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| 1 | Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4显示文摘补充 32 的反应基因(RGC-32 ) 是涉及房间的增长,区别和迁居的一个房间周期管理者并且也在 angiogenesis 被含有。这里,我们证明在巨噬细胞的那 RGC-32 表情被 IL-4 导致并且由 LPS 减少了,显示在 RGC-32 表示和 M2 极化之间的一个连接。我们证明 RGC-32 的增加的表示或者激活的巨噬细胞,这蛋白质在压制支持 inflammatory cytokine IL-6 的生产并且支持反煽动性的调停人 TGF-β 的生产是特征的;。与一致在 vitro,数据, RGC-32 高级的联系肿瘤的巨噬细胞(TAM ) 快车,和这个表达式被导出肿瘤的腹水的液体以一种 M-CSF- 或 IL-4-dependent 方式导致。一起,这些结果为 M2 巨噬细胞极化作为一个标记建立 RGC-32 并且显示这蛋白质是为癌症免疫疗法的一个潜在的目标,指向联系肿瘤的巨噬细胞。 | Peng Zhao Daiqing Gao Qingjie Wang Bingfeng Song Qianqian Shao Jintang Sun Chunyan Ji Xingang Li Peng Li Xun Qu | 2015 | Cellular & Molecular Immunology2015，12，6： | 12 |
| 2 | Effects of a two-meal daily feeding pattern with varied crude protein levels on growth performance and antioxidant indexes in pigs显示文摘The present study aimed to evaluate the effects of daily feeding pattern on growth performance, blood biochemistry, and antioxidant indexes in pigs. One hundred and eighty female Duroc x Landrace x Yorkshire(DLY) pigs with similar body weight(11.00 ± 0.12 kg) were randomly assigned to 3 groups: the control group(fed 17.01% CP diet, twice daily); high-low group(H-L group, fed18.33% CP diet in the morning, followed by 15.70% CP diet in the afternoon); and low-high group(L-H group, fed 15.70% CP diet in the morning, followed by 18.33% CP diet in the afternoon)(n = 6). Comparable amounts of their respective diets were given at 05:30 and 15:00 throughout the experimental periods to make all the treatments consumed the same type of food and the same amount of calories on a daily basis. On day 30, one pig was randomly selected per litter for blood samples. Compared with the control group, ADG in the H-L and L-H groups increased by 8.11% and 16.23%, but not significant(P > 0.05); and blood urea nitrogen(BUN) in the H-L and L-H groups decreased by 26.76% and 41.04%(P < 0.05), respectively. The H-L group feeding pattern could significantly improve levels of serum superoxide dismutase(SOD), when compared with the control group. These findings suggest that the twomeal daily feeding pattern with varied levels of CP affects serum levels of BUN and SOD. These changes could effectively silightly improve growth performance and antioxidant capacity in pigs without incurring increased feeding costs. | Xin Wu Xiaoyun Guo Chunyan Xie Tianyong Zhang Pengfei Gao Tianzeng Gao Yulong Yin | 2016 | Animal Nutrition2016，，4： | 6 |
| 3 | Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018显示文摘Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging populations.The prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by far.What is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was collected.The overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in females.What are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control. | Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang | 2022 | China CDC weekly2022，4，29： | 4 |
| 4 | Diversity of metabolite accumulation patterns in inner and outer seed coats of pomegranate:exploring their relationship with genetic mechanisms of seed coat development显示文摘The expanded outer seed coat and the rigid inner seed coat of pomegranate seeds,both affect the sensory qualities of the fruit and its acceptability to consumers.Pomegranate seeds are also an appealing model for the study of seed coat differentiation and development.We conducted nontarget metabolic profiling to detect metabolites that contribute to the morphological differentiation of the seed coats along with transcriptomic profiling to unravel the genetic mechanisms underlying this process.Comparisons of metabolites in the lignin biosynthetic pathway accumulating in seed coat layers at different developmental stages revealed that monolignols,including coniferyl alcohol and sinapyl alcohol,greatly accumulated in inner seed coats and monolignol glucosides greatly accumulated in outer seed coats.Strong expression of genes involved in monolignol biosynthesis and transport might explain the spatial patterns of biosynthesis and accumulation of these metabolites.Hemicellulose constituents and flavonoids in particular accumulated in the inner seed coat,and candidate genes that might be involved in their accumulation were also identified.Genes encoding transcription factors regulating monolignol,cellulose,and hemicellulose metabolism were chosen by coexpression analysis.These results provide insights into metabolic factors influencing seed coat differentiation and a reference for studying seed coat developmental biology and pomegranate genetic improvement. | Gaihua Qin Chunyan Liu Jiyu Li Yongjie Qi Zhenghui Gao Xiaoling Zhang Xingkai Yi Haifa Pan Ray Ming Yiliu Xu | 2020 | Horticulture Research2020，7，1： | 4 |
