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| 1 | QTL analysis of rice low temperature germinability显示文摘A double haploid population, derived from anther culture of F, hybrid between a typical indica and a japonica (ZYQ8/JX17), has been used to investigate the low temperature germinability (LTG) at 15℃. The low temperature germinability of two parents was significantly different. In 6-11 d, the germination percentage of ZYQ8 was higher than that of JX17. In 12-16 d, the germination percentage of JX17 was higher than that of ZYQ8. The quantitative trait loci (QTLs) of every day for low temperature germinabilityhave been mapped based on a molecular linkage map constructed from this population. In 8-11 d, qLTG-9 was identified in C397B-RZ617B on chromosome 9, the additive effect was positive, showing that, the allele from JX17 could increase low temperature germinability. In 12-16 d, qLTG-4 was mapped between RG908 and CT563 on chromosome 4, the additive effect was negative, showing that the allele from ZYQ8 could increase low temperature germinability. These two QTLs were detected at different stages, | TENG Sheng ZENG Dali QIAN Qian Kunihifo Yasufumi HUANG Danian Zhu Lihuang | 2001 | Chinese Science Bulletin2001，46，21： | 14 |
| 2 | New technology to examine and improve the purity of hybrid rice with herbicide resistant gene显示文摘The herbicide resistant bar gene has been widely used as selectable marker genes in the study on plant genetic transformation. Owing to the integration of the gene into rice genome, transgenic rice was resistant to the herbicide Basta. Therefore, selection of transgenic plant and genetic analysis became easier. In the studies, bar gene was introduced as a genetic marker gene into rice restore line variety of two-line or three-line. Combined with conventional breeding method, the good herbicide resistant individual plant was derived as the new restore line for hybrid combination. After sprayed with Basta at seedling phase, the real hybrid rice that had herbicide resistance could grow normally, while the fake hybrid rice and weeds, having no bar gene, were killed by herbicide. The method described above helped rapidly to examine and improve the purity of hybrid rice. | Danian Huang Jingyang Li Shanqing Zhang Rui Xue Wei Yang Zhihua Hua Xiaobo Xie Xiaoling Wang | 1998 | Chinese Science Bulletin1998，43，9： | 7 |
| 3 | Salt tolerance of transgenic rice (Oryza sativa L.) with mtlD gene and gutD gene显示文摘Southern blot analysis indicated that mtID gene (encoding mannitol-1 -phosphate dehydrogenase) and gutD gene (encoding glucitol-6-phosphate dehydrogenase) had been integrated into the rice genome mediated by Agrobacterium tumefaciens LBA4404(pBIGM). The expression of the above two genes in transgenic rice plants was demonstrated by Northern blot analysis and enzymatic activity assay. Analysis of sugar alcohol showed that transgenic rice plants could produce and accumulate mannitol and sorbitol. The salt tolerance of transgenic plants was much higher than that of their controls. | WANG Huizhong HUANG Danian LU Ruifang LIU Junjun QIAN Qian PENG Xuexian | 2000 | Chinese Science Bulletin2000，45，18： | 5 |
| 4 | A new method to identify and improve the purity of hybrid rice with herbicide resistant gene显示文摘There is a dose relationship between the hybrid rice production and seed purity, Two-line bybrid rice with bigher beterosis is produced through the hybridization between a photothermo sensitive genetic male sterile (GMS) rice line and a paternat variety, But the fertilety of photo-thermo sensitive GMS rice line is not stable because it changes with the total climate. | HUANG Danian,ZHANG Shanging,XUE Rui,HUA Zhihua,XIU Xiaobo,and WANG Xiaoling,CNRRI,Hangzhou 310006,China | 1998 | Chinese Rice Research Newsletter1998，6，1： | 3 |
| 5 | Studies on the inheritance of transgenic rice with bar gene显示文摘Bar gene driven under the control of CaMV 35s promotor was delivered into the immature embroys of a japonica rice cultivar Jingying 119 through biolistic approach. Two putative transgenic plants were produced, which ex-pressed Basra-resistance. One of the Basra-re-sistance transgenic rices was completely sterile(JY 119-3), the other was self-fertile (JY119-4). | HUANG Danian, LI Jingyang, XIAO Han, ZHANG Shanqing, XUE Rui, WANG Xiaoling, YANG Wei, HUA Zhi-hua, and XIE Xiaobo, CNRRI, Hangzhou 310006, China | 1997 | Chinese Rice Research Newsletter1997，5，4： | 3 |
| 6 | Characterization of major water-soluble inorganic ions in size-fractionated particulate matters in Shanghai campus ambient air显示文摘 | Guangli Xiu Danian Zhang Jizhang Chen Xuejuan Huang Zhixiang Chen Honglian Guo Jinfang Pan | 2003 | Atmospheric Environment2003，，2： | 2 |
