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| 1 | Developing the Science Product Algorithm Testbed for Chinese Next-Generation Geostationary Meteorological Satellites:Fengyun-4 Series显示文摘Fengyun-4A(FY-4A), the first of the Chinese next-generation geostationary meteorological satellites, launched in2016, offers several advances over the FY-2: more spectral bands, faster imaging, and infrared hyperspectral measurements. To support the major objective of developing the prototypes of FY-4 science algorithms, two science product algorithm testbeds for imagers and sounders have been developed by the scientists in the FY-4 Algorithm Working Group(AWG). Both testbeds, written in FORTRAN and C programming languages for Linux or UNIX systems, have been tested successfully by using Intel/g compilers. Some important FY-4 science products, including cloud mask, cloud properties, and temperature profiles, have been retrieved successfully through using a proxy imager, Himawari-8/Advanced Himawari Imager(AHI), and sounder data, obtained from the Atmospheric Infra Red Sounder, thus demonstrating their robustness. In addition, in early 2016, the FY-4 AWG was developed based on the imager testbed—a near real-time processing system for Himawari-8/AHI data for use by Chinese weather forecasters.Consequently, robust and flexible science product algorithm testbeds have provided essential and productive tools for popularizing FY-4 data and developing substantial improvements in FY-4 products. | Min MIN Chunqiang WU Chuan LI Hui LIU Na XU Xiao WU Lin CHEN Fu WANG Fenglin SUN Danyu QIN Xi WANG Bo LI Zhaojun ZHENG Guangzhen CAO Lixin DONG | 2017 | Journal of Meteorological Research2017，31，4： | 35 |
| 2 | Artificial intelligence in drug design显示文摘Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical trials.Owing to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design. | Feisheng Zhong Jing Xing Xutong Li Xiaohong Liu Zunyun Fu Zhaoping Xiong Dong Lu Xiaolong Wu Jihui Zhao Xiaoqin Tan Fei Li Xiaomin Luo Zhaojun Li Kaixian Chen Mingyue Zheng Hualiang Jiang | 2018 | Science China(Life Sciences)2018，61，10： | 10 |
| 3 | Subdiffraction optical manipulation of the charge state of nitrogen vacancy center in diamond显示文摘As a potential candidate for quantum computation and metrology,the nitrogen vacancy(NV)center in diamond presents both challenges and opportunities resulting from charge-state conversion.By utilizing different lasers for the photon-induced charge-state conversion,we achieved subdiffraction charge-state manipulation.The charge-state depletion(CSD)microscopy resolution was improved to 4.1 nm by optimizing the laser pulse sequences.Subsequently,the electron spin-state dynamics of adjacent NV centers were selectively detected via the CSD.The experimental results demonstrated that the CSD can improve the spatial resolution of the measurement of NV centers for nanoscale sensing and quantum information. | Xiangdong Chen Changling Zou Zhaojun Gong Chunhua Dong Guangcan Guo Fangwen Sun | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 4 | Genetic Analysis of an Emerging GII.P2–GII.2 Norovirus Associated with a 2016 Outbreak of Acute Gastroenteritis in China显示文摘Dear Editor,Noroviruses are positive-sense, single-stranded RNA viruses belonging to Caliciviridae and account for more than 50%of all acute gastroenteritis (AGE) outbreaks worldwide and cause an estimated 200,000 deaths per year among children\5 years of age, primarily in developing countries (Hall et al. 2012;Glass et al. 2009). The norovirus genome contains three open reading frames (ORFs). | Yuanyun Ao Xiaolu Xie Xiaogen Dong Miao Jin Zhaojun Duan | 2019 | Virologica Sinica2019，34，1： | 4 |
