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| 1 | Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails显示文摘 | Yanbin Fu Chenwen Huang Xinxiu Xu Haifeng Gu Youqiong Ye Cizhong Jiang Zilong Qiu Xin Xie | 2015 | Cell Research2015，25，9： | 24 |
| 2 | Comparison of the toxicity of silver nanoparticles and silver ions on the growth of terrestrial plant model Arabidopsis thaliana显示文摘Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials, but the mechanism of AgNP toxicity in terrestrial plants is still unclear. We compared the toxic effects of AgNPs and Ag+ on Arabidopsis thaliana at the physiological, ultrastructural and molecular levels. AgNPs did not affect seed germination; however, they showed stronger inhibitory effect on root elongation than Ag+ . The results of transmission electron microscopy and metal content analysis showed that AgNPs could be accumulated in leaves. These absorbed AgNPs disrupted the thylakoid membrane structure and decreased chlorophyll content, which can inhibit plant growth. By comparison, a small amount of Ag+ was absorbed by seedlings, and it did not pronouncedly affect chloroplast structure and other metal ion absorption as AgNPs did. Compared with Ag+ , AgNPs could alter the transcription of antioxidant and aquaporin genes, indicating that AgNPs changed the balance between the oxidant and antioxidant systems, and also affected the homeostasis of water and other small molecules within the plant body. All the data from physiological, ultrastructural and molecular levels suggest that AgNPs were more toxic than Ag+ . | Haifeng Qian Xiaofeng Peng Xiao Han Jie Ren Liwei Sun Zhengwei Fu | 2013 | Journal of Environmental Sciences2013，25，9： | 14 |
| 3 | Characteristics of Cd isotopic compositions and their genetic significance in the lead-zinc deposits of SW China显示文摘Up to now,the evaporation and condensation,as well as the biological absorption and inorganic absorptions,have been proved to be major factors in Cd isotope fractionation.And Cd isotopes have been widely applied in studies on the universal evolution and marine environment and so on.However,only a few researches have been conducted in applying Cd isotopes to trace the source of metallogenic material and the evolution of the ore-forming fluid in a complex mineralization environment,especially in a hydrothermal ore-formation system.We measured the Cd isotopic compositions of sphalerite,galena,and ores from five lead-zinc deposits in SW China,and found that the 114/110Cd values varied from 1.53‰to 0.34‰,with a total range of1.87‰,which is greater than most of measured geological samples.Meanwhile,through contrasting the Cd content with Cd isotopic compositions of different deposits,it may be concluded that different genetic lead-zinc deposits have different Cd content and isotopic compositions,which could be a tool for the studies on the origin of ore deposits.Also,the biomineralization and crystal fractionation may also result in Cd isotope fractionation.In a word,although the research of Cd isotopes is presently at the preliminary stage(especially in hydrothermal ore-formation system),this study demonstrated that Cd isotopes can give a clue in tracing the evolution of ore-forming fluid and metallogenic environment. | ZHU ChuanWei WEN HanJie ZHANG YuXu FAN HaiFeng FU ShaoHong XU Juan QIN TingRong | 2013 | Science China Earth Sciences2013，56，12： | 14 |
| 4 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 5 | Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell selfrenewal and somatic cell reprogramming显示文摘 | Guofang Chen Xinxiu Xu Lihong Zhang Yanbin Fu Min Wang Haifeng Gu Xin Xie | 2014 | Cell Research2014，24，9： | 8 |
| 6 | Diclofop-methyl affects microbial rhizosphere community and induces systemic acquired resistance in rice显示文摘Diclofop-methyl(DM),a widely used herbicide in food crops,may partly contaminate the soil surface of natural ecosystems in agricultural area and exert toxic effects at low dose to nontarget plants.Even though rhizosphere microorganisms strongly interact with root cells,little is known regarding their potential modulating effect on herbicide toxicity in plants.Here we exposed rice seedlings(Xiushui 63) to 100 μg/L DM for 2 to 8 days and studied the effects of DM on rice rhizosphere microorganisms,rice systemic acquired resistance(SAR) and rice-microorganisms interactions.The results of metagenomic 16 S rDNA Illumina tags show that DM increases bacterial biomass and affects their community structure in the rice rhizosphere.After DM treatment,the relative abundance of the bacterium genera Massilia and Anderseniella increased the most relative to the control.In parallel,malate and oxalate exudation by rice roots increased,potentially acting as a carbon source for several rhizosphere bacteria.Transcriptomic analyses suggest that DM induced SAR in rice seedlings through the salicylic acid(but not the jasmonic acid) signal pathway.This response to DM stress conferred resistance to infection by a pathogenic bacterium,but was not influenced by the presence of bacteria in the rhizosphere since SAR transcripts did not change significantly in xenic and axenic plant roots exposed to DM.The present study provides new insights on the response of rice and its associated microorganisms to DM stress. | Si Chen Xingxing Li Michel Lavoie Yujian Jin Jiahui Xu Zhengwei Fu Haifeng Qian | 2017 | Journal of Environmental Sciences2017，29，1： | 8 |
