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| 1 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 2 | Effective gene silencing in Drosophila ovarian germline by artificial microRNAs显示文摘 | Hailong Wang YanJun Mu Dahua Chen | 2011 | Cell Research2011，21，4： | 3 |
| 3 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 4 | Spatiotemporal characteristics of cultivated land use eco-efficiency and its influencing factors in China from 2000 to 2020显示文摘Improving cultivated land use eco-efficiency(CLUE)can effectively promote agricultural sustainability,particularly in developing countries where CLUE is generally low.This study used provincial-level data from China to evaluate the spatiotemporal evolution of CLUE from 2000 to 2020 and identified the influencing factors of CLUE by using a panel Tobit model.In addition,given the undesirable outputs of agricultural production,we incorporated carbon emissions and nonpoint source pollution into the global benchmark-undesirable output-super efficiency-slacks-based measure(GB-US-SBM)model,which combines global benchmark technology,undesirable output,super efficiency,and slacks-based measure.The results indicated that there was an upward trend in CLUE in China from 2000 to 2020,with an increase rate of 2.62%.The temporal evolution of CLUE in China could be classified into three distinct stages:a period of fluctuating decrease(2000-2007),a phase of gradual increase(2008-2014),and a period of rapid growth(2015-2020).The major grain-producing areas(MPAs)had a lower CLUE than their counterparts,namely,non-major grain-production areas(non-MPAs).The spatial agglomeration effect followed a northeast-southwest strip distribution;and the movement path of barycentre revealed a'P'shape,with Luoyang City,Henan Province,as the centre.In terms of influencing factors of CLUE,investment in science and technology played the most vital role in improving CLUE,while irrigation index had the most negative effect.It should be noted that these two influencing factors had different impacts on MPAs and non-MPAs.Therefore,relevant departments should formulate policies to enhance the level of science and technology,improve irrigation condition,and promote sustainable utilization of cultivated land. | LI Shaoting MU Na REN Yanjun Thomas GLAUBEN | 2024 | Journal of Arid Land2024，16，3： | 0 |
| 5 | Surface Plasmon Effect Dominated High-Performance Triboelectric Nanogenerator for Traditional Chinese Medicine Acupuncture显示文摘Available,effectively converting low-frequency vibration into available electricity,triboelectric nanogenerator(TENG)is always research hot nowadays.However,the enhancing effect of the existing methods for the output have all sorts of drawbacks,i.e.. | Xin Chen Fayang Wang Yanjun Zhao Pengfan Wu Lingxiao Gao Chun Ouyang Ya Yang Xiaojing Mu | 2023 | Research2023，，2： | 0 |
| 6 | Structure regulation of land use and landscape pattern changes based on matter element analysis in a small watershed in Sichuan,China显示文摘The agricultural land suitability assessment based on the natural characteristics of land blocks is traditionally the basis for agricultural and/or land use planning.The assessment,however,is static and cannot be incorporated with potential land use changes.Recently,a dynamic approach,i.e.,matter element analysis,has been effectively applied for land use planning.In the present study,based on matter element analysis,we estab-lished a matter element analysis model for land use suitability assessment using the suitability grade of land use,evaluation indicators and their characteristic values as matter elements,and also using sutra field,controlled field,weight value and correlation degree from field survey,as well as an expert system.This model was applied to the structure regulation of the land use in the small Yuejiagou watershed of the Langzhong Municipality in Sichuan Province,China.Results show that the proportion among agriculture,forestry and animal husbandry tended to rationalize land use.The economic and eco-logical indices of the lands were increased from 1529.8 to 1719.99 and from 1460.94 to 1758.21 after the regulation,respectively.The regulation also caused changes in landscape patterns as follows:The indices of diversity and evenness were increased from 1.3028 to 2.0920 and from 0.6108 to 0.8463,or by 60.58%and 38.56%,respectively.However,the indices of dominance and contagion were decreased from 0.6431 to 0.2106 and from 0.7467 to 0.7125,respectively.This indicated that the land use in the small watershed was rational.The spatial distribution of patches tended to be uniform.The patch congregation was gradually dispersed.This study verified that the matter element analysis approach can not only overcome the factitious influences and improve the precision of land assessment,but also can be used for the structure regu-lation of specific patches. | Junhua CHEN Changlong MU Xiuming CHEN Chenghua XIANG Chengrong LUO Huabai HAN Guoxian CHEN Yanjun DU | 2008 | Frontiers in Biology2008，3，3： | 0 |
| 7 | Preparation of Bimodal Mesoporous Silica Molecular Sieves from Organotrialkoxysilane and Tetraethoxysilane显示文摘The synthesis of silica with bimodal,disordered mesopores structure,by template-mediated sol-gel processing and subsequent heat-treatment process,was investigated. In the presence of nonionic surfactant Tx-15,the organically modified mesostructured nano-particles were synthesized by co-condensation of organosiloxane (RTES) and tetraethoxysilane (TEOS) in the first step,and then the bimodal porous silica was formed by the removal of the incorporated organic groups using programmed calcination. Here,RTES used was methyltriethoxysilane (MTES),vinyltriethoxysilane (VTES) and phenyltriethoxysilane (PhTES),respectively. Organotrialkoxysilane,TEOS and Tx-15 formed MSU-2-liked assemblies,around which the nano-particles aggregated and cross-linked,considerably influencing the pore size distribution of both primary pores and secondary pores. By changing the type and amount of the organotrialkoxysilane added,a broad variety of silica with a controlled bimodal mesopore distribution could be easily synthesized. Textural and structural properties were determined by X-ray diffraction,high-resolution transmission electron microscopy,N2 adsorption/desorption,and thermogravimetric analysis. | Gong Yanjun Mu Lin Dou Tao | 2007 | Petroleum Science2007，4，4： | 0 |
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