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| 1 | A phase I study of different doses and frequencies of pegylated recombinant human granulocyte-colony stimulating factor(PEG rhG-CSF) in patients with standard-dose chemotherapy-induced neutropenia显示文摘Objective: The recommended dose of prophylactic pegylated recombinant human granulocyte-colony stimulating factor(PEG rhG-CSF) is 100 μg/kg once per cycle for patients receiving intense-dose chemotherapy.However, few data are available on the proper dose for patients receiving less-intense chemotherapy. The aim of this phase I study is to explore the proper dose and administration schedule of PEG rhG-CSF for patients receiving standard-dose chemotherapy.Methods:Eligible patients received 3-cycle chemotherapy every 3 weeks.No PEG rhG-CSF was given in the first cycle.Patients experienced grade 3 or 4 neutropenia would then enter the cycle 2 and 3.In cycle 2,patients received a single subcutaneous injection of prophylactic PEG rhG-CSF on d 3,and received half-dose subcutaneous injection in cycle 3 on d 3 and d 5,respectively.Escalating doses(30,60,100 and 200μg/kg)of PEG rhG-CSF were investigated.Results:A total of 26 patients were enrolled and received chemotherapy,in which 24 and 18 patients entered cycle 2 and cycle 3 treatment,respectively.In cycle 2,the incidence of grade 3 or 4 neutropenia for patients receiving single-dose PEG rhG-CSF of 30,60,100 and 200 μg/kg was 66.67%,33.33%,22.22% and 0,respectively,with a median duration less than 1(0–2)d.No grade 3 or higher neutropenia was noted in cycle 3 in all dose cohorts.Conclusions:The pharmacokinetic and pharmacodynamic profiles of PEG rhG-CSF used in cancer patients were similar to those reported,as well as the safety.Double half dose administration model showed better efficacy result than a single dose model in terms of grade 3 neutropenia and above.The single dose of 60 μg/kg,100 μg/kg and double half dose of 30 μg/kg were recommended to the phase Ⅱ study,hoping to find a preferable method for neutropenia treatment. | Yan Qin Xiaohong Han Lin Wang Ping Du Jiarui Yao Di Wu Yuanyuan Song Shuxiang Zhang Le Tang Yuankai Shi | 2017 | Chinese Journal of Cancer Research2017，29，5： | 11 |
| 2 | Polarization microwave-induced thermoacoustic imaging for quantitative characterization of deep biological tissue microstructures显示文摘Polarization optical imaging can be used to characterize anisotropy in biological tissue microstructures and has been demonstrated to be a powerful tool for clinical diagnosis. However, the approach is limited by an inability to image targets deeper than ~1 mm due to strong optical scattering in biological tissues. As such, we propose a novel polarization microwave-induced thermoacoustic imaging(P-MTAI) technique to noninvasively detect variations in deep tissue by exploiting the thermoacoustic signals induced by four pulsed microwaves of varying polarization orientations. The proposed P-MTAI method overcomes the penetration limits of conventional polarization optical imaging and provides submillimeter resolution over depths of several centimeters. As part of the paper, the structural characteristics of tissues were quantified using a new parameter, the degree of microwave absorption anisotropy. P-MTAI was also applied to the noninvasive detection of morphological changes in cardiomyocytes as they transitioned from ordered to disordered states, providing a potential indication of myocardial infarction. | YUJING LI SHANXIANG ZHANG LINGHUA WU ZHONGWEN CHENG ZHENHUI ZHANG HAOHAO WANG SHUXIANG ZHAO MINGYANG REN SIHUA YANG DA XING HUAN QIN | 2022 | Photonics Research2022，10，5： | 2 |
| 3 | Massage treatment of chronic persistent pediatric asthma显示文摘Objective:We observed the clinical effect of massage in treating chronic persistent pediatric asthma and the changes in expression of TLR1,TLR2,and TLR4 on macrophages.Methods:One hundred sixty pediatric patients with persistent chronic asthma were col-lected,and divided into treatment and control groups of 80 each in strict accordance with the principle of random allocation.The patients in the control group received general nebulizer therapy,and the patients in the treatment group received infantile massage.Both groups of patients were observed for 3 months with respect to the following indicators:the frequency of asthmatic attacks;the frequency of respiratory tract infections(RTIs);C-ACT rating;and the PEF%of peripheral blood(PB)before and after treatment to detect macrophage TLR1,TLR2,and TLR4.Results:After treatment,the frequency of asthmatic attacks,frequency of RTIs,C-ACT rat-ing,and the PEF%and macrophage TLR1,TLR2,and TLR4 expression of fluorescence intensity in the treatment group showed a statistically significant increase when compared with the control group(P<0.05).Conclusion:Pediatric massage can improve the clinical symptoms of pediatric asthma by up-regulating the expression of macrophage TLR1,TLR2,and TLR4. | Fuling Tian Qi Li Jianmei Cui Shuxiang Ma Hongbin Wang Xueqing Li | 2014 | Family Medicine and Community Health2014，2，2： | 2 |
