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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Real-time Health Condition Evaluation on Wind Turbines Based on Operational Condition Recognition显示文摘针对大型风电机组运行工况和状态信息复杂,健康状态难以准确评价的问题,提出基于工况辨识的健康状态实时评价方法。该方法充分考虑机组运行工况的复杂性和多变性,采用工况辨识实现运行工况空间的划分。在各运行工况子空间,建立基于高斯混合模型(gaussianmixturemodel,GMM)多状态特征融合的健康状态评价模型。采用健康衰退指数(healthdegradationindex,HDI)作为机组健康状态评价指标,并给出健康衰退报警限的确定方法。该方法用于某1.5MW风电机组传动系统故障前的健康状态评价。结果表明,该方法提前监测到机组健康状态的衰退趋势,可实现故障的早期预报,避免严重故障发生,并为合理调整运行和安排维修提供依据。 | DONG Yuliang LI Yaqiong CAO Haibin HE Chengbing GU Yujiong | 2013 | 中国电机工程学报2013，33，11： | 12 |
| 3 | Microsegregation and Rayleigh number variation during the solidification of superalloy Inconel 718显示文摘The microstructure and composition of the residual liquid at different temperatures were investigated by scanning electron microscopy (SEM) and energy dispersive X-ray spectrometer (EDX) associated with the Thermo-calc software calculation of the equilibrium phase diagrams of Inconel 718 and segregated liquid. The liquid density difference and Rayleigh number variation dur-ing solidification were estimated as well. It is found that the heavy segregation of Nb in liquid prompts the precipitation of δ and Laves phase directly from liquid and the resultant quenched liquid microstructure consists of pro-eutectic γ+eutectic,or complete eutectic according to the content of Nb from low to high. The liquid density increases with decreasing temperature during the solidi-fication of Inconel 718 and the liquid density difference is positive. The largest relative Rayleigh number occurs at 1320°C when the liquid fraction is about 40vol%. | Ling Wang Jianxin Dong Yuliang Tian Lei Zhang | 2008 | Journal of University of Science and Technology Beijing2008，15，5： | 5 |
| 4 | In situ observation of C_(60)(C(COOH)_(2))_(2) interacting with living cells using fluorescence microscopy显示文摘The interactions between nanoparticles and living cells were investigated by an imaging technique of fluorescence microscopy. For this pur- pose, the C60 derivative C60(C(COOH)2)2, a thera- peutic agent for degeneration diseases of central nervous system, was synthesized, purified and characterized. Its interaction with the living cell and penetration of the cellular membrane were in situ studied using the real time imaging technique, and its potential cytotoxicity was also examined by flow cy- tometry. The results indicate that C60(C(COOH)2)2 can easily enter cells, and is mainly located in cytoplasm by fluorescein labeling. Furthermore, C60(C(COOH)2)2 can carry the molecule that cannot cross cellular membranes into cells, because fluo- rescein compound itself cannot enter the cell or ad- here to membrane. At concentrations ranging from 1×10?2 to 1×102 mg/L, C60(C(COOH)2)2 does not show any detectable cytotoxicity. | YE Chang CHEN Chunying CHEN Zhen MENG Huan XING Li JIANG Yaxin YUAN Hui XING Gengmei ZHAO Feng ZHAO Yuliang CHAI Zhifang FANG Xiaohong HAN Dong CHEN Long WANG Chen WEI Taotao | 2006 | Chinese Science Bulletin2006，51，9： | 4 |
| 5 | System Reliability Analysis of an Offshore Jacket Platform显示文摘This study investigates strategies for solving the system reliability of large three-dimensional jacket structures.These structural systems normally fail as a result of a series of different components failures.The failure characteristics are investigated under various environmental conditions and direction combinations.Theβ-unzipping technique is adopted to determine critical failure components,and the entire system is simplified as a series-parallel system to approximately evaluate the structural system reliability.However,this approach needs excessive computational effort for searching failure components and failure paths.Based on a trained artificial neural network(ANN),which can be used to approximate the implicit limit-state function of a complicated structure,a new alternative procedure is proposed to improve the efficiency of the system reliability analysis method.The failure probability is calculated through Monte Carlo simulation(MCS)with Latin hypercube sampling(LHS).The features and applicability of the above procedure are discussed and compared using an example jacket platform located in Chengdao Oilfield,Bohai Sea,China.This study provides a reference for the evaluation of the system reliability of jacket structures. | ZHAO Yuliang DONG Sheng JIANG Fengyuan GUEDES SOARES Carlos | 2020 | Journal of Ocean University of China2020，19，1： | 3 |
| 6 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 7 | Current status and technical description of Chinese 2<ce:hsp sp='0.25'/>×<ce:hsp sp='0.25'/>250<ce:hsp sp='0.25'/>MW th HTR-PM demonstration plant显示文摘 | Zuoyi Zhang Zongxin Wu Dazhong Wang Yuanhui Xu Yuliang Sun Fu Li Yujie Dong | 2009 | Nuclear Engineering and Design2009，，7： | 2 |