| 5 | Adenosine monophosphate-activated protein kinase attenuates cardiomyocyte hypertrophy through regulation of FOXO3a/MAFbx signaling pathway显示文摘心肌质量的控制被认为被蛋白质合成和降级的动态平衡决定。最近的研究表明了表明小径戏的那萎缩相关的 forkhead 盒子 O 3a (FOXO3a )/muscle 萎缩 F 盒子(MAFbx ) 在解朊作用的调整的一个中央角色并且在 cardiomyocyte 肥大上施加禁止的效果。在这研究,我们测试了假设激活 monophosphate 的蛋白质 kinase (AMPK ) 激活稀释的那腺苷由调整表明小径和它的下游的蛋白质降级的 FOXO3a/MAFbx 的 cardiomyocyte 肥大。结果证明有 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR ) 的 AMPK 的激活稀释了血管收缩素 II (Ang II ) 导致的 cardiomyocyte 肥大。AICAR 的 antihypertrophic 效果被 AMPK 禁止者混合物 C 弄钝。另外, AMPK 戏剧性地增加了抄写因素 FOXO3a 的活动,起来调整它的下游的 ubiquitin ligase MAFbx 的表示,和提高的 cardiomyocyte 解朊作用。同时,在 MAFbx 是由有 MAFbx-siRNA 的 cardiomyocytes 的 transfection 的 silenced 以后,蛋白质降级和 cardiomyocyte 肥大上的 AMPK 的效果被堵住。这些结果显示 AMPK 由经由表明小径的 FOXO3a/MAFbx 激活蛋白质降级在 cardiomyocyte 肥大的抑制起一个重要作用。 | Baolin Chen Qiang WU Zhaojun Xiong Yuedong Ma Sha Yu Dandan Chen Shengwen Huang Yugang Dong | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 4 |
| 6 | Two novel bocaparvovirus species identified in wild Himalayan marmots显示文摘Bocaparvovirus(BOV) is a genetically diverse group of DNA viruses and a possible cause of respiratory, enteric, and neurological diseases in humans and animals. Here, two highly divergent BOVs(tentatively named as Himalayan marmot BOV,HMBOV1 and HMBOV2) were identified in the livers and feces of wild Himalayan marmots in China, by viral metagenomic analysis. Five of 300 liver samples from Himalayan marmots were positive for HMBOV1 and five of 99 fecal samples from these animals for HMBOV2. Their nearly complete genome sequences are 4,672 and 4,887 nucleotides long, respectively, with a standard genomic organization and containing protein-coding motifs typical for BOVs. Based on their NS1, NP1, and VP1,HMBOV1 and HMBOV2 are most closely related to porcine BOV SX/1-2(approximately 77.0%/50.0%, 50.0%/53.0%, and79.0%/54.0% amino acid identity, respectively). Phylogenetic analysis of these three proteins showed that HMBOV1 and HMBOV2 formed two distinctly independent branches in BOVs. According to these results, HMBOV1 and HMBOV2 are two different novel species in the Bocaparvovirus genus. Their identification expands our knowledge of the genetic diversity and evolution of BOVs. Further studies are needed to investigate their potential pathogenicity and their impact on Himalayan marmots and humans. | Yuanyun Ao Xiaoyue Li Lili Li Xiaolu Xie Dong Jin Jiemei Yu Shan Lu Zhaojun Duan | 2017 | Science China(Life Sciences)2017，60，12： | 4 |
| 7 | MG132, a proteasome inhibitor, attenuates pressure-overload-induced cardiac hypertrophy in rats by modulation of mitogen-activated protein kinase signals显示文摘Proteasome 禁止者涉及细胞周期控制,生长并且煽动性的发信号,和有丝分裂的细胞的 transcriptional 规定。最近的研究建议了特定的 proteasome 禁止者 MG132 可以在 vitro 压制 cardiomyocyte 肥大。然而,内在的分子的机制不是清楚的。在这研究,我们在 vivo 在心脏的肥大和相关分子的机制上调查了长期的 MG132 处理的效果。MG132 (0.1 mg/kg/day ) intraperitoneally 与腹的大动脉的 banding (AAB ) 被注射到老鼠 8 个星期。结果证明有显著地稀释的 MG132 的处理留给室(LV ) myocyte 区域, LV 重量 / 身体重量,和肺重量 / 身体重量比率,减少的 LV 心脏舒张的直径和墙厚度,并且在 AAB 老鼠的增加的部分弄短。AAB 在心脏的 myocytes 导致了 ERK1/2, JNK1,和 p38 的 phosphorylation。在 AAB 老鼠的 ERK1/2 和 JNK1 的提高的 phosphorylation 层次被 MG132 处理显著地颠倒。在结论,我们的结果建议有 MG132 的长期的处理稀释 pressure-overload-induced 心脏的肥大并且通过表明小径的 ERK1/2 和 JNK1 的规定在 AAB 老鼠改进心脏的功能。 | Baolin Chen Yuedong Ma Rongsen Meng Zhaojun Xiong Chengxi Zhang Guangqin Chen Aixia Zhang Yugang Dong | 2010 | Acta Biochimica et Biophysica Sinica2010，42，4： | 3 |
