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| 1 | The molecular mechanisms that underlie the tumor suppressor function of LKB1显示文摘在 PeutzJeghers 症候群(PJS ) 的 LKB1 肿瘤 suppressor 基因结果的 Germline 变化由肠的 hamartomas 描绘了并且增加了上皮的癌症的发生。在 LKB1 使变化失去活性也在肺癌症在某些分散的人的癌症并且与特别地高的频率被发现了。LKB1 现在被表明了在肺的 tumorigenesis 起一个关键作用,控制开始,区别,和转移。最近的证据证明 LKB1 是多任务 kinase,与在安排房间活动的大潜力。因此远, LKB1 被发现了在房间极性,精力新陈代谢, apoptosis,房间周期拘捕,和房间增长起一个作用,所有哪个可以要求这 kinase 或它的催化活动的肿瘤 suppressor 功能。这评论有关 LKB1 蛋白质 kinase 作为肿瘤 suppressor 由操作并且讨论合理治疗策略到受不了与 LKB1 发信号有关的 PJS 和另外的普通混乱的个人的分子的机制集中于显著最近的调查结果。 | Dahua Fan Chao Ma Haitao Zhang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，2： | 21 |
| 2 | Embedding based quantile regression neural network for probabilistic load forecasting显示文摘Compared to traditional point load forecasting,probabilistic load forecasting(PLF) has great significance in advanced system scheduling and planning with higher reliability. Medium term probabilistic load forecasting with a resolution to an hour has turned out to be practical especially in medium term energy trading and can enhance the performance of forecasting compared to those only utilizing daily information. Two main uncertainties exist when PLF is implemented: the first is the temperature fluctuation at the same time of each year; the second is the load variation which means that even if observed indicators are fixed since other observed external indicators can be responsible for the variation. Therefore, we propose a hybrid model considering both temperature uncertainty and load variation to generate medium term probabilistic forecasting with hourly resolution. An innovative quantile regression neural network with parameter embedding is established to capture the load variation, and a temperature scenario based technique is utilized to generate temperatureforecasting in a probabilistic manner. It turns out that the proposed method overrides commonly used benchmark models in the case study. | Dahua GAN Yi WANG Shuo YANG Chongqing KANG | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，2： | 9 |
| 3 | Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation显示文摘许多干细胞人口被他们的本地微型环境(壁龛) 紧调整,它包括 stromal 房间的不同类型。然而,很少对壁龛亚群并列地由决定干细胞命运的机制被知道。这里,我们识别那 Yki,关键河马小径部件,为护卫房间(EC ) 是必要的在在果蝇卵巢支持 germline 区别的功能。我们发现那个刺猬(Hh ) 发信号首先从帽子房间发出,支持 EC 的功能肘脉 interruptus (Ci ) ,表明受动器的 Hh,禁止河马 kinase 的行为串联活动。机械学地,我们发现 Ci 竞争地与 Hpo 交往并且损害表明复杂形成的 Hpo-Wts,从而支持的 Yki 原子本地化。Ci 的行动保证发信号在 EC 反对 Sd/Tgi/Vg-mediated 缺省压抑的有效 Yki。这研究揭开解释壁龛房间的亚群怎么协调经由表明串音的 Hh 河马决定干细胞命运的机制,并且提高我们发信号的 oncogenic Yki/YAP 的机械学的规定的理解。 | Chaoyi Li Lijuan Kan Yan Chen Xiudeng Zheng Weini Li Wenxin Zhang Lei Cao Xiaohui Lin Shanming Ji Shoujun Huang Guoqiang Zhang Xiaohui Liu Yi Tao Shian Wu Dahua Chen | 2015 | Cell Research2015，25，10： | 5 |
| 4 | Definition and sturcture characteristics of pores in mylonitized organic-rich shales显示文摘Gas shales with a high gas content were drilled in the Lower Cambrian Lujiaping Formation in the northeastern Sichuan Basin,close to the Chengkou Fault in the Dabashan arc-like thrust fold belt.The equivalent vitrinite reflectance values of organic matters are over 4.0%Ro.The pore structures of the shales were investigated based on microscopy,field emission scanning electron microscopy(FESEM)observations,and low temperature N2 adsorption analysis.The study suggests that cleavages,comprising clay minerals mixed up with organic matter and other insoluble residues,were developed in the rock layers.The clay minerals are directionally arranged,displaying a mylonitized texture.Abundant nanometer-size organic matter and clay mineral particles are well mixed in the cleavage domains,which developed the mylonitized pore system that consists of nanometer-size intergranular pore spaces,aggregate pore spaces in clay mineral flakes and pore network.This mylonitized pore system has high specific surface area,high methane adsorption capacity,and high capillary pressure,which collectively contributes to the preservation of shale gas in such a complex tectonic area.The discovery of the mylonitized pore structure in organic-rich shales may reveal a new mechanism of shale gas enrichment in complex tectonic areas with over-mature organic matter in the northeastern part of Sichuan Basin. | MA Yong ZHONG NingNing HAN Hui LI DaHua ZHANG Yi CHENG LiJun | 2014 | Science China Earth Sciences2014，57，12： | 5 |
