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| 1 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 2 | Comparative assessment of SAS and DES turbulence modeling for massively separated flows显示文摘经过在雷纳兹数字\的圆形的柱体的流动的数字研究( 1.4 \times 10 ^{ 5 }\)并且在攻击\的角度的 NACA0021 机翼( 60 ^{ \circ }\)被规模适应的模拟( SAS )执行了并且分开旋涡模拟( DES ),与存在比较试验性的数据。Egorov 和 Menter 开发的模型的新版本被估计,并且 SAS 模拟的优点和劣势详细被分析以后为工业申请提供指导。而且,在分开的区域的规模适应的特征的机制被讨论,它在以前的分析是阴暗的。它被结束那:吝啬的流动性质令人满意地为 SAS 模拟同意试验性的结果,尽管第二份订单的预言狂暴的统计在近醒来区域只是合理的。SAS 模型能在再通行水泡生产狂暴的动能的更大的大小,并且,因而,一个更小的再通行区域和在再通行区域外面的吝啬的速度的更快速的恢复与一样的格子决定比 DES 来临。流的旋涡比与 DES 途径与 SAS 模型一起是稍微不太不规则的,可能由于在粗糙的网孔的条件下面的 SAS 模拟的更高的驱散。 | Weilin Zheng Chao Yan Hongkang Liu Dahai Luo | 2016 | Acta Mechanica Sinica2016，32，1： | 3 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | Functional interplay among the flavivirus NS3 protease, helicase, and cofactors显示文摘Flaviviruses are positive-sense RNA viruses, and many are important human pathogens. Nonstructural protein 2B and 3 of the flaviviruses(NS2BNS3) form an endoplasmic reticulum(ER) membrane-associated hetero-dimeric complex through the NS2B transmembrane region. The NS2BNS3 complex is multifunctional. The N-terminal region of NS3, and its cofactor NS2B fold into a protease that is responsible for viral polyprotein processing, and the C-terminal domain of NS3 possesses NTPase/RNA helicase activities and is involved in viral RNA replication and virus particle formation. In addition, NS2BNS3 complex has also been shown to modulate viral pathogenesis and the host immune response. Because of the essential functions that the NS2BNS3 complex plays in the flavivirus life cycle, it is an attractive target for antiviral development. This review focuses on the recent biochemical and structural advances of NS2BNS3 and provides a brief update on the current status of drug development targeting this viral protein complex. | Kuohan Li Wint Wint Phoo Dahai Luo | 2014 | Virologica Sinica2014，29，2： | 1 |
| 5 | High Impedance Fault Detection Based on Attention Mechanism and Object Identification显示文摘Detection of high impedance faults(HIFs)has been traditionally a main challenge in the protection of distribution systems,since they do not generate enough current to be reliably detected by conventional over-current relays.Data-based methods are alternative HIF detection methods which avoid threshold settings by training a classification or regression model.However,most of them lack interpretability and are not compatible with various distribution networks.This paper proposes an object detection-based HIF detection method,which has higher visualization and can be easily applied to different scenarios.First,based on the analysis of HIFs,a Butterworth band-pass filter is designed for HIF harmonic feature extraction.Subsequently,based on the synchronized data provided by distribution-level phasor measurement units,global HIF feature gray-scale images are formed through combining the topology information of the distribution network.To further enhance the feature information,a locally excitatory globally inhibitory oscillator region attention mechanism(LEGIO-RAM)is proposed to highlight the critical feature regions and inhibit useless and fake information.Finally,an object detection network based You Only Look Once(YOLO)v2 is established to achieve fast HIF detection and section location.The obtained results from the simulation of the proposed approach on three different distribution networks and one realistic distribution network verify that the proposed method is highly effective in terms of reliability and generalization. | Yongjie Zhang Xiaojun Wang Yiping Luo Dahai Zhang Sohrab Mirsaeidi Jinghan He | 2024 | CSEE Journal of Power and Energy Systems2024，10，1： | 0 |
