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| 1 | Hi-TOM: a platform for high-throughput tracking of mutations induced by CRISPR/Cas systems显示文摘The CRISPR/Cas system has been extensively applied to make precise genetic modifications in various organisms. Despite its importance and widespread use, large-scale mutation screening remains time-consuming, labour-intensive and costly. Here, we developed Hi-TOM(available at http://www.hi-tom.net/hi-tom/), an online tool to track the mutations with precise percentage for multiple samples and multiple target sites. We also described a corresponding next-generation sequencing(NGS) library construction strategy by fixing the bridge sequences and barcoding primers. Analysis of the samples from rice, hexaploid wheat and human cells reveals that the Hi-TOM tool has high reliability and sensitivity in tracking various mutations, especially complex chimeric mutations frequently induced by genome editing. Hi-TOM does not require special design of barcode primers,cumbersome parameter configuration or additional data analysis. Thus, the streamlined NGS library construction and comprehensive result output make Hi-TOM particularly suitable for high-throughput identification of all types of mutations induced by CRISPR/Cas systems. | Qing Liu Chun Wang Xiaozhen Jiao Huawei Zhang Lili Song Yanxin Li Caixia Gao Kejian Wang | 2019 | Science China(Life Sciences)2019，62，1： | 37 |
| 2 | The endoplasmic reticulum-associated degradation is necessary for plant salt tolerance显示文摘真核细胞的有机体有允许错误褶层或 unassembled 蛋白质在 endoplasmic 蜂窝胃被保留的质量控制的机制(嗯) 并且随后由嗯联系降级(ERAD ) 降级了。ERAD 小径很好在酵母和哺乳动物被学习;然而,植物 ERAD 的生物功能没被报导。通过分子、细胞的生物途径,我们发现 ERAD 是必要的让植物克服盐应力。在蛋白质在植物房间增加了的盐处理 ubiquitinated 之上,特别展开了快速在 ER 积累了并且随后导致了的蛋白质嗯压力回答。在 ERAD 小径的 HRD1/HRD3 建筑群的 HRD3A 的缺点导致了展开的蛋白质反应(UPR ) 的改变,腌的增加的植物敏感,和在植物房间的 ERAD 底层的保留。而且,我们证明从 ER 的那个 Ca 2+ 版本涉及 UPR 的举起,反应的氧种类(ROS ) 参与 ERAD 相关的植物盐反应小径。 | Lijing Liu Feng Cui Qingliang Li Bojiao Yin Huawei Zhang Baoying Lin Zaorong Wu Ran Xia Sanyuan Tang Qi Xie | 2011 | Cell Research2011，21，6： | 19 |
| 3 | Generation of thermosensitive male-sterile maize by targeted knockout of the ZmTMS5 gene显示文摘Maize(Zea mays L.)is one of the most important cereal crops,with a global production of 1.02 billion tons in 2013(Baldaufa et al.,2016).Heterosis is widely used to increase the productivity of maize,and the first commercial hybrid maize was introduced in the 1930s(Duvick,2001).The high-yield maize varieties used today are all hybrids,and the production of hybrid maize seed requires sterilization to prevent self-pollination.Conventional seed produc- | Jun Li Huawei Zhang Xiaomin Si Youhui Tian Kunling Chen Jinxing Liu Huabang Chen Caixia Gao | 2017 | Journal of Genetics and Genomics2017，44，9： | 14 |
| 4 | High-precision bio-replication of synthetic drag reduction shark skin显示文摘Nano-long chains were grafted over the replicated micro-grooves of shark skin in a novel attempt to replicate bio-synthetic drag reduction structure with high precision through synthetic bio-replication. Pre-treated shark skin was used as casting template to prepare a flexible female die of silicone rubber by soft die formation. A waterborne epoxy resin was then used to graft long-chains of drag reduction agent and prepare a synthetic drag reduction shark skin with nano-long chain drag reduction interface and lifelike micro-grooves. Replication precision analysis shows that this technology could replicate the complicated three-dimensional morphology of a biological drag reduction surface with high precision. Drag reduction experiments show that the material had an excellent synthetic drag reduction effect, with a maximal drag reduction rate of up to 24.6% over the velocities tested. | ZHANG DeYuan LI YuanYue HAN Xin LI Xiang CHEN HuaWei | 2011 | Chinese Science Bulletin2011，56，9： | 13 |