| 8 | Genetic Analysis of Chromosomal Loci Affecting the Content of Insoluble Glutenin in Common Wheat显示文摘In common wheat, insoluble glutenin(IG) is an important fraction of flour glutenin macropolymers, and insoluble glutenin content(IGC)is positively associated with key end-use quality parameters. Here, we present a genetic analysis of the chromosomal loci affecting IGC with the data collected from 90 common wheat varieties cultivated in four environments. Statistical analysis showed that IGC was controlled mainly genetically and influenced by the environment. Among the major genetic components known to affect end-use quality,1BL/1RS translocation had a significantly negative effect on IGC across all four environments. As to the different alleles of Glu-A1,-B1 and-D1 loci, Glu-A1 a, Glu-B1 b and Glu-D1 d exhibited relatively strong positive effects on IGC in all environments. To identify new loci affecting IGC, association mapping with 1355 DAr T markers was conducted. A total of 133 markers were found associated with IGC in two or more environments(P < 0.05), ten of which consistently affected IGC in all four environments. The phenotypic variance explained by the ten markers varied from 4.66% to 8.03%, and their elite alleles performed significantly better than the inferior counterparts in enhancing IGC. Among the ten markers, w Pt-3743 and w Pt-733835 reflected the action of Glu-D1, and w Pt-664972 probably indicated the effect of Glu-A1. The other seven markers, forming three clusters on 2AL, 3BL or 7BL chromosome arms, represented newly identified genetic determinants of IGC. Our work provided novel insights into the genetic control of IGC, which may facilitate wheat enduse quality improvement through molecular breeding in the future. | Huaibing Jin Zhaojun Wang Da Li Peipei Wu Zhengying Dong Chaowu Rong Xin Liu Huanju Qin Huili Li Daowen Wang Kunpu Zhang | 2015 | Journal of Genetics and Genomics2015，42，9： | 3 |
| 9 | Phosphomolybdic acid-modified highly organized TiO2 nanotube arrays with rapid photochromic performance显示文摘TiO2 nanotube arrays were prepared by means of an electrochemical anodization technique in an organic electrolyte solution doped with polyvinyl pyrrolidone (PVP) and were subsequently modified with phosphomolybdic acid (PMoA) to obtain PMoA/TiO2 nanotube arrays. The microstructure and photochromic properties were investigated via X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV-vis), and X-ray photoelectron spectroscopy (XPS). The results indicated that the Keggin structure of PMoA and the nanotube structure of TiO2 were not destroyed, and there was a strong degree of interaction between PMoA and TiO2 at the biphasic interface with lattice interlacing during the compositing process. The XPS results further indicated that there was a change in the chemical microenvironment during the formation process of the composite, and a new charge transfer bridge was formed through the Mo-O-Ti bond. Under visible light irradiation, the colorless PMoA/TiO2 nanotube array quickly turned blue and exhibited a photochromic response together with reversible photochromism in the presence of H2O2. After visible light irradiation for 60s, the appearance of Mo^5+ species in the XPS spectra indicated a photoreduction process in accordance with a photoinduced electron transfer mechanism. | Yuanyuan Wei Bing Han Zhaojun Dong Wei Feng | 2019 | Journal of Materials Science & Technology2019，35，9： | 3 |