| 5 | Parametric design strategy of a novel cylindrical negative Poisson's ratio jounce bumper for ideal uniaxial compression load-displacement curve显示文摘A cylindrical negative Poisson's ratio(CNPR) structure based on two-dimensional double-arrow negative Poisson's ratio(NPR)structure was introduced in this paper. The CNPR structure has excellent stiffness, damping and energy absorption performances,and can be applied as spring, damper and energy absorbing components. In this study, the CNPR structure was used as a jounce bumper in vehicle suspension, and the load-displacement curve of NPR jounce bumper was discussed. Moreover, the influences of structural parameters and materials on the load-displacement curve of NPR jounce bumper were specifically researched. It came to the conclusion that only the numbers of cells and layers impact the hardening displacement of NPR jounce bumper. And all parameters significantly affect the structure stiffness at different displacement periods. On the other hand, the load-displacement curve of NPR jounce bumper should be in an ideal region which is difficult to be achieved applying mathematical optimization method. Therefore, a parametric design strategy of NPR jounce bumper was proposed according to the parametric analysis results. The design strategy had two main steps: design of hardening displacement and design of stiffness. The analysis results proved that the proposed method is reliable and is also meaningful for relevant structure design problem. | WANG YuanLong ZHAO WanZhong ZHOU Guan WANG ChunYan GAO Qiang | 2018 | Science China(Technological Sciences)2018，61，10： | 4 |
| 6 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 7 | Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways显示文摘 | Yonggang Cao Xiaoyuan Mao Chunyan Sun Ping Zheng Jingquan Gao Xiaorui Wang Dongyu Min Hongli Sun Ni Xie Jiqun Cai | 2011 | Brain Research Bulletin2011，，6： | 2 |
| 8 | Characteristics and Formation Mechanisms of Tight Sandstone Reservoirs in the Huahai Depression,Jiuquan Basin显示文摘It is significant to study the reservoir features and formation mechanisms of unconventional reservoirs.The reservoir characteristics of tight sandstone reservoirs in the Huahai Depression,Jiuquan Basin are systematically described in this paper,and in particular the micro pore structures of observed core samples are qualitatively classified.Fundamentally,this research is benefit for | FAN Chunyan SONG Yan JANG Zhenxue LUO Qun YAO Limiao GAO Xiongxiong LUO Qun | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 2 |
| 9 | Crystal structure of histidine-containing phosphocarrier protein from Thermoanaerobacter tengcongensis MB4 and the implications for thermostability显示文摘Protein thermostability is an inherent characteristic of proteins from thermophilic microorganisms,and therefore enables these organisms to survive at extreme temperatures.Although it is well-known that thermostable proteins are critical for the growth of thermophilic organisms,the structural basis of protein thermostability is not yet fully understood.The histidine-containing phosphocarrier (HPr) protein,a phosphate shuttle protein in the phosphoenolpyruvate-dependent sugar transport system (PTS) of bacterial species,is an ideal model for investigating protein thermostability with respect to its small size and deficiency in disulphide bonds or cofactors.In this study,the HPr protein from Thermoanaerobacter tengcongensis (TtHPr) is cloned and purified.Crystal structure with good quality has been determined at 2.3 resolution,which provides a firm foundation for exploring the thermostable mechanism.However,it shows that the crystal structure is conserved and no clue can be obtained from this single structure.Furthermore,detailed comparison of sequence and structure with the homologs from mesoor thermophilic bacteria shows no obvious rule for thermostability,but the extra salt-bridge existing only in thermophilic bacteria might be a better explanation for thermostability of HPr.Thus,mutations are performed to interrupt the salt-bridge in HPrs in thermophilic bacteria.Using site-directed mutations and the circular dichroism method,thermostability is evaluated,and the mutational variations are shown to have a faster denaturing rate than for wild-type viruses,indicating that mutations cause instability in the HPrs.Understanding the higher-temperature resistance of thermophilic and hyperthermophilic proteins is essential to studies on protein folding and stability,and is critical in engineering efficient enzymes that can work at a high temperature. | FENG ChunYan GAO Feng LIU YiWei WANG GuiHua PENG Hao MA YanHe YAN JingHua GAO George Fu | 2011 | Science China(Life Sciences)2011，54，6： | 2 |