| 5 | Mercury oxidation and adsorption characteristics of potassium permanganate modified lignite semi-coke显示文摘The adsorption characteristics of virgin and potassium permanganate modified lignite semi-coke(SC)for gaseous Hg0 were investigated in an attempt to produce more effective and lower price adsorbents for the control of elemental mercury emission.Brunauer-EmmettTeller(BET)measurements,X-ray powder diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)were used to analyze the surface physical and chemical properties of SC,Mn-SC and Mn-H-SC before and after mercury adsorption.The results indicated that potassium permanganate modification had significant influence on the properties of semi-coke,such as the specific surface area,pore structure and surface chemical functional groups.The mercury adsorption efficiency of modified semi-coke was lower than that of SC at low temperature,but much higher at high temperature.Amorphous Mn7+,Mn6+ and Mn 4+ on the surface of Mn-SC and Mn-H-SC were the active sites for oxidation and adsorption of gaseous Hg0,which oxidized the elemental mercury into Hg2+ and captured it.Thermal treatment reduced the average oxidation degree of Mnx+ on the surface of Mn-SC from 3.80 to 3.46.However,due to the formation of amorphous MnOx,the surface oxidation active sites for gaseous Hg0 increased,which gave Mn-H-SC higher mercury adsorption efficiency than that of Mn-SC at high temperature. | Huawei Zhang Jitao Chen Peng Liang Li Wang | 2012 | Journal of Environmental Sciences2012，24，12： | 12 |
| 6 | A novel mutation in the MITF may be digenic with GJB2 mutations in a large Chinese family of Waardenburg syndrome type Ⅱ显示文摘Waardenburg syndrome typeⅡ(WS2) is associated with syndromic deafness.A subset of WS2,WS2A,accounting for approximately 15%of patients,is attributed to mutations in the microphthalmia-associated transcription factor(MITF) gene.We examined the genetic basis of WS2 in a large Chinese family.All 9 exons of the MITF gene,the single coding exon(exon 2) of the most common hereditary deafness gene GJB2 and the mitochondrial DNA(mtDNA) 12S rRNA were sequenced.A novel heterozygous mutation c.[742_743delAAinsT;746_747delCA]in exon 8 of the MITF gene co-segregates with WS2 in the family.The MITF mutation results in a premature termination codon and a truncated MITF protein with only 247 of the 419 wild type amino acids.The deaf proband had this MITF gene heterozygous mutation as well as a c.[109G>A]+ [235delC]compound heterozygous pathogenic mutation in the GJB2 gene.No pathogenic mutation was found in mtDNA 12S rRNA in this family.Thus,a novel compound heterozygous mutation,c.[742_743delAAinsT;746_747delCA]in MITF exon 8 was the key genetic reason for WS2 in this family,and a digenic effect of MITF and GJB2 genes may contribute to deafness of the proband. | Xukun Yan Tianyu Zhang Zhengmin Wang Yi Jiang Yan Chen Hongyan Wang Duan Ma Lei Wang Huawei Li | 2011 | Journal of Genetics and Genomics2011，38，12： | 8 |
