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| 1 | Improved Base Editor for Efficiently Inducing Genetic Variations in Rice with CRISPR/Cas9- Guided Hyperactive hAID Mutant显示文摘 | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 46 |
| 2 | Base-Editing-Mediated Artificial Evolution of OsALS1 In Planta to Develop Novel Herbicide-Tolerant Rice Germplasms显示文摘Recently developed CRISPR-mediated base editors,which enable the generation of num erous nucleotide changes in target genomic regions,have been widely adopted for gene correction and generation of crop germ plasms containing im portant gain-of-function genetic variations.How ever,to engineer target genes with unknown functional SNPs remains challenging.To address this issue,we present here abase-e diting-mediated gene evolution(BEMGE)m ethod,employing both Cas9n-based cytosine and adenine base editors as well as a single-guide RNA(sgRNA)library tiling the full-length coding region,for developing novel rice germ plasm swith mutations in any endogenous gene.To this end,OsALS1 was artificially evolved in rice cells using BEMGE through both Agrobacterium-mediated and particle-bom bardment-mediated transform ation.Four different types of amino acid substitutions in the evolved OsALS1,derived from two sites that have never been targeted by natural or human selection during rice dom estication,were identified,conferring varying levels of tolerance to the herbicide bispyribac-sodium.Furtherm ore,the P171F substitution identified in a strong OsALS1 allele was quickly introduced into the commercial rice cultivar Nangeng 46 through precise base editing w ith the corresponding base editor and sgRNA.Collectively,these data indicate great potential of BEMGE in creating important genetic variants of target genes for crop improvement. | Yongjie Kuang Shaofang Li Bin Ren Fang Yan Carl Spetz Xiangju Li Xueping Zhou Huanbin Zhou | 2020 | Molecular Plant2020，13，4： | 37 |
| 3 | A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice显示文摘Dear Editor,Gene-targeting technologies using sequence specific nucleases have been widely adopted to induce genetic modifications in both plant molecular biology research and crop improvement,of which generating targeted point mutation for gain-of-function phenotype is of great value.Although tremendous efforts have been made in developing geneinsertion or replacement approaches by | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Honghui Lin Huanbin Zhou | 2017 | Science China(Life Sciences)2017，60，5： | 28 |
| 4 | Highly Efficient A. T to G. C Base Editing by Cas9n- 3uided tRNA Adenosine Deaminase in Rice显示文摘 | Fang Yan Yongjie Kuang Bin Ren Jingwen Wang Dawei Zhang Honghui Lin Bing Yang Xueping Zhou Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 26 |
| 5 | Reflections on stability technology for reducing risk of system collapse due to cascading outages显示文摘This paper aims at putting forward viewpoints regarding the use of stability technology to prevent and control cascading outages by examining recent blackout events.Based on the inquiry reports of the 2011 SouthwestAmerica blackout and the 2012 India power blackouts,event evolution features are first summarized from a stability perspective.Then a comparative analysis is conducted so as to propose suggestions of effective measures,either preventive or emergency,which could have avoided the blackouts.It is shown that applications of several mature technologies can create opportunities of preventing or interrupting the cascading development.These include offline dynamic simulation,online stability analysis and preventive control,real-time situational awareness and automatic emergency control.Further R&D directions are given to address the challenges of modern power systems as well.They cover system fault identification criterion of protection and control devices,verification of adaptability of control effect to system operating conditions,real-time operational management of emergency control measures and improvement of simulation accuracy. | Yongjie FANG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，3： | 18 |
