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| 1 | Effects of tourmaline on nitrogen removal performance and biofilm structures in the sequencing batch biofilm reactor显示文摘The effects of tourmaline on nitrogen removal performance and biofilm structures were comparatively investigated in two identical laboratory-scale sequencing batch biofilm reactors(SBBRs)(denoted SBBR1 and SBBR2) at different nitrogen loading rates(NLRs) varying from(0.24 ± 0.01) to(1.26 ± 0.02) g N/(L·day). SBBR1 was operated in parallel with SBBR2, but SBBR1 was filled with polyurethane foam loaded tourmaline(TPU) carriers and another(SBBR2) filled with polyurethane foam(PU) carriers. Results obtained from this study showed that the excellent and stable performance of SBBR1 was obtained. Ammonia nitrogen removal and total nitrogen removal were higher in SBBR1 than that in SBBR2 with increase of NLR. At an NLR of(0.24 ± 0.01) g N/(L·day), the majority of the spherical and elliptical bacteria were surrounded by the extracellular polymeric substance(EPS) and bacillus or filamentous bacteria in two SBBRs biofilms. When NLR increased to(1.26 ± 0.02) g N/(L·day), the clusters were more obvious in the SBBR1 biofilm than that in the SBBR2 biofilm. Bacteria in SBBR1 were inclined to synthesis more EPS, and the formed EPS could protect the bacteria from free ammonia(FA) under extreme condition NLR(1.26 ± 0.02) g N/(L·day). The results of polymerase chain reaction-denaturing gradient gel electrophoresis analysis showed that the microbial community similarity in SBBR2 decreased more obviously than that in SBBR1 with the increase of NLR, which the microbial community in SBBR1 was relatively stable. | Chong Tan Haoran Xu Di Cui Jinlong Zuo Junsheng Li Yubin Ji Shan Qiu Lin Yao Ying Chen Yingjie Liu | 2018 | Journal of Environmental Sciences2018，30，5： | 10 |
| 2 | 国产清梳联的发展现状及展望显示文摘根据国产清梳联的几种主要模式、流程特点、主要质量指标水平、运行稳定性、生产环境等问题,说明国产清梳联日臻成熟。并且简述了当前国产清梳联的技术动态;提出了促进国产清梳联发展的六条具体建议。 | Zuo Di (Shandong Textile Industry Department) | 1998 | 棉纺织技术1998，26，2： | 8 |
| 3 | Design of a Carbon Nanotube/Magnetic Nanoparticle-Based Peroxidase-Like Nanocomplex and Its Application for Highly Efficient Catalytic Oxidation of Phenols显示文摘We report a novel nanotechnology-based approach for the highly efficient catalytic oxidation of phenols and their removal from wastewater.We use a nanocomplex made of multi-walled carbon nanotubes(MWNTs)and magnetic nanoparticles(MNPs).This nanocomplex retains the magnetic properties of individual MNPs and can be effectively separated under an external magnetic fi eld.More importantly,the formation of the nanocomplex enhances the intrinsic peroxidase-like activity of the MNPs that can catalyze the reduction of hydrogen peroxide(H2O2).Significantly,in the presence of H2O2,this nanocomplex catalyzes the oxidation of phenols with high effi ciency,generating insoluble polyaromatic products that can be readily separated from water. | Xiaolei Zuo Cheng Peng Qing Huang Shiping Song Lihua Wang Di Li Chunhai Fan | 2009 | Nano Research2009，2，8： | 8 |
| 4 | The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling显示文摘Dry eye disease(DED)is a multifactorial disorder of the tears and ocular surface characterized by manifestations of dryness and irritation.Although the pathogenesis is not fully illuminated,it is recognized that inflammation has a prominent role in the development and deterioration of DED.