| 7 | Experimental investigation on a high subsonic compressor cascade flow显示文摘With the aim of deepening the understanding of high-speed compressor cascade flow,this paper reports an experimental study on NACA-65 K48 compressor cascade with high subsonic inlet flow.With the increase of passage pressurizing ability, endwall boundary layer behavior is deteriorated, and the transition zone is extended from suction surface to the endwall as the adverse pressure gradient increases.Cross flow from endwall to midspan, mixing of corner boundary layer and the main stream, and reversal flow on the suction surface are caused by corner separation vortex structures.Passage vortex is the main corner separation vortex.During its movement downstream, the size grows bigger while the rotating direction changes, forming a limiting circle.With higher incidence, corner separation is further deteriorated, leading to higher flow loss.Meanwhile, corner separation structure, flow mixing characteristics and flow loss distribution vary a lot with the change of incidence.Compared with low aspect-ratio model, corner separation of high aspect-ratio model moves away from the endwall and is more sufficiently developed downstream the cascade.Results obtained present details of high-speed compressor cascade flow,which is rare in the relating research fields and is beneficial to mechanism analysis, aerodynamic optimization and flow control design. | Zhang Haideng Wu Yun Li Yinghong Lu Huawei | 2015 | Chinese Journal of Aeronautics2015，28，4： | 8 |
| 8 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017，27，2： | 6 |
| 9 | Effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis:a multi-center,double-blind,randomized controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis.METHODS:This was a multi-center,double-blind,double-dummy,positive-controlled,parallel randomized controlled clinical trial with 1∶1 allocation.We recruited 404 patients with dizziness caused by cerebral arteriosclerosis(blood stasis symptom pattern)in 10 hospitals in China.GBE50 group received GBE50 and Naoxinqing tablet(NXQ)of mimetic agent,control group received NXQ and GBE50 of mimetic agent.The main outcome was Traditional Chinese Medicine(TCM)symptom pattern score of blood stasis after 6 weeks.The secondary outcomes were changes in the dizziness handicap inventory(DHI)score,vertigo visual analogue scale(VAS)score,the university of California vertigo questionnaire(UCLA-DQ)score and single-item symptom score of TCM from baseline to 2,4 and 6 weeks.Safety indicators included the incidence of adverse events,severe adverse events and laboratory examination including blood routine,liver function,renal function,and so forth.RESULTS:The total effective rate of TCM symptom pattern score in the GBE50 group after 6 weeks of treatment was higher than that in the control group,the difference in rate was statistically significant(92.67%vs 83.07%,P=0.004).Compared with the control group,there was no difference in the incidence of adverse reactions(9.95%vs 14.85%,P=0.136).CONCLUSION:The treatment of dizziness caused by cerebral arteriosclerosis with GBE50 is effective,safe and reliable. | SHA Rina TANG Lu DU Yawei WU Shengxian SHI Huawei ZOU Hongxin ZHANG Xuran DONG Xinglu ZHOU Li | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 5 |
| 10 | HTDet:A Clustering Method Using Information Entropy for Hardware Trojan Detection显示文摘Hardware Trojans(HTs)have drawn increasing attention in both academia and industry because of their significant potential threat.In this paper,we propose HTDet,a novel HT detection method using information entropybased clustering.To maintain high concealment,HTs are usually inserted in the regions with low controllability and low observability,which will result in that Trojan logics have extremely low transitions during the simulation.This implies that the regions with the low transitions will provide much more abundant and more important information for HT detection.The HTDet applies information theory technology and a density-based clustering algorithm called Density-Based Spatial Clustering of Applications with Noise(DBSCAN)to detect all suspicious Trojan logics in the circuit under detection.The DBSCAN is an unsupervised learning algorithm,that can improve the applicability of HTDet.In addition,we develop a heuristic test pattern generation method using mutual information to increase the transitions of suspicious Trojan logics.Experiments on circuit benchmarks demonstrate the effectiveness of HTDet. | Renjie Lu Haihua Shen Zhihua Feng Huawei Li Wei Zhao Xiaowei Li | 2021 | Tsinghua Science and Technology2021，26，1： | 4 |
