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| 1 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 2 | Characteristics of atmospheric single particles during haze periods in a typical urban area of Beijing:A case study in October,2014显示文摘To investigate the composition and possible sources of particles, especially during heavy haze pollution, a single particle aerosol mass spectrometer(SPAMS) was deployed to measure the changes of single particle species and sizes during October of 2014, in Beijing. A total of 2,871,431 particles with both positive and negative spectra were collected and characterized in combination with the adaptive resonance theory neural network algorithm(ART-2a). Eight types of particles were classified: dust particles(dust, 8.1%), elemental carbon(EC, 29.0%), organic carbon(OC, 18.0%), EC and OC combined particles(ECOC, 9.5%),Na-K containing particles(Na K, 7.9%), K-containing particles(K, 21.8%), organic nitrogen and potassium containing particles(KCN, 2.3%), and metal-containing particles(metal,3.6%). Three haze pollution events(P1, P2, P3) and one clean period(clean) were analyzed,based on the mass and number concentration of PM_(2.5)and the back trajectory results from the hybrid single particle Lagrangian integrated trajectory model(Hysplit-4 model). Results showed that EC, OC and K were the major components of single particles during the three haze pollution periods, which showed clearly increased ratios compared with those in the clean period. Results from the mixing state of secondary species of different types of particles showed that sulfate and nitrate were more readily mixed with carbon-containing particles during haze pollution episodes than in clean periods. | Lang Liu Yanli Wang Shiyong Du Wenjie Zhang Lujian Hou Sverre Vedal Bin Han Wen Yang Mindong Chen Zhipeng Bai | 2016 | Journal of Environmental Sciences2016，28，2： | 19 |
| 3 | Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing显示文摘Tracing the emergence of the first hematopoietic stem cells(HSCs)in human embryos,particularly the scarce and transient precursors thereof,is so far challenging,largely due to the technical limitations and the material rarity.Here,using single-cell RNA sequencing,we constructed the first genome-scale gene expression landscape covering the entire course of endothelial-to-HSC transition during human embryogenesis.The transcriptomically defined HSC-primed hemogenic endothelial cells(HECs)were captured at Carnegie stage(CS)12-14 in an unbiased way,showing an unambiguous feature of arterial endothelial cells(ECs)with the up-regulation of RUNX1,MYB and ANGPTL Importantly,subcategorizing CD34+CD45-ECs into a CD44+population strikingly enriched HECs by over 10-fold.We further mapped the developmental path from arterial ECs via HSC-primed HECs to hematopoietic stem progenitor cells,and revealed a distinct expression pattern of genes that were transiently over-represented upon the hemogenic fate choice of arterial ECs#including EMCN,PROCR and RUNX1T1.We also uncovered another temporally and molecularly distinct intra-embryonic HEC population,which was detected mainly at earlier CS 10 and lacked the arterial feature.Finally,we revealed the cellular components of the putative aortic niche and potential cellular interactions acting on the HSCprimed HECs.The cellular and molecular programs that underlie the generation of the first HSCs from HECs in human embryos,together with the ability to distinguish the HSC-primed HECs from others,will shed light on the strategies for the production of clinically useful HSCs from pluripotent stem cells. | Yang Zeng Jian He Zhijie Bai Zongcheng Li Yandong Gong Chen Liu Yanli Ni Junjie Du Chunyu Ma Lihong Bian Yu Lan Bing Liu | 2019 | Cell Research2019，29，11： | 14 |
| 4 | Adaptive recurrent-functional-link-network control for hypersonic vehicles with atmospheric disturbances显示文摘The controller design for a near-space hypersonic vehicle (NHV) is challenging due to its plant uncertainties and sensitivity to atmospheric disturbances such as gusts and turbulence. This paper first derives 12 states equations of NHVs subjected to variable wind field, and presents a novel recurrent neural network (RNN) control method for restraining atmospheric disturbances. The method devises a new B-spline recurrent functional link network (BRFLN) and combines it with the nonlinear generalized predictive control (NGPC) algorithm. Moreover, the proportional-derivative (PD) correction BRFLN is proposed to approximate atmo- spheric disturbances in flight. The weights of BRFLN are online tuned by the adaptive law based on Lyapunov stability theorem. Finally, simulation results show a satisfactory performance for the attitude tracking of the NHV in the mesosphere, and also illustrate the controller's robustness to wind turbulence. | DU YanLi WU QingXian JIANG ChangSheng XUE YaLi | 2011 | Science China(Information Sciences)2011，54，3： | 8 |
