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| 1 | 针对亚洲男性前列腺疾病及特征的概观显示文摘本文综述了在亚洲男性中良性前列腺增生症、前列腺癌及慢性前列腺炎等三种常见前列腺疾病的特征。与西方男性相比,亚洲男性在前列腺疾病方面有着独特的特征。通过总结这些疾病的流行病学,症状学及诊断和治疗,我们发现亚洲男性前列腺癌的发病率低于西方人,但是良性前列腺增生症和慢性前列腺炎的发病率与西方人相似。患有慢性前列腺炎的亚洲男性,相比于西方男性,通常表现为较少的疾病位点,但是更容易出现排尿时,非性高潮后的疼痛感。前列腺特异抗原(PSA)作为一种前列腺癌诊断的生物标记物,在东西方均被广泛应用。尽管亚洲人PSA的基础水平较西方人低,但是目前使用的诊断闽值仍是以西方人为标准制定所得。在回顾这些前列腺疾病可用的治疗方法之后,我们没有在亚洲男性和西方男性间找到根本的差异。再者,基于病人的个体需要选择最适当的治疗方法仍是亚洲泌尿科医生所面临的挑战。在考虑针对亚洲男性前列腺疾病的特点之后,我们希望本文为针对亚洲男性前列腺疾病诊疗方案的发展提供信息。 | Shu-Jie Xia Di Cui Qi Jiang | 2012 | Asian Journal of Andrology2012，14，3： | 22 |
| 2 | Simulated Microgravity Conditions and Carbon Ion Irradiation Induce Spermatogenic Cell Apoptosis and Sperm DNA Damage显示文摘Objective To investigate the effect of simulated microgravity and carbon ion irradiation(CIR) on spermatogenic cell apoptosis and sperm DNA damage to the testis of male Swiss Webster mice,and assess the risk associated with space environment.Methods Sperm DNA damage indicated by DNA fragmentation index(DFI) and high DNA stainability(HDS) was measured by sperm chromatin structure assay(SCSA).Apoptosis of spermatogenic cells was detected by annexin V-propidium iodide assay.Bax(the expression levels of p53) and proliferating cell nuclear antigen(PCNA) were measured by immunoblotting;p53 and PCNA were located by immunohistology.Results HDS,DFI,apoptosis index,and the expression levels of p53 and Bax were detected to be significantly higher in the experimental groups(P<0.05) compared with those in the control group;however,the PCNA expression varied to a certain degree.p53-and PCNA-positive expression were detected in each group,mainly in relation to the spermatogonic cells and spermatocytes.Conclusion The findings of the present study demonstrated that simulated microgravity and CIR can induce spermatogenic cell apoptosis and sperm DNA damage.Sperm DNA damage may be one of the underlying mechanisms behind male fertility decline under space environment.These findings may provide a scientific basis for protecting astronauts and space traveler's health and safety. | LI Hong Yan ZHANG Hong MIAO Guo Ying XIE Yi SUN Chao DI Cui Xia LIU Yang LIU Yuan Yuan ZHANG Xin MA Xiao Fei XU Shuai GAN Lu ZHOU Xin | 2013 | Biomedical and Environmental Sciences2013，26，9： | 10 |
| 3 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 4 | Low serum testosterone predicts upgrading and upstaging of prostate cancer after radical prostatectomy显示文摘经常,病理学的格利森分数(GS ) 和前列腺癌症(PCa ) 的舞台与活体检视 GS 和临床的舞台不一致。然而,没有预言升级的广泛地接受的方法和 upstaging PCa。在我们的学习,我们调查了在浆液睾丸激素之间的协会并且升级或在激进的前列腺切除术(RP ) 以后的 PCa 的 upstaging。我们与活体检视 GS ≤ 与 PCa 注册了 167 个病人; 6,临床的阶段 ≤ T2c,和前列腺特定的抗原(PSA )<从 2009 年 4 月的 10 ng ml −1 到 2015 年 4 月。数据包括年龄,身体团索引,外科手术前的 PSA 水平, comorbidity,临床的演讲,和外科手术前的浆液总计睾丸激素水平被收集。升级发生在 62 (37.1%) 病人,和 upstaging 发生在 73 (43.7%) 病人。外科手术前的睾丸激素在比 nonupgrading 组升级是更低的(3.72 对 4.56, P<0.01 ) 。在有的 upstaging 组的病人在 nonupstaging 组比那些降低外科手术前的睾丸激素(3.84 对 4.57, P= 0.01 ) 。在 multivariate 逻辑回归分析作为连续、范畴的变量,低浆液睾丸激素被证实是病理学的升级的一个独立预言者(P = 0.01 并且 P= 0.01 ) 并且 upstaging (P = 0.01 并且 P = 0.02 ) 在 RP 以后。我们建议那低浆液睾丸激素(< 3 ng ml −1) 与在 RP 以后升级和 upstaging 的高率被联系。外科医生近保证,并且在当与低浆液睾丸激素为病人选择 RP 治疗时,执行扩大淋巴节点解剖热心更好 PSA 层次和成像检查监视是否选择 non-RP 治疗,到在继续神经圆材外科小心。 | Yuan Gao Chen-Yi Jiang Shi-Kui Mao Di Cui Kui-Yuan Hao Wei Zhao Qi Jiang Yuan Ruan Shu-Jie Xia Bang-Min Han | 2016 | Asian Journal of Andrology2016，18，4： | 3 |
| 5 | Androgen receptors expressed by prostatic stromal cells obtained from younger versus older males exhibit opposite roles in prostate cancer progression显示文摘老化是为前列腺癌症(PCa ) 的一个主要风险因素,并且 prostatic stromal 房间可以也支持 PCa 前进。因此, stromal 房间同等地不在更老的男性和更年轻的男性支持 PCa。因此,由在更老对更年轻的男性的 prostatic stromal 房间的雄激素受体(艺术) 的表示在 PCa 前进起不同作用,也是可能的。用基因击倒的技术和 coculture 系统,我们发现在从更年轻的男性获得的房间能支持的 prostatic stromal 的 AR 击倒在 vitro 的 cocultured PC3/LNCaP 房间的侵略和转移。由对比,当时, LNCaP 房间的侵略和转移被禁止有从当 AR 表示被敲时,击倒的更老的男性的 prostatic stromal 房间的 cocultured。而且在与小发卡 RNA (shRNA ) 指向 AR 表示以后,在 stromal 房间的矩阵 metalloproteinase (MMP ) 表示被观察到更年轻的组的增加,但是减少或在更老的组仍然保持未改变。然而,一个例外与 MMP9 被观察。在 vivo,在在 prostatic stromal 房间将 AR 表示击倒以后,变形淋巴节点的发生被观察在更年轻的年龄组增加,但是在老年组减少了。一起,这些数据建议在 prostatic stromal 房间的 AR 为更老对更年轻的男性在 PCa 转移在角色对面玩了。一起,因此,在 prostatic stromal 房间的 AR 的函数看起来随着变化变老,并且这可以在更老的男性说明 PCa 的增加的发生。 | You-Yi Lu Bo Jian Fu-Jun Zhao Di Cui Qi Jiang Jun-Jie Yu En-Hui Li Xiao-Hai Wang Bang-Min Han Shu-Jie Xia | 2013 | Asian Journal of Andrology2013，15，5： | 2 |