| 11 | Evolution of Pore Size Distribution and Mean Pore Size in Lotus-type Porous Magnesium Fabricated with Gasar Process显示文摘吝啬的毛孔上的压力缩放的气体的效果,孔和毛孔缩放莲花类型的分发与 Gasar 过程制作的多孔的镁被调查。理论分析和试验性的结果都显示那在那里存在到为与更狭窄的毛孔尺寸分发和更小的毛孔尺寸生产 lotus-typestructures 的氩 p_(Ar ) 的氢 p_(H_2 ) 的部分压力的最佳的比率。毛孔尺寸分发和毛孔尺寸上的团结模式的效果也被讨论。 | Yuan LIU Yanxiang LI Huawei ZHANG Jiang WAN | 2006 | Journal of Materials Science & Technology2006，22，3： | 3 |
| 12 | PtNi-W/C with Atomically Dispersed Tungsten Sites Toward Boosted ORR in Proton Exchange Membrane Fuel Cell Devices显示文摘The performance of proton exchange membrane fuel cells is heavily dependent on the microstructure of electrode catalyst especially at low catalyst loadings.This work shows a hybrid electrocatalyst consisting of PtNi-W alloy nanocrystals loaded on carbon surface with atomically dispersed W sites by a two-step straightforward method.Single-atomic W can be found on the carbon surface,which can form protonic acid sites and establish an extended proton transport network at the catalyst surface.When implemented in membrane electrode assembly as cathode at ultra-low loading of 0.05 mgPt cm^(−2),the peak power density of the cell is enhanced by 64.4%compared to that with the commercial Pt/C catalyst.The theoretical calculation suggests that the single-atomic W possesses a favorable energetics toward the formation of*OOH whereby the intermediates can be efficiently converted and further reduced to water,revealing a interfacial cascade catalysis facilitated by the single-atomic W.This work highlights a novel functional hybrid electrocatalyst design from the atomic level that enables to solve the bottle-neck issues at device level. | Huawei Wang Jialong Gao Changli Chen Wei Zhao Zihou Zhang Dong Li Ying Chen Chenyue Wang Cheng Zhu Xiaoxing Ke Jiajing Pei Juncai Dong Qi Chen Haibo Jin Maorong Chai Yujing Li | 2023 | Nano-Micro Letters2023，15，9： | 3 |
| 13 | Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice显示文摘Dear Editor,Hearing loss is the most common sensory disorder in the world.Among cases of non-syndromic hearing loss,which account for 70%of all cases of genetic hearing loss,around 80%of cases arise from autosomal recessive loss-of-function mutations that require repair,rather than disruption,of the mutant allele.1 CRISPR/Cas9-mediated homology-directed repair(HDR)-based therapies have the potential to cure many genetic diseases because this class of therapeutics can achieve arbitrary base changes as well as the insertion or deletion of DNA fragments/However. | Xi Gu Xinde Hu Daqi Wang Zhijiao Xu Fang Wang Di Li Geng-lin Li Hui Yang Huawei Li Erwei Zuo Yilai Shu | 2022 | Cell Research2022，32，7： | 3 |
| 14 | Dual-channel type tunable field-effect transistors based on vertical bilayer WS2(1−x)Se2x/SnS2 heterostructures显示文摘Layered semiconductor heterostructures are essential elements in modern electronic and optoelectronic devices.Dynamically engineering the composition of these heterostructures may enable the flexible design of the properties of heterostructure-based electronics and optoelectronics as well as their optimization.Here,we report for the first time a two-step chemical vapor deposition approach for a series of WS2(1−x)Se2x/SnS2 vertical