| 7 | STAGED PROGRESSION MODEL FOR EPIDEMIC SPREAD ON HOMOGENEOUS AND HETEROGENEOUS NETWORKS显示文摘在这份报纸,与同类、异构的网络上的上演前进模型一起的流行传播被学习。首先,简单上演前进模型的流行阀值被给。然后,有出生和死亡的上演前进模型也被考虑。传染性是节点度的非线性的功能的盒子也被讨论。最后,分析结果被数字模拟验证。 | Haifeng ZHANG Michael SMALL Xinchu FU | 2011 | Journal of Systems Science & Complexity2011，24，4： | 7 |
| 8 | Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta. | Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin | 2022 | China CDC weekly2022，4，4： | 7 |
| 9 | Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells显示文摘 | Yan Yuan Quan Zhou Haifeng Wan Bin Shen Xuepeng Wang Mei Wang Chunjing Feng Mingming Xie Tiantian Gu Tao Zhou Rui Fu Xingxu Huang Qi Zhou Jiahao Sha Xiao-Yang Zhao | 2015 | Cell Research2015，25，7： | 7 |
| 10 | Mammalian cell display for rapid screening scFv antibody therapy显示文摘人的抗体开始在有免疫力的基因治疗为使用正在引起注意。对癌症和传染疾病的治疗合适的有效治疗学的 monoclonal 抗体的有效产生将是极其珍贵的。抗体显示方法逐渐地被用来屏蔽人的 monoclonal 抗体。这里,我们报导一个哺乳动物的房间显示方法的构造源于一个天真的抗体全部剧目,为人,单个链的变量碎裂短暂地基于 pDisplay 向量在 293T 房间表面上被显示了。当前的 pDisplayscFv 抗体全部剧目的尺寸被估计了是 0. | Jing Zhang Xiao'ai Zhang Qiang Liu Mengyi Li Liucun Gao Xin Gao Shensi Xiang Liangliang Wu Jie Fu Haifeng Song | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 6 |
| 11 | X-ray pulsar-based navigation using pulse phase and Doppler frequency measurements显示文摘In order to eliminate the impact of the Doppler effects caused by the motion of the spacecraft on the X-ray pulsar-based navigation, an innovative navigation method using the pulse phase and Doppler frequency measurements of the X-ray pulsars is proposed. Given the initial estimate of the spacecraft's state,the real-time photon arrival model is established at the spacecraft with respect to the spacecraft's position and velocity predicted by the orbit dynamic model and their estimation errors. On this basis, a maximum likelihood estimation algorithm directly using the observed photon event timestamps is developed to extract a single pair of pulse phase and Doppler frequency measurements caused by the spacecraft's state estimation error. Since the phase estimation error increases as the observation time increases, we propose a new measurement updating scheme of referring the measurements to the middle time of an observation interval. By using the ground-based simulation system of X-ray pulsar signals, a series of photon-level simulations are performed. The results testify to the feasibility and real-timeliness of the proposed navigation method, and show that the incorporation of the Doppler measurement as well as the pulse phase into the navigation filter can improve the navigation accuracy. | XUE MengFan LI XiaoPing FU LingZhong FANG HaiYan SUN HaiFeng SHEN LiRong | 2015 | Science China Chemistry2015，58，12： | 5 |
| 12 | Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs显示文摘Blastocyst complementation by pluripotent stem cell(PSC)injection is believed to be the most promising method to generate xenogeneic organs.However,ethical issues prevent the study of human chimeras in the late embryonic stage of development.Primate embryonic stem cells(ESCs),which have similar pluripotency to human ESCs,are a good model for studying interspecies chimerism and organ generation.However,whether primate ESCs can be used in xenogenous grafts remains unclear.In this study,we evaluated the chimeric ability of cynomolgus monkey(Macaca fascicularis)ESCs(cmESCs)in pigs,which are excellent hosts because of their many similarities to humans.We report an optimized culture medium that enhanced the anti-apoptotic ability of cmESCs and improved the development of chimeric embryos,in which domesticated cmESCs(D-ESCs)injected into pig blastocysts differentiated into cells of all three germ layers.In addition,we obtained two neonatal interspecies chimeras,in which we observed tissue-specific D-ESC differentiation.Taken together,the results demonstrate the capability of D-ESCs to integrate and differentiate into functional cells in a porcine model,with a chimeric ratio of 0.001-0.0001 in different neonate tissues.We believe this work will facilitate future developments in xenogeneic organogenesis,bringing us one step closer to producing tissue-specific functional cells and organs in a large animal model through interspecies blastocyst complementation. | Rui Fu Dawei Yu Jilong Ren Chongyang Li Jing Wang Guihai Feng Xuepeng Wang Haifeng Wan Tianda Li Libin Wang Ying Zhang Tang Hai Wei Li Qi Zhou | 2020 | Protein & Cell2020，11，2： | 4 |