| 6 | Relationships between Interannual and Intraseasonal Variations of the Asian–Western Pacific Summer Monsoon Hindcasted by BCC CSM 1.1(m)显示文摘Using hindcasts of the Beijing Climate Center Climate System Model, the relationships between interannual variability(IAV) and intraseasonal variability(ISV) of the Asian–western Pacific summer monsoon are diagnosed. Predictions show reasonable skill with respect to some basic characteristics of the ISV and IAV of the western North Pacific summer monsoon(WNPSM) and the Indian summer monsoon(ISM). However, the links between the seasonally averaged ISV(SAISV) and seasonal mean of ISM are overestimated by the model. This deficiency may be partially attributable to the overestimated frequency of long breaks and underestimated frequency of long active spells of ISV in normal ISM years, although the model is capable of capturing the impact of ISV on the seasonal mean by its shift in the probability of phases.Furthermore, the interannual relationships of seasonal mean, SAISV, and seasonally averaged long-wave variability(SALWV; i.e., the part with periods longer than the intraseasonal scale) of the WNPSM and ISM with SST and low-level circulation are examined. The observed seasonal mean, SAISV, and SALWV show similar correlation patterns with SST and atmospheric circulation, but with different details. However, the model presents these correlation distributions with unrealistically small differences among different scales, and it somewhat overestimates the teleconnection between monsoon and tropical central-eastern Pacific SST for the ISM, but underestimates it for the WNPSM, the latter of which is partially related to the too-rapid decrease in the impact of El Nino–Southern Oscillation with forecast time in the model. | LIU Xiangwen WU Tongwen YANG Song LI Qiaoping CHENG Yanjie LIANG Xiaoyun FANG Yongjie JIE Weihua NIE Suping | 2014 | Advances in Atmospheric Sciences2014，31，5： | 9 |
| 7 | A High Spatial Resolution FBG Sensor Array for Measuring Ocean Temperature and Depth显示文摘Exploring and understanding the ocean is an important field of scientific study.Acquiring accurate and high-resolution temperature and depth profiles of the oceans over relatively short periods of time is an important basis for understanding ocean currents and other associated physical parameters.Traditional measuring instruments based on piezoelectric ceramics have a low spatial resolution and are not inherently waterproof.Meanwhile,sensing systems based on fiber Bragg grating(FBG)have the advantage of facilitating continuous measurements and allow multi-sensor distributed measurements.Therefore,in this paper,an all-fiber seawater temperature and depth-sensing array is used to obtain seawater temperature and depth profiles.In addition,by studying the encapsulation structure of the FBG sensors,this paper also solves the problem of the measurement error present in traditional FBG sensors when measuring seawater temperature.Through a theoretical analysis and seaborne test in the Yellow Sea of China,the sampling frequency of the all-fiber seawater temperature and depth profile measurement system is 1 Hz,the accuracy of the FBG sensors reaches 0.01℃,and the accuracy of the FBG depth sensors reaches 0.1%of the full scale.The resulting parameters for these sensors are therefore considered to be acceptable for most survey requirements in physical oceanography. | Li WANG Yongjie WANG Jianfeng WANG Fang LI | 2020 | Photonic Sensors2020，10，1： | 7 |
| 8 | Temperature dependent Raman and photoluminescence of vertical WS2/MoS2 monolayer heterostructures显示文摘Heterostructures from two-dimensional transition-metal dichalcogenides MX_2 have emerged as a hot topic in recent years due to their various fascinating properties. Here, we investigated the temperature dependent Raman and photoluminescence(PL) spectra in vertical stacked WS_2/MoS_2 monolayer heterostructures. Our result shows that both E_(2g)~1 and A_(1g) modes of WS_2 and MoS_2 vary linearly with temperature increasing from 300 to 642 K. The PL measurement also reveals strong temperature dependencies of the PL intensity and peak position. The activation energy of the thermal quenching of the PL emission has been found to be equal to 69.6 meV. The temperature dependence of the peak energy well follows the bandgap shrinkage of bulk semiconductor. | Zhijian Hu Yanjun Bao Ziwei Li Yongji Gong Rui Feng Yingdong Xiao Xiaochun Wu Zhaohui Zhang Xing Zhu Pulickel M. Ajayan Zheyu Fang | 2017 | Science Bulletin2017，62，1： | 5 |