| 10 | Blind channel estimation algorithm for MIMO-OFDM systems显示文摘 | GAO Chunyan ZHAO Ming ZHOU Shidong | 2003 | Electronics Letter2003，39，19： | 1 |
| 11 | An infectious clone of the highly pathogenic porcine reproductive and respiratory syndrome virus: Topology of glycoprotein 3 (GP3) addressing the intrachain disulfide bonds显示文摘The highly pathogenic porcine reproductive and respiratory virus (hpPRRSV) with discontinuous 30 amino acid (aa) deletion as a gene marker has caused great economic loss in pig industry and since 2007 has become the dominant strain prevalent in China and Vietnam since 2007.Reverse genetics method is a powerful tool urgently needed to be used on the hpPRRSV to study the intriguing molecular mechanism of transcription,replication and the virulence determinant factors.In our study,we successfully constructed a fulllength infectious clone,prBJSY07,based on hpPRRSV isolate,BJSY07.The rescued virus,vrBJSY07,showed similar growth characters to those of the parental virus,BJSY07.We also found that a rescued virus vBJSY07 generated from pBJSY07 was viable but displayed decreased and delayed reproductive capacity,which might be caused by two amino acids mutations,S83C and S117C in glycoprotein 3 (GP3),acquired during the preparation of the infectious clone.The topology of the wild type GP3 and the mutant were further analyzed by bioinformatics and revealed that the mutated GP3 possessed slightly altered structure,most likely by forming a new disulfide bond between the two new cysteine residues.As GP3 is a cysteine-rich glycoprotein,common for viral glycoproteins,our results show that GP3 can accommodate even more cysteine mutations.Based on this,a topological model of GP3 is proposed by addressing the intrachain disulfides. | FENG ChunYan LIU YueHuan YAN JingHua George F. Gao | 2011 | Chinese Science Bulletin2011，56，26： | 1 |
| 12 | An efficient algorithm for DNA fragment assembly in MapReduce 显示文摘 | Baomin Xu Jin Gao Chunyan Li | 2012 | Bioche:ical and Biophysical Research Communications2012，426，3： | 1 |
| 13 | Kinetics of Ozonation of Typical Sulfonamides in Water显示文摘Objective To investigate the kinetic rate constants ozone and hydroxyl radicals towards two groups of antimicrobials-sulfadiazine (SD) and sulfamethoxazole (SMX).Methods The solute consumption method was used to detect the rate constants of ozone alone with sulfadiazine and sulfamethoxazole,and tertiary butanol was selected as a scavenging agent and pH was adjusted to 2.5 by adding orthophosphate buffers (OB);and the competition kinetics studying methodwith nitrobenzene as a reference was applied to measure the rate constants of hydroxyl radicals towards sulfadiazine and sulfamethoxazole,and pH was adjusted to 7.0 by adding OB.Results The rate constants of SD and SMX with ozone alone were 261 mol ‐1 dm 3 s ‐1 and 303 mol ‐1 dm3 s ‐1 by calculating in low reaction system.The rate constants of hydroxyl radicals with SD and SMX were 2.2×1010 mol ‐1 dm 3 s ‐1 and 2.7×1010 mol ‐1 dm 3 s ‐1,respectively.Moreover,the rate constants of hydroxyl radicals with SMX were found to have increased from 3.6×109 mol ‐1 dm 3 s ‐1 to 2.8×1010 mol ‐1 dm 3 s ‐1 with pH value rising from 5.0 to 7.8.Conclusion SMX and SD are both refractory to ozone oxidation alone,and are liable to be degraded by hydroxyl radicals,and the rate constants of SMX with the hydroxyl radical slightly increases with pH rise. | SUI MingHao XING SiChu ZHU ChunYan SHENG Li LU KeXiang GAO NaiYun | 2011 | Biomedical and Environmental Sciences2011，24，3： | 1 |
| 14 | One step synthesis of azo compounds from nitroaromatics and anilines显示文摘 | Rui Zhao Chunyan Tan Yonghua Xie Chunmei Gao Hongxia Liu Yuyang Jiang | 2011 | Tetrahedron Letters2011，，29： | 1 |
| 15 | Synthesis and photoresponsive behavior of azobenzene‐containing side‐chain liquid crystalline diblock polymers with polypeptide block显示文摘 | Xiaohua He Chunyan Gao Wuqiong Sun Wei Huang Shaoliang Lin Deyue Yan | 2012 | J Polym Sci A Polym Chem2012，，5： | 1 |