| 8 | Estimating Design Loads with Environmental Contour Approach Using Copulas for an Offshore Jacket Platform显示文摘Jacket-type offshore platforms are widely used for oil, gas field, and energy development in shallow water. The design of a jacket structure is highly dependent on target environmental variables. This study focuses on a strategy to estimate design loads for offshore jacket structures based on an environmental contour approach. In addition to the popular conditional distribution model, various classes of bivariate copulas are adopted to construct joint distributions of environmental variables. Analytical formulations of environmental contours based on various models are presented and discussed in this study. The design loads are examined by dynamic response analysis of jacket platform. Results suggest that the conditional model is not recommended for use in estimating design loads in sampling locations due to poor fitting results. Independent copula produces conservative design loads and the extreme response obtained using the conditional model are smaller than those determined by copulas. The suitability of a model for contour construction varies with the origin of wave data. This study provides a reference for the design load estimation of jacket structures and offers an alternative procedure to determine the design criteria for offshore structures. | ZHAO Yuliang LIU Dahui DONG Sheng | 2020 | Journal of Ocean University of China2020，19，5： | 2 |
| 9 | Morbidity Analysis of the Notifiable Infectious Diseases in China,2018显示文摘Introduction Notifiable infectious disease surveillance is important for understanding the trends in morbidity for certain diseases,especially detection of acute infectious disease outbreaks and changing epidemiology.A web-based reporting system was deployed in January 2004,which has improved data collection and speed tremendously.This report provides an updated analysis for reports published in 2013 and 2015.Methods Data from the National Notifiable Disease Reporting System(NNDRS)was used.The NNRDS shows data from 39 notifiable diseases split into three categories(A,B,and C)based on severity and importance.A descriptive analysis was conducted to analyze the morbidity of notifiable diseases in China.Results In 2018,the morbidity of national notifiable diseases was 559.41 per 100,000 population,an increase of 12.88% compared with the average of 2015–2017.The proportion of laboratory confirmed cases was 36.22%,which decreased 4.03% compared with the average of that in the recent three years.Diseases transmitted by direct contact/fecal–oral transmission accounted for the largest proportion,49.37% of the total reported cases,followed by the respiratory transmitted diseases,blood-borne/sexually transmitted diseases,and the zoonotic and vectorborne diseases with a proportion of 25.18%,24.60%,and 0.85%,respectively.Pathogenic descriptive analysis showed that the viral-infected cases accounted for 73.78% of the totals,followed by the bacterialinfected and parasitic diseases.Conclusion The national morbidity of notifiable infectious diseases showed increases in 2018,mostly due to higher morbidity of category C diseases,such as HFMD,infectious diarrhea,and influenza,and these diseases need to be further prioritized in disease control and prevention efforts.Laboratory confirmed cases remain low and need to be improved to improve data quality. | Shuaibing Dong Xiang Ren Cuihong Zhang Mengjie Geng Yuliang Zhu Lusha Shi Lijie Zhang Zhongjie Li Liping Wang | 2019 | China CDC weekly2019，1，4： | 2 |
| 10 | Managing supplychain backorders under vendor managed inventory: an incen-tive approach and empirical analysis显示文摘 | YAO Yuliang DONG Yan DRESNER D | 2010 | European Journal ofOperational Research2010，203，1： | 1 |
| 11 | Research on short- term maintenance risk decision model of power plant equipment显示文摘 | DONG YULIANG MA LUAO GU YUJIONG | 2007 | Jo- urnal of North China Electric Power University2007，34，3： | 1 |
| 12 | Terminal group effects on the fluorescence spectra of Eu(Ⅲ)nitrate complexes with a family of amide-based 1,10-phenanthroline derivatives显示文摘 | YULIANG Z DONG Wei | 2005 | pectrochimica Acta Part A2005，62，： | 1 |
| 13 | Dynamic modelling and simulation of a multi-regime hybrid vehicle powertrain architecture 显示文摘 | Wishart Jeffrey Zhou Yuliang Leon Dong Zuomin | 2008 | International Journal of Electric and Hybrid Vehicles2008，1，2： | 1 |
| 14 | Mie series for electromagnetic scattering of chiral metamaterials sphere显示文摘The electromagnetic scattering of chiral metamaterials is simulated with the Mie series method.Based on the spherical harmonics vector function in chiral metamaterials,the electromagnetic fields inside and outside of chiral metamaterials sphere are expanded.By applying the continuous boundary condition between the chiral metamaterials and surrounding medium,and the transformation from linearly to circularly polarized electric field components,the co-polarized and cross-polarized bistatic radar cross scattering(RCS) of chiral metamaterials sphere are given.How to overcome the instability of chiral metamaterials sphere of Mie series formula is discussed.The electromagnetic scattering of chiral metamaterials,normal media and metamaterials are compared.The numerical results show that the existence of chirality ξ of chiral metamaterials can decrease the bistatic RCS compared with the same size as normal media sphere. | Maoyan Wang Chengwei Qiu Jun Xu Yuliang Dong Hu Zheng Hailong Li | 2011 | Journal of Systems Engineering and Electronics2011，22，6： | 1 |