β-aminoarteether maleate(SM934)is a water-soluble artemisinin derivative with antiinflammatory and immunosuppressive activities.In this study,we established scopolamine hydrobromide(SCOP)-induced rodent model as well as benzalkonium chloride(BAC)-induced rat model to investigate the therapeutic potential of SM934 for DED.We showed that topical application of SM934(0.1%,0.5%)significantly increased tear secretion,maintained the number of conjunctival goblet cells,reduced corneal damage,and decreased the levels of inflammatory mediators(TNF-α,IL-6,IL-10,or IL-1β)in conjunctiva in SCOP-induced and BAC-induced DED models.Moreover,SM934 treatment reduced the accumulation of TLR4-expressing macrophages in conjunctiva,and suppressed the expression of inflammasome components,i.e.,myeloid differentiation factor88(MyD88),Nod-like receptor protein 3(NLRP3),apoptosis-associated speck-like protein containing CARD(ASC),and cleaved caspase 1.In LPS-treated RAW 264.7 cells,we demonstrated that pretreatment with SM934(10μM)impeded the upregulation of TLR4 and downstream NF-κB/NLRP3 signaling proteins.Collectively,artemisinin analog SM934 exerts therapeutic benefits on DED by simultaneously reserving the structural integrity of ocular surface and preventing the corneal and conjunctival inflammation,suggested a further application of SM934 in ophthalmic therapy,especially for DED. | Fang-ming Yang Di Fan Xiao-qian Yang Feng-hua Zhu Mei-juan Shao Qian Li Yu-ting Liu Ze-min Lin Shi-qi Cao Wei Tang Shi-jun He Jian-ping Zuo | 2021 | Acta Pharmacologica Sinica2021，42，4： | 7 |
| 5 | Uncertainty-optimized deep learning model for small-scale person re-identification显示文摘In recent years, deep learning has developed rapidly and is widely used in various fields, such as computer vision, speech recognition, and natural language processing. For end-to-end person re-identification,most deep learning methods rely on large-scale datasets. Relatively few methods work with small-scale datasets. Insufficient training samples will affect neural network accuracy significantly. This problem limits the practical application of person re-identification. For small-scale person re-identification, the uncertainty of person representation and the overfitting problem associated with deep learning remain to be solved.Quantifying the uncertainty is difficult owing to complex network structures and the large number of hyperparameters. In this study, we consider the uncertainty of pedestrian representation for small-scale person re-identification. To reduce the impact of uncertain person representations, we transform parameters into distributions and conduct multiple sampling by using multilevel dropout in a testing process. We design an improved Monte Carlo strategy that considers both the average distance and shortest distance for matching and ranking. When compared with state-of-the-art methods, the proposed method significantly improve accuracy on two small-scale person re-identification datasets and is robust on four large-scale datasets. | Cairong ZHAO Kang CHEN Di ZANG Zhaoxiang ZHANG Wangmeng ZUO Duoqian MIAO | 2019 | Science China(Information Sciences)2019，62，12： | 6 |
| 6 | Loss of Wip1 aggravates brain injury after ischaemia/reperfusion by overactivating microglia显示文摘Background and purpose The inflammatory response mediated by microglia/macrophages is closely related to cerebral ischaemia/reperfusion injury.Wild-type p53-induced protein phosphatase 1(Wip1),a serine/threonine phosphatase,is expressed in various tissues.A growing number of reports have suggested that Wip1 is a negative regulator of inflammation in peripheral tissue;however,its role in the central nervous system(CNS)remains unclear.This study aimed to clarify whether Wip1 can inhibit CNS inflammation by regulating microglia/macrophage functions after ischaemic injury.Methods A model of middle cerebral artery occlusion and reperfusion was established in mice.CNS inflammation was simulated by lipopolysaccharide treatment of primary microglia.Laser speckle imaging was used to monitor regional cerebral blood flow.Behavioural outcomes were assessed with a TreadScan gait analysis system.TTC staining was used to evaluate the infarct volume,and western blotting and immunofluorescence staining were applied to detect the phenotypical transformation of microglia.ELISA was performed to detect the levels of inflammatory factors.Results Wip1 expression was increased after ischaemia/reperfusion.Wip1-knockout(KO)mice displayed more severe