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| 1 | Influence of Surface Nanocrystallization on Ti Ion Implantation of Pure Iron显示文摘In order to increase the depth or concentration of Ti ion implantation of pure iron, the surface mechanical attrition treatment(SMAT), which can fabricate a nanometer-grained surface layer without porosity and contamination in a pure iron plate, was used before ion implantation. Ti ion was implanted into the SMA treated sample and coarse-grained counterpart by using a metal vapor vacuum arc source implanter. The changing of depth and concentration of Ti was studied in a function of implantation time.By optical microscopy, transmission electron microscopy and X-ray diffraction, the grain size of the nano structured surface was studied. Micro-hardness, friction and wear behavior of nano surface layers were studied. By energy dispersive X-ray spectroscopy and Auger electron spectroscopy, the chemical composition and concentration of Ti ion in the surface implantation layer were studied. Experimental results showed that the concentration of Ti increased dramatically compared with untreated coarsegrained samples, which is attributed to the existence of higher density of defects(supersaturated vacancies, dislocations, non-equilibrium grain boundaries etc.) and compression stress field in the SMA treated nanocrystallined surface layer. The interaction between the defects and the implanted solute atoms leads to the increment of solid solubility. But the implantation depth showed inconspicuous change. It is shown that the ion range is just relevant to the energy and mass of the ion, dose of injection,the mass and density of target material. | Xu Li Yanli An Yinghui Wei Huayun Du Lifeng Hou Chunli Guo Hongbo Qu Yide Wang | 2015 | Journal of Materials Science & Technology2015，31，3： | 2 |
| 2 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 3 | 显示文摘 | Lu Limin Li Hongbo Qu Fengli | 2011 | Biosens Bioelec- tron2011，26，8： | 1 |
| 4 | In situ synthesis of palladium nanoparticle-graphene nanohybrids and their appli- cation in nonenzymatic glucose biosensors显示文摘 | Lu Limin Li Hongbo Qu Fengli | 2011 | Biosensors Bioelectron2011，26，8： | 1 |
| 5 | Export of dissolved carbonaceous and nitrogenous substances in rivers of the “Water Tower of Asia”显示文摘Rivers are critical links in the carbon and nitrogen cycle in aquatic,terrestrial,and atmospheric environments.Here riverine carbon and nitrogen exports in nine large rivers on the Tibetan Plateau—the'Water Tower of Asia'—were investigated in the monsoon season from 2013 to 2015.Compared with the world average,concentrations of dissolved inorganic carbon(DIC,30.7 mg/L)were high in river basins of the plateau due to extensive topographic relief and intensive water erosion.Low concentrations of dissolved organic carbon(DOC,1.16 mg/L)were likely due to the low temperature and unproductive land vegetation environments.Average concentrations of riverine DIN(0.32 mg/L)and DON(0.35 mg/L)on the Tibetan Plateau were close to the world average.However,despite its predominantly pristine environment,discharge from agricultural activities and urban areas of the plateau has raised riverine N export.In addition,DOC/DON ratio(C/N,~6.5)in rivers of the Tibetan Plateau was much lower than the global average,indicating that dissolved organic carbon in the rivers of this region might be more bioavailable.Therefore,along with global warming and anthropogenic activities,increasing export of bioavailable riverine carbon and nitrogen from rivers of the Tibetan Plateau can be expected in the future,which will possibly influence the regional carbon and nitrogen cycle. | Bin Qu Mika Sillanpaa Shichang Kang Fangping Yan Zhiguo Li Hongbo Zhang Chaoliu Li | 2018 | Journal of Environmental Sciences2018，30，3： | 1 |
| 6 | A large-scale copper ore-forming event accompanying rapid uplift of the southern Tibetan Plateau: Evidence from zircon SHRIMP U–Pb dating and LA ICP-MS analysis显示文摘 | Qu Xiaoming Hou Zengqian Khin Zaw Mo Xuanxue Xu Wenyi Xin Hongbo | 2009 | Ore Geology Reviews2009，，1： | 1 |
| 7 | Self-adaptive mechanism based genetic algorithms for combinatorial optimization problems显示文摘To improve the evolutionary algorithm performance,especially in convergence speed and global optimization ability,a self-adaptive mechanism is designed both for the conventional genetic algorithm(CGA)and the quantum inspired genetic algorithm(QIGA).For the self-adaptive mechanism,each individual was assigned with suitable evolutionary parameter according to its current evolutionary state.Therefore,each individual can evolve toward to the currently best solution.Moreover,to reduce the running time of the proposed self-adaptive mechanism-based QIGA(SAM-QIGA),a multi-universe parallel structure was employed in the paper.Simulation results show that the proposed SAM-QIGA have better performances both in convergence and global optimization ability. | Qu Zhijian Wang Shasha Xu Hongbo Li Panjing Li Caihong | 2019 | The Journal of China Universities of Posts and Telecommunications2019，26，5： | 0 |
| 8 | Delivery of therapeutic oligonucleotides in nanoscale显示文摘Therapeutic oligonucleotides(TOs)represent one of the most promising drug candidates in the targeted cancer treatment due to their high specificity and capability of modulating cellular pathways that are not readily druggable.However,efficiently delivering of TOs to cancer cellular targets is still the biggest challenge in promoting their clinical translations.Emerging as a significant drug delivery vector,nanoparticles(NPs)can not only protect TOs from nuclease degradation and enhance their tumor accumulation,but also can improve the cell uptake efficiency of TOs as well as the following endosomal escape to increase the therapeutic index.Furthermore,targeted and on-demand drug release of TOs can also be approached to minimize the risk of toxicity towards normal tissues using stimuli-responsive NPs.In the past decades,remarkable progresses have been made on the TOs delivery based on various NPs with specific purposes.In this review,we will first give a brief introduction on the basis of TOs as well as the action mechanisms of several typical TOs,and then describe the obstacles that prevent the clinical translation of TOs,followed by a comprehensive overview of the recent progresses on TOs delivery based on several various types of nanocarriers containing lipid-based nanoparticles,polymeric nanoparticles,gold nanoparticles,porous nanoparticles,DNA/RNA nanoassembly,extracellular vesicles,and imaging-guided drug delivery nanoparticles. | Lei Wu Wenhui Zhou Lihua Lin Anhong Chen Jing Feng Xiangmeng Qu Hongbo Zhang Jun Yue | 2022 | Bioactive Materials2022，7，1： | 0 |
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