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| 1 | Rett syndrome-causing mutations compromise MeCP2- mediated liquid—liquid phase separation of chromatin显示文摘Rett syndrome(RTT),a severe postnatal neurodevelopmental disorder,is caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2(MeCP2).MeCP2 is a chromatin organizer regulating gene expression.RTT-causing mutations have been shown to affect this function.However,the mechanism by which MeCP2 organizes chromatin is unclear.In this study,we found that MeCP2 can induce compaction and liquid-liquid phase separation of nudeosomal arrays in vitro,and DNA methylation further enhances formation of chromatin condensates by MeCP2.Interestingly,RTT-causing mutations compromise MeCP2-mediated chromatin phase separation,while benign variants have little effect on this process.Moreover,MeCP2 competes with linker histone H1 to form mutually exclusive chromatin condensates in vitro and distinct heterochromatin foci in vivo.RTT-causing mutations reduce or even abolish the ability of MeCP2 to compete with histone H1 and to form chromatin condensates.Together,our results identify a novel mechanism by which phase separation underlies MeCP2-mediated heterochromatin formation and reveal the potential link between this process and the pathology of RTT. | Liang Wang Mingli Hu Mei-Qing Zuo Jicheng Zhao Di Wu Li Huang Yongxin Wen Yunfan Li Ping Chen Xinhua Bao Meng-Qiu Dong Guohong Li Pilong Li | 2020 | Cell Research2020，30，5： | 3 |
| 2 | Characteristics of mass distributions of aerosol particle and its inorganic water-soluble ions in summer over a suburb farmland in Beijing显示文摘Agricultural activity is one of the most important sources of aerosol particles.To understand the mass distribu-tion and sources of aerosol particles and their inorganic water-soluble ions in a suburb farmland of Beijing,particle samples were collected using a microorifice uniform deposit impactor(MOUDI)in the summer of 2004 in a suburb vege-table field.The distribution of the particles and their inor-ganic water-soluble ions in the diameter range of 0.18-18 mm were measured.The dominant fine particle ions were SO_(4)^(2−),NO^(3−),and NH_(4)^(+).The association of day-to-day variation of the concentration of these ions with temperature,humidity,and solar radiation suggested that they are formed by the reac-tion of NH_(3) released from the vegetable field with the acid species produced from photochemical reactions.Fine particle K+is likely from vegetation emission and biomass burning.Coarse particles like Ca^(2+),Mg^(2+),NO_(3)^(−),and SO_(4)^(2−)are sug-gested to come from the mechanical process by which the soil particle entered the atmosphere,and from the reaction of the acid species at the surface of the soil particle.The results show that fertilizer and soil are important factors determining the aerosol particle over agricultural fields,and vegetable fields in suburban Beijing contribute significantly to the aerosol particle. | ZHAO Peng ZHU Tong LIANG Baosheng HU Min KANG Ling GONG Jicheng | 2007 | Frontiers of Environmental Science & Engineering2007，1，2： | 2 |
| 3 | Quantification of levornidazole and its metabolites in human plasma and urine by ultra-performance liquid chromatography - mass spectrometry显示文摘 | Yuran Cao Miao Zhao Xiaojie Wu Beining Guo Yuancheng Chen Jicheng Yu Guoying Cao Jing Zhang Yaoguo Shi Yingyuan Zhang | 2014 | Journal of Chromatography B2014，，： | 1 |
| 4 | Synthesis and properties of Fe 3 O 4 /polyaniline and its tiny magnetic field functions during oxygen transfer processes显示文摘 | Jicheng Shi Hongfeng Xu Hong Zhao Lu Lu | 2012 | Journal of Power Sources2012，，： | 1 |
| 5 | Preliminary evaluation:the effects of Aloe ferox Miller and Aloe arboresers Miller on word healing显示文摘 | Jia Yimei Zhao Guodong Jia Jicheng | 2008 | Journal of Ethnopharmacology2008，120，2： | 1 |
| 6 | Preliminary evaluation: The effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing显示文摘 | Yimei Jia Guodong Zhao Jicheng Jia | 2008 | Journal of Ethnopharmacology2008，，2： | 1 |
| 7 | Microwave-treated graphite felt as the positive electrode for all-vanadium redox flow battery显示文摘 | Xiaoxin Wu Hongfeng Xu Pengcheng Xu Yang Shen Lu Lu Jicheng Shi Jie Fu Hong Zhao | 2014 | Journal of Power Sources2014，，： | 1 |
