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| 1 | Up-conversion fluorescence biosensor for sensitive detection of CA-125 tumor markers显示文摘Sensitive and specific bioassays of tumor markers are critical for early cancer detection and treatment.In recent years,lanthanide(Ln3+)doped upconversion nanoparticles(UCNPs)have attracted wide attentions in tumor markers detectio n.Herein,we co mbined NaYF4:Yb,Tm and silver nanoparticles,serving as energy donor and receptor,respectively,to form an up-conversion fluorescence based inhibitory tumor marker biosensor system.The tumor marker CA-125 molecules are labeled with silver NPs,and the energy transfer fluorescent signal can be detected between the UCNPs and the silver NP receptors.The biosensor shows good stability,high sensitivity and selectivity in the tumor marker concentration range from 5 to 100 ng/mL,as well as a detection limit of 120 pg/mL.Due to the advantage of ease of fabrication and operation,low cost and high information capacity,this technology holds great potential for the clinical applications. | Jingshi Liu Sai Xu Liheng Sun Songtao Hu Jiao Sun Min Liu Cui Ma Haipeng Liu Ziqing Wang Ying Yang Biao Dong Decheng Hong | 2019 | Journal of Rare Earths2019，37，9： | 3 |
| 2 | Multifunctional microcapsules:A theranostic agent for US/MR/PAT multi-modality imaging and synergistic chemo-photothermal osteosarcoma therapy显示文摘Development of versatile theranostic agents that simultaneously integrate therapeutic and diagnostic features remains a clinical urgent.Herein,we aimed to prepare uniform PEGylated(lactic-co-glycolic acid)(PLGA)microcapsules(PB@(Fe_(3)O_(4)@PEG-PLGA)MCs)with superparamagnetic Fe3O4 nanoparticles embedded in the shell and Prussian blue(PB)NPs inbuilt in the cavity via a premix membrane emulsification(PME)method.On account of the eligible geometry and multiple load capacity,these MCs could be used as efficient multi-modality contrast agents to simultaneously enhance the contrasts of US,MR and PAT imaging.In-built PB NPs furnished the MCs with excellent photothermal conversion property and embedded Fe_(3)O_(4)NPs endowed the magnetic location for fabrication of targeted drug delivery system.Notably,after further in-situ encapsulation of antitumor drug of DOX,(PB+DOX)@(Fe_(3)O_(4)@PEG-PLGA)MCs possessed more unique advantages on achieving near infrared(NIR)-responsive drug delivery and magnetic-guided chemo-photothermal synergistic osteosarcoma therapy.In vitro and in vivo studies revealed these biocompatible(PB+DOX)@(Fe_(3)O_(4)@PEG-PLGA)MCs could effectively target to the tumor tissue with superior therapeutic effect against the invasion of osteosarcoma and alleviation of osteolytic lesions,which will be developed as a smart platform integrating multi-modality imaging capabilities and synergistic effect with high therapy efficacy. | Hufei Wang Sijia Xu Daoyang Fan Xiaowen Geng Guang Zhi Decheng Wu Hong Shen Fei Yang Xiao Zhou Xing Wang | 2022 | Bioactive Materials2022，7，1： | 2 |
| 3 | Construction of versatile multilayered composite nanoparticles from a customized nanogel template显示文摘We present a highly adaptable design platform for multi-responsive,multilayered composite nanoparticles(MC-NPs)with fine-tunable functional layers.A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method,enabling a high degree of control over each successive layer.From this template,we optimize“smart”biomaterials with biofunctional surfaces,tunable drug release kinetics,and magnetic or pH-responsive functionality,fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo.Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics. | Jian Zhang Jinpeng Jia Jimin P.Kim Fei Yang Xing Wang Hong Shen Sijia Xu Jian Yang Decheng Wu | 2018 | Bioactive Materials2018，3，1： | 1 |
| 4 | Multiwalled carbon nanotube grafted with hyperbranehed polymer shell viaSCVP 显示文摘 | Hong Chunyan You Yezi Wu Decheng | 2005 | Maeremoleeules2005，38，7： | 1 |
| 5 | Research and Implementation of FTAM File Transfer System显示文摘ResearchandImplementationofFTAMFileTransferSystemCaoYangColegeofElectronicInformation,WuhanUniversity,Wuhan430072,ChinaWuKui,... | Shi Jing Xia Haibo Tang Wufang Tian Decheng Qing Xiaokui Chen Hong | 1997 | Wuhan University Journal of Natural Sciences1997，2，2： | 0 |