| 9 | Seasonal and Intraseasonal Variations of East Asian Summer Monsoon Precipitation Simulated by a Regional Air-Sea Coupled Model显示文摘一个地区性的由空至海的联合模型的表演,包括地区性的综合环境模型系统(RIEMS ) 和普林斯顿海洋模型(POM ) ,在模仿季节并且东方的 intraseasonal 变化亚洲夏天季风(EASM ) 降雨被调查。通过在联合模型,解开的 RIEMS,和观察之中的模型结果的比较,在模仿 EASM 上的由空至海的联合的影响也被评估。结果证明地区性的由空至海的联合气候模型在模仿降水气候学的空间模式更好表演了并且以它的振幅和主要文件结束模式生产了 EASM 降雨的更现实主义的变化。联合模型也在复制 EASM 降雨的 climatological intraseasonal 摆动(CISO ) 的主要特征比解开的 RIEMS 显示出更大的技巧,包括它的主导的时期,紧张,并且向北方繁殖。进一步的分析显示在在联合模型的 EASM 降雨气候学和它的季节的变化的模拟的改进由于西方的向北和平的副热带的高度的更好的模拟,当 CISO 模拟的改进由于在 intraseasonal 传送对流和内在的 SST 之间的现实主义的阶段关系源于由空至海的联合时。 | FANG Yongjie ZHANG Yaocun HUANG Anning LI Bo | 2013 | Advances in Atmospheric Sciences2013，30，2： | 5 |
| 10 | Effects of irrigation on precipitation in the arid regions of Xinjiang,China显示文摘Soil moisture is an important parameter for the interaction between soil and atmosphere.It is the second important factor that influences climate change,next to sea surface temperature(SST).Most previous studies focused on the monsoon regions in East China,and only a few laid emphases on arid environments.In Xinjiang, which is located in Northwest China,the climate is typically arid and semi-arid.During the past 20 years,the precipitation in Xinjiang has shown a significant increasing trend,and it is closely related to oasis irrigation.This paper aims at discussing whether abnormal soil moisture in spring can be the signal to forecast summer precipitation.The effects of abnormal soil moisture due to farm irrigation in spring in arid environments on regional climate are investigated by using a regional climate model(RegCM3).The results indicate that positive soil moisture anomaly in irrigated cropland surface in May led to an increase in precipitation in spring as well as across the whole summer. The impact could last for about four months.The effects of soil moisture on the surface air temperature showed a time-lagging trend.The summer air temperature declined by a maximum amplitude of 0.8oC.The increased soil moisture could enhance evaporation and ascending motion in the low troposphere,which brought in more precipitation.The soil moisture affected regional weather and climate mainly by altering the surface sensible and latent heat fluxes. | Yong ZHAO YongJie FANG CaiXia CUI AnNing HUANG | 2012 | Journal of Arid Land2012，4，2： | 4 |
| 11 | Neuro-protective effects of CNTF on hippocampal neurons via an unknown signal transduction pathway显示文摘In our previous study, we proposed that there may be an unknown pathway in the upper stream of the known signal transduction pathway of Ciliary neurotrophic factor (CNTF) that mediates the neuro-protective function of CNTF. In the present experiment, we observed that the neuro-protective function of the non-classic signal transduction path- way in a L-NMDA (a glutamic acid ion type receptor atagonist) induced hippocampal neuron injury model, using primary culture rat hippocampal neurons, con- tinuous photography and gp130 immunohistochemi- cal assay. The results showed that L-NMDA induced injurious reaction of hippocampal neurons, and CNTF was able to inhibit the toxic action of L-NMDA on hippocampal neurons. Additionally, when JAK/STATs in the known classic signal transduction pathway of CNTF were blocked by PTPi-2, the protective effect of CNTF against L-NMDA injury still existed. L-NMDA caused a rapid increase in the concentration of hip- pocampal intracellular free [Ca2+]i. CNTF was able to attenuate L-NMDA-induced elevation of [Ca2+]i, and blocking JAK/STATs in the known classic signal trans- duction pathway of CNTF did not affect L-NMDA- induced elevation of [Ca2+]i, indicating that, apart from the known classic signal transduction pathway, there may be some other transduction pathways for CNTF to exert the protective effect on hippocampal neurons, and this pathway is related to [Ca2+]. | LI Ping WANG Zongwen YAN Jin Li Zhaoshen JIANG Chunlei NI Xin YANG Yongji LIU Fang LU Changlin | 2006 | Chinese Science Bulletin2006，51，1： | 4 |
