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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Single-shot spectral-volumetric compressed ultrafast photography显示文摘In ultrafast optical imaging,it is critical to obtain the spatial structure,temporal evolution,and spectral composition of the object with snapshots in order to better observe and understand unrepeatable or irreversible dynamic scenes.However,so far,there are no ultrafast optical imaging techniques that can simultaneously capture the spatial–temporal–spectral five-dimensional(5D)information of dynamic scenes.To break the limitation of the existing techniques in imaging dimensions,we develop a spectral-volumetric compressed ultrafast photography(SV-CUP)technique.In our SV-CUP,the spatial resolutions in the x,y and z directions are,respectively,0.39,0.35,and 3 mm with an 8.8 mm×6.3 mm field of view,the temporal frame interval is 2 ps,and the spectral frame interval is 1.72 nm.To demonstrate the excellent performance of our SV-CUP in spatial–temporal–spectral 5D imaging,we successfully measure the spectrally resolved photoluminescent dynamics of a 3D mannequin coated with CdSe quantum dots.Our SV-CUP brings unprecedented detection capabilities to dynamic scenes,which has important application prospects in fundamental research and applied science. | Pengpeng Ding Yunhua Yao Dalong Qi Chengshuai Yang Fengyan Cao Yilin He Jiali Yao Chengzhi Jin Zhengqi Huang Li Deng Lianzhong Deng Tianqing Jia Jinyang Liang Zhenrong Sun Shian Zhang | 2021 | Advanced Photonics2021，3，4： | 3 |
| 4 | Optimal Control of Slurry Pressure during Shield Tunnelling Based on Random Forest and Particle Swarm Optimization显示文摘The control of slurry pressure aiming to be consistent with the external water and earth pressure during shield tunnelling has great significance for face stability,especially in urban areas or underwater where the surrounding environment is very sensitive to the fluctuation of slurry pressure.In this study,an optimal control method for slurry pressure during shield tunnelling is developed,which is composed of an identifier and a controller.The established identifier based on the random forest(RF)can describe the complex non-linear relationship between slurry pressure and its influencing factors.The proposed controller based on particle swarm optimization(PSO)can optimize the key factor to precisely control the slurry pressure at the normal state of advancement.A data set from Tsinghua Yuan Tunnel in China was used to train the RF model and several performance measures like R2,RMSE,etc.,were employed to evaluate.Then,the hybrid RF-PSO control method is adopted to optimize the control of slurry pressure.The good agreement between optimized slurry pressure and expected values demonstrates a high identifying and control precision. | Weiping Luo Dajun Yuan Dalong Jin Ping Lu Jian Chen | 2021 | Computer Modeling in Engineering & Sciences2021，，7： | 3 |
| 5 | High-fidelity image reconstruction for compressed ultrafast photography via an augmented-Lagrangian and deep-learning hybrid algorithm显示文摘Compressed ultrafast photography(CUP) is the fastest single-shot passive ultrafast optical imaging technique,which has shown to be a powerful tool in recording self-luminous or non-repeatable ultrafast phenomena.However, the low fidelity of image reconstruction based on the conventional augmented-Lagrangian(AL)and two-step iterative shrinkage/thresholding(Tw IST) algorithms greatly prevents practical applications of CUP, especially for those ultrafast phenomena that need high spatial resolution. Here, we develop a novel AL and deep-learning(DL) hybrid(i.e., AL+DL) algorithm to realize high-fidelity image reconstruction for CUP. The AL+DL algorithm not only optimizes the sparse domain and relevant iteration parameters via learning the dataset but also simplifies the mathematical architecture, so it greatly improves the image reconstruction accuracy. Our theoretical simulation and experimental results validate the superior performance of the AL+DL algorithm in image fidelity over conventional AL and Tw IST algorithms, where the peak signalto-noise ratio and structural similarity index can be increased at least by 4 d B(9 d B) and 0.1(0.05) for a complex(simple) dynamic scene, respectively. This study can promote the applications of CUP in related fields, and it will also enable a new strategy for recovering high-dimensional signals from low-dimensional detection. | CHENGSHUAI YANG YUNHUA YAO CHENGZHI JIN DALONG QI FENGYAN CAO YILIN HE JIALI YAO PENGPENG DING LIANG GAO TIANQING JIA JINYANG LIANG ZHENRONG SUN SHIAN ZHANG | 2021 | Photonics Research2021，9，2： | 2 |
| 6 | Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8显示文摘 | Caining Jin Peiguo Ding Dalong Ma | 2005 | FEBS Lett2005，579，28： | 1 |
