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| 1 | The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats显示文摘Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. | MIAO Zhu Lin GUO Liang WANG Yong Xia CUI Rong YANG Ning HUANG Mi Qiong QIN Wei Bing CHEN Jin LI Hong Mei WANG Zi Neng WEI Xiang Cai | 2012 | Biomedical and Environmental Sciences2012，25，1： | 14 |
| 2 | Influence of Inclusion on Crack Initiation in Wheel Rim显示文摘Speed increase and heavy haul of the railway freight car are the effective measures to raise the transport ability of railway,and they have been the new trend for railway freight car development.The increase of speed and axle load will lead to the increase of wheel-rail contact stress,which will make a great change of stress distribution in the whole wheel rim.Goodier equation was employed to analyze the stress state around inclusion and cavity.In the operation of wheel-rail contact stress,stress concentration occurred in the pole of Al2O3 spherical inclusion,while it appeared on the equator of cavity.The critical inclusion sizes of 250 kN axle load freight car wheel at different velocities,a certain distance away from the tread,were calculated by Murakami equation.Comparing the inclusion in cast steel wheel with that in rolled steel wheel,it is found that the inclusion in cast steel wheel has much more excellent crack resistance than that in rolled steel wheel.In the meantime,in order to reduce the probability of rim crack,some suggestions were put forward. | MI Guo fa NAN Hong yan LIU Yan-lei ZHANG Bin ZHANG Hong SONG Guo xiang | 2011 | Journal of Iron and Steel Research(International)2011，18，1： | 8 |
| 3 | Preparation of Mg-Li alloys by electrolysis in molten salt at low temperature显示文摘A new technology for preparation of low cost Mg-Li alloys was studied. The alloys were prepared by electrolysis in molten LiCl-KCl (weight ratio is 1:1) electrolyte with Mg rod severing as the consumed cathode. Main factors that affect current efficiency were investigated, and optimal electrolysis parameters were obtained. Mg-Li alloys with low lithium content (about 25%) were prepared by the unique method of a higher post-thermal treatment temperature after electrolysis at low temperature. The results showed that the electrolysis can be carried out at low temperature, which resulted in reducing preparation cost due to energy saving.The new technology for the preparation of Mg-Li alloy by electrolysis in molten salt was proved to be feasible. | Mi Lin Zhang Yong De Yan Zhi Yao Hou Lu An Fan Zeng Chen Ding Xiang Tang | 2007 | Chinese Chemical Letters2007，18，3： | 5 |
| 4 | Novel endo-to exo-isomerization of dicyclopentadiene显示文摘Endo-dicyclopentadiene was isomerized to exo-isomer by thermal treatment at evaluated temperature and pressure. The reaction temperature and pressure are key factors for this novel isomerization. This result may have great potential for practical application. | Xiang Wen Zhang Kai Jiang Qiang Jiang Ji Jun Zou Li Wang Zhen Tao Mi | 2007 | Chinese Chemical Letters2007，18，6： | 5 |
| 5 | Neurological manifestations of patients with COVID-19:potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has caused a global pandemic in only 3 months.In addition to major respiratory distress,characteristic neurological manifestations are also described,indicating that SARS-CoV-2 may be an underestimated opportunistic pathogen of the brain.Based on previous studies of neuroinvasive human respiratory coronaviruses,it is proposed that after physical contact with the nasal mucosa,laryngopharynx,trachea,lower respiratory tract,alveoli epithelium,or gastrointestinal mucosa,SARS-CoV-2 can induce intrinsic and innate immune responses in the host involving increased cytokine release,tissue damage,and high neurosusceptibility to COVID-19,especially in the hypoxic conditions caused by lung injury.In some immunecompromised individuals,the virus may invade the brain through multiple routes,such as the vasculature and peripheral nerves.Therefore,in addition to drug treatments,such as pharmaceuticals and traditional Chinese medicine,non-pharmaceutical precautions,including facemasks and hand hygiene,are critically important. | Zhengqian Li Taotao Liu Ning Yang Dengyang Han Xinning Mi Yue Li Kaixi Liu Alain Vuylsteke Hongbing Xiang Xiangyang Guo | 2020 | Frontiers of Medicine2020，14，5： | 5 |