| 8 | MRS Bulletin显示文摘 | Zhao Jicheng | 2002 | 27(4): 3242002，27，4： | 1 |
| 9 | Effect of annealing temperature on the structure and optical properties of sputtered TiO 2 films显示文摘 | Baoxing Zhao Jicheng Zhou Yu Chen Yinqiao Peng | 2011 | Journal of Alloys and Compounds2011，，9： | 1 |
| 10 | Synthesis, characterization of Ag/MCM41 and the catalyic performance for liquid-phase oxidation of cyclohexane显示文摘 | Zhao Hong Zhou Jicheng Luo Hean | 2006 | Catalysis Letters2006，108，1： | 1 |
| 11 | Adenovirus-mediated ING4/IL-24 double tumor suppressor gene co-transferenhances antitumor activity in human breast cancer cells显示文摘 | Yaodong Zhao Zhengyi Li Weihua Sheng Jingchen Miao Jicheng Yang | 2012 | Oncology Reports2012，，4： | 1 |
| 12 | Synthesis and characterization ofp-perfluoroethylated poly(a-methylstyrene)显示文摘 | Ni Hongbo Yang Jicheng Zhao Chengxue | 2005 | Reactive & Functional Polymers2005，66，： | 1 |
| 13 | Synthesis,characterization of Ag/MCM41 and the catalyic performance for liquid-phase oxidation of cyclohexane显示文摘 | Zhao Hong Zhou Jicheng Luo Hean | 2006 | Catal Lett2006，108，1： | 1 |
| 14 | Synthesis and electrochemical properties of a series of novel tetra(4-benzoyl)phenoxyphthalocyanine derivatives显示文摘A novel phthalocyanine,2,9(10),16(17),23(24)-tetra(4-benzoyl)phenoxyphthalocyanine,and its complexes with Zn(II),Cu(II),Co(II),and Ni(II) have been synthesized and characterized by a combination of elemental analysis,IR,1 H NMR,UV-vis spectroscopy and mass spectrometry.All of the materials are very soluble in common organic solvents such as dichloromethane,chloroform,tetrahydrofuran,N,N-dimethylformamide and dimethyl sulfoxide.The Q band wavelengths of the complexes decrease in the order:Zn > Cu > Ni > Co.Redox processes were observed at 1.06,0.74,0.51 and 0.98 V for the free phthalocyanine,at 0.72 and 1.04 V for the Co(II) complex,at 1.24,0.77,0.24,0.61 and 0.91 V for the Cu(II) complex,and at 0.74 and 1.20 V for the Ni(II) complex.The cyclic voltammograms of the phthalocyanine ring of the four species are similar,with reduction and oxidation couples each involving a one-electron transfer process. | WANG Kun FU Qiang MA JiCheng LI WeiLi LlWenJu HOU Yang CHEN LiLi ZHAO BaoZhong | 2012 | Science China Chemistry2012，55，9： | 0 |
| 15 | Basophils as a potential therapeutic target in cancer显示文摘Basophils,which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation,have been neglected by researchers in the past decades.Previous studies have revealed their vital roles in allergic diseases and parasitic infections.Intriguingly,recent studies even reported that basophils might be associated with cancer development,as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers.However,it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components;the answer may depend on the tumor biology and the microenvironment.Herein,we reviewed the role of basophils in cancers,and highlighted some potential and promising therapeutic strategies. | Jicheng ZHANG Hanlin YIN Qiangda CHEN Guochao ZHAO Wenhui LOU Wenchuan WU Ning PU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，12： | 0 |
| 16 | Interface profile evolution between binary immiscible fluids induced by high magnetic field gradients显示文摘A mechanical analysis is done to find the evolution of the interface profile between binary immiscible fluids induced by a three-dimensional orthogonal magnetic field gradient.In the experiments,the changes of the interface profile between four groups of binary immiscible fluids are investigated under the same horizontal magnetic field gradients.The binary immiscible fluids are made of benzene and other liquids,like CuSO4,Fecl3,FeSO4 or Cucl2 aqueous solutions.In addition,the interface profile between the benzene and CuSO4 aqueous solution is examined under different horizontal magnetic field gradients.The experimental results are consistent with the theoretical analysis.This study explains the enhanced Moses effect from a mechanics standpoint.Furthermore,a new method for susceptibility measurement is proposed based on this enhanced Moses effect. | ZHAO LiJia,YOU Yue,TIAN YongHua,YANG HongKai,WANG Qiang * & HE JiCheng Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education),Northeastern University,Shenyang 110004,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，7： | 0 |