brain injury than wild-type mice,as indicated by aggravated motor dysfunction,greater brain infarct volumes and higher expression of inflammatory cytokines(interleukin-6 and tumour necrosis factor alpha)in the brain.We also found that Wip1 depletion increased microglial/macrophage activation in both in vitro and in vivo models,which all showed activation of microglia/macrophages.Lentivirus-Ppm1d reversed the injury induced by Wip1-KO.Conclusions Our results suggest that Wip1 may inhibit neuroinflammation by inhibiting microglial/macrophage activation after brain ischaemia/reperfusion injury. | Feng Yan Xiang Cheng Ming Zhao Shenghui Gong Ying Han Liping Ding Di Wu Yumin Luo Wei Zuo Lingling Zhu Ming Fan Xunming Ji | 2021 | Stroke & Vascular Neurology2021，6，3： | 4 |
| 7 | Controllable synthesis of nitrogen-doped porous carbon from metal-polluted miscanthus waste boosting for supercapacitors显示文摘High-value reclamation of metal-polluted plants involved in phytoremediation is a big challenge.In this study,nitrogen-doped nanoporous carbon with large specific area of 2359.1 m^(2)g^(-1) is facilely fabricated from metal-polluted miscanthus waste for efficient energy storage.The synergistic effect of KOH,urea and ammonia solution greatly improve the nitrogen quantity and surface area of the synthesized carbon.Electrodes fabricated with this carbon exhibit the excellent capacitance performance of 340.2 F g^(-1) at 0.5 A g^(-1) and a low combined resistance of 0.116Ω,which are competitive with most of previously reported carbon-based electrodes.In addition,the as-obtained carbon electrode shows a high specific capacitance retention of over 99.6%even after 5000 cycles.Furthermore,the symmetric supercapacitor fabricated using the synthesized carbon achieves a superior energy density of 25.3 Wh kg^(-1)(at 400 W kg^(-1))in 1 mol L^(-1) Na_(2)SO_(4)aqueous solution.This work provides an efficient route to upcycle metal-polluted plant waste for supercapacitor applications. | Zuo Chen Man Zhang Yuchen Wang Zhiyu Yang Di Hu Yetao Tang Kai Yan | 2021 | Green Energy & Environment2021，6，6： | 4 |
| 8 | Synthesis,structure and physical properties of the one-dimensional chain complex of tetrathiafulvalene carboxylate显示文摘A new Co(Ⅱ) coordination polymer bearing TTF carboxylate group, [{Co2(trioTTF)2(H2O)6}·5H2O]n (1) (trioTTF=2-(5,6,8,9,11,12,14,15-octahydro-[1,3]dithiolo[4,5-h][1,4,13,7,10]trioxadithiacyclopentadecin-2-ylidene)-1,3-dithiole-4,5-dicarboxylate), has been prepared and characterized. In the structure of 1, shorter intermolecular S····S contacts (3.565 △) are found between the trioTTF groups from neighboring chains. The electric conductivity of 1 is poor due to the bulky crown-ether group, but it exhibits ferromagnetic interaction at low temperature. | CHEN Ya LI ChengHui WANG CaiFeng WU Di ZUO JingLin YOU XiaoZeng | 2009 | Science China Chemistry2009，52，10： | 4 |
| 9 | A hybrid deep neural network based on multi-time window convolutional bidirectional LSTM for civil aircraft APU hazard identification显示文摘Safety is one of the important topics in the field of civil aviation. Auxiliary Power Unit(APU) is one of important components in aircraft, which provides electrical power and compressed air for aircraft. The hazards in APU are prone to cause economic losses and even casualties. So,actively identifying the hazards in APU before an accident occurs is necessary. In this paper, a Hybrid Deep Neural Network(HDNN) based on multi-time window convolutional neural network-Bidirectional Long Short-Term Memory(CNN-Bi LSTM) neural network is proposed for active hazard identification of APU in civil aircraft. In order to identify the risks caused by different types of failures, the proposed HDNN simultaneously integrates three CNN-Bi LSTM basic models with different time window sizes in parallel by using a fully connected neural network. The CNN-Bi LSTM basic model can automatically extract features representing the system state from the input data and learn the time information of irregular trends in the time series data. Nine benchmark models are compared with the proposed HDNN. The comparison results show that the proposed HDNN has the highest identification accuracy. The HDNN has the most stable identification performance for data with imbalanced samples. | Di ZHOU Xiao ZHUANG Hongfu ZUO | 2022 | Chinese Journal of Aeronautics2022，35，4： | 4 |