| 5 | Molecular Cytogenetic Characterization of a Wheat-Leymus mollis 3D(3Ns) Substitution Line with Resistance to Leaf Rust显示文摘Leymus mollis(Trin.)Pilger(NsNsXmXm,2n?28),a wild relative of common wheat,possesses many potentially valuable traits that could be transferred to common wheat during breeding programs.In this study,the karyotypic constitution of a wheat e L.mollis 3D(3Ns#1)disomic substitution line isolated from the F5progeny of octoploid Tritileymus M842-16 Triticum durum cv.D4286,which was designated as 10DM57,was determined using genomic in situ hybridization(GISH),fluorescent in situ hybridization(FISH),SSR markers,and ESTSTS markers.Screening of mitosis and meiosis showed that 10DM57 had a chromosome karyotype of 2n?42?21II.GISH indicated that10DM57 was a line with 40 chromosomes from wheat and two of the Ns chromosomes from L.mollis,which formed a ring bivalent in pollen mother cells at metaphase I.FISH analysis showed that the chromosome 3D may be replaced by 3Ns#1 in 10DM57.DNA markers,including SSR and EST-STS primers,showed that the pair of wheat chromosome 3D in 10DM57 was substituted by the pair of chromosome 3Ns#1from L.mollis.Evaluation of the agronomic traits showed that,compared with its common wheat relative 7182,10DM57 was resistant to leaf rust while the spike length and number of spikes per plant were improved significantly,which correlated with a higher wheat yield.The new germplasm,10DM57,could be exploited as an intermediate material in wheat genetic and breeding programs. | Yuhui Pang Xinhong Chen Jixin Zhao Wanli Du Xueni Cheng Jun Wu Yanli Li Liangming Wang Jing Wang Qunhui Yang | 2014 | Journal of Genetics and Genomics2014，41，4： | 6 |
| 6 | Adaptive functional link network control of near-space vehicles with dynamical uncertainties显示文摘The control law design for a near-space hypersonic vehicle(NHV) is highly challenging due to its inherent nonlinearity,plant uncertainties and sensitivity to disturbances.This paper presents a novel functional link network(FLN) control method for an NHV with dynamical thrust and parameter uncertainties.The approach devises a new partially-feedback-functional-link-network(PFFLN) adaptive law and combines it with the nonlinear generalized predictive control(NGPC) algorithm.The PFFLN is employed for approximating uncertainties in flight.Its weights are online tuned based on Lyapunov stability theorem for the first time.The learning process does not need any offline training phase.Additionally,a robust controller with an adaptive gain is designed to offset the approximation error.Finally,simulation results show a satisfactory performance for the NHV attitude tracking,and also illustrate the controller's robustness. | Yanli Du Qingxian Wu Changsheng Jiang Jie Wen | 2010 | Journal of Systems Engineering and Electronics2010，21，5： | 5 |
| 7 | Pseudocapacitance boosted N-doped carbon coated Fe7S8 nanoaggregates as promising anode materials for lithium and sodium storage显示文摘Herein,the core-shell structured N-doped carbon coated Fe7S8 nano-aggregates(Fe7S8@NC)were controllably prepared via a simple three-step synthesis strategy.The appropriate thickness of N-doped carbon layer outside Fe7S8 nano-aggregates can not only inhibit the particle pulverization induced by the big volume changes of Fe7S8,but can increase the electron transfer efficiency.The hierarchical Fe7S8 nano-aggregates composed of some primary nanoparticles can accelerate the lithium or sodium diffusion kinetics.As anode materials for Li-ion batteries(LIBs),the well-designed Fe7S8@NC nanocomposites exhibit outstanding lithium storage performance,which is better than that of pure Fe7S8,Fe3O4@NC and Fe7S8@C.Among these nanocomposites,the N-doped carbon coated Fe7S8 with carbon content of 26.87 wt.%shows a high reversible specific capacity of 833 mAh·g^−1 after 1,000 cycles at a high current density of 2 A·g^−1.The above electrode also shows excellent high rate sodium storage performance.The experimental and theoretical analyses indicate that the outstanding electrochemical performance could be attributed to the synergistic effect of hierarchical Fe7S8 nanostructure and conductive N-doped carbon layer.The quantitative kinetic analysis indicates that the charge storage of Fe7S8@NC electrode is a combination of diffusion-controlled battery behavior and surface-induced capacitance behavior. | Yanli Zhou Ming Zhang Qi Wang Jian Yang Xingyun Luo Yanlu Li Rong Du Xinsheng Yan Xueqin Sun Caifu Dong Xiaoyu Zhang Fuyi Jiang | 2020 | Nano Research2020，13，3： | 4 |