| 6 | Two tandem multicomponent reactions for the synthesis of sequence-defined polymers显示文摘Multicomponent polymerizations have become powerful tools for the construction of sequence-defined polymers. Although the Passerini multicomponent reaction has been widely used in the synthesis of sequence-defined polymers, the tandem usage of the Passerini multicomponent reaction and other multicomponent reactions in one-pot for the synthesis of sequence-defined polymers has not been developed until now. In this contribution, we report the tandem usage of the Passerini three-component reaction and the three-component amine-thiol-ene conjugation reaction in one pot for the synthesis of sequence-defined polymers. The Passerini reaction between methacrylic acid, adipaldehyde, and 2-isocyanobutanoate was carried out, affording a new molecule containing two alkene units. Subsequently, an amine and a thiolactone were added to the reaction system, whereupon the three-component amine-thiol-ene conjugating reaction occurred to yield a sequence-defined polymer. This method offers more rapid access to sequence-defined polymers with high molecular diversity and complexity. | Lu Yang Ze Zhang Bofei Cheng Yezi You Decheng Wu Chunyan Hong | 2015 | Science China Chemistry2015，58，11： | 0 |
| 7 | Synergistic control of dual cross-linking strategy toward tailor-made hydrogels显示文摘Simple, efficient and accurate controllable systems for materials are becoming more essential, in response to the explosively growing demands in the fields of chemistry and material science. Herein, tailored hydrogels are explored depending on synergistic regulation of p H-responsive chemical networks with an 'on/off' function and physical networks with dynamic selfoptimized arrangement. Thiol-disulfide exchange reaction endows hydrogels with controlled architectures while hydrogen bondstrengthened 2-ureido-4[1H]-pyrimidinone(UPy) moieties contributes a significant increase in mechanical strengths. The integration of that dual cross-linking(DC) network ensures the hydrogels with customized structure and enhanced mechanical property. Such controllably strategy is universally applicable and will open a new avenue to flexibly fabricate desired hybrid hydrogels with distinctive features and functions for their potential applications. | Xueyu Dou Qingchen Cao Feifei Sun Yaqiang Wang Hufei Wang Hong Shen Fei Yang Xing Wang Decheng Wu | 2020 | Science China Chemistry2020，63，12： | 0 |
| 8 | In situ Injectable Tetra-PEG Hydrogel Bioadhesive for Sutureless Repair of Gastrointestinal Perforation显示文摘Hydrogel bioadhesives represent promising and efficient alternatives to sutures or staples for gastrointestinal(GI)perforation management.However,several concerns remain for the existing bioadhesives including slow and/or weak adhesive,poor mechanical strength,low biocompatibility,and poor biodegradability,which largely limit their clinical application in GI perforation repair.In this work,we introduce an in situ injectable Tetra-PEG hydrogel bioadhesive(SS)composed of tetra-armed poly(ethylene glycol)amine(Tetra-PEG-NH2)and tetra-armed poly(ethylene glycol)succinimidyl succinate(Tetra-PEG-SS)for the sutureless repair of GI defects.The SS hydrogel exhibits rapid gelation behavior and high burst pressure and is capable of providing instant robust adhesion and fluid-tight sealing in the ex vivo porcine intestinal and gastric models.Importantly,the succinyl ester linkers in the SS hydrogel endow the bioadhesive with suitable in vivo degradability to match the new GI tissue formation.The in vivo evaluation in the rat GI injured model further demonstrates the successful sutureless sealing and repair of the intestine and stomach by the SS hydrogel with the advantages of neglectable postsurgical adhesion,suppressed inflammation,and enhanced angiogenesis.Together,our results support potential clinical applications of the SS bioadhesive for the high-efficient repair of GI perforation. | Shurong Li Yiwen Xian Gang He Luyuan Chen Zhihui Chen Yonglong Hong Chong Zhang Decheng Wu | 2023 | Chinese Journal of Chemistry2023，41，23： | 0 |
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