| 13 | Experimental Study on the Dynamic Mechanical Properties of Reinforced Concrete under Shock Loading显示文摘A simple experimental method was introduced to study the mechanical properties of reinforced concrete under shock loading. The one-stage light gas gun was used to test the mechanical properties of reinforced concrete with different reinforcement ratios under various impact velocities. Three Mn-Cu piezoresistive pressure gauges embedded in the target were used to record the voltage-time signals, from which the stress-strain curves of reinforced concrete were obtained using Lagrangian analysis. Experimental results indicated that the load-bearing capacities of reinforced concrete increased greatly with the impact velocity and the reinforcement ratio. The peak stress of the shock wave decreased exponentially with the propagation distance. | Haifeng Liu Jie Fu Jianguo Ning | 2016 | Acta Mechanica Solida Sinica2016，29，1： | 4 |
| 14 | Identification of genes for normalization of quantitative real-time PCR data in ovarian tissues显示文摘增加的注意在最近的年里为卵巢的癌症对潜在的 biomarker 和治疗学的目标的决心被给予了。然而,量的即时 PCR 的正规化是重要的获得精确基因表示数据。我们在不同条件下面在卵巢的纸巾调查了 20 参考基因的稳定性决定为这应用最足够。学习在包含正常、非恶意、主要的卵巢的癌的 52 件卵巢的织物样品之中描绘了 20 可能的参考基因的表示。变化(ANOVA ) 的单程的分析方法被用来比较疾病前进引起的候选人基因变化。没有统计差别的基因的稳定性和适用性是进一步的采用 geNorm 和 NormFinder 软件验证。当尽管有不同卵巢的织物条件, RPL4, RPLP0, HSPCB, TPT1, RPL13A, 18S rRNA, PPIA, TBP,和 GUSB 使稳定性统计时,结果证明 20 参考基因的表示层次变化了。RPL4, RPLP0,和 HSPCB 作为最稳定的参考基因和 RPLP0 的联合被表明, RPL4 应该被推荐为更可靠的正规化策略。 | Jie Fu Lihong Bian Li Zhao Zhouhuan Dong Xin Gao Haofei Luan Yunjuan Sun Haifeng Song | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 4 |
| 15 | In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect显示文摘In the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank’s solution. In vitro cytotoxicity test showed that Mg69Zn27Ca4 metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original φ6 mm to φ3.35 ± 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. | Junxiu Chen Jiahui Dong Huameng Fu Haifeng Zhang Lili Tan Dewei Zhao Ke Yang | 2019 | Journal of Materials Science & Technology2019，35，10： | 4 |
| 16 | Fe-based metallic glass:An efficient and energy-saving electrode material for electrocatalytic degradation of water contaminants显示文摘Excessive consumption of electrical energy has hampered the widespread application of electrochemical technology for degradation of various contaminants. In this paper, a Fe-based metallic glass(MG) was demonstrated as a new type of electrocatalyst to effectively and economically degrade an azo dye. In comparison to other typical electrodes, Fe-based MG electrodes exhibit a minimized degradation time, and the specific energy is 4-6 orders of magnitude lower than that of dimensionally stable anode(DSA), metal-like boron-doped diamond(BDD) and other electrodes. As sacrificial electrode materials, Fe-based MGs have less specific electrode mass consumption than iron electrodes. The use of Fe-based MGs will promote the practical application of electrochemical technology and the use of MGs as functional materials. | Xindong Qin Zhengkun Li Zhengwang Zhu Huameng Fu Hong Li Aimin Wang Hongwei Zhang Haifeng Zhang | 2018 | Journal of Materials Science & Technology2018，34，12： | 3 |
| 17 | Progress and prospects of horizontal well fracturing technology for shale oil and gas reservoirs显示文摘By systematically summarizing horizontal well fracturing technology abroad for shale oil and gas reservoirs since the “13th Five-Year Plan”, this article elaborates new horizontal well fracturing features in 3D development of stacked shale reservoirs, small well spacing and dense well pattern, horizontal well re-fracturing, fracturing parameters optimization and cost control. In light of requirements on horizontal well fracturing technology in China, we have summarized the technological progress in simulation of multi-fracture propagation, horizontal well frac-design, electric-drive fracturing equipment, soluble tools and low-cost downhole materials and factory-like operation. On this basis, combined with the demand analysis of horizontal well fracturing technology in the “14th Five-Year Plan” for unconventional shale oil and gas, we suggest strengthening the research and development in the following 7 aspects:(1) geology-engineering integration;(2) basic theory and design optimization of fracturing for shale oil and gas reservoirs;(3) development of high-power electric-drive fracturing equipment;(4) fracturing tool and supporting equipment for long horizontal section;(5) horizontal well flexible-sidetracking drilling technology for tapping remaining oil;(6) post-frac workover technology for long horizontal well;(7) intelligent fracturing technology. | LEI Qun XU Yun CAI Bo GUAN Baoshan WANG Xin BI Guoqiang LI Hui LI Shuai DING Bin FU Haifeng TONG Zheng LI Tao ZHANG Haoyu | 2022 | Petroleum Exploration and Development2022，49，1： | 3 |
| 18 | Pilose antler polypeptides ameliorates hypoxic- ischemic encephalopathy by activated neurotrophic factors and SDF1/CXCR4 axis in rats显示文摘Hypoxic-ischemic encephalopathy (催促) 是与高死亡和病态被