| 10 | Precipitation behaviors of X80 acicular ferrite pipeline steel显示文摘The precipitation behaviors of X80 acicular ferrite pipeline steel were investigated by using transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS). The results show that dendritic precipitates in the as-cast steel slabs precipitate mainly in grain boundaries, and these dendritic precipitates dissolve and re-precipitate to two kinds of carbonitrides: Ti- and Nb-rich (Ti, Nb)(C, N) carbonitrides during reheating. Four types of precipitates mainly exist in the hot rolled plate: Ti-rich carbonitrides resulted from the dendritic carbonitrides undissolved during the reheating process; Ti-rich carbonitrides re-precipitated along austenite grain boundaries during the re-heating process; NbC carbides mainly heterogeneously nucleated on the small pre-existing Nb-rich carbonitrides in the hot rolling process; and NbC carbides precipitated on dislocations during hot rolling. | Ai-min Zhao Yan Wang1 Yin-li Chen Di Tang Xu-tao Gao Bi-qiang Zuo | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，3： | 4 |
| 11 | Broadband mid-infrared molecular spectroscopy based on passive coherent optical–optical modulated frequency combs显示文摘Mid-infrared dual-comb spectroscopy is of great interest owing to the strong spectroscopic features of trace gases,biological molecules,and solid matter with higher resolution,accuracy,and acquisition speed. However,the prerequisite of achieving high coherence of optical sources with the use of bulk sophisticated control systems prevents their widespread use in field applications. Here we generate a highly mutually coherent dual midinfrared comb spectrometer based on the optical–optical modulation of a continuous-wave (CW) interband or quantum cascade laser. Mutual coherence was passively achieved without post-data processes or active carrier envelope phase-locking processes. The center wavelength of the generated mid-infrared frequency combs can be flexibly tuned by adjusting the wavelength of the CW seeds. The parallel detection of multiple molecular species,including C_(2)H_(2),CH_(4),H_(2)CO,H_(2)S,COS,and H_(2)O,was achieved. This technique provides a stable and robust dual-comb spectrometer that will find nonlaboratory applications including open-path atmospheric gas sensing,industrial process monitoring,and combustion. | ZHONG ZUO CHENGLIN GU DAOWANG PENG XING ZOU YUANFENG DI LIAN ZHOU DAPING LUO YANG LIU WENXUE LI | 2021 | Photonics Research2021，9，7： | 3 |
| 12 | Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice显示文摘Dear Editor,Hearing loss is the most common sensory disorder in the world.Among cases of non-syndromic hearing loss,which account for 70%of all cases of genetic hearing loss,around 80%of cases arise from autosomal recessive loss-of-function mutations that require repair,rather than disruption,of the mutant allele.1 CRISPR/Cas9-mediated homology-directed repair(HDR)-based therapies have the potential to cure many genetic diseases because this class of therapeutics can achieve arbitrary base changes as well as the insertion or deletion of DNA fragments/However. | Xi Gu Xinde Hu Daqi Wang Zhijiao Xu Fang Wang Di Li Geng-lin Li Hui Yang Huawei Li Erwei Zuo Yilai Shu | 2022 | Cell Research2022，32，7： | 3 |