| 6 | Protecting healthcare personnel from 2019-nCoV infection risks:lessons and suggestions显示文摘The outbreak of a novel coronavirus disease(COVID-19,caused by the 2019-nCoV infection)in December 2019 is one of the most severe public health emergencies since the founding of People’s Republic of China in 1949.Healthcare personnel(HCP)nationwide are facing heavy workloads and high risk of infection,especially those who care for patients in Hubei Province.Sadly,as of February 20,2020,over two thousand COVID-19 cases are confirmed among HCP from 476 hospitals nationwide,with nearly 90%of them from Hubei Province.Based on literature search and interviews with some HCP working at Wuhan,capital city of Hubei,we have summarized some of the effective measures taken to reduce infection among HCP,and also made suggestions for improving occupational safety during an infectious disease outbreak.The experience and lessons learned should be a valuable asset for international health community to contain the ongoing COVID-19 epidemic around the world. | Zhiruo Zhang Shelan Liu Mi Xiang Shijian Li Dahai Zhao Chaolin Huang Saijuan Chen | 2020 | Frontiers of Medicine2020，14，2： | 4 |
| 7 | Coordinated Modulation Strategy Considering Multi-HVDC Emergency for Enhancing Transient Stability of Hybrid AC/DC Power Systems显示文摘This paper presents a multi-HVDC emergency coordinated modulating strategy to enhance the transient stability of hybrid AC/DC power systems.First,the main factors that affect the unbalanced energy distribution during a fault are analyzed,and the dominant generators are determined online.Next,considering the influence on both generators in the sending and receiving ends,the assessment index that evaluates the effects of DC power support is established.On the basis of this,a dynamic DC power support strategy is put forward,and the DC support sequence table is promptly updated by the changing dominant generators.The AC/DC hybrid power system with multi-DC lines is built and used as a test system.The simulation results of different scenarios demonstrate that the proposed method could follow the dominant generator dynamically and adjust the DC participating in modulation to enhance the transient stability effectively and quickly. | Tong Wang Congcong Li Dengkai Mi Zengping Wang Yuwei Xiang | 2020 | CSEE Journal of Power and Energy Systems2020，6，4： | 4 |
| 8 | Visible-light-driven photocatalytic inactivation of bacteriophage f2 by Cu-TiO_2 nanofibers in the presence of humic acid显示文摘Pathogenic viruses in drinking water are great threats to public health. Visible-lightdriven photocatalysis is a promising technology for virus inactivation. However, the existing photocatalytic antiviral research studies have mostly been carried out in single-component systems, neglecting the effect of natural organic matter, which exists widely in actual water bodies. In this paper, electrospun Cu-TiO2 nanofibers were prepared as photocatalysts, and their photocatalytic antiviral performance in the presence of humic acid(HA) was comprehensively studied for the first time. The properties of the reaction mixture were measured during the reaction. In addition, the safety, reliability and stability of photocatalytic disinfection in the mixed system were evaluated. The results showed that the virus removal efficiency decreased with the increase of the HA concentration. The type of reaction solution, such as PBS buffer solution or water, did not affect the removal efficiency noticeably. Under acidic conditions, the electrostatic forces between photocatalysts and viruses were strengthened, leading to higher virus removal efficiency. As the reaction time went on, the pH value in the solution increased first and then tended to be stable, the conductivity remained stable, and the dissolved oxygen increased first and then decreased. The safety test showed that the concentration of Cu ions released into the solution was lower than specified by the international standards. No photoreactivation was observed, and the addition of HA significantly reduced the reutilization efficiency of the photocatalysts. | Rong Cheng Mi Kang Zhi-peng Shen Lei Shi Xiang Zheng | 2019 | Journal of Environmental Sciences2019，31，3： | 2 |
| 9 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 10 | Adaptive scale model reconstruction for radio synthesis imaging显示文摘A sky model from CLEAN deconvolution is a particularly effective high dynamic range reconstruction in radio astronomy,which can effectively model the sky and remove the sidelobes of the point spread function(PSF)caused by incomplete sampling in the spatial frequency domain.Compared to scale-free and multi-scale sky models,adaptive-scale sky modeling,which can model both compact and diffuse features,has been proven to have better sky modeling capabilities in narrowband simulated data,especially for large-scale features in high-sensitivity observations which are exactly one of the challenges of data processing for the Square Kilometre Array(SKA).However,adaptive scale CLEAN algorithms have not been verified by real observation data and allow negative components in the model.In this paper,we propose an adaptive scale model algorithm with non-negative constraint and wideband imaging capacities,and it is applied to simulated SKA data and real observation data from the Karl G.Jansky Very Large Array(JVLA),an SKA precursor.Experiments show that the new algorithm can reconstruct more physical models with rich details.This work is a step forward for future SKA image reconstruction and developing SKA imaging pipelines. | 张利 Li-Gong Mi Long Xu Ming Zhang Dan-Yang Li Xiang Liu Feng Wang Yi-Fan Xiao Zhong-Zu Wu | 2021 | Research in Astronomy and Astrophysics2021，21，3： | 2 |