heterostructures with high-quality and large areas.The steady-state photoluminescence results exhibit an obvious composition-related quenching ratio,revealing a strong coherence between the band offset and the charge transfer efficiency at the junction interface.Based on the achieved heterostructures,dual-channel backgate field-effect transistors were successfully designed and exhibited typical composition-dependent transport behaviors,and pure n-type unipolar transistors to ambipolar transistors were realized in such systems.The direct vapor growth of these novel vertical WS2(1−x)Se2x/SnS2 heterostructures could offer an interesting system for probing new physical properties and provide a series of layered heterostructures for high-quality devices. | Biyuan Zheng Dong Li Chenguang Zhu Jianyue Lan Xingxia Sun Weihao Zheng Huawei Liu Xuehong Zhang Xiaoli Zhu Yexin Feng Tao Xu Litao Sun Gengzhao Xu Xiao Wang Chao Ma Anlian Pan | 2020 | InfoMat2020，2，4： | 3 |
| 15 | Ambient TSP concentration and dustfall variation in Urumqi,China显示文摘Total suspended particulate(TSP, particle diameter≤100 μm) was the dominant air pollutant and significantly influenced local air quality. In this paper, we investigated the interannual and seasonal variations of TSP and dustfall of the atmosphere over Urumqi, the capital city of Xinjiang Uygur autonomous region, northwestern China, basing on environmental monitoring records and meteorological data from 1986–2012. The results showed that during the study period, annual average TSP concentration decreased from 716 to 260 μg/m3, with an average level of 422.9 μg/m3, while dustfall intensity reduced from 350.4 to 166.6 t/(km2?a), with an average level of 259 t/(km2?a). Over 50% of the annual pollution days were induced mainly by TSP. Spring and winter had relatively higher dustfall intensities, and dense traffic and residential areas had the highest dustfall intensities in the Urumqi metropolitan area. With an annual average precipitation of less than 300 mm, atmospheric particulates in Urumqi could be hardly removed through wet deposition. During spring and summertime prevailing winds from northwest and northeast could carry aeolian dust particles from sandy deserts to Urumqi. Aeolian dusts from deserts would remain to be a priority regarding air pollution control in arid oasis cities. | XiaoXiao ZHANG Xi CHEN YuHong GUO ZiFa WANG LianYou LIU Cottle PAUL ShengYu LI HuaWei PI | 2014 | Journal of Arid Land2014，6，6： | 3 |
| 16 | Nitrogen-doped carbon stabilized Li Fe0.5Mn0.5PO4/rGO cathode materials for high-power Li-ion batteries显示文摘Exploring high ion/electron conductive olivine-type transition metal phosphates is of vital significance to broaden their applicability in rapid-charging devices.Herein,we report an interface engineered Li Fe0.5Mn0.5PO4/rGO@C cathode material by the synergistic effects of r GO and polydopamine-derived N-doped carbon.The well-distributed Li Fe0.5Mn0.5PO4nanoparticles are tightly anchored on r GO nanosheet benefited by the coating of N-doped carbon layer.The design of such an architecture can effectively suppress the agglomeration of nanoparticles with a shortened Li+transfer path.Meantime,the high-speed conducting network has been constructed by r GO and N-doped carbon,which exhibits the face-to-face contact with Li Fe0.5Mn0.5PO4nanoparticles,guaranteeing the rapid electron transfer.These profits endow the Li Fe0.5Mn0.5PO4/rGO@C hybrids with a fast charge-discharge ability,e.g.a high reversible capacity of 105 m Ah·g^-1at 10 C,much higher than that of the Li Fe0.5Mn0.5PO4@C nanoparticles(46 mA·h·g^-1).Furthermore,a 90.8%capacity retention can be obtained even after cycling 500 times at 2 C.This work gives a new avenue to fabricate transition metal phosphate with superior electrochemical performance for high-power Li-ion batteries. | Haifeng Yu Zhaofeng Yang Huawei Zhu Hao Jiang Chunzhong Li | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 3 |
