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| 1 | Contributions of climate change and human activities to ET and GPP trends over North China Plain from 2000 to 2014显示文摘确定土壤水分蒸发蒸腾损失总量(et ) 和粗野主要生产率(GPP ) 改变的生态系统的气候变化和人的活动的贡献为改编评价和持续开发是重要的。et 和 GPP 的空间与时间的模式与一个物理、遥远的基于感觉的模型一起在诺思中国平原(NCP ) 上从 2000 ~ 2014 被估计。et 和 GPP 趋势的气候变化和人的活动的贡献被第一个差别趋势 de 方法和 multivariate 回归分开并且确定。结果显示出那年度 et , GPP 微弱地增加了,与气候变化和人的活动贡献 0.188 公里 yr-2 和 0.466 公里年-2到 0.654 公里年-2,的 et 趋势 and-1.321 g C m -2年-2和 7.542 g C m -2年-2到 GPP 6.221 的趋势 g C m -2年-2,分别地。在农田,增加的趋势主要在种舞台的小麦发生了;小麦和玉米的气候变化的贡献两个都是否定的。降水和阳光持续时间是调整 et 和 GPP 趋势的主要气候的因素。人的活动在 NCP 是到水消费和粗野主要生产率的长期的趋势的主要司机,这被结束。 | CHEN Xuejuan MO Xingguo HU Shi LIU Suxia | 2017 | Journal of Geographical Sciences2017，27，6： | 11 |
| 2 | miR-21 promotes the differentiation of hair folliclederived neural crest stem cells into Schwann cells显示文摘Hair follicle-derived neural crest stem cells can be induced to differentiate into Schwann cells in vivo and in vitro. However, the underlying regulatory mechanism during cell differentiation remains poorly understood. This study isolated neural crest stem cells from human hair follicles and induced them to differentiate into Schwann cells. Quantitative RT-PCR showed that microRNA(miR)-21 expression was gradually increased during the differentiation of neural crest stem cells into Schwann cells. After transfection with the miR-21 agonist(agomir-21), the differentiation capacity of neural crest stem cells was enhanced. By contrast, after transfection with the miR-21 antagonist(antagomir-21), the differentiation capacity was attenuated. Further study results showed that SOX-2 was an effective target of miR-21. Without compromising SOX2 mRNA expression, miR-21 can down-regulate SOX protein expression by binding to the 3′-UTR of miR-21 mRNA. Knocking out the SOX2 gene from the neural crest stem cells significantly reversed the antagomir-21 inhibition of neural crest stem cells differentiating into Schwann cells. The results suggest that miR-21 expression was increased during the differentiation of neural crest stem cells into Schwann cells and miR-21 promoted the differentiation through down-regulating SOX protein expression by binding to the 3′-UTR of SOX2 mRNA. | Yuxin Ni Kaizhi Zhang Xuejuan Liu Tingting Yang Baixiang Wang Li Fu Lan A Yanmin Zhou | 2014 | Neural Regeneration Research2014，9，8： | 9 |
| 3 | Influence of physical properties of carrier on the performance of dry powder inhalers显示文摘Dry powder inhalers(DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to completely understand how they individually influence DPI performance.The purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs. | Tingting Peng Shiqi Lin Boyi Niu Xinyi Wang Ying Huang Xuejuan Zhang Ge Li Xin Pan Chuanbin Wu | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 8 |
| 4 | DEVELOPMENT OF A COUPLED REGIONAL AIR-SEA MODEL AND ITS NUMERICAL SIMULATION FOR SUMMER MONSOON IN 1998显示文摘coupled regional air-sea model is developed by using the regional climate model (P-σ RCM)and the regional ocean model (POM), which is used to simulate East Asian monsoon and oceanic elements in East Asian coastal waters. The simulated surface layer oceanic elements are basically consistent with the reality and can reflect the interaction between the monsoon and the surface layer currents. The great difference with the reality is 'cold drift' of the simulated surface temperature. The coupled model hascertain ability to simulate the atmosphere geopotential height fields, precipitation and low-level southwest wind from May to August in 1998. It can display the process of summer monsoon onset during the third dekad of May and the evolution features after the onset. The differences between the simulation results of the coupled model and that of the single P-σ RCM are shown mainly in the low-level atmosphere and the model internal regions. | REN Xuejuan(任雪娟) QIAN Yongfu(钱永甫) | 2001 | Acta meteorologica Sinica2001，15，4： | 5 |
