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| 1 | Virtual population pharmacokinetic using physiologically based pharmacokinetic model for evaluating bioequivalence of oral lacidipine formulations in dogs显示文摘The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dissolution behaviors of three lacidipine formulations including one commercial product and two self-made amorphous solid dispersions(ASDs)capsules were determined in 0.07% Tween 80 media. A randomized 3-period crossover design in 6 healthy beagle dogs after oral administration of the three formulations at a single dose of 4 mg was conducted. The PBPK modeling was utilized for the virtual bioequivalence study.In vitro dissolution experiment showed that the dissolution behaviors of lacidipine amorphous solid dispersions(ASDs) capsules, which was respectively prepared by HPMC-E5 or Soluplus, as polymer displayed similar curves compared with the reference formulation in 0.07% Tween 80 media. In vivo pharmacokinetics experiments showed that three formulations had comparable maximum plasma drug concentration(Cmax), and the time(Tmax) to reach Cmax of lacidipine tablet, which was prepared by Soluplus, as polymer was slower than other two formulations in consistency with the in vitro dissolution rate. The 90% confidence interval(CI) for the Cmax, AUC0–24 h and AUC0–∞ of the ratio of the test drug to the reference drug exceeded the acceptable bioequivalence(BE) limits(0.80–1.25). However, the 90% CI of the AUC0–24 h, AUC0–∞ and Cmax of the ratio of test to reference drug were within the BE limit,calculated using PBPK modeling when the virtual subjects reached 24 dogs. The results all demonstrated that virtual bioequivalence study can overcome the inequivalence caused by inter-subject variability of the 6 beagle dogs involved in in vivo experiments. | Bin Yang Chunnuan Wu Bin Ji Mingrui Wu Zhonggui He Lei Shang Jin Sun | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，1： | 5 |
| 2 | Development and evaluation of taste-masked dry suspension of cefuroxime axetil for enhancement of oral bioavailability显示文摘Cefuroxime axetil(CA)is an ester prodrug of cefuroxime with an unpleasant taste when administrated orally.This work was to mask the bitter taste of CA and enhance its oral bioavailability.Dry suspensions were prepared by means of wet granulation method and solid dispersion method.Binders,suspending agents and other compositions involved in the formulation were optimized.The differential scanning calorimetry(DSC)analysis indicated that CA was amorphous in the solid dispersion with stearic acid as the carrier,which contributed to an improvement of the dissolution rate.Taste evaluation was performed by three volunteers and taste masking was successfully achieved by the methods mentioned above.A pH 7.0 phosphate buffer was adopted to study the in vitro dissolution performance of the three formulations,i.e.,two self-made dry suspensions and the commercial one.With a better release characteristic and a satisfying taste masking ability,the solid dispersion suspension was selected as the optimal formulation for the further pharmacokinetic study in beagle dogs.The values of Cmax and AUC0e12 for the solid dispersion suspension were about 1.78-fold and 2.17-fold higher than these of reference suspension,respectively.The obtained results demonstrated that the solid dispersion can efficiently mask the bitter taste of CA and significantly enhance its oral bioavailability. | Yuqian Du Yinglei Zhai Juhong Zhang Chunnuan Wu Cong Luo Jin Sun Zhonggui He | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，5： | 1 |
| 3 | Adsorption of Pb(II) from aqueous solution by silica-gel supported hyperbranched polyamidoamine dendrimers显示文摘 | Yuzhong Niu Rongjun Qu Changmei Sun Chunhua Wang Hou Chen Chunnuan Ji Ying Zhang Xia Shao Fanling Bu | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 4 | Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson’s disease显示文摘 | Nian Xiong Jinsha Huang Chunnuan Chen Ying Zhao Zhaowen Zhang Min Jia Zhentao Zhang Lingling Hou Hecheng Yang Xuebing Cao Zhihou Liang Yongxue Zhang Shenggang Sun Zhicheng Lin Tao Wang | 2012 | Neurobiology of Aging2012，，8： | 1 |