| 17 | Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma显示文摘Glioblastoma(GBM),one of the most common primary intracranial malignant tumours,is very difficult to be completely excised by surgery due to its irregular shape.Here,we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles(SPIONs)modified with indocyanine(Cy7)molecules and peptides(ANG orDANG)to locate malignant gliomas and guide accurate excision.Both peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro. | Ruoxi Xie Zijun Wu Fanxin Zeng Huawei Cai Dan Wang Lei Gu Hongyan Zhu Su Lui Gang Guo Bin Song Jinxing Li Min Wu Qiyong Gong | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 3 |
| 18 | Robust Recommendation Algorithm Based on Kernel Principal Component Analysis and Fuzzy C-means Clustering显示文摘面临先令攻击,存在建议算法有更低的坚韧性。就这个问题而言,我们在场一个柔韧的建议算法基于聚类的核主管部件分析和模糊 c 工具。第一,我们使用核主管部件分析方法减少原来的等级矩阵的维数,它能提取用户和项目的有效特征。根据在攻击侧面之间的减少尺寸的等级矩阵和高关联特征,然后,我们使用聚类方法聚类用户概况的模糊 c 工具,它能认识到真侧面和攻击侧面的有效分离。最后,我们基于攻击察觉结果构造指示物功能到攻击的影响在建议上介绍的减少,并且把它合并到矩阵因式分解技术设计相应柔韧的建议算法。实验结果显示建议算法比在建议精确性和坚韧性的存在方法优异。 | YI Huawei NIU Zaiseng ZHANG Fuzhi LI Xiaohui WANG Yajun | 2018 | Wuhan University Journal of Natural Sciences2018，23，2： | 2 |
| 19 | Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo显示文摘Astaxanthine(AST) has important biological activities including antioxidant and antiinflammatory effects that could alleviate neurological and heart diseases, but its role in the prevention of cisplatin-induced hearing loss(CIHL) is not yet well understood. In our study, a steady interaction between AST and the E3 ligase adapter Kelch-like ECH-associated protein 1, a predominant repressor of nuclear factor erythroid 2-related factor 2(NRF2), was performed and tested via computer molecular docking and dynamics. AST protected against cisplatin-induced ototoxicity via NRF2 mediated pathwayusing quantitative PCR and Western blotting. The levels of reactive oxygen species(ROS) and mitochondrial membrane potential revealed that AST reduced ROS overexpression and mitochondrial dysfunction.Moreover, AST exerted anti-apoptosis effects in mouse cochlear explants using immunofluorescence staining and HEI-OC1 cell lines using quantitative PCR and Western blotting. Finally, AST combined with poloxamer was injected into the middle ear through the tympanum, and the protection against CIHL was evaluated using the acoustic brain stem test and immunofluorescent staining in adult mice. Our results suggest that AST reduced ROS overexpression, mitochondrial dysfunction, and apoptosis via NRF2-mediated pathway in cisplatin-exposed HEI-OC1 cell lines and mouse cochlear explants, finally promoting cell survival. Our study demonstrates that AST is a candidate therapeutic agent for CIHL. | Benyu Nan Zirui Zhao Kanglun Jiang Xi Gu Huawei Li Xinsheng Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 20 | Regeneration of hair cells in the mammalian vestibular system显示文摘毛细胞在整个非哺乳动物的脊椎动物的一生再生,允许这些动物从听觉恢复并且平衡赤字。如此的新生不在人和另外的哺乳动物高效地发生。因此,平衡赤字变得永久并且是在整个世界的普通感觉混乱。后来前进并且 Warchol 在成熟哺乳动物在 gentamicininduced 损坏以后发现了门厅的毛细胞的有限自发的新生,重要努力被施加了在毛细胞损失以后在哺乳动物跟踪有限门厅的新生的起源。而且,最近,许多策略被开发了支持毛细胞新生和门厅的系统的随后的功能的恢复包括操作 Wnt,槽口和 Atoh1。这篇文章在哺乳动物的门厅的 epithelia 在毛细胞新生提供最近的进展的概述。而且,这评论加亮毛细胞新生的当前的限制并且提供可能的答案改革功能的毛细胞并且部分恢复门厅的功能。 | Wenyan Li Dan You Yan Chen Renjie Chai Huawei Li | 2016 | Frontiers of Medicine2016，10，2： | 2 |
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