| 4 | Calcium-magnesium-alumina-silicate(CMAS)resistant high entropy ceramic(Y_(0.2)Gd_(0.2)Er_(0.2)Yb_(0.2)Lu_(0.2))_(2)Zr_(2)O_(7) for thermal barrier coatings显示文摘A novel high-entropy material,(Y_(0.2)Gd_(0.2)Er_(0.2)Yb_(0.2)Lu_(0.2))_(2)Zr_(2)O_(7)was successfully synthesized by the solid state reaction method and spark plasma sintering,and investigated as a promising thermal barrier coating material.Rare-earth elements were distributed homogeneously in the pyrochlore structure.It was found that the prepared high-entropy ceramic maintains pyrochlore structure at the temperature up to 1600℃,and it possesses a similar thermal expansion coefficient(10.2×10^(−6)K^(−1) at 25-900℃)to that of YSZ,low thermal conductivity(<0.9 W m^(-1)K^(−1) at 100-1000℃)and good CMAS resistance(infiltration depth is 22μm after annealed at 1300℃for 24 h).The corrosion process was investigated,and RE elements distributing homogeneously in(Y_(0.2)Gd_(0.2)Er_(0.2)Yb_(0.2)Lu_(0.2))_(2)Zr_(2)O_(7)show different diffusion rates in CMAS.RE^(3+) with a larger radius(closer to Ca^(2+))is easier to react with CMAS to form an apatite phase. | Shuxiang Deng Gang He Zengchao Yang Jingxia Wang Jiangtao Li Lei Jiang | 2022 | Journal of Materials Science & Technology2022，，12： | 2 |
| 5 | N-carbamylglutamate restores nitric oxide synthesis and attenuates high altitudeinduced pulmonary hypertension in Holstein heifers ascended to high altitude显示文摘Background: High-altitude pulmonary hypertension(HAPH) is a life-threating condition for animals in high altitude,and disturbance of endothelial nitric oxide(NO) synthesis contributes to its pathogenesis. N-carbamylglutamate(NCG), which enhances arginine synthesis, promotes endogenous synthesis of NO. In this study, we determined the effects of NCG on alleviating HAPH in Holstein heifers that ascended to Tibet(Lhasa, 3,658 m).Methods: Exp. 1, 2,000 Holstein heifers were transported from low elevation(1,027 m) to Lhasa. After being exposed to hypoxia for 1 yr, Holstein heifers were assigned to a healthy group(Control, n = 6) with mean pulmonary hypertension(mPAP) < 41 mmHg, and an HAPH affected group(HAPH, n = 6) with mPAP > 49 mmHg.Lung tissues were collected to evaluate histopathological changes and the expression of endothelial nitric oxide synthase(eNOS). Exp. 2, ten healthy heifers and 10 HAPH affected heifers were supplemented with NCG(20 g/d per heifer) for 4 wk. Physiological parameters were determined and blood samples were collected on d-1 and d 28 of the feeding trial.Results: Expression of e NOS in small pulmonary arteriole intima was higher in the healthy than HAPH group(P = 0.006), whereas HAPH group had significantly thicker media and adventitia than healthy group(all P < 0.05). The mRNA of eNOS and protein level of eNOS were higher in the lungs of heifers in the healthy group than in the HAPH group(both P < 0.001), whereas endothelin-1 protein levels were higher in HAPH group than in the healthy group(P = 0.025). NCG supplementation decreased mPAP and ammonia(both P = 0.001), whereas it increased the expression of eNOS, arginine, and plasma NO(all P < 0.05).Conclusions: The expression of eNOS was decreased in Holstein heifers with HAPH. NCG supplementation decreased m PAP through the restoration of eNOS and endogenous NO synthesis. | Shuxiang Wang Arash Azarfar Yajing Wang Zhijun Cao Shengli Li | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 2 |