| 17 | Histone Variants in Development and Diseases显示文摘真核细胞的 genomic DNA 被 histones 高度包装进染色质在内适合原子核。除在 S 阶段和联合复制的免职与一座表达式山峰包装正规 histones 的角色的体积以外,不同 histone 变体为他们的表达式,免职和功能的含意发展了不同规章的机制。histone 变体的差异导致染色质的结构的粘性并且加亮机能上地不同的 chromosomal 领域,它从一个受精卵在开发,以及在老化和疾病起关键作用进一个复杂有机体。然而,这个基本过程的机制到目前为止糟糕被理解。调查变体怎么被合并到染色质并且标记特定的染色质状态调整基因表示,并且他们怎么涉及开发和疾病具有特别兴趣。在这评论,我们在三广泛地调查的变体包括的 epigenetic 规定的研究集中于最近的进步 H2A.Z, macroH2A 和 H3.3,和他们在开发和疾病的功能的含意。 | Ping Chen Jicheng Zhao Guohong Li | 2013 | Journal of Genetics and Genomics2013，40，7： | 0 |
| 18 | Construction of Technology System on Development and Repropagation in Vitro of Several Cultivars in Pear显示文摘It is the most available way to obtain self-rooted seedlings by tissue culture,which could breed de-virus seedlings with uniform traits and contribute to improve seedling quality.To construct a complete and efficient technology system,this test used stem with buds of 16 cultivars and super lines including Yali,Jingbaili,03-04-034,03-08-080 and so on as materials to study the best way for explant sampling time and position,sterilization time using HgCl 2 and hormone concentrations.The result indicated that the optimum technology system was that the middle parts of longest shoots before 20 d after full-blossom were sterilized for 8 min by 0.1%HgCl 2 and inoculated on the development medium MS+6-BA 0.5 mg/L+IBA 0.2 mg/L+saccharose 3%+agar 0.6%(pH=5.8),and then trans-inoculated into propagation medium MS+6-BA 1.0 mg/L+IBA 0.3 mg/L+saccharose 3%+agar 0.6%(pH=5.8). | Yu WANG Baofeng HAO Jicheng HAN Lijuan GAO Longfei LI Shujun ZHAO Jintao XU Minghui JI Jie LI Haie ZHANG | 2020 | Agricultural Biotechnology2020，9，4： | 0 |
| 19 | Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury显示文摘Vision depends on accurate signal conduction from the retina to the brain through the optic nerve,an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.The mammalian optic nerve,an important part of the central nervous system,cannot regenerate once it is injured,leading to permanent vision loss.To date,there is no clinical treatment that can regenerate the optic nerve and restore vision.Our previous study found that the mobile zinc(Zn^(2+))level increased rapidly after optic nerve injury in the retina,specifically in the vesicles of the inner plexiform layer.Furthermore,chelating Zn^(2+)significantly promoted axonal regeneration with a long-term effect.In this study,we conditionally knocked out zinc transporter 3(ZnT3)in amacrine cells or retinal ganglion cells to construct two transgenic mouse lines(VGAT^(Cre)ZnT3^(fl/fl)and VGLUT2^(Cre)ZnT3^(fl/fl),respectively).We obtained direct evidence that the rapidly increased mobile Zn^(2+)in response to injury was from amacrine cells.We also found that selective deletion of ZnT3 in amacrine cells promoted retinal ganglion cell survival and axonal regeneration after optic nerve crush injury,improved retinal ganglion cell function,and promoted vision recovery.Sequencing analysis of reginal ganglion cells revealed that inhibiting the release of presynaptic Zn^(2+)affected the transcription of key genes related to the survival of retinal ganglion cells in postsynaptic neurons,regulated the synaptic connection between amacrine cells and retinal ganglion cells,and affected the fate of retinal ganglion cells.These results suggest that amacrine cells release Zn^(2+)to trigger transcriptomic changes related to neuronal growth and survival in reginal ganglion cells,thereby influencing the synaptic plasticity of retinal networks.These results make the theory of zinc-dependent retinal ganglion cell death more accurate and complete and provide new insights into the complex interactions between retinal cell networks. | Zhe Liu Jingfei Xue Canying Liu Jiahui Tang Siting Wu Jicheng Lin Jiaxu Han Qi Zhang Caiqing Wu Haishun Huang Ling Zhao Yehong Zhuo Yiqing Li | 2023 | Neural Regeneration Research2023，18，12： | 0 |
| 20 | 4π△E_β Detector and Its Application in Researching Neutron-rich Nuclide显示文摘4π△E_β Detector and Its Application in Researching Neutron-rich Nuclide￥WangJicheng;ZhaoJinhua;GuoGuanghui;YangYongfengandZha?.. | Wang Jicheng Zhao Jinhua Guo Guanghui Yang Yongfeng and Zhang Li | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
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