| 8 | A new approach to spatial source apportionment of haze pollution in large scale and its application in China显示文摘Long-lasting expansion of haze pollution in China has already presented a stern challenge to regional joint prevention and control. There is an urgent need to enlarge and reconstruct the coverage of joint prevention and control of air pollution in key area. Air quality models can identify and quantify the regional contribution of haze pollution and its key components with the help of numerical simulation, but it is difficult to be applied to larger spatial scale due to the complexity of model parameters. The time series analysis can recognize the existence of spatial interaction of haze pollution between cities, but it has not yet been used to further identify the spatial sources of haze pollution in large scale. Using econometric framework of time series analysis, this paper developed a new approach to perform spatial source apportionment. We applied this approach to calculate the contribution from spatial sources of haze pollution in China, using the monitoring data of particulate matter(PM_(2.5)) across 161 Chinese cities. This approach overcame the limitation of numerical simulation that the model complexity increases at excess with the expansion of sample range, and could effectively deal with severe large-scale haze episodes. | Huajun Liu Guangjie Du Yanli Liu | 2018 | Chinese Journal of Population,Resources and Environment2018，16，2： | 2 |
| 9 | Significantly enhanced robustness and electrochemical performance of flexible carbon nanotube-based supercapacitors by electrodepositing polypyrrole显示文摘 | Yanli Chen Lianhuan Du Peihua Yang Peng Sun Xiang Yu Wenjie Mai | 2015 | Journal of Power Sources2015，，： | 2 |
| 10 | Study of the Corrosion Resistance of Electroless Ni-P Deposits in a Sodium Chloride Medium显示文摘The corrosion resistance of electroless Ni-P deposits with phosphorous contents from 12% to 14% in sodium chloride solutions was studied. The deposits were immersed in 3.5% NaCl solutions for 29 d to obtain the electrochemical parameters and were examined in a standard salt spray test for 15 d respectively. The corrosion resistance of the deposits was studied by poten- tio-dynamic scan, electrochemical impedance spectroscopy (EIS), X-ray diffraction (XRD) and cold-field emission scanning electron microscopy (FE-SEM) equipped with an energy dispersive X-ray detector (EDX). The patterns of XRD and the results of FE-SEM showed that the prepared deposits were amorphous. But after a 15 d standard salt spray test, a few pinholes appeared on the surface of the deposit and the weight content of phosphorus on the surface of the deposit was higher (which was beneficial to the formation of the passivation films) than that before the standard salt spray test when the nickel content was lower because the dissolved weight of nickel was greater than that of phosphorus. The results from potentio-dynamic scan and EIS showed that passivation films formed on the Ni-P deposit after immersion in the NaCl solutions, which decreased the corrosion rate of Ni-P samples. The results of this work show their potential applications in marine corrosion. | GAO Rongjie DU Min SUN Xiaoxia PU Yanli | 2007 | Journal of Ocean University of China2007，6，4： | 2 |
| 11 | Influence of Surface Nanocrystallization on Ti Ion Implantation of Pure Iron显示文摘In order to increase the depth or concentration of Ti ion implantation of pure iron, the surface mechanical attrition treatment(SMAT), which can fabricate a nanometer-grained surface layer without porosity and contamination in a pure iron plate, was used before ion implantation. Ti ion was implanted into the SMA treated sample and coarse-grained counterpart by using a metal vapor vacuum arc source implanter. The changing of depth and concentration of Ti was studied in a function of implantation time.By optical microscopy, transmission electron microscopy and X-ray diffraction, the grain size of the nano structured surface was studied. Micro-hardness, friction and wear behavior of nano surface layers were studied. By energy dispersive X-ray spectroscopy and Auger electron spectroscopy, the chemical composition and concentration of Ti ion in the surface implantation layer were studied. Experimental results showed that the concentration of Ti increased dramatically compared with untreated coarsegrained samples, which is attributed to the existence of higher density of defects(supersaturated vacancies, dislocations, non-equilibrium grain boundaries etc.) and compression stress field in the SMA treated nanocrystallined surface layer. The interaction between the defects and the implanted solute atoms leads to the increment of solid solubility. But the implantation depth showed inconspicuous change. It is shown that the ion range is just relevant to the energy and mass of the ion, dose of injection,the mass and density of target material. | Xu Li Yanli An Yinghui Wei Huayun Du Lifeng Hou Chunli Guo Hongbo Qu Yide Wang | 2015 | Journal of Materials Science & Technology2015，31，3： | 2 |
| 12 | One way of surface alloying treatment on iron surface based on surface mechanical attrition treatment and heat treatment显示文摘 | Huayun Du Yinghui Wei Wanming Lin Lifeng Hou Zengqing Liu Yanli An Wenfu Yang | 2009 | Applied Surface Science2009，，20： | 1 |