| 15 | Managing Supply Chain Backorders under Vendor Managed Inventory:A Principal-Agent Approach and Empirical Analysis显示文摘 | Yuliang Yao Yan Dong Martin Dresner | 2004 | Preliminary Draft2004，，4： | 1 |
| 16 | Current status and technical description of Chinese 2<ce:hsp sp='0.25'/>×<ce:hsp sp='0.25'/>250<ce:hsp sp='0.25'/>MW th HTR-PM demonstration plant显示文摘 | Zuoyi Zhang Zongxin Wu Dazhong Wang Yuanhui Xu Yuliang Sun Fu Li Yujie Dong | 2009 | Nuclear Engineering and Design2009，，7： | 1 |
| 17 | Probabilistic Methods for Reliability Assessment of Floating Structures Based on Extreme Wave Simulation显示文摘With the increasing application of floating platforms in deep waters and harsh environments,a proper assessment of the reliability of floating structures is important to ensure that these structures can operate safely during their design lives.This study outlines a practical methodology for reliability analysis of a semi-submersible platform based estimating the probability distribution of the extreme response in rough sea conditions(survival conditions).The Constrained NewWave(CNW)theory combined with Monte Carlo simulations was first applied to simulate the random wave surface elevation process in the time domain.A Gumbel distribution was the best fitting to describe the dynamically sensitive extreme response statistics under extreme waves(drift and mooring tension).The derived probability distribution of the extreme response was subsequently used in estimation of the associated limit state func-tion,and a reliability analysis of the floating structure was conducted using the Monte Carlo method.A semi-submersible platform in a water depth of 1500 m subjected to extreme wave loads was used to demonstrate the efficiency of the proposed methodology.The probability of failure of the semi-submersible when considering mooring lines tension is greater than considering drift. | ZHAO Yuliang CHU Xinjie DONG Sheng | 2022 | Journal of Ocean University of China2022，21，2： | 0 |
| 18 | Novel rice genes involved in compatible and incompatible interaction with Magnaporthe grisea显示文摘The rice blast disease has been recognized asthe most devastative disease to rice. Because of the diversity of the fungus races, frequent resistance breakdown has become a barrier totraditional breeding. | DONG Haitao, HE Zuhua, DONG Jixin, WU Yuliang, and Li Debao, Biotechnology Inst, Zhejiang Agri Univ, Hangzhou 310029, China | 1998 | Chinese Rice Research Newsletter1998，6，2： | 0 |
| 19 | Isolating cDNA clones from rice induced by Magnaporthe grisea using PCR based differential screening method显示文摘The differential hybridization teehnique has been widely used 10 identify genes that are differentially expressed. However, this approach has several drawbacks. First, the screening procedures are rather labor-intensive and time. consuming. Second, the amoont of phage DNAs transferred onto the two filters may not be equivalent, | DONG Haitao, DONG Jixin, WU Yuliang, HE Zuhua,and Li Debao,Biotechnology Institute,ZheJiang Agri Univ, Hangzhou 310029, China | 1998 | Chinese Rice Research Newsletter1998，6，3： | 0 |
| 20 | Hybrid molecular nanostructures with donor-acceptor chains显示文摘We have fabricated hybrid molecular chain structures formed by electron acceptor compound 1 and electron donor molecules 2 and 3 at the liquid/solid interface of graphite surface.The structural details of the mono-component and the binary assemblies are revealed by high resolution scanning tunneling microscopy (STM).Compound 1 can form two well-ordered lamellar patterns at different concentrations.In the co-adsorption structures,compounds 2 and 3 can insert into the space between molecular chains of compound 1 and form large area well-ordered nanoscale phase separated lamellar structures.The unit cell parameters for the coassemblies can be 'flexibly' adjusted to make the electron donors and acceptors perfectly match along the molecular chains.Scanning tunneling spectroscopy (STS) results indicate that the electronic properties of individual molecular donors and acceptors are preserved in the binary self-assembly.These results provide molecular insight into the nanoscale phase separation of organic electron acceptors and donors on surfaces and are helpful for the fabrication of surface supramolecular structures and molecular devices. | YANG Liu GUAN CuiZhong YUE Wan WU JingYi YAN HuiJuan ZHANG Xu WANG ZhaoHui ZHAN XiaoWei LI YuLiang WANG Dong WAN LiJun | 2013 | Science China Chemistry2013，56，1： | 0 |
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