| 7 | 3D inversion of borehole gravity data using cokriging显示文摘Borehole gravity has been used in mineral exploration recently with the advent of slim-hole gravimeters. It is logical to perform inversion to utilize the information in the newly acquired data. The inversions were carried out by using cokriging,which is a geostatistical method of estimation that minimizes the error variance by applying cross-correlation between several variables. In this study the estimated densities are derived by using boreholes gravity and known densities along the borehole. This method does not need iterative process and computes efficiently. The selection of examples demonstrates that this method has the ability to include physical property from borehole measurements in the inversion. The synthetic examples demonstrate the density variation along a borehole can be well determined without depth constraints in the inversion. The resolution of the recovered model can be further improved by including the densities along the borehole for inversion. However,this capability decreases dramatically with the increasing of distance between the anomalous body and the borehole. | GENG Meixia HUANG Danian XU Bowen | 2014 | Global Geology2014，17，4： | 2 |
| 8 | Edge detection using directional eigenvalues of potential field gradient tensor data显示文摘Edge detection of potential field interpretation is an important task. The traditional edge detection methods have poor ability in outlining weak amplitude anomalies clearly. The resolved edges position is blurred.We purposed new edge detection methods based on directional eigenvalues of potential field gradient tensor for the causative sources. In order to balance strong and weak amplitude anomalies simultaneously,we present one normalization method using different orders of vertical derivatives to improve the new filters. The presented filters were tested on synthetic and real potential field data to verify its feasibility. All of the results have shown that the new edge detection methods can not only display the sources edges precisely and clearly,but also bring out more geological subtle details. | ZHOU Shuai HUANG Danian | 2015 | Global Geology2015，18，3： | 2 |
| 9 | Detection of UXO magnetic anomaly in Jinshan area显示文摘Magnetic survey is one of the most successful techniques for locating buried unexploded ordnances( UXO). For the location and identification of buried UXO in Jinshan area,a total-field magnetic survey is applied. The analytic signal of magnetic field is widely used to outline the boundaries of geology bodies,slightly dependent on the magnetization direction. In order to locate the UXO position,the analytic signal is applied to process the magnetic UXO data,which performs better than the conventional magnetic data. Then a typical UXO anomaly is extracted from the original data to invert for its depth by an improved Euler method proposed.The calculated depth is close to the real buried depth. | WU Guochao HUANG Danian ZHANG Chong YUAN Yuan | 2015 | Global Geology2015，18，1： | 2 |
| 10 | Speciated mercury in size-fractionated particles in Shanghai ambient air显示文摘 | Guangli Xiu Ji Cai Wenying Zhang Danian Zhang Andreas Büeler Shuncheng Lee Yan Shen Lihang Xu Xuejuan Huang Ping Zhang | 2008 | Atmospheric Environment2008，，19： | 1 |
| 11 | Primary study on the resistance to bacterial blight(X. oryzae)in Cecropin B gene transgenic rices显示文摘Bacterial blight (BB) is one of the major diseases to rice. Antibacterial Cecropin B gene has been cloned and transformed into rice. We studied the resistance to bacterial blight in Cecropin B gene tronsgenic rices. | HUA Zhihua HUANG Danian XUE Rui WANG Xiaoling GAO Zhenyu CNRRI,Hangzhou 310006,China. | 1998 | Chinese Rice Research Newsletter1998，6，3： | 0 |
| 12 | Quercetin induces autophagy-associated death in HL-60 cells through CaMKKβ/AMPK/mTOR signal pathway显示文摘Acute myeloid leukemia(AML)is one of the most common malignancies of the hematopoietic progenitor cell in adults.Quercetin has gained recognition over the years because of its anti-cancer effect with minimal toxicity.Herein,we aim to investigate the anti-leukemia mechanism of quercetin and to decipher the signaling pathway of quercetin in HL-60 leukemic cells.We observed that quercetin induces apoptosis and autophagic cell death,in which both pathways play an important role in suppressing the viability of leukemia cells.Phosphorylated AMPK(p-AMPK)protein expressions are lower in primary AML cells,HL-60 cells,KG-1 and THP-1 cells than in peripheral blood monocular cells.After quercetin treatment,the expression of p-AMPK is increased while the expression of pmTOR is decreased in a