| 7 | Hydraulic fracturing pressure of concentric double-layered cylinder in cohesive soil显示文摘This study aims to investigate hydrofracturing in double-layered soil through theoretical and experimental analysis,as multilayered soils where the difference in mechanical properties exists are generally encountered in practical engineering.First,an analytical solution for fracturing pressure in two different concentric regions of soil was presented based on the cavity expansion theory.Then,several triaxial hydraulic fracturing tests were carried out to validate the analytical solution.The comparison between the experimental and analytical results indicates the remarkable accuracy of the derived formula,and the following conclusions were also obtained.First,there is a linear relationship between the fracturing pressure and confining pressure in concentric double-layered cohesive soil.Second,when the internal-layer soil is softer than the external-layer soil,the presence of internal soil on the fracturing pressure approximately brings the weakening effect,and the greater strength distinction between the two layers,the greater the weakening effect.Third,when the internal-layer soil is harder than the external-layer soil,the existence of the internal-layer soil has a strengthening effect on the fracturing pressure regardless of the proportion of internal-layer soil.Moreover,the influence of strength distinction between the two layers on the fracturing pressure is significant when the proportion of internal-layer soil is less than half,while it’s limited when the proportion is more than half.The proposed solution is potentially useful for geotechnical problems involving aspects of cohesive soil layering in a composite formation. | Dajun YUAN Weiping LUO Dalong JIN Ping LU | 2021 | Frontiers of Structural and Civil Engineering2021，15，4： | 0 |
| 8 | European Integration:Reality and Ideal显示文摘In the present world, the European Union is the largest union of states with the highest level of integration. From the creation of the | Jin Dalong Shi Dongmei | 2010 | International Understanding2010，，1： | 0 |
| 9 | Experimental study on slurry-induced fracturing during shield tunneling显示文摘Facial support in slurry shield tunneling is provided by slurry pressure to balance the external earth and water pressure.Hydraulic fracturing may occur and cause a significant decrease in the support pressure if the slurry pressure exceeds the threshold of the soil or rock material,resulting in a serious face collapse accident.Preventing the occurrence of hydraulic fracturing in a slurry shield requires investigating the effects of related influencing factors on the hydraulic fracturing pressure and fracture pattern.In this study,a hydraulic fracturing apparatus was developed to test the slurry-induced fracturing of cohesive soil.The effects of different sample parameters and loading conditions,including types of holes,unconfined compressive strength,slurry viscosity,and axial and circumferential loads,on the fracturing pressure and fracture dip were examined.The results indicate that the fracture dip is mainly affected by the deviator stress.The fracturing pressure increases linearly with the increase in the circumferential pressure,but it is almost independent of the axial pressure.The unconfined compressive strength of soil can reflect its ability to resist fracturing failure.The fracturing pressure increases with an increase in the unconfined compressive strength as well as the slurry viscosity.Based on the test results,an empirical approach was proposed to estimate the fracturing pressure of the soil. | Teng WANG Dajun YUAN Dalong JIN Xinggao LI | 2021 | Frontiers of Structural and Civil Engineering2021，15，2： | 0 |
| 10 | Temporal compressive super-resolution microscopy at frame rate of 1200 frames per second and spatial resolution of 100 nm显示文摘Various super-resolution microscopy techniques have been presented to explore fine structures of biological specimens.However,the super-resolution capability is often achieved at the expense of reducing imaging speed by either point scanning or multiframe computation.The contradiction between spatial resolution and imaging speed seriously hampers the observation of high-speed dynamics of fine structures.To overcome this contradiction,here we propose and demonstrate a temporal compressive super-resolution microscopy(TCSRM)technique.This technique is to merge an enhanced temporal compressive microscopy and a deep-learning-based super-resolution image reconstruction,where the enhanced temporal compressive microscopy is utilized to improve the imaging speed,and the deep-learning-based super-resolution image reconstruction is used to realize the resolution enhancement.The high-speed super-resolution imaging ability of TCSRM with a frame rate of 1200 frames per second(fps)and spatial resolution of 100 nm is experimentally demonstrated by capturing the flowing fluorescent beads in microfluidic chip.Given the outstanding imaging performance with high-speed super-resolution,TCSRM provides a desired tool for the studies of high-speed dynamical behaviors in fine structures,especially in the biomedical field. | Yilin He Yunhua Yao Dalong Qi Yu He Zhengqi Huang Pengpeng Ding Chengzhi Jin Chonglei Zhang Lianzhong Deng Kebin Shi Zhenrong Sun Xiaocong Yuan Shian Zhang | 2023 | Advanced Photonics2023，5，2： | 0 |
| 11 | Identification,characterization,and verification of miR399 target gene in grape显示文摘The microRNA miR399 plays an important role in phosphorus signal transduction pathways in plants.Previously,miR399 was shown to be closely associated with berry ripening in grape(Vitis vinifera).The objective of the present study was to elucidate the evolutionary characteristics of the miR399 gene family in grape and to verify the cleavage effect on the target genes.Grape miR399s were identified by miRNA sequencing and retrieval from the miRBase database.The mature sequences and precursor sequences were subjected to phylogenetic analysis to reconstruct evolutionary trees,as well as secondary structure analysis of the precursor sequence,and prediction of target genes.The cisacting elements in the miR399 promoter were predicted and the cleavage effect of grape miR399b on its target genes was verified.The grape miR399 family comprised nine precursor sequences and nine mature