| 5 | Redefining the modular organization of the core Mediator complex显示文摘调停人建筑群在真核细胞的抄写的规定起一个必要作用。Saccharomyces cerevisiae 核心调停人包括 21 个子单元,它被组织成头,中间和尾巴模块。以前,头模块在底被分到一个不同稠密的领域,并且中间和尾巴模块被识别在头模块上面形成紧密的结构,它显然从许多生物化学、功能的研究与调查结果矛盾。这里,我们比较了核心调停人和它的 subcomplexes 的结构,头 + 的第一特别 3D 结构;中间的模块,它允许三个模块的一项不含糊的任务。而且,标记决定性地从不同模块指出四个调停人子单元的 nanogold 验证了模块化的赋值,头和中间的模块互相在回来上在合拢并且形成核心调停人的上面的部分,当尾巴模块在库形成不同的稠密的域时。核心调停人的新模块化的模型调解了在在结构上之间的以前的矛盾并且机能上地定义调停人模块。一起,这些分析完全重新定义核心调停人的模块化的组织,它允许我们在抄写开始为调停人的模块化和规定把结构、功能的信息集成到协调机制。 | Xuejuan Wang Qianqian Sun Zhenrui Ding Jinhua Ji Jianye Wang Xiao Kong Jianghong Yang Gang Cai | 2014 | Cell Research2014，24，7： | 5 |
| 6 | Prognostic value of interim ^(18)F-FDG PET/CT in diffuse large B-cell lymphoma显示文摘Objective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim 18F-FDG PET/CT after first-line treatment in patients with DLBCL. Methods: Thirty-two patients with DLBCL underwent baseline, interim and post-treatment 18F-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively. Results: Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim 18F-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival (PFS) rates were significantly different between the groups above and below SUV max cut-off value of 2.5 (P=0.039). No significant differences were found in the 2-year PFS rates if SUV max cut-off values were set as 2.0 and 3.0, respectively (P=0.360; P=0.113). Conclusions: Interim PET/CT could predict the prognosis of DLBCL patients with the SUV max cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion. | Zhitao Ying Xuejuan Wang Yuqin Song Wen Zheng Xiaopei Wang Yan Xie Ningjing Lin Meifeng Tu Lingyan Ping Weiping Liu Lijuan Deng Chen Zhang Zhi Yang Jun Zhu | 2013 | Chinese Journal of Cancer Research2013，25，1： | 4 |
| 7 | Atmospheric eddy anomalies associated with the wintertime North Pacific subtropical front strength and their influences on the seasonal-mean atmosphere显示文摘This study investigates transient eddy activity anomalies in the mid-latitude upper troposphere associated with intensity variability of the wintertime North Pacific subtropical front. Our results show that the meridional gradient of air temperature and baroclinic instability in the mid-latitude atmosphere become stronger as the subtropical front intensifies, and the mid-latitude westerly jet accelerates with barotropic structure. We further divide the mid-latitude atmospheric eddy activities into high-(2–7 days) and low-frequency(10–90 days) eddy activities according to their life periods. We find that, when the oceanic subtropical front intensifies, the high-frequency atmospheric eddy activity in the mid-latitudes strengthens while the low-frequency eddy activity weakens. The stronger high-frequency eddy activity tends to moderate the air temperature gradient and baroclinicity in the mid-latitudes. High-frequency eddy anomalies accelerate the westerly jet on the northern side and downstream of the westerly jet, and enhance the jet with equivalent barotropic structure. In contrast, the weaker low-frequency eddy activity has a negative contribution to zonal wind speed tendency and attenuates the zonal homogenization of the jet. The anomalous thermodynamic forcing of the low-frequency eddy activity helps maintain the meridional gradient of air temperature in the mid-troposphere. | WANG LiYing HU HaiBo YANG XunQun REN XueJuan | 2016 | Science China Earth Sciences2016，59，10： | 4 |