dose-dependent manner.Mechanistically,compound C,an AMPK phosphorylation inhibitor,upregulates the phosphorylation of mTOR and inhibits autophagy and apoptosis in quercetin-induced HL-60 cells,while silencing of CaMKKβinhibits the quercetin-induced phosphorylation of AMPK,resulting in increased mTOR phosphorylation.Furthermore,silencing of CaMKKβinhibits the autophagy in HL-60 cells.Taken together,our data delineate that quercetin plays its anti-leukemia role by inhibiting cell viability and inducing apoptosis and autophagy in leukemia cells.Quercetin inhibits the phosphorylation of mTOR by regulating the activity of AMPK,thus playing a role in the regulation of autophagy and apoptosis.CaMKKβis a potential upstream molecule for AMPK/mTOR signaling pathway,through which quercetin induces autophagy in HL-60 cells. | Jie Xiao Ben Zhang Songmei Yin Shuangfeng Xie Kezhi Huang Jieyu Wang Wenjuan Yang Hongyun Liu Guoyang Zhang Xiaoyan Liu Yiqing Li Danian Nie | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 0 |
| 13 | Haploidentical transplantation has a superior graft-versus-leukemia effect than HLA-matched sibling transplantation for Ph- high-risk B-cell acute lymphoblastic leukemia显示文摘Background: Compared with human leukocyte antigen (HLA)-matched sibling donor (MSD) transplantation, it remains unclear whether haploidentical donor (HID) transplantation has a superior graft-versus-leukemia (GVL) effect for Philadelphia-negative (Ph-) high-risk B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to compare the GVL effect between HID and MSD transplantation for Ph- high-risk B-ALL.Methods: This study population came from two prospective multicenter trials (NCT01883180, NCT02673008). Immunosuppressant withdrawal and prophylactic or pre-emptive donor lymphocyte infusion (DLI) were administered in patients without active graft-versus-host disease (GVHD) to prevent relapse. All patients with measurable residual disease (MRD) positivity posttransplantation (post-MRD+) or non-remission (NR) pre-transplantation received prophylactic/pre-emptive interventions. The primary endpoint was the incidence of post-MRD+.Results: A total of 335 patients with Ph- high-risk B-ALL were enrolled, including 145 and 190, respectively, in the HID and MSD groups. The 3-year cumulative incidence of post-MRD+ was 27.2% (95% confidence interval [CI]: 20.2%-34.7%) and 42.6% (35.5%-49.6%) in the HID and MSD groups(P = 0.003), respectively. A total of 156 patients received DLI, including 60 (41.4%) and 96 (50.5%), respectively, in the HID and MSD groups (P= 0.096). The 3-year cumulative incidence of relapse was 18.6% (95% CI: 12.7%-25.4%) and 25.9% (19.9%-32.3%;P = 0.116) in the two groups, respectively. The 3-year overall survival (OS) was 67.4% (95% CI: 59.1%-74.4%) and 61.6% (54.2%-68.1%;P = 0.382), leukemia-free survival (LFS) was 63.4% (95% CI: 55.0%-70.7%) and 58.2% (50.8%-64.9%;P= 0.429), and GVHD-free/relapse-free survival (GRFS) was 51.7% (95% CI: 43.3%-59.5%) and 37.8% (30.9%-44.6%;P= 0.041), respectively, in the HID and MSD groups.Conclusion: HID transplantation has a lower incidence of post-MRD+ than MSD transplantation, suggesting that HID transplantation might have a superior GVL effect than MSD transplantation for Ph- high-risk B-ALL patients.Trial registration: ClinicalTrials.gov: NCT01883180, NCT02673008. | Fan Menglin Wang Yu Lin Ren Lin Tong Huang Fen Fan Zhiping Xu Yajing Yang Ting Xu Na Shi Pengcheng Nie Danian Lin Dongjun Jiang Zujun Wang Shunqing Sun Jing Huang Xiaojun Liu Qifa Xuan Li | 2022 | Chinese Medical Journal2022，，8： | 0 |
| 14 | Edge detection of gravity anomaly with an improved 3D structure tensor显示文摘Edge detection plays an important role in geological interpretation of potential field data,which can indicate the subsurface faults,contact,and other tectonic features.A variety of methods have been proposed to detect and enhance the edges.3 D structure tensor can well delineate the edges of geological bodies,however,it is sensitive to noise and additional false edges need to be removed artificially.In order to overcome these disadvantages,this paper redefines the 3 D structure tensor with a Gaussian envelop and proposes a new normalized edge detector,which can remove the additional false edges and reduce the influence of noise effectively,and balance the edges of different amplitude anomalies completely.This method has been tested on the synthetic and measured gravity data,showing that the new improved method achievesbetter results and reveals more details. | DAI Weiming LI Tonglin HUANG Danian YUAN Yuan LIU Kai QIAO Zhongkun | 2018 | Global Geology2018，21，2： | 0 |
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