| 6 | Defect-related luminescent bur-like hydroxyapatite microspheres induced apoptosis of MC3T3-E1 cells by lysosomal and mitochondrial pathways显示文摘When orthopedic joints coated by hydroxyapatite(HA) were implanted in the human body, they release wear debris into the surrounding tissues. The generation and accumulation of wear particles will induce aseptic loosening. However, the potential bioeffect and mechanism of HA-coated orthopedic implants on bone cells are poorly understood. In this study, defect-related luminescent bur-like hydroxyapatite(BHA) microspheres with the average diameter of 7–9 μm which are comparable to that of the wear-debris particles from aseptically loosened HA implants or HA debris have been synthesized by hydrothermal synthesis and the MC3 T3-E1 cells were set as a cells model to study the potential bioeffect and mechanism of BHA microspheres. The studies demonstrated that BHA microspheres could be taken into MC3 T3-E1 cells via endocytosis involved in micropinocytosisand clathrin-mediated endocytosis process, and exert cytotoxicity effect. BHA microspheres could induce the cell apoptosis by intracellular production of reactive oxygen species(ROS), which led to not only an increase in the permeability of lysosome and release of cathepsins B, but also mitochondrial dysfunction and DNA damage. Our results provide novel evidence to elucidate their toxicity mechanisms and might be helpful for more reasonable applications of HA-based orthopaedic implants in the future. | Yi Jin Shizhu Chen Nan Li Yajing Liu Gong Cheng Cuimiao Zhang Shuxiang Wang Jinchao Zhang | 2018 | Science China(Life Sciences)2018，61，4： | 2 |
| 7 | A miniature piezoelectric ultrasonic motor based on circular bending vibration mode显示文摘 | Shuxiang Dong Shuxin Wang Wenjiang Shen | 2000 | IEEE/ASME Transactions on Mechatronics2000，5，4： | 1 |
| 8 | Size-dependent cytotoxicity of europium doped NaYF 4 nanoparticles in endothelial cells显示文摘 | Shizhu Chen Cuimiao Zhang Guang Jia Jianlei Duan Shuxiang Wang Jinchao Zhang | 2014 | Materials Science & Engineering C2014，，： | 1 |
| 9 | Cytotoxic sesquiterpenoids from the fruits of Lindera communis显示文摘 | Zhipeng Deng Hao Zhong Shuxiang Cui Fengling Wang Yanying Xie Qingqiang Yao | 2011 | Fitoterapia2011，，7： | 1 |
| 10 | Study of cement mortars modified by emulsifier-free latexes 显示文摘 | Wang Jingang Zhang Shuxiang | 2005 | Cement and Concerte Composites2005，27，910： | 1 |
| 11 | A small,linear,piezoelectric ultrasonic cryomotor显示文摘 | Dong Shuxiang Yan Li Wang Naigang | 2005 | Applied Physics Letters2005，86，05： | 1 |
| 12 | A Miniature Piezoelectric Ultrasonic Motor Based on Circular Bending Vibration Mode显示文摘 | Dong Shuxiang Wang Shuxin Shen Wenjing | 2000 | IEEE/ASME TRANSACTION ON MECHATRONICS2000，5，4： | 1 |
| 13 | A miniature piezoelectric ultrasonic motor based on circular bending vibration mode显示文摘 | Dong Shuxiang Wang Shuxin Shen Wenjiang | 2000 | IEEE/ASME Transactions on Mechatronics2000，5，4： | 1 |
| 14 | A phase I clinical trial assessing the safety and tolerability of combretastatin A4 phosphate injections显示文摘 | Peng Liu Yan Qin Lingying Wu Sheng Yang Nan Li Haijun Wang Haiyan Xu Kelin Sun Shuxiang Zhang Xiaohong Han Yan Sun Yuankai Shi | 2014 | Anti-Cancer Drugs2014，，4： | 1 |
| 15 | Release of Chrome Tanning and Post Tanning Process 显示文摘 | Zhou Jian Hu Shuxiang Wang Yanan etc | 2012 | JSLTC2012，96，： | 1 |
| 16 | Effectsof cross-linking on mechanical and physical properties ofagricultural residues/recycled thermoplastics composites显示文摘 | Wang Zhiling Wang Enju Zhang Shuxiang | 2009 | Industrial Crops and Products2009，29，1： | 1 |
| 17 | A miniature piezoelectric ultrasonic motor based on circular bending vibration mode显示文摘 | DONG Shuxiang WANG Shuxin SHEN Wenjiang | 2000 | IEEE/ASME Transactions on Mechatronics2000，5，4： | 1 |
| 18 | Release of chrome tanning and post tanning process 显示文摘 | Zhou Jian Hu Shuxiang Wang Yanan | 2012 | JSLTC2012，96，4： | 1 |
| 19 | Gas-liquid-liq- uid three-phase reactive extraction for the hydrogen peroxide preparation by anthraquinone process 显示文摘 | Cheng Yongxi Wang Li Lu Shuxiang | 2008 | Ind Eng Chem Res2008，47，19： | 1 |
| 20 | Fabrication and Performances of 1-3-2 Piezoelectric Ceramic/Polymer Composite显示文摘A novel 1-3-2 piezoelectric composite has been developed,which consists of piezoelectric ceramic plate and 1-3 piezoelectric composite.The composite was fabricated by dicing PZT ceramic along mutual perpendicular two directions and then filling epoxy into grooves.The piezoelectric and electromechanical properties of the novel composite were determined. The results show a coefficient d_ (33) of 405pC/N,a vibration displacement of 113.5pm,an acoustic impendence of 13.3 Mraly, a bandwidth of 12kHz and a thickness electromechanical coupling coefficient of 0.56. | Likun Wang Guang Li Hongliang Du Lei Qin Shuxiang Li | 2006 | 稀有金属材料与工程2006，35，A03： | 1 |
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