| 6 | Integral imaging-based tabletop light field 3D display with large viewing angle显示文摘Light field 3D display technology is considered a revolutionary technology to address the critical visual fatigue issues in the existing 3D displays.Tabletop light field 3D display provides a brand-new display form that satisfies multi-user shared viewing and collaborative works,and it is poised to become a potential alternative to the traditional wall and portable display forms.However,a large radial viewing angle and correct radial perspective and parallax are still out of reach for most current tabletop light field 3D displays due to the limited amount of spatial information.To address the viewing angle and perspective issues,a novel integral imaging-based tabletop light field 3D display with a simple flat-panel structure is proposed and developed by applying a compound lens array,two spliced 8K liquid crystal display panels,and a light shaping diffuser screen.The compound lens array is designed to be composed of multiple three-piece compound lens units by employing a reverse design scheme,which greatly extends the radial viewing angle in the case of a limited amount of spatial information and balances other important 3D display parameters.The proposed display has a radial viewing angle of 68.7°in a large display size of 43.5 inches,which is larger than the conventional tabletop light field 3D displays.The radial perspective and parallax are correct,and high-resolution 3D images can be reproduced in large radial viewing positions.We envision that this proposed display opens up possibility for redefining the display forms of consumer electronics. | Yan Xing Xing-Yu Lin Lin-Bo Zhang Yun-Peng Xia Han-Le Zhang Hong-Yu Cui Shuang Li Tong-Yu Wang Hui Ren Di Wang Huan Deng Qiong-Hua Wang | 2023 | Opto-Electronic Advances2023，6，6： | 1 |
| 7 | Very large cathode current and long term stability of vacuum sealed tubes with engrafted-carbon-nanotube emitters显示文摘 | Qilong Wang Yunkang Cui Yunsong Di Chen Li Xinquan Chen Xiaobing Zhang Wei Lei Jun Xia | 2014 | Diamond & Related Materials2014，，： | 1 |
| 8 | Inhibition of Fatty-acid Synthase Suppresses P-AKT and Induces Apoptosis in Bladder Cancer显示文摘 | Bo Jiang En-Hui Li You-Yi Lu Qi Jiang Di Cui Yi-Feng Jing Shu-Jie Xia | 2012 | Urology2012，，2： | 1 |
| 9 | miR-200b suppresses cell proliferation, migration and enhances chemosensitivityin prostate cancer by regulating Bmi-1显示文摘 | Junjie Yu Youyi Lu Di Cui Enhui Li Yipin Zhu Yuyang Zhao Fujun Zhao Shujie Xia | 2014 | Oncology Reports2014，，2： | 1 |
| 10 | An improved evaluation of the neutron background in the PandaX-Ⅱ experiment显示文摘In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering signals.In this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel approach.Instead of fully relying on the Monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the data.In addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete Monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into consideration.With this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively. | QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan DeQing Fang ChangBo Fu LiSheng Geng Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 11 | Constraining self-interacting dark matter with the full dataset of PandaX-II显示文摘Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of galaxies.Many SIDM models predict the existence of a light force carrier that mediates strong dark matter self-interactions.If the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection experiments.We report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 tonne-days.No significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling strength.We further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator. | Jijun Yang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，11： | 0 |