| 8 | Jurassic Black Shales Facies from Qiangtang Basin (Northern Tibet): Rare Earth and Trace Elements for Paleoceanographic Implications显示文摘The Biluo Co and Amdo 114 station, northern Tibet, cropping out the Early Toarcian and Middle-Late Tithonian (Jurassic) organic-rich black shales, have been a focus to petroleum geologists in discussing their oil-producing potential. This paper first reports the trace elements and rare earth elements to discuss the paleoenvironments, redox conditions and sedimentary mechanisms of those black shales. Both sections exhibit variation in trace element abundances with concentrations <0.1 ppm to 760 ppm, mostly enriched in V, Cr, Ni, Cu, Zn, Mo, Ba and U. Element ratios of Ni/Co, V/Cr, U/Th and V/(V+Ni) plus U were used to identify redox conditions. The shale-normalized rare earth element (REE) patterns are characterized by the flat-shale type with instable Ce anomalies and very weekly positive Eu anomalies. Positive Ceanom values are significant with values varying between - 0.064 and 0.029 in Biluo Co, which may be interpreted as release of REE and input of riverine terrestrial matter with rich Ce (resulting in pH change) during the anoxic conditions. In the middle parts of Amdo 114 station, distinct negative Ceanom values are observed (-0.238 to -0.111) and associated surface water warming were interpreted as being related to a major sea level rise. In contrast, the formation of the black shales in the lower and upper part of the studied succession took place during a cooler (Ceanom values >-0.10), lower surface water productivity, and lower sea-level stage. Thus, we emphasize the role of different factors that control the formation of local and regional black shales. The most important factors are sea-level fluctuations and increasing productivity. | CHEN Lan YI Haisheng TSAI Louis Loung-Yie XU Guiwen DA Xuejuan LIN Andrew Tien-Shun | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 4 |
| 9 | Prognostic value of pre-and post-transplantation 18F-fluorodeoxyglucose positron emission tomography results in non-Hodgkin lymphoma patients receiving autologous stem cell transplantation显示文摘Objective: High-dose chemotherapy(HDC) followed by autologous stem cell transplantation(ASCT) is the standard of care in the upfront or relapsed/refractory setting in some patients with non-Hodgkin lymphoma(NHL).However,a proportion of patients do not respond to ASCT.^(18)F-fluorodeoxyglucose(FDG) positron emission tomography(PET)/computed tomography(CT) has been widely used for staging,response evaluation,and prognosis prediction.Here,we investigated the prognostic role of PET/CT in NHL patients before and after ASCT.Methods: A retrospective study was conducted at Peking University Cancer Hospital.All NHL patients who underwent ASCT between March 2010 and July 2016 were identified.Patients who had PET/CT scan before and after ASCT were included.Deauville criteria(5-point scale) were used to interpret PET scans.Univariate and multivariate survival analyses were performed using Cox regression.The predictive value of PET scanning was estimated by comparing the area under the receiver operating characteristic(ROC) curve.Results: In total,79 patients were enrolled in this study.In univariate analysis,pre-and post-ASCT PET result was identified as prognostic factors for 3-year progression-free survival(PFS) and overall survival(OS).Patients with negative pre-ASCT PET result demonstrated significantly better PFS(84.2% vs.54.2%) and OS(89.2% vs.63.6%) than patients with positive pre-ASCT PET result.PFS(91.6% vs.25.3%) and OS(96.5% vs.36.8%) were also significantly different between patients with negative and positive post-ASCT PET result.Multivariate analysis also showed a significant association between survival and post-ASCT PET result.ROC analysis revealed that the predictive value of post-ASCT PET result was superior to that of pre-ASCT PET result alone.Combined pre-and post-ASCT PET result is better for predicting outcomes in patients with NHL receiving transplantation.Deauville criteria score >3 was identified as the best cutoff value for post-ASCT PET.Conclusions: Post-ASCT PET result was more important than pre-ASCT PET result in predicting outcomes for NHL patients who underwent ASCT.The prognostic significance can be improved when combining preASCT PET result with post-ASCT PET result.Deauville criteria can be used for interpreting PET scans in this scenario. | Zhitao Ying Lan Mi Xuejuan Wang Yuewei Zhang Zhi Yang Yuqin Song Xiaopei Wang WenZheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu LijuanDeng Jun Zhu | 2017 | Chinese Journal of Cancer Research2017，29，6： | 3 |