| 12 | Impacts of SIS and CICE as Sea Ice Components in BCC_CSM on the Simulation of the Arctic Climate显示文摘Sea ice is a sensitive indicator of climate change and an important component of climate system models. The Los Alamos Sea Ice Model 5.0(CICE5.0) was introduced to the Beijing Climate Center Climate System Model(BCC_CSM) as a new alternative to the Sea Ice Simulator(SIS). The principal purpose of this paper is to analyze the impacts of these two sea ice components on simulations of basic Arctic sea ice, atmosphere, and ocean states. Two sets of experiments were conducted with the same configurations except for the sea ice component used, i.e., SIS and CICE. The distributions of sea ice concentration and thickness reproduced by the CICE simulations in both March and September were closer to actual observations than those reproduced by SIS simulations, which presented a very thin sea ice cover in September. Changes in sea ice conditions also brought about corresponding modifications to the atmosphere and ocean circulation. CICE simulations showed higher agreement with the reference datasets than did SIS simulations for surface air temperature, sea level pressure, and sea surface temperature in most parts of the Arctic Ocean. More importantly, compared with simulations with SIS, BCC_CSM with CICE revealed stronger Atlantic meridional overturning circulation(AMOC), which is more consistent with actual observations. Thus, CICE shows better performance than SIS in BCC_ CSM. However, both components demonstrate a number of common weaknesses, such as overestimation of the sea ice cover in winter, especially in the Nordic Sea and the Sea of Okhotsk. Additional studies and improvements are necessary to develop these components further. | CHU Min SHI Xueli FANG Yongjie ZHANG Lujun WU Tongwen ZHOU Bing | 2019 | Journal of Ocean University of China2019，18，3： | 3 |
| 13 | Calibration of Mars Energetic Particle Analyzer (MEPA)显示文摘The first Mars exploration mission of China(Tianwen-1)is scheduled to be launched in 2020;a charged particle telescope,the Mars Energetic Particle Analyzer(MEPA),is carried as one of the payloads on the orbiter.The MEPA is designed to measure solar energetic particles(SEPs)and galactic cosmic rays(GCRs)in the near-Mars space and in the transfer orbit from Earth to Mars.Before the launch,the MEPA was calibrated in ground experiments with radioactive sources,electronic pulses,and accelerator beams.The calibration parameters,such as energy conversion constants,threshold values for the triggers,and particle identification criteria,were determined and have been stored for onboard use.The validity of the calibration parameters has been verified with radioactive sources and beams.The calibration results indicate that the MEPA can measure charged particles reliably,as designed,and that it can satisfy the requirements of the Tianwen-1 mission. | ShuWen Tang Yi Wang HongYun Zhao Fang Fang Yi Qian YongJie Zhang HaiBo Yang CunHui Li Qiang Fu Jie Kong XiangYu Hu Hong Su ZhiYu Sun YuHong Yu BaoMing Zhang Yu Sun ZhiPeng Sun | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 14 | Fuzzy C-means combined with improved particle swarm optimization for clustering problem显示文摘 | HAN Pu GAO Fang ZHAI Yongjie | 2011 | Intelligent Information Management Systems and Technologies2011，7，3： | 1 |
| 15 | Defect Passivation on Lead-Free CsSnI_(3) Perovskite Nanowires Enables High-Performance Photodetectors with Ultra-High Stability显示文摘In recent years,Pb-free CsSnI_(3) perovskite materials with excellent photoelectric properties as well as low toxicity are attracting much atten-tion in photoelectric devices.However,deep level defects in CsSnI_(3),such as high density of tin vacancies,structural deformation of SnI_(6)−octahedra and oxidation of Sn^(2+)states,are the major challenge to achieve high-performance CsSnI_(3)-based photoelectric devices with good stability.In this work,defect passivation method is adopted to solve the above issues,and the ultra-stable and high-performance CsSnI_(3) nanowires(NWs)photodetectors(PDs)are fabricated via incorporating 1-butyl-2,3-dimethylimidazolium chloride salt(BMIMCl)into perovskites.Through materials analysis and theoretical calculations,BMIM+ions can effectively passivate the Sn-related defects and reduce the dark current of CsSnI_(3) NW PDs.To further reduce the dark current of the devices,the polymethyl methacrylate is introduced,and finally,the dual passivated CsSnI_(3) NWPDs show ultra-high performance with an ultra-low dark current of 2×10^(-11) A,a responsivity of up to 0.237 A W^(−1),a high detectivity of 1.18×10^(12) Jones and a linear dynamic range of 180 dB.Furthermore,the unpackaged devices exhibit ultra-high stability in device performance after 60 days of storage in air(25℃,50% humidity),with the device performance remaining above 90%. | Zheng Gao Hai Zhou Kailian Dong Chen Wang Jiayun Wei Zhe Li Jiashuai Li Yongjie Liu Jiang Zhao Guojia Fang | 2022 | Nano-Micro Letters2022，14，12： | 1 |