| 16 | The thermal transformation mechanism of chlorinated paraffins:An experimental and density functional theory study显示文摘The increasing production and usage of chlorinated paraffins(CPs) correspondently increase the amount of CPs that experience thermal processes. Our previous study revealed that a significant amount of medium-chain chlorinated paraffins(MCCPs), short-chain chlorinated paraffins(SCCPs) as well as aromatic and chlorinated polycyclic aromatic hydrocarbons(Cl-PAHs) were formed synergistically during the thermal decomposition of CP-52(a class of CP products).However, the transformation mechanisms of CP-52 to these compounds are still not very clear.This article presents a mechanistic analysis on the decomposition of CP-52 experimentally and theoretically. It was found that CP-52 initially undergoes dehydrochlorination and carbon chain cleavage and it transformed into chlorinated and unsaturated hydrocarbons. Cyclization and aromatization were the most accessible pathways at low temperatures(200–400°C), both of which produce mostly aromatic hydrocarbons. As the temperature exceeds 400°C, the hydrocarbons could decompose into small molecules, and the subsequent radical-induced reactions become the predominant pathways, leading to the formation of Cl-PAHs. The decomposition of CP-52 was investigated by using density functional theory and calculations demonstrating the feasibility and rationality of PCB and PCN formation from chlorobenzene. The results improve the understanding of the transformation processes from CP-52 to SCCPs and Cl-PAHs as well as provide data for reducing their emissions during thermal-related processes. | Shanzhi Xin Wei Gao DANDan Cao Kun Lv Yaquan Liu Chunyan Zhao Yawei Wang Guibin Jiang | 2019 | Journal of Environmental Sciences2019，31，1： | 1 |
| 17 | Grafting voltage and pharmacological sensitivity in potassium channels显示文摘一条古典电压门离子隧道由四个察觉到电压的领域(VSD ) 组成。然而,在隧道的每 VSD 的角色留下逃犯。我们开发了 GVTDT (到缺乏内长的 VSD 的二聚的 TASK3 隧道的接枝 VSD ) 与 VSD 的一个减少的数字生产电压门隧道的策略。没有防碍 TASK3 选择过滤器的内在的性质, TASK3 隧道展出高主人忍耐到各种各样的电压门离子隧道的 VSD。构造隧道,从 Kv7.1 隧道与一个或二 VSD 由隧道 grafted 例示,展出古典电压敏感,包括电压依赖者开并且关门。而且, grafted Kv7.1 VSD 转移 benzbromarone 的 potentiation 活动,对施主隧道的 VSD 起作用的使活跃之物,到构造隧道。我们的学习显示那一 VSD 对足够 voltage-dependently 门毛孔并且提供新卓见进 VSD 的角色。 | Xi Lan | 2016 | Cell Research2016，26，8： | 1 |
| 18 | Development of simple repeat(SSR)markers from a genome survey of Chinese bayberry(Myrica rubra)显示文摘 | JIAO Yun JIA Huimin LI Xiongwei CHAI Mingliang JIA Huijuan CHEN Zhe WANG Guoyun CHAI Chunyan Eric van deWeg GAO Zhongshan | 2012 | BMC Genomics2012，13，： | 1 |
| 19 | N-Linked Glycosylation of GP5 of Porcine Reproductive and Respiratory Syndrome Virus Is Critically Important for Virus Replication In Vivo显示文摘 | Zuzhang Wei Tao Lin Lichang Sun Yanhua Li Xiaoming Wang Fei Gao Runxia Liu Chunyan Chen Guangzhi Tong Shishan Yuan | 2012 | Journal of Virology2012，，18： | 1 |
| 20 | In vitro anther culture and Agrobacterium-mediated transformation of the AP1 gene from Salix integra Linn. in haploid poplar(Populus simonii × P. nigra)显示文摘A reliable,efficient anther culture system,the dominant technique for generating haploid plants in breeding programs,that can be used for generating transgenic poplar plants has been needed.In the present study,therefore,an anther culture system was developed using isolated mid-and late-uninucleate anthers of poplar(Populus simonii x P.nigra).From a combination of SSR and ploidy analyses,six double haploid and two haploid lines were characterized from 86 plants grown from 16 regenerated anther cultured lines.After 48 months of development,two plant lines from the regenerated plants maintained their haploid level in vitro for over 2 years.A number of haploid plants from the different lines weretransferred to soil.The leaves of these transplants were then used as explants for transformation with the APETALA1(AP1) gene using Agrobacterium tumefaciens.Overexpression of AP1 in haploid poplar induced early flowering with obvious petals when ectopically expressed.To our knowledge,this is the first report on changes in flowering time in AP1-trangenic poplar,which is important for elucidating the regulatory mechanism of tree flower development. | Jingli Yang Kun Li Chunyan Li Junxiu Li Bo Zhao Wei Zheng Yuchi Gao Chenghao Li | 2018 | Journal of Forestry Research2018，29，2： | 1 |
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