| 13 | Sphere-like kesterite Cu2ZnSnS4 nanoparticles synthesized by a facile solvothermal method显示文摘 | Zhou Yanli Zhou Wenhui Du Yanfang | 2011 | Mater Lett2011，65，： | 1 |
| 14 | Estimates for the Lower Order Eigenvalues of Elliptic Operators in Weighted Divergence Form显示文摘In this paper, we firstly give a general inequality for the lower order eigenvalues of elliptic operators in weighted divergence form on compact smooth metric measure spaces with boundary(possibly empty). Then using this general inequality, we get some universal inequalities for the lower order eigenvalues of elliptic operators in weighted divergence form on a connected bounded domain in the smooth metric measure spaces. | Yanli LI Feng DU | 2017 | Journal of Mathematical Research with Applications2017，37，3： | 1 |
| 15 | Fabrication and characterization of a hydroxyapatite-methylcellulose composite coating on the surface of AZ31 Magnesium alloy显示文摘 | Fan Wei Du Huayun An Yanli | 2015 | Materials Letters2015，152，： | 1 |
| 16 | 1 H-Magnetic resonance spectroscopy correlates with injury severity and can predict coma duration in patients following severe traumatic brain injury显示文摘 | Yanli Du Yu Li Qing Lan | 2011 | Neurology India2011，59，5： | 1 |
| 17 | CARMA3 is upregulated in human pancreatic carcinoma, and its depletion inhibits tumor proliferation, migration, and invasion显示文摘 | Shiyu Du Liping Jia Yanli Zhang Long Fang Xiang Zhang Yanhua Fan | 2014 | Tumor Biology2014，，6： | 1 |
| 18 | Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets:Recent progress and challenges in food safety hazards analysis显示文摘Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of food.Personal glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food safety.Currently,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards.Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety analysis.This review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal output.Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are reviewed.Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed.Despite the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis. | Feng He Haijie Wang Pengfei Du Tengfei Li Weiting Wang Tianyu Tan Yaobo Liu Yanli Ma Yuanshang Wang A.M.Abd El-Aty | 2023 | Journal of Pharmaceutical Analysis2023，13，3： | 0 |
| 19 | Effect of levetiracetam and valproate on late‑onset post‑traumatic seizures显示文摘Background To compare the preventive effects of levetiracetam and valproate on late-onset post-traumatic seizures in patients with traumatic brain injury(TBI).Methods A total of 95 patients with TBI were recruited from 2017 to 2020.They were randomized into three groups:levetiracetam(LEV)group(n=30)receiving LEV treatment(500 mg,bid,po);valproate group(n=32)receiving sodium valproate(500 mg/d,once daily,po);and control group(n=33)receiving no anti-seizure medication.LEV and valproate were given to corresponding groups within seven days after TBI,and the administration lasted for one month.The incidence of epilepsy and adverse events were evaluated at 7 days and 12 months post-TBI.Results The cumulative incidences of late post-traumatic seizures at the 12-month follow-up in the LEV,valproate,and control groups were 3.33%,12.50%and 15.63%,respectively.The cumulative incidence of late post-traumatic seizures in the LEV group was significantly lower than those in the valproate and control groups(P<0.05).The cumulative incidence of late post-traumatic seizure in the valproate group was not significantly different from that in the control group(P>0.05).Conclusions LEV can reduce the cumulative incidence of late post-traumatic seizures,whereas valproate can not. | Yanli Wang Yiqi Wang Huifang Wang Xiaoping Du Jie Miao James X.Tao Meizhen Sun | 2023 | Acta Epileptologica2023，6，2： | 0 |
| 20 | A Stable,Function-Separated Hierarchical P2P Overlay Based on Node Heterogeneity显示文摘Current peer-to-peer(P2P) applications suffer performance degradation from the problems such as load imbalance,topology mismatch between overlay and underlay,and instability caused by node joining and leaving.In this paper,we propose the idea of implementing 2 functions of routing message and maintaining service index on different layers of overlay to deal with the aforementioned problems.Taking Chord as example,we design algorithms for building cluster and overlay and implement function-separated(FUSE) overlay with 2-dimensional address ID space.We further propose an analytic model for describing node's load for evaluation.Simulation results indicate that,compared with 2-layer Chord-centered overlay in previous researches,this overlay excels in the metrics such as query path length,load,and query delivery ratio. | LI Wenxiang,DU Zhaojun,SHENG Zhichao,ZHU Yanli,HU Tao School of Information Science and Engineering,Wuhan University of Science and Technology,Wuhan 430081,Hubei,China | 2009 | Wuhan University Journal of Natural Sciences2009，14，4： | 0 |
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