| 16 | Recent advances of sorafenib nanoformulations for cancer therapy:Smart nanosystem and combination therapy显示文摘Sorafenib,a molecular targeted multi-kinase inhibitor,has received considerable interests in recent years due to its significant profiles of efficacy in cancer therapy.However,poor pharmacokinetic properties such as limited water solubility,rapid elimination and metabolism lead to low bioavailability,restricting its further clinical application.Over the past decade,with substantial progress achieved in the development of nanotechnology,various types of smart sorafenib nanoformulations have been developed to improve the targetability as well as the bioavailability of sorafenib.In this review,we summarize various aspects from the preparation and characterization to the evaluation of antitumor efficacy of numerous stimuli-responsive sorafenib nanodelivery systems,particularly with emphasis on their mechanism of drug release and tumor microenvironment response.In addition,this review makes great effort to summarize the nanosystem-based combination therapy of sorafenib with other antitumor agents,which can provide detailed information for further synergistic cancer therapy.In the final section of this review,we also provide a detailed discussion of future challenges and prospects of designing and developing ideal sorafenib nanoformulations for clinical cancer therapy. | Fangmin Chen Yifan Fang Xiang Chen Rui Deng Yongjie Zhang Jingwei Shao | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 1 |
| 17 | Diameter - dependent dopant lo- cation in silicon and germanium nanowires 显示文摘 | Ping Xie Yongjie Hu Ying Fang | 2009 | Pans2009，106，15： | 1 |
| 18 | Ion–Electron Coupling Enables Ionic Thermoelectric Material with New Operation Mode and High Energy Density显示文摘Ionic thermoelectrics(i-TE) possesses great potential in powering distributed electronics because it can generate thermopower up to tens of millivolts per Kelvin. However,as ions cannot enter external circuit, the utilization of i-TE is currently based on capacitive charge/discharge, which results in discontinuous working mode and low energy density. Here,we introduce an ion–electron thermoelectric synergistic(IETS)effect by utilizing an ion–electron conductor. Electrons/holes can drift under the electric field generated by thermodiffusion of ions, thus converting the ionic current into electrical current that can pass through the external circuit. Due to the IETS effect, i-TE is able to operate continuously for over 3000 min.Moreover, our i-TE exhibits a thermopower of 32.7 mV K^(-1) and an energy density of 553.9 J m^(-2), which is more than 6.9 times of the highest reported value. Consequently, direct powering of electronics is achieved with i-TE. This work provides a novel strategy for the design of high-performance i-TE materials. | Yongjie He Shaowei Li Rui Chen Xu Liu George Omololu Odunmbaku Wei Fang Xiaoxue Lin Zeping Ou Qianzhi Gou Jiacheng Wang Nabonswende Aida Nadege Ouedraogo Jing Li Meng Li Chen Li Yujie Zheng Shanshan Chen Yongli Zhou Kuan Sun | 2023 | Nano-Micro Letters2023，15，7： | 1 |
| 19 | Very high cycle fatigue behavior of bridge steel welded joint显示文摘<正>Very high cycle fatigue(VHCF) behaviors of bridge steel(Q345) welded joints were investigated using an ultrasonic fatigue test system at room temperature with a stress ratio R = -1. The results show that the fatigue strength of welded joints is dropped by an average of 60% comparing to the base metal and the fatigue failure still occurred beyond 10~7 cycles.The fatigue fracture of welded joints in the low cycle regime generally occurred at the solder while at the heat-affected zone(HAZ) in the very high cycle regime.The fatigue fracture surface was analyzed with scanning electron microscopy(SEM),showing welding defects such as pore,micro-crack and inclusion were the main factors on decreasing the fatigue properties of welded joints.The effect of welding defects on the fatigue behaviors of welded joints was discussed in terms of experimental results and finite element simulations. | Chao He Yongjie Liu Donghui Fang Qingyuan Wang | 2012 | Theoretical & Applied Mechanics Letters2012，2，3： | 1 |
| 20 | Effects of irrigation on precipitation in arid Xinjiang, China显示文摘 | Zhao Yong Fang Yongjie Cui Caixia Huang Anning | | 0，，02： | 1 |
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