| 6 | Exosome/metformin-loaded self-healing conductive hydrogel rescues microvascular dysfunction and promotes chronic diabetic wound healing by inhibiting mitochondrial fission显示文摘Chronic diabetic wounds remain a globally recognized clinical challenge.They occur due to high concentrations of reactive oxygen species and vascular function disorders.A promising strategy for diabetic wound healing is the delivery of exosomes,comprising bioactive dressings.Metformin activates the vascular endothelial growth factor pathway,thereby improving angiogenesis in hyperglycemic states.However,multifunctional hydrogels loaded with drugs and bioactive substances synergistically promote wound repair has been rarely reported,and the mechanism of their combinatorial effect of exosome and metformin in wound healing remains unclear.Here,we engineered dual-loaded hydrogels possessing tissue adhesive,antioxidant,self-healing and electrical conductivity properties,wherein 4-armed SH-PEG cross-links with Ag^(+),which minimizes damage to the loaded goods and investigated their mechanism of promotion effect for wound repair.Multiwalled carbon nanotubes exhibiting good conductivity were also incorporated into the hydrogels to generate hydrogen bonds with the thiol group,creating a stable three-dimensional structure for exosome and metformin loading.The diabetic wound model of the present study suggests that the PEG/Ag/CNT-M+E hydrogel promotes wound healing by triggering cell proliferation and angiogenesis and relieving peritraumatic inflammation and vascular injury.The mechanism of the dual-loaded hydrogel involves reducing the level of reactive oxygen species by interfering with mitochondrial fission,thereby protecting F-actin homeostasis and alleviating microvascular dysfunction.Hence,we propose a drug-bioactive substance combination therapy and provide a potential mechanism for developing vascular function-associated strategies for treating chronic diabetic wounds. | Yue Zhang Meng Li Yunchuan Wang Fei Han Kuo Shen Liang Luo Yan Li Yanhui Jia Jian Zhang Weixia Cai Kejia Wang Ming Zhao Jing Wang Xiaowen Gao Chenyang Tian Baolin Guo Dahai Hu | 2023 | Bioactive Materials2023，，8： | 0 |
| 7 | Effect of nozzle inlet parameters on the dry granulation atomization process of Si_(3)N_(4) ceramic bearing balls显示文摘In this paper,the atomization characteristics of Si3N4 ceramic dry granulation affect the performance of Si3N4 ceramic bearing balls.In order to improve the dry granulation characteristics and the comprehensive performance of Si3N4 ceramic bearing balls,the atomization mechanism of the spinning nozzle used for Si3N4 dry granulation was studied in detail.The interaction between air and binder in the pressure-swirl nozzle is analyzed based on VOF method,the modified realizable k−εturbulence model is used to simulate the flow field inside and outside the pressure-swirl nozzle,the effects of nozzle inlet parameters including the number of tangential inlets and the deflection angle of tangential inlets on the binder volume fraction,velocity distribution and pressure distribution are analyzed.The results show that when the number of tangential inlets increases from 1 to 4,the swirl strength of gas–liquid two-phase in the nozzle increases,the mean diameter of air core increases from 1.51 mm to 2.01 mm,and the spray cone angle increases from 18.5◦to 26.4◦.Besides,when the deflection angle of tangential inlet increases from 0◦to 15◦,the swirl strength of gas–liquid two-phase in the nozzle with the deflection angle of tangential inlet of 10◦is the largest,and the mean diameter of air core and spray cone angle is 3.04 mm and 30.7◦,respectively.Based on the atomization experiment platform of the electric control fuel system,the mean diameter of air core and spray cone angle are measured,the micromorphology of Si3N4 particles is observed,which verifies the correctness of numerical simulation.When the Si3N4 particles are prepared by dry granulation,taking the atomization performance of nozzle into consideration,the pressure-swirl nozzle with 4 tangential inlets and 10◦deflection angle should be selected. | Dongling Yu Xiaohui Zhang Hongbin Luo Dahai Liao Nanxing Wu | 2021 | International Journal of Modeling, Simulation, and Scientific Computing2021，12，6： | 0 |
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