| 5 | Synthesis and characterization of crosslinked phenolie-typed beads by dispersion polyeondensation of 2-phe- noxyethanol with formaldehyde 显示文摘 | Ji Chunnuan Shi Jingxi Sun Changmei | 2010 | Journal of Applied Polymer Seience2010，117，1： | 1 |
| 6 | Adsorption of Au(III) from aqueous solution using cotton fiber/chitosan composite adsorbents显示文摘 | Rongjun Qu Changmei Sun Minghua Wang Chunnuan Ji Qiang Xu Ying Zhang Chunhua Wang Hou Chen Ping Yin | 2009 | Hydrometallurgy2009，，1： | 1 |
| 7 | Adsorption of Pb(II) from aqueous solution by silica-gel supported hyperbranched polyamidoamine dendrimers显示文摘 | Yuzhong Niu Rongjun Qu Changmei Sun Chunhua Wang Hou Chen Chunnuan Ji Ying Zhang Xia Shao Fanling Bu | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 8 | Preparation and metal binding behaviour of ehitosan functionalized by ester- and amino-terminated hyperbranched polyamidoamine polymers 显示文摘 | Qu Rongjun Sun Changmei Ji Chunnuan | 2008 | Carbohydrate Research2008，343，2： | 1 |
| 9 | Chemical modification of silica-gel with hydroxyl- or amino-terminated polyamine for adsorption of Au(III)显示文摘 | Rongjun Qu Minghua Wang Changmei Sun Ying Zhang Chunnuan Ji Hou Chen Yanfeng Meng Ping Yin | 2008 | Applied Surface Science2008，，5： | 1 |
| 10 | Photoluminescence from Ge-SiO_2 thin films and its mechanism显示文摘Ge-SiO2 thin films were deposited on p-type Si substrates using the radio frequency (rf) magnetron sputtering technique with a Ge-SiO2 composite target. Films were annealed in N2 ambience for 30 min at 300℃-1000℃ with an interval of 100℃. Through the X-ray diffraction, the average size of Ge nanocrystals (nc-Ge) was determined. They increased from 3.9 to 6.1 nm with increasing annealing temperature in the range of 600℃-1000℃. Under ultraviolet excitation, all samples emit a strong violet band centered at 396 nm. With the formation of nc-Ge, the samples exhibit another emission of orange band with the peak at 580 nm and its intensity increases with the increasing size of nc-Ge.The peak positions of two bands do not shift obviously. Experimental data indicate that the violet band comes from GeO defect and the orange band originates mainly from the luminescence centers at the interface between the nc-Ge and SiO2 matrix. | DONG Yemin, CHEN Jing, TANG Naiyun, YE Chunnuan, WU Xuemei, ZHUGE Lanjian & YAO Weiguo1. Department of Physics, Suzhou University, Suzhou 215006, China 2. Shanghai Institute of Metallurgy, Chinese Academy of Sciences, Shanghai 200050, China | 2001 | Chinese Science Bulletin2001，46，15： | 1 |
| 11 | A Chelating Resin with Bis: Synthesis, Characterization and Properties for The Removal of Trace Samples显示文摘 | Chunnuan Ji Rongjun Qu Chunhua Wang | 2007 | Talanta2007，73，： | 1 |
| 12 | Evaluation of pharmacokinetics underlies the collaborated usage of lamivudine and oxymatrine in beagle dogs显示文摘Combinational therapy of lamivudine and oxymatrine has been employed in the battle against hepatitis B virus in clinical setting. However, the pharmacokinetic behavior of the drug or active metabolism in intravenous/oral co-administration regime is poorly investigated. Herein,we evaluated the pharmacokinetic characteristic through a tailor-designed 3 way crossoverLatin square experiment in adult male beagle dogs. Six dogs were randomly treated by intravenous administration of lamivudine(2.5 mg/kg), oxymatrine(15 mg/kg) and combinational dosage, named as intravenous regime. Meanwhile the other six dogs were orally administrated with lamivudine(2.5 mg/kg), oxymatrine(15 mg/kg) and combinational dosage,named as oral regime. The pharmacokinetic feature in simultaneous oral treatment appeared to have no significant difference when compared with individual administration,even including matrine, the active metabolite of oxymatrine. In intravenous regime, the main pharmacokinetic parameters of simultaneous administration were nearly consistent with intravenous regime remedy. The collaborated application of lamivudine and oxymatrine contributed to non-distinctive pharmacokinetic fluctuations of beagle dogs in intravenous/oral regime, compared with individual employment, which established a vital base for the clinical co-administration against hepatitis B. Furthermore, the present study demonstrated that the determination of pharmacokinetics between combinational and individual therapy might assist in the development of drug compatibility in clinical therapy. | Zhenbao Li Lei Shang Chang Liu Panqin Ma Chunnuan Wu Wenjuan Zhang Yinghua Sun Yongjun Wang Xiaohong Liu Jin Sun | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 1 |