| 10 | Oil Shale Resources and Its Distribution in China显示文摘油页岩是有高灰内容,油收益比 3.5% 高的一种稳固的易燃的器官的矿物质,热产量比 4187J/g 等于或高。它也在有机物的高内容展示,主要象 sapropel 腐殖一样 sapropel 和腐殖的物质创作了。页岩油能在低温度通过干燥蒸馏被获得。作为一种重要精力和非常规的油和煤气的资源,油页岩尽最大努力起一个重要作用燃料和热电。 | Liu Zhaojun Dong Qingshui Zhu Jianwei Guo Wei Ye Songqing Liu Rong Zhang Hailong | 2007 | China Oil & Gas2007，14，3： | 2 |
| 11 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 12 | The Parkinson’s disease-related genes act in mitochondrial homeostasis显示文摘 | Yan Sai Zhongmin Zou Kaige Peng Zhaojun Dong | 2012 | Neuroscience and Biobehavioral Reviews2012，，9： | 1 |
| 13 | Infrared gait recognition based on wavelet transform and support vector machine显示文摘 | Xue Zhaojun Ming Dong Song Wei | 2010 | Pattern Recognition2010，43，： | 1 |
| 14 | Infrared gait recog- nition based on wavelet Transform and support vector machine 显示文摘 | Xue Zhaojun Ming Dong Song Wei | 2010 | Pattern Recognition2010，43，8： | 1 |
| 15 | Phosphorylated-ERK 1/2 and neuronal degeneration induced by rotenone in the hippocampus neurons显示文摘 | Yan Sai Junfeng Chen Qiang Wu Hiu Liu Jiqing Zhao Zhaojun Dong | 2009 | Environmental Toxicology and Pharmacology2009，，3： | 1 |
| 16 | Enhanced catalytic oxidation of 2,4-dichlorophenol via singlet oxygen dominated peroxymonosulfate activation on CoOOH@Bi_(2)O_(3)composite显示文摘Cobalt oxyhydroxide(CoOOH)has been turned out to be a high-efficiency catalyst for peroxymonosulfate(PMS)activation.In this study,CoOOH was loaded on bismuth oxide(Bi_(2)O_(3))using a facile chemical precipitation process to improve its catalytic activity and stability.The result showed that the catalytic performance on the 2,4-dichlorophenol(2,4-DCP)degradation was significantly enhanced with only 11 wt%Bi_(2)O_(3)loading.The degradation rate in the CoOOH@Bi_(2)O_(3)/PMS system(0.2011 min−1)was nearly 6.0 times higher than that in the CoOOH/PMS system(0.0337 min−1).Furthermore,CoOOH@Bi_(2)O_(3)displayed better stability with less Co ions leaching(16.4%lower than CoOOH)in the PMS system.These phenomena were attributed to the Bi_(2)O_(3)loading which significantly increased the conductivity and specific surface area of the CoOOH@Bi_(2)O_(3)composite.Faster electron transfer facilitated the redox reaction of Co(III)/Co(II)and thus was more favorable for reactive oxygen species(ROS)generation.Meanwhile,larger specific surface area furnished more active sites for PMS activation.More importantly,there were both non-radical(^(1)O_(2))and radicals(SO_(4)^(−)•,O_(2)^(−)•,and OH•)in the CoOOH@Bi_(2)O_(3)/PMS system and^(1)O_(2)was the dominant one.In general,this study provided a simple and practical strategy to enhance the catalytic activity and stability of cobalt oxyhydroxide in the PMS system. | Tianhao Xi Xiaodan Li Qihui Zhang Ning Liu Shu Niu Zhaojun Dong Cong Lyu | 2021 | Frontiers of Environmental Science & Engineering2021，15，4： | 1 |
| 17 | Infrared gait recognition based on wavelet transform and support vector machine显示文摘 | Zhaojun Xue Dong Ming Wei Song Baikun Wan Shijiu Jin | 2010 | Pattern Recognition2010，，8： | 1 |
| 18 | Visible-light Photochromism of Phosphomolybdic Acid/ZnO Composite显示文摘 | SUN Wentian SI Yunheng JING Haitao DONG Zhaojun WANG Chunxu ZHANG Yupeng ZHAO Lichen FENG Wei YAN Yon | 2018 | Chemical Research in Chinese Universities2018，34，3： | 1 |
