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| 1 | Defect-related luminescent bur-like hydroxyapatite microspheres induced apoptosis of MC3T3-E1 cells by lysosomal and mitochondrial pathways显示文摘When orthopedic joints coated by hydroxyapatite(HA) were implanted in the human body, they release wear debris into the surrounding tissues. The generation and accumulation of wear particles will induce aseptic loosening. However, the potential bioeffect and mechanism of HA-coated orthopedic implants on bone cells are poorly understood. In this study, defect-related luminescent bur-like hydroxyapatite(BHA) microspheres with the average diameter of 7–9 μm which are comparable to that of the wear-debris particles from aseptically loosened HA implants or HA debris have been synthesized by hydrothermal synthesis and the MC3 T3-E1 cells were set as a cells model to study the potential bioeffect and mechanism of BHA microspheres. The studies demonstrated that BHA microspheres could be taken into MC3 T3-E1 cells via endocytosis involved in micropinocytosisand clathrin-mediated endocytosis process, and exert cytotoxicity effect. BHA microspheres could induce the cell apoptosis by intracellular production of reactive oxygen species(ROS), which led to not only an increase in the permeability of lysosome and release of cathepsins B, but also mitochondrial dysfunction and DNA damage. Our results provide novel evidence to elucidate their toxicity mechanisms and might be helpful for more reasonable applications of HA-based orthopaedic implants in the future. | Yi Jin Shizhu Chen Nan Li Yajing Liu Gong Cheng Cuimiao Zhang Shuxiang Wang Jinchao Zhang | 2018 | Science China(Life Sciences)2018，61，4： | 2 |
| 2 | Rare earth fluorides nanowires/nanorods derived from hydroxides: Hydrothermal synthesis and luminescence properties 显示文摘 | Xu Zhenhe Li Chunxia Yang Piaoping Zhang Cuimiao Huang Shanshan Lin Jun | 2009 | Crystal Growth & Design2009，9，11： | 1 |
| 3 | Highly efficient adsorption of bulky dye molecules in wastewater on ordered mesoporous carbons显示文摘 | ZHUANG Xin WAN Ying FENG Cuimiao | 2009 | Chemistry of Materials2009，21，4： | 1 |
| 4 | Size-dependent cytotoxicity of europium doped NaYF 4 nanoparticles in endothelial cells显示文摘 | Shizhu Chen Cuimiao Zhang Guang Jia Jianlei Duan Shuxiang Wang Jinchao Zhang | 2014 | Materials Science & Engineering C2014，，： | 1 |
| 5 | Highly efficient ad- sorption of bulky dye molecules in wastewater on ordered mesoporous carbons显示文摘 | Xin Zhuang Ying Wan Cuimiao Feng | 2009 | Chem Mater2009，21，4： | 1 |
| 6 | Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery显示文摘 | Cuimiao Zhang Chunxia Li Shanshan Huang Zhiyao Hou Ziyong Cheng Piaoping Yang Chong Peng Jun Lin | 2010 | Biomaterials2010，，12： | 1 |
| 7 | Magnetic Fe304@ mesoporous silica composites for drug delivery and bioadsorption显示文摘 | Huang Shanshan Li Chunxia Cheng Ziyong Fan Yong Yang Piaoping Zhang Cuimiao Yang Kuiyue Lin Jun | 2012 | Journal of Colloid and lnterface Science2012，376，： | 1 |
| 8 | Hydrothermal synthesis and luminescent properties of LuBO3: Tb^3+ microfl- owers显示文摘 | Yang Jun Zhang Cuimiao Wang Lili | 2008 | Journal of Solid State Chemistry2008，181，10： | 1 |
| 9 | Preparation and characterization of upconversion luminescent NaYF 4 :Yb, Er (Tm)/PS bulk transparent nanocomposites through in situ polymerization显示文摘 | Ruitao Chai Hongzhou Lian Ziyong Cheng Cuimiao Zhang Zhiyao Hou Zhenhe Xu Jun Lin | 2010 | Journal of Colloid And Interface Science2010，，2： | 1 |
| 10 | Mesoporous SrF2 and SrF2:Ln3+(Ln=Ce,Tb,Yb,Er) hierarchical microspheres:hydrothermal synthesis,growing mechanism,and luminescent properties显示文摘 | ZHANG Cuimiao HOU Zhiyao LIN Jun | 2010 | Journal of Physical Chemistry C2010，114，15： | 1 |
| 11 | Con- trolled synthesis of Ln3+ (Ln= Tb, Eu, Dy) and Vs+ ion-doped YPO4 nano/microstructures with tunable lu- minescent colors显示文摘 | Li Chunxia Hou Zhiyao Zhang Cuimiao | 2009 | Chemistry of Materials2009，21，19： | 1 |
| 12 | Highly effi- cient adsorption of bulky dye molecules in wastewater on ordered mesopomus carbons 显示文摘 | Zhuang Xin Wan Ying Feng Cuimiao | 2009 | Chemistry of Materials2009，4，21： | 1 |
| 13 | Mesoporous SrFz and SrF2: Ln3+ (Ln=Ce, Tb, Yb, Er) hierarchical microspheres: Hydrothermal synthesis, growing mechanism and luminescent properties显示文摘 | Zhang Cuimiao Hou Zhiyao Chai Ruitao | 2010 | J Phys Chem C2010，114，15： | 1 |
| 14 | Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery 显示文摘 | ZHANG Cuimiao LI Chunxia HUANG Shanshan | 2010 | Biomaterials2010，31，12： | 1 |
| 15 | Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery显示文摘 | Zhang Cuimiao Li Chunxia | 2010 | Biomaterials2010，31，： | 1 |
| 16 | Con- trolled synthesis of Ln^3+ (Ln=Tb,Eu,Dy) and V^5+ ion -doped YPO4 nano-/microstructures with tunable lumi nescent colors 显示文摘 | Li Chunxia Hou Zhiyao Zhang Cuimiao | 2009 | Chemistry of Materials2009，21，19： | 1 |
| 17 | Highly efficient adsorption of bulky dye molecules in wastewater on ordered mesoporous carbons 显示文摘 | Zhuang Xin Wan Ying Feng Cuimiao | 2009 | Chem Mater2009，21，4： | 1 |
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