| 13 | Rett syndrome-causing mutations compromise MeCP2- mediated liquid—liquid phase separation of chromatin显示文摘Rett syndrome(RTT),a severe postnatal neurodevelopmental disorder,is caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2(MeCP2).MeCP2 is a chromatin organizer regulating gene expression.RTT-causing mutations have been shown to affect this function.However,the mechanism by which MeCP2 organizes chromatin is unclear.In this study,we found that MeCP2 can induce compaction and liquid-liquid phase separation of nudeosomal arrays in vitro,and DNA methylation further enhances formation of chromatin condensates by MeCP2.Interestingly,RTT-causing mutations compromise MeCP2-mediated chromatin phase separation,while benign variants have little effect on this process.Moreover,MeCP2 competes with linker histone H1 to form mutually exclusive chromatin condensates in vitro and distinct heterochromatin foci in vivo.RTT-causing mutations reduce or even abolish the ability of MeCP2 to compete with histone H1 and to form chromatin condensates.Together,our results identify a novel mechanism by which phase separation underlies MeCP2-mediated heterochromatin formation and reveal the potential link between this process and the pathology of RTT. | Liang Wang Mingli Hu Mei-Qing Zuo Jicheng Zhao Di Wu Li Huang Yongxin Wen Yunfan Li Ping Chen Xinhua Bao Meng-Qiu Dong Guohong Li Pilong Li | 2020 | Cell Research2020，30，5： | 3 |
| 14 | Sevoflurane promotes migration,invasion,and colony-forming ability of human glioblastoma cells possibly via increasing the expression of cell surface protein 44显示文摘Surgical resection of primary solid tumor under anesthesia remains a common practice.It has been concerned whether general anesthetics,especially volatile anesthetics,may promote the growth,migration,and invasion of cancer cells.In this study,we examined the effects of sevo?urane on human glioblastoma cells and determined the role of cluster of differentiation(CD)44,a cell surface protein involved in cell growth,migration,and invasion,in sevo?urane’s effects.We showed that exposure to 1%–4%sevo?urane did not change the cell proliferation,but concentration-dependently increased the invasion of human glioblastoma U251 cells.Furthermore,4%sevo?urane signi?cantly increased the migration and colony-forming ability of U251 cells.Similar results were observed in human glioblastoma A172 cells.Exposure to sevo?urane concentration-dependently increased the activity of calpains,a group of cysteine proteinases,and CD44 protein in U251 and A172 cells.Knockdown of CD44 with siRNA abolished sevo?urane-induced increases in calpain activity,migration,invasion,and colony-forming ability of U251 cells.Inhalation of 4%sevo?urane signi?cantly increased the tumor volume and invasion/migration distance of U87 cells from the tumor mass in the nude mice bearing human glioblastoma U87 xenograft in the brain.The aggravation by sevo?urane was attenuated by CD44 silencing.In conclusion,sevo?urane increases the migration,invasion,and colony-forming ability of human glioblastoma cells in vitro,and their tumor volume and invasion/migration in vivo.Sevo?urane enhances these cancer cell biology features via increasing the expression of CD44. | Ren-chun Lai Wei-ran Shan Di Zhou Xiao-qing Zeng Kendrick Zuo Dong-feng Pan Wei-an Zeng Zhi-yi Zuo | 2019 | Acta Pharmacologica Sinica2019，40，11： | 3 |
| 15 | Comparative Study on Inorganic Composition and Crystallographic Properties of Cortical and Cancellous Bone显示文摘Objective To comparatively investigate the inorganic composition and crystallographic properties of cortical and cancellous bone via thermal treatment under 700 ℃.Methods Thermogravimetric measurement,infrared spectrometer,X-ray diffraction,chemical analysis and X-ray photo-electron spectrometer were used to test the physical and chemical properties of cortical and cancellous bone at room temperature 250 ℃,450 ℃,and 650 ℃,respectively.Results The process of heat treatment induced an extension in the a-lattice parameter and changes of the c-lattice parameter,and an increase in the crystallinity reflecting lattice rearrangement after release of lattice carbonate and possible lattice water.The mineral content in cortical and cancellous