sequences.The precursor sequences formed a typical and stable stem—loop structure.The minimum folding free energy ranged from-55.70 kcal·mol^(-1)to-37.40 kcal·mol^(-1).Multiple sequence alignment revealed that the miR399 family was highly conserved.The grape miR399 family was phylogenetically closely related to peach,apple,and citrus miR399s.Grape miR399s were predicted to target inorganic phosphate transporter 1—3,phospholipase D delta-like,and beta-glucuronosyltransferase.The cleavage effect of grape miR399b on the target genes was verified by means of a dual-luciferase assay and 5’RLM-RACE.Histochemical GUS staining showed that the promoter activity of miR399b was promoted by GA3treatment. | Maosong Pei Hainan Liu Tonglu Wei Huiying Jin Yihe Yu Mengting Ma Xiaomeng Song Rundong Dai Dalong Guo | 2024 | Horticultural Plant Journal2024，10，1： | 0 |
| 12 | Effect of cutterhead configuration on tunnel face stability during shield machine maintenance outages显示文摘Owing to long-distance advancement or obstacles,shield tunneling machines are typically shut down for maintenance.Engineering safety during maintenance outages is determined by the stability of the tunnel face.Pressure maintenance openings are typically used under complicated hydrogeological conditions.The tunnel face is supported by a medium at the bottom of the excavation chamber and compressed air at the top.Owing to the high risk of face failure,the necessity of support pressure when cutterhead support is implemented and a method for determining the value of compressed air pressure using different support ratios must to be determined.In this study,a non-fully chamber supported rotational failure model considering cutterhead support is developed based on the upper-bound theorem of limit analysis.Numerical simulation is conducted to verify the accuracy of the proposed model.The results indicate that appropriately increasing the specific gravity of the supporting medium can reduce the risk of collapse.The required compressed air pressure increases significantly as the support ratio decreases.Disregarding the supporting effect of the cutterhead will result in a tunnel face with underestimated stability.To satisfy the requirement of chamber openings at atmospheric pressure,the stratum reinforcement strength and range at the shield end are provided based on different cutterhead aperture ratios. | Yinzun YANG Dajun YUAN Dalong JIN | 2023 | Frontiers of Structural and Civil Engineering2023，17，4： | 0 |
| 13 | Single-shot real-time imaging of ultrafast light springs显示文摘Light springs(LSs) have played essential roles in particle rotation and manipulation, optical super-resolution imaging, and optical information coding. In related research areas, it is important to accurately measure spatiotemporal information on LSs to understand and analyze their applications. However, there is no experimental method that can accurately detect the drastic spatial evolution of ultrafast LSs to date. Therefore, in this study, we propose a compressed ultrafast photography(CUP) technique to observe LSs in spatial and temporal dimensions with a snapshot. Using our home-built CUP system, we successfully capture spatiotemporal information on picosecond LSs with two and four petals, involving spatial structure and rotation velocity;furthermore, the experimental measurements are in good agreement with theoretical simulations. This study provides a novel visualization method for specifically measuring the spatial structure and temporal evolution of LSs, thus establishing a new idea for accurately characterizing spatiotemporal information on complex ultrafast laser fields. | Chengzhi Jin Dalong Qi Yunhua Yao Fengyan Cao Li Deng Shixiang Xu Zhenrong Sun Shian Zhang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 0 |
| 14 | Probabilistic analysis of secant piles with random geometric imperfections显示文摘The failure to achieve minimum design overlap between secant piles compromises the ability of a structure to perform as designed,resulting in water leakage or even ground collapse.To establish a more realistic simulation and provide guidelines for designing a safe and cost-effective secant-pile wall,a three-dimensional model of a secant pile,considering the geometric imperfections of the diameter and direction of the borehole,is introduced.An ultrasonic cross-hole test was performed during the construction of secant piles in a launching shaft in Beijing,China.Based on the test results,the statistical characteristics of the pile diameters and orientation parameters were obtained.By taking the pile diameter D,inclination angleβ,and azimuth angleαas random variables,Monte Carlo simulations were performed to discuss the influence of different design parameters on the probability density functions of the overlap of secant piles.The obtained results show that the randomness of the inclination angle and pile diameter can be well described by a normal distribution,whereas the azimuth angle is more consistent with a uniform distribution.The integrity of the secant-pile wall can be overestimated without considering the uncertainty of geometric imperfections.The failure of the secant-pile wall increases substantially with increasing spatial variability in drilling inclination and diameter.A design flowchart for pile spacing under the target safety level is proposed to help engineers design a safe and economical pile wall. | Yi YANG Dalong JIN Xinggao LI Weilin SU Xuyang WANG | 2021 | Frontiers of Structural and Civil Engineering2021，15，3： | 0 |
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