| 12 | Highly durable machine-learned waterproof electronic glove based on low-cost thermal transfer printing for amphibious wearable applications显示文摘Gesture recording,modeling,and understanding based on a robust electronic glove(E-glove)are of great significance for efficient human-machine cooperation in harsh environments.However,such robust edge-intelligence interfaces remain challenging as existing E-gloves are limited in terms of integration,waterproofness,scalability,and interface stability between different components.Here,we report on the design,manufacturing,and application scenarios for a waterproof E-glove,which is of low cost,lightweight,and scalable for mass production,as well as environmental robustness,waterproofness,and washability.An improved neural network architecture is proposed to implement environment-adaptive learning and inference for hand gestures,which achieves an amphibious recognition accuracy of 100%in 26 categories by analyzing 2,600 hand gesture patterns.We demonstrate that the E-glove can be used for amphibious remote vehicle navigation via hand gestures,potentially opening the way for efficient human-human and human-machine cooperation in harsh environments. | Shengshun Duan Jiayi Wang Yong Lin Jianlong Hong Yucheng Lin Yier Xia Yinghui Li Di Zhu Wei Lei Wenming Su Baoping Wang Zheng Cui Wei Yuan Jun Wu | 2023 | Nano Research2023，16，4： | 0 |
| 13 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 14 | Nutritional Risk Screening with NRS2002 among Hospitalized Cancer Patients in China显示文摘Objective The Nutritional Risk Screening 2002(NRS 2002)was used to assess the nutritional risk of hospitalized oncology patients in China.This study explored the factors affecting the risk of nutrition to provide a scientific basis for the assessment and treatment of malnutrition in oncology patients.Methods We used the NRS 2002 to evaluate the nutritional risk in 48,831 hospitalized cancer patients.Descriptive statistical methods were used to describe the general patient information.A Chi-squared test was applied to analyze the relationship between NRS 2002 scores and different demographic characteristics,and the NRS 2002 scores of cancer patients with different characteristics were compared by one-way ANOVA.Results Among 48,831 patients,43.3%were women and 57.7%were men,and 36.5%(17,802)of patients were at risk of nutrition(score≥3).The NRS 2002 score was the highest in leukemia patients(2.93±1.28).A one-way ANOVA revealed that the differences in NRS 2002 scores among patients of different gender,ages,TNM stages,education levels,occupations and areas of residence were statistically significant(P<0.001).Male patients had slightly higher NRS 2002 scores than females(2.33 vs.2.17).The lowest NRS 2002 scores were in patients aged 45-59(2.00±1.26)years and the highest scores were in patients aged≥70(2.76±1.43)years.The NRS 2002 score of patients receiving surgery was the highest(2.45±1.41),and patients receiving surgery plus radiotherapy/chemotherapy was the lowest(2.00±1.26).The risk of nutrition was highest in patients who were farmers(2.34±1.37 scores)and lowest in office staff(2.15±1.32 scores).Patients living in rural areas had the highest risk of nutrition(2.32±1.37 scores).There were significant differences in the NRS 2002 scores for different cancer sub-types for different ethnic groups(P<0.05),except for Zhuang individuals(P=0.124).The risk of nutrition was highest in Uyghur patients(3.35±1.33 scores)and lowest in Mongolians(2.04±1.37 scores).Conclusion More attention should be paid to people at high risk of nutrition,such as elderly patients,patients with a high TNM stage,patients receiving surgical treatment,and patients living in rural areas.Active nutritional interventions should be carried out to improve the nutritional status of malnourished patients. | Ming Ming Zhou Tian Tian Wu Yu Han Wang Yuan Lin Zou Ke Di Xu Jiu Wei Cui Zeng Ning Li Jun Qiang Chen Ming Liu Zeng Qing Guo Hong Xia Xu Han Ping Shi Chun Hua Song Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 0 |
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