| 5 | Effective gene silencing in Drosophila ovarian germline by artificial microRNAs显示文摘 | Hailong Wang YanJun Mu Dahua Chen | 2011 | Cell Research2011，21，4： | 3 |
| 6 | Melt graft- ing of maleic anhydride onto polypropylene with 1-Decene as a second monomer显示文摘 | Lei Caihong Li Shanliang Chen Dahua | 2011 | Journal of Applied Polymer Sci- ence2011，119，1： | 1 |
| 7 | Influence of silicone phosphate on the transesterification in PBT/PC blends 显示文摘 | CAIHONG L DAHUA C YUHUI G | 2009 | J Appl Polym Sci2009，113，1： | 1 |
| 8 | Geochemistry of the late Permian No. 30 coal seam, Zhijin Coalfield of Southwest China: influence of a siliceous low-temperature hydrothermal fluid显示文摘 | Shifeng Dai Dahua Li Deyi Ren Yuegang Tang Longyi Shao Huibo Song | 2004 | Applied Geochemistry2004，，8： | 1 |
| 9 | Beyond Adomian Method: The Vriational Iteration Method for Solving Heat - like and Wave - like Equations with Variable Coefficients显示文摘 | DaHua Shoe JiHuan He | 2008 | Physics letters A 20082008，，： | 1 |
| 10 | A Survey of English Teaching in China 显示文摘 | Sui Dahua | 1992 | ELT Newsletter1992，，24： | 1 |
| 11 | Continuum visible spectra from InBr discharge excited in a microwave resonant cavity 显示文摘 | Chen Yuming Chen Dahua | 2007 | Applied physics letters2007，91，： | 1 |
| 12 | Strength of concrete slabs in punching shear 显示文摘 | Jiang Dahua Shen Jinghua | 1986 | American Society of Civil Engineers1986，112，12： | 1 |
| 13 | The effect of spectrum on visual field in road lighting显示文摘 | Lin Yandan Chen Wencheng Chen Dahua | 2004 | Building and Environ ment2004，39，： | 1 |
| 14 | Organic matter/clay mineral intergranular pores in the Lower Cambrian Lujiaping Shale in thenorth-eastern part of the upper Yangtze area,China: A possible microscopic mechanism for gas preservation显示文摘 | Ma Yong Zhong Ningning Li Dahua | 2015 | International Journal ofCoal Geology2015，137，： | 1 |
| 15 | Geochemistry and environmental effect of cadmium in the super-large Jinding Pb-Zn deposit,Yunnan Province, China显示文摘The Jinding Pb-Zn deposit in Yunnan Province is the representative of a Cd-enriched area and mining activities lead to the release of Cd into the hypergenic ecosystem, resulting in Cd pollution. The concentrations of Cd vary greatly from one type to another type of rocks in the mining district. In the host rock, Cd concentrations range from 50×10-6 to 650×10-6 with an average of 310×10-6. In primary ores, Cd concentrations range from 14×10-6 to 2800×10-6 with an average of 767×10-6. However, in oxidized ores, Cd concentrations are highest, varying within the range of 110×10-6 to 8200×10-6 , averaging 1661×10-6. It is shown that the oxidized ores are the main carrier and environmental source of Cd. Leaching test showed that Pb/Zn ores are easy to oxidize and thereafter release Cd and other harmful elements. These leached elements in the leachate may be precipitated rapidly in the order of Zn>Pb>Cd. As for the concentration distribution of Cd in the Bijiang River, it is estimated to be 15.7 μg/L Cd in water, 49.3 mg/L in suspended substances, and 203.7 mg/L in sediments. The average value of Cd in soil from the polluted area is 83.0 mg/kg. Natural weathering of Cd-rich rocks and minerals imposes a potential environmental risk on the aquatic ecosystem of the Bijiang catchment. | LI Hang LI Dahua XIAO Tangfu HE Libin NING Zengping SUN Jialong ZHU Changsheng SHUANG Yan | 2008 | Chinese Journal Of Geochemistry2008，27，1： | 1 |
| 16 | Multicompartment micelles from star and linear triblock copolymer blends显示文摘 | Xin Jing Liu Dahua Zhong Chongli | | 0，，： | 1 |
| 17 | Shear strength of reinforced concrete deep beams显示文摘 | Wang Wei Jiang Dahua Thomas Hsu Chengtzu | 1993 | Journal of Structures Engineering ASCE1993，119，22： | 1 |
| 18 | Strength of concrete slabs in punching shear 显示文摘 | JIANG DAHUA SHEN JINGHUA | 1986 | Journal of Structural Engineering1986，112，12： | 1 |
| 19 | LED' s: a Promising Energy-Saving Light Source for Road Lighting 显示文摘 | FuSheng Li DaHua Chen XianJie Song | 2009 | Power and Energy Engineering Conference2009，13，： | 1 |
| 20 | Antibacterial effect of nano-scale TiO2 on parasitic bacterium of nanfeng citrus in storage period显示文摘 | Long Xiaoyi Liu Yuying Yu Dahua | 2010 | Agricultural Science & Technology 20102010，14，： | 1 |
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