve the quality and efficiency of meteorological observations. | Yiping LIN Xuanying XIE Jianbo PAN Liqing ZHOU Yali TAN | 2022 | Meteorological and Environmental Research2022，13，3： | 0 |
| 20 | Microstructure,mechanical properties and wear resistance of Ti particles reinforced AZ31 magnesium matrix composites显示文摘The compromise between strength and plasticity has greatly limited the potential application of particles reinforced magnesium matrix composites(MMCs).In this work,the Ti particles reinforced AZ31 magnesium(Mg)matrix composites achieved simultaneous improvement in strength,elongation and wear resistance.The Ti particles reinforced AZ31 composites were fabricated by ultrasonic-assisted stir casting with hot extrusion.The results showed that a strong interfacial bonding was obtained at Ti/Mg interface because of the formation of semicoherent orientation relationship of Ti Al/Mg,Ti Al/Al_(2)Ti and Al_(2)Ti/Mg interfaces.The as-extruded 6 wt.%Ti/AZ31 composite presented the best compressive mechanical properties and wear resistance with ultimate tensile strength,elongation and wear rate of 327 MPa,20.4%and 9.026×10^(-3)mm^(3)/m,obviously higher than those of AZ31 alloys.The enhanced mechanical properties were attributed to the grain refinement and strong interfacial bonding.The improved wear resistance was closely related to the increased hardness of composites and the formation of protective oxidation films. | Junliu Ye Xianhua Chen Huan Luo Jie Zhao Jianbo Li Jun Tan Hong Yang Bo Feng Kaihong Zheng Fusheng Pan | 2022 | Journal of Magnesium and Alloys2022，10，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员