| 19 | RNA-Seq analysis and development of SSR and KASP markers in lentil(Lens culinaris Medikus subsp. culinaris)显示文摘Lentil(Lens culinaris Medikus subsp.culinaris,2 n=14)is a cool-season legume with high production potential for multiple uses.However,limited molecular research has been conducted in this species owing to its large genome,which impedes the generation of genome sequences and the development of molecular markers.In this study,more than 1.37 billion filtered clean reads were collected by RNA-Seq of six diverse lentil accessions and217,836 transcripts and 161,095 unigenes were de novo assembled,yielding respectively 257.1 and 240.6 million nucleotides.The mean transcript length was 1180 bp and the N50 and N90 lengths were respectively 2075 and 479 bp.The mean length of the unigenes was 1494 bp and their N50 and N90 values were respectively 2203 and 714 bp.The unigenes were annotated against seven databases.The FLOWERING LOCUS T(FT)gene homolog in lentil showed high protein sequence similarity to the FT gene homologs of pea and alfalfa.On the basis of the RNA-Seq analysis,26,449 EST-SSR markers were designed in silico,and 276 preliminarily screened markers were selected to evaluate polymorphism in 94 diverse lentil accessions.In total,125(45.29%)of 276 EST-SSR markers were found to be polymorphic.A total of 130,073 SNP loci were detected and 78(61.41%)of 127 SNPs were successfully converted to KASP markers.Population genetic analyses of the lentil accessions with EST-SSR and KASP markers revealed similar genetic structures,suggesting that the RNA-Seq-generated resources and the developed markers are reliable for use in molecular marker-assisted breeding of lentil. | Dong Wang Tao Yang Rong Liu Nana Li Xiaomu Wang Ashutosh Sarker Xiaodong Zhang Runfang Li Yanyan Pu Guan Li Yuning Huang Yishan Ji Zhaojun Li Qian Tian Xuxiao Zong Hanfeng Ding | 2020 | The Crop Journal2020，8，6： | 1 |
| 20 | Zoning strategy of zonal modeling for thermally stratified large spaces显示文摘Large space buildings play a significant role in modern society because of their environmental advantages and market value.While the zonal model is promising for the efficient and rapid evaluation of the stratified thermal environment,there is a lack of a reasonable and convenient zoning strategy with the advent of modern computing.This paper presents a universal and practical zonal model,in which a simplified momentum equation is applied to consider air momentum preservation,transformation,and dissipation.Hence,the zoning structure is generalized and flexible.Moreover,limiting the dimensionless temperature constraint between adjacent zones establishes the connection between thermal nonuniformity and zoning results automatically.Simultaneously,the dimension and number of zones should be restricted within reasonable ranges to satisfy the characteristics of zonal simulation and reach the criteria of convergence.To further explore and validate the zonal model,a reduced-scale experimental model was constructed to replicate the thermal stratification in a mechanically ventilated large space by considering many crucial realistic factors.A particle image velocimetry(PIV)measurement was then conducted to visualize the airflow pattern and support the partition of zones.The results showed that the zonal simulation with adaptive zoning method can realize a similar accuracy with fewer zones and exhibit a better tolerance for zoning results compared to the conventional empirical zoning method.Furthermore,a case study of an atrium was performed to demonstrate the practicality and efficiency of the method for long-term dynamic simulations of complex thermal environments and building energy use. | Yanyu Lu Zhaojun Wang Jing Liu Jiankai Dong | 2021 | Building Simulation2021，14，5： | 1 |
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