| 11 | Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis 显示文摘 | Sha Mi Xinhua Lee Xiang -ping Li | 2000 | Nature2000，403，17： | 1 |
| 12 | Novel phage amplified multichannel series piezoelectric quartz crystal sensor for rapid and sensitive detection of Mycobacterium tuberculosis 显示文摘 | Mi X W He F J Xiang M Y | 2012 | Anal Chem2012，84，2： | 1 |
| 13 | Glypican3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling显示文摘 | Capurro MI Xiang YY Lobe C | 2005 | Cancer Research2005，65，： | 1 |
| 14 | High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China显示文摘 | Huating Li Kun Dong Qichen Fang Xuhong Hou Mi Zhou Yuqian Bao Kunsan Xiang Aimin Xu Weiping Jia | 2012 | Journal of Hepatology2012，，： | 1 |
| 15 | Analysis of Changes in Energy Consumption and Demand Trend in China's Agricultural Production显示文摘China's energy consumption for agricultural production has relied on petroleum and coal with relatively low input from power and other types of energy for a long time.Projections indicate that as China's existing development trend leads to substantial growth of energy demand for agricultural production,such a long term irrational energy consumption pattern would unlikely be able to meet the needs of the country's developing agricultural sector.As such,it is recommended that China's agricultural sector should follow the national energy development strategy guideline by gradually increasing the use of wind power,solar energy,biomass and other new energy sources while advancing technological innovations on traditional energy sources.Meanwhile,as the consumption structure of three major energy sources(i.e.petroleum,coal,and power)is optimized,development and application of biomass from agriculture as raw materials for alternative energy should be enhanced.Lastly,the development and application of wind power,solar energy,and hydropower in agricultural production should be increased in areas where appropriate. | ZHU Li-zhi1,LIU Jing1,XU Ran2,XIANG Meng1 1.Institute of Agricultural Economics and Development,Chinese Academy of Agricultural Sciences(CAAS),Beijing 100081,China 2.University of Michigan,Ann Arbor,MI(48104),USA | 2011 | Asian Agricultural Research2011，3，3： | 1 |
| 16 | Glypican -3 promotes the growth of hepatocelular carcinoma by stimulating canonical Wnt signaling 显示文摘 | Capurro MI Xiang YY Lobe C | 2005 | Cancer Res2005，65，14： | 1 |
| 17 | Reciprocal repression between TUSC 7 and mi R ‐23b in gastric cancer显示文摘 | Peng Qi Mi‐die Xu Xiao‐Han Shen Shu‐Juan Ni Dan Huang Cong Tan Wei‐Wei Weng Wei‐Qi Sheng Xiao‐Yan Zhou Xiang Du | 2015 | Cancer2015，，6： | 1 |
| 18 | Glypican- 3 promotes the growth of hepatocellular carcinoma by stimulating canonical wnt signaling显示文摘 | Capurro MI Xiang YY Lobe C | 2005 | Cancer Res2005，65，： | 1 |
| 19 | Glypican -3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling 显示文摘 | Capurro MI Xiang YY Lobe C | 2005 | Cancer Res2005，65，： | 1 |
| 20 | Unveiling the role of Fe_(3)O_(4)in polymer spin valve near Verwey transition显示文摘The spinterface formed between ferromagnetic(FM)electrode and organic materials is vital for performance optimization in organic spin valve(OSV).Half-metallic Fe_(3)O_(4)with drastic change in structure,conductivity and magnetic property near Verwey transition can serve as an intrinsic spinterface regulator.However,such modulating effect of Fe_(3)O_(4)in OSV has not been comprehensively investigated,especially below the Verwey transition temperature(Tv).Here,we highlight the important role of Fe_(3)O_(4)electrode in reliable-working and controllable Fe_(3)O_(4)/P3HT/Co polymer spin valves by investigating the magnetoresistance(MR)above and below 7V.In order to distinguish between different contributions to charge transport and related MR responses,the systematic electronic and magnetic characterizations were carried out in full temperature range.Particularly,the first-order metal-insulator transition in Fe_(3)O_(4)has a dramatic effect on the MR enhancement of polymer spin valves at 7V.Moreover,both the conducting mode transformation and MR line shape modulation could be accomplished across 7V.This research renders unique scenario to multimodal storage by external thermodynamic parameters,and further reveals the importance of spin-dependent interfacial modification in polymer spin valves. | Shuaishuai Ding Yuan Tian Xiang Liu Ye Zou Huanli Dong Wenbo Mi Wenping Hu | 2021 | Nano Research2021，14，1： | 1 |
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