bone was 73.2wt% and 71.5wt%,respectively.For cortical bone,the weight loss was 6.7% at the temperature from 60 ℃ to 250 ℃,17.4% from 250 ℃ to 450 ℃,and 2.7% from 450 ℃ to 700 ℃.While the weight loss for the cancellous bone was 5.8%,19.9%,and 2.8 % at each temperature range,the Ca/P ratio of cortical bone was 1.69 which is higher than the 1.67 of stoichiometric HA due to the B-type CO32- substitution in apatite lattice.The Ca/P ratio of cancellous bone was lower than 1.67,suggesting the presence of more calcium deficient apatite.Conclusion The collagen fibers of cortical bone were arrayed more orderly than those of cancellous bone,while their mineralized fibers ollkded similar.The minerals in both cortical and cancellous bone are composed of poorly crystallized nano-size apatite crystals with lattice carbonate and possible lattice water.The process of heat treatment induces a change of the lattice parameter,resulting in lattice rearrangement after the release of lattice carbonate and lattice water and causing an increase in crystal size and crystallinity.This finding is helpful for future biomaterial design,preparation and application. | XIAO-YAN WANG,YI ZUO,DI HUANG,XIAN-DENG HOU,AND YU-BAO LI 2 Research Center for Nano-Biomaterials Analysis and Testing,Sichuan University,Chengdu 610064,Sichuan,China | 2010 | Biomedical and Environmental Sciences2010，23，6： | 2 |
| 16 | Doppler velocimeter based on dual-comb absorption spectroscopy显示文摘The determination of airflow parameters is essential to the research of critical information on environment monitoring,chemical kinetics,and aerodynamic and propulsion applications.During the past few decades,tunable diode laser absorption spectroscopy has become a common and efficient tool for the flow velocity measurement based on the Doppler shift of the absorption line.Dual-comb absorption spectroscopy(DCAS),as a state-of-theart Fourier-transform broadband spectroscopic technique,not only can detect multiple trace molecules in parallel but also can extract Doppler shifts to derive the flow velocity through the analysis of dozens of molecular absorption lines simultaneously with high precision.Here,we report a proof-of-principle demonstration of the velocity measurements of acetylene at various flow velocities by means of a high-resolution and broadband DCAS.Mode-resolved Doppler-shifted rotational-vibrational lines in the P branch of acetylene molecules are obtained.A model for multiline Doppler frequency determination is investigated and experimentally verified.The flow velocity measurements with a measuring uncertainty down to the submeter per second over the range from 8.7 m/s to 44.8 m/s at an effective time resolution of 1 s and a measuring uncertainty of 1.97 m/s at 0.1 s are demonstrated.With broadband mid-infrared frequency combs covering atmospheric transmission windows,the open-path measurement for monitoring diffusion of the weak pollutant source would be realized. | CHENGLIN GU XING ZOU ZHONG ZUO DAOWANG PENG YUANFENG DI YANG LIU DAPING LUO WENXUE LI | 2020 | Photonics Research2020，8，12： | 2 |
| 17 | Bioactive composite gradient coa- tings of nano-hydroxyapatitdpolyamide66 fabricated on polyamide66 substrates 显示文摘 | Huang Di Zuo Yi Li Jidong | 2012 | Joumal of the Royal Society Interface2012，9，72： | 1 |
| 18 | Reinforced nanohydroxyapatite/ polyamide66 scaffolds by chitosan coating for bone tissue engineer- ing 显示文摘 | Huang Di Zuo Yi Zou Qin | 2012 | Journal of Biomedical Materials Research Part B : Applied Biomaterials2012，100，1： | 1 |
| 19 | Growing together and growing apart: regional and sex differences in the li{espan devel- opmental trajectories o{ functional homotopy 显示文摘 | Zuo X N Kelly C Di Martino A | 2010 | J Neurosci2010，30，15： | 1 |
| 20 | Graphene oxide- facilitated electron transfer of metalloproteins at electrodesurfaces 显示文摘 | Xiao-Li Zuo Shi-Jiang He Di Li | 2010 | Langrnuir2010，26，3： | 1 |
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