| 13 | Synthesis and properties of monocleavable amphiphilic comblike copolymers with alternating PEG and PCL grafts显示文摘 | Shixian Li Chunnuan Ye Guangdong Zhao Meijing Zhang Youliang Zhao | 2012 | J Polym Sci A Polym Chem2012，，15： | 1 |
| 14 | Preparation and adsorption properties of chelating resins containing 3-aminopyridine and hydrophilic spacer arms for Hg(Ⅱ)显示文摘 | Chunnuan Ji Shuhui Song Chunrong Wang | 2010 | Chemical Engineering Journal2010，165，2： | 1 |
| 15 | Preparation and adsorption properties of crosslinked polystyrene-supported low-generation diethanolamine-typed dendrimer for metal ions显示文摘 | Changmei Sun Rongjun Qu Chunnuan Ji Chunhua Wang Yanzhi Sun Zhongwen Yue Guoxiang Cheng | 2006 | Talanta2006，70，1： | 1 |
| 16 | European Polymer Journal 显示文摘 | Sun Changmei Qu Rongjun Ji Chunnuan Wang Qun Wang Chunhua Sun Yanzhi Cheng Guoxiang | 2006 | 42(1): 188-1942006，42，1： | 1 |
| 17 | Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson’s disease显示文摘 | Nian Xiong Jinsha Huang Chunnuan Chen Ying Zhao Zhaowen Zhang Min Jia Zhentao Zhang Lingling Hou Hecheng Yang Xuebing Cao Zhihou Liang Yongxue Zhang Shenggang Sun Zhicheng Lin Tao Wang | 2012 | Neurobiology of Aging2012，，8： | 1 |
| 18 | Synthesis of porous acrylonitrile/methyl acrylate copolymer beads by suspended emulsion polymerization and their adsorption properties after amidoximation显示文摘 | Xin Liu Hou Chen Chunhua Wang Rongjun Qu Chunnuan Ji Changmei Sun Ying Zhang | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 19 | Degradation kinetic study of lysine in lysine hydrochloride solutions for injection by determining its main degradation product显示文摘A limited number of researches have been reported to apply the Arrhenius equation to study the relationship between drugs and its degradation products so far.In the present work,the thermal degradation kinetics of lysine hydrochloride solutions for injection,the special solvent for ademetionine 1,4-butanedisulfonate(SAM)for injection,was investigated at selected temperatures and pH values.The main degradation product of lysine was separated,purified,and confirmed as lysine lactam.A reversed-phase high performance liquid chromatographic(RP-HPLC)method without derivation was developed for the simultaneous determination of lysine and lysine lactam.The results confirmed that both the lysine degradation and lysine lactam generation followed zero-order reaction kinetics.The degradation and generation rate constants increased with increasing temperatures and decreasing pH values.The temperature-dependent degradation and generation reaction could be sufficiently modeled on the Arrhenius equation with the activation energy of 80.14 and 83.22 kJ/mol,respectively.Meanwhile,a linear relationship existed between the amount of lysine degradation and lysine lactam generation since the approximate activation energy.Considering there could be other side effects,we established an upper limit of lysine lactam(500 mg/ml),as the acceptable criteria for stability to estimate the shelf life together with lysine,which made the prediction more accurate and credible.Extrapolation data demonstrated that the lysine hydrochloride solutions for injection could be stable for two years stored at room temperature. | Mengying Tao Meng Zhu Chunnuan Wu Zhonggui He | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，1： | 1 |
| 20 | A chelating resin with bis[2-(2-benzothiazolylthioethyl)sulfoxide]: Synthesis, characterization and properties for the removal of trace heavy metal ion in water samples显示文摘 | Chunnuan Ji Rongjun Qu Chunhua Wang Hou Chen Changmei Sun Qiang Xu Yanzhi Sun Chao Wei | 2007 | Talanta2007，，2： | 1 |
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