| 10 | Perturbation characteristics of ambient sea noise caused by submerged objects显示文摘沉没目标散布引起的周围的海噪音地的不安特征理论上被讨论。与Gaussian关联振幅基于海噪音来源模型,并且使用不可分的表达式因为任意的来源分发和格林的球形的波浪表达式在一半无限的空格为单极工作,直接到达的噪音域的表达式,在单极和偶极子的照耀下面散布域和一个僵硬球形的对象的全部的噪音域采购原料,以及在在二收到的那些噪音域之中的协变性指被获得。散布僵硬球形的目标和可见性的方向性的模式的数字结果被给。全部的噪音地被目标,接收装置的方向,而且在在直接到达、散布的地之间的表面来源,和干扰之间的关联的不仅阻抗特征极大地影响,这被显示出。一个僵硬球形的目标的健全可见性关于在近的范围和在表面来源的照耀下面的一个僵硬球形的目标的散布择向性特征的 4-5 dB 的结果表演与飞机波浪发生的那些不同。 | LIN Jianheng YI Xuejuan YIN Baoyou GUO Shengming | 2010 | Chinese Journal of Acoustics2010，29，2： | 3 |
| 11 | Subseasonal Zonal Oscillation of the Western Pacific Subtropical High during Early Summer显示文摘This study examines the features and dynamical processes of subseasonal zonal oscillation of the western Pacific subtropical high(WPSH) during early summer, by performing a multivariate empirical orthogonal function(MVEOF) analysis on daily winds and a diagnosis on potential vorticity(PV) at 500 hPa for the period 1979–2016. The first MV-EOF mode is characterized by an anticyclonic anomaly occupying southeastern China to subtropical western North Pacific regions. It has a period of 10–25 days and represents zonal shift of the WPSH. When the WPSH stretches more westward, the South Asian high(SAH) extends more eastward. Above-normal precipitation is observed over the Yangtze–Huaihe River(YHR) basin. Suppressed convection with anomalous descending motion is located over the subtropical western North Pacific. The relative zonal movement of the SAH and the WPSH helps to establish an anomalous local vertical circulation of ascending motion with upper-level divergence over the YHR basin and descending motion with upper-level convergence over the subtropical western Pacific. The above local vertical circulation provides a dynamic condition for persistent rainfall over the YHR basin. An enhanced southwest flow over the WPSH's western edge transports more moisture to eastern China, providing a necessary water vapor condition for the persistent rainfall over the YHR basin. A potential vorticity diagnosis reveals that anomalous diabatic heating is a main source for PV generation. The anomalous cooling over the subtropical western Pacific produces a local negative PV center at 500 hPa. The anomalous heating over the YHR basin generates a local positive PV center. The above south–north dipolar structure of PV anomaly along with the climatological southerly flow leads to northward advection of negative PV. These two processes are conducive to the WPSH's westward extension. The vertical advection process is unfavorable to the westward extension but contributes to the eastward retreat of the WPSH. | Weina GUAN Xuejuan REN Wei SHANG Haibo HU | 2018 | Journal of Meteorological Research2018，32，5： | 3 |
| 12 | Characterization of major water-soluble inorganic ions in size-fractionated particulate matters in Shanghai campus ambient air显示文摘 | Guangli Xiu Danian Zhang Jizhang Chen Xuejuan Huang Zhixiang Chen Honglian Guo Jinfang Pan | 2003 | Atmospheric Environment2003，，2： | 2 |
| 13 | A 18FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer显示文摘Objective: The present study investigated the prognosis value of preoperative fluorodeoxyglucose(FDG)positron emission tomography/computed tomography(PET/CT) in patients with local advanced gastric cancer(LAGC).Methods: In total, 144 patients [median age 63(range: 48-80) years old] with LAGC underwent 18 F-FDG PET/CT prior to any treatment. The maximum standardized uptake values(SUVmax), mean standardized uptake values(SUVmean), metabolic tumor volume(MTV) and total lesion glycolysis(TLG) of the primary lesion were measured on PET/CT and correlated with clinicopathological features and survival.Results: Significant differences in SUVmean, SUVmax, MTV and TLG were found according to Lauren’s classification, histologic grade and T category(P<0.05). During the 26.5-month follow-up, 51(35.4%) patients died and 70(48.6%) exhibited disease progression. The optimal thresholds of MTV and TLG were 15.1 cm^3 and 47.3 cm^3, respectively. The 3-year progression-free survival(PFS) and overall survival(OS) for patients with high TLG values were 30% and 38% compared to 38% and 47% for low TLG values, respectively(P<0.05). Univariate and multifactor analyses demonstrated that lymph node metastasis and T stage were independent prognostic factors for PFS;T stage, histologic grade and TLG were independent prognostic factors for OS(P<0.05). Molecular markers had no relationship with patient’s outcomes.Conclusions: Metabolic activity of primary gastric tumors from 18 F-FDG PET/CT is a prognostic factor in patients with LAGC. | Jinling Song Zhongwu Li Puyun Chen Jiangyuan Yu Feng Wang Zhi Yang Xuejuan Wang | 2019 | Chinese Journal of Cancer Research2019，31，4： | 2 |
| 14 | Facile synthesis of dendrimer-like star-branched poly(isopropylacrylamide) via combination of click chemistry and atom transfer radical polymerization显示文摘We report a facile synthesis method of dendrimer-like star-branched poly(N-isopropylacrylamide) (PNIPAM) via the combination of click chemistry and atom transfer radical polymerization (ATRP) by employing the arm-first approach.First,the α-azido-ω-chloro-heterodifunctionalized building block,N3-PNIPAM-Cl (G0-Cl),was synthesized via ATRP by 3-azidopropyl 2-chloropropionate as the initiator.Taking advantage of click chemistry,the first generation (G1) of dendrimer-like star-branched PNIPAM,G1-(Cl)3,was facilely prepared via the click coupling reaction between G0-Cl and tripropargylamine.For the construction of second generation (G2) dendrimer-like star-branched PNIPAM,G2-(Cl)6,terminal chloride moieties of G1-(Cl)3 were first converted to azide,and then reacted with excess tripropargylamine to give G1-(alkynyl)6 ;G2-(Cl)6 was subsequently prepared via click reaction between G1-(alkynyl) 6 and G0-Cl.Gel permeation chromatography (GPC) and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry were employed to confirm the successful construction of dendrimer-like star-branched polymers.The unique thermal phase transition behavior of this dendrimer-like star-branched polymer in aqueous solutions was further investigated by turbidimetry and micro-differential scanning calorimetry (Micro-DSC). | WAN XueJuan,XU Jian & LIU ShiYong CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering,Hefei National Laboratory for Physical Sciences at the Microscale,University of Science and Technology of China,Hefei 230026,China | 2010 | Science China Chemistry2010，53，12： | 2 |
| 15 | Preclinical characterization and validation of a dual-labeled trastuzumab-based imaging agent for diagnosing breast cancer显示文摘Objective: The combination of both nuclear and fluorescent reporters provides unique opportunities for noninvasive nuclear imaging with subsequent fluorescence image-guided resection and pathology. Our objective was to synthesize and optimize a dual-labeled trastuzumab-based imaging agent that can be used to validate an optical imaging agent with potential use in identifying tumor metastases in human epidermal growth factor receptor 2(HER2) positive breast cancer patients.Methods: [111In]-DTPA-trastuzumab-IRDye 800 was synthesized by a three-step procedure. Purity, stability, immunoreactivity, internalization and biodistribution were explored in HER2+ SKBR-3 cells. Biodistribution of [111In]-DTPA-trastuzumab-IRDye 800 was performed in a SKBR-3 xenograft model.Results: [111In]-DTPA-trastuzumab-IRDye 800 demonstrated high purity by both chemical and fluorometric determinations. Both flow cytometry and the Lindmo assay demonstrated a high binding affinity of [111In]-DTPA-trastuzumab-IRDye 800 to HER2-overexpressing cells. The dual-labeled conjugate was stable in PBS, but not in serum after 24 h at 37 ℃. Larger molecules(>150 k D) were seen after a 24 h-incubation in human serum. Biodistribution studies revealed tumor-specific accumulation of [111In]-DTPAtrastuzumab-IRDye 800 in SKBR-3 tumors, and tumor uptakes at 24 and 48 h were(12.42±1.72)% and(9.96±1.05)%, respectively, following intravenous administration. The tumor-to-muscle ratio was 9.13±1.68 at 24 h, and increased to 12.79±2.13 at 48 h. Liver and kidney showed marked uptake of the dual-labeled imaging agent.Conclusions: [111In]-DTPA-trastuzumab-IRDye 800 is an effective diagnostic biomarker that can be used to validate dual-labeled, molecularly targeted imaging agents and can allow these agents to be translated into clinical practice for identifying HER2+ lesions. | Xuejuan Wang Melissa B. Aldrich Milton V. Marshall Eva M. Sevick-Muraca | 2015 | Chinese Journal of Cancer Research2015，27，1： | 2 |
| 16 | Chemo-and Biostratigraphy of the Jurassic Oil Shales from the Qiangtang Basin,Northern Tibet,China:A Case Study of the Toarcian Oceanic Anoxic Event显示文摘The marine oil shales of the Qiangtang Basin, northern Tibet, exposed in the Biluo Co, Tuonamu, Shenglihe and Changsheshan areas are believed to be important petroleum source rocks. This work comprehensively analyzed the carbon isotopes, trace elements, and calcareous nannofosills, ammonites and bivalves of the Biluo Co section in the Qiangtang Basin. The organic carbon isotopes show a positive excursion close to 2.17‰(relative to PDB), which, albeit significantly smaller, may also be associated with other Early Toarcian Oceanic Anoxic Events(T-OAE) in the European epicontinental seas and the Tethyan continental margins. Coinciding with the Early Toarcian transgression, the oxygen deficiency in bottom water had led to dysoxic-anoxic conditions and deposition of black shales lacking benthic fauna. Under such condition, the redox-sensitive trace metals such as Mo, V, Ni, Cr, and U were enriched, in conjunction with high planktonic productivity of Watznaueriaceae calcareous nannofossils. Comparison of the results with the records of chemo-and biostratigraphy, as well as the palaeogeography during the Early Jurassic suggests that the anoxia linked to the Early Toarcian oceanic anoxic event was mainly caused by the high surface water temperature, sea-level rise and an increase of surface water productivity. | CHEN Lan XU Guiwen DA Xuejuan YI Haisheng ZHU Zhangxiong HUANG Zhaohui LI Xiaogang | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 2 |
| 17 | Sources,dynamics in vivo,and application of astaxanthin and lutein in laying hens:A review显示文摘Astaxanthin(Ax)and lutein are important fat-soluble pigments and essential nutrients for human and animal health.Haematococcus pluvialis microalga and Phaffia rhodozyma yeast are ideal species for commercial Ax production.Marigold flowers are a main source of commercial lutein.Dynamics of dietary Ax and lutein in the gastrointestinal tract are similar to lipids,but their activities are tremendously challenged by many physiological and dietary factors;few data are available about these in poultry.Dietary Ax and lutein have insignificant effects on egg production and egg physical properties,but have pronounced effects on yolk color,nutrition,and functionality.The two pigments can also enhance antioxidative capacity and immune function of laying hens.A few studies have shown that Ax and lutein can improve fertilization and hatchability of laying hens.Considering the pigmentation and health benefits of Ax and lutein from hen feed to human food,the commercial availability,chicken yolk improvement,and immune function of Ax and lutein are the focuses of this review.The potential roles of carotenoids in the cytokine storm and gut microbiota are also briefly presented.The bioavailability,metabolism,and deposition of Ax and lutein in laying hens are suggested for future research. | Hanyi Shi Xuejuan Deng Xiaoyu Ji Ning Liu Huiyi Cai | 2023 | Animal Nutrition2023，，2： | 2 |
| 18 | Geometric attack resistant image watermarking based on MSER显示文摘 | Xuejuan ZHANG Xiaochun CAO Jingjie LI | 2013 | Frontiers of Computer Science2013，7，1： | 2 |
| 19 | Structure and functional interactions of IN080 actin/Arp module显示文摘The presence and functions of nuclear actin have been controversial due to the lack of molecular mechanisms.Nuclear actin and actin?『elated proteins (Arps) are subunits of several chromatin remodelers, including the evolutionarily conserved IN080 chromatin-remodeling complex. Here, we present an improved cryo-EM structure of the yeast IN080 complex and the first 3D reconstruction of the IN080 actin/Arp module.The modular and subunit architecture is defined using a combination of subunit deletion analysis and published crosslinking-mass spectrometry. The functional interactions of the IN080 actin/Arp module with a nucleosome is 3D EM reconstructed in two different binding states. Nucleosomes initially bind to the Arp8 subunit and the substantial conformational changes maximize nucleosome contacts of the actin/Arp module, which could promote the bound nucleosome to be engaged onto the IN080 ATPase domain. Our findings suggest that the conserved nuclear actin/Arp module acts a conformational switch of the IN080 for nucleosome binding. | Xuan Zhang Xuejuan Wang Zhihui Zhang Gang Cai | 2019 | Journal of Molecular Cell Biology2019，11，5： | 2 |
| 20 | Prognostic value of ^(18)F-fluorodeoxyglucose positron emission tomography using Deauville criteria in diffuse large B cell lymphoma treated with autologous hematopoietic stem cell transplantation显示文摘Objective: High-dose chemotherapy(HDC) followed by autologous hematopoietic stem cell transplantation(auto-HSCT) plays an important role in improving outcomes of diffuse large B cell lymphoma(DLBCL) patients.18 F-fluorodeoxyglucose(18 F-FDG) positron emission tomography(PET)/computed tomography(CT) has been widely accepted in response assessment and prediction of prognosis in DLBCL. Here, we report the value of 18 FFDG PET/CT pre-and post-HSCT in predicting outcomes of patients with DLBCL.Methods: DLBCL patients who had PET/CT scan before and after HSCT were included. PET results were interpreted based upon Deauville criteria. The prognostic value of 18 F-FDG PET/CT in auto-HSCT was evaluated.Results: Eighty-four patients were enrolled. In univariate analysis, pre-and post-HSCT PET findings were correlated with 3-year progression-free survival(PFS) [hazard ratio(HR)=4.391, P=0.001; HR=7.607, P<0.001] and overall survival(OS)(HR=4.792, P=0.008; HR=26.138, P<0.001). Patients receiving upfront auto-HSCT after firstline treatment had better outcomes than relapsed/refractory DLBCL patients(3-year PFS, P<0.001; 3-year OS,P<0.001). In the relapsed/refractory patients, pre-and post-HSCT PET findings were also associated with 3-year PFS(P=0.003 vs. P<0.001) and OS(P=0.027 vs. P<0.001). A significant correlation was observed between clinical response to chemotherapy before auto-HSCT and outcomes of patients in the entire cohort(3-year PFS, P<0.001;3-year OS, P<0.001) and in the subgroup of 21 patients with positive pre-HSCT PET(3-year PFS, P=0.084; 3-year OS, P=0.240). A significant association between survival and post-HSCT PET findings was observed in multivariate analysis(HR=5.168, P<0.001).Conclusions: PET results before and after HSCT are useful prognostic factors for DLBCL patients receiving HSCT. Patients who responded to chemotherapy, even those with positive pre-HSCT PET, are appropriate candidates for auto-HSCT. | Zhitao Ying Lan Mi Nina Zhou Xuejuan Wang Zhi Yang Yuqin Song Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu Lijuan Deng Jun Zhu | 2019 | Chinese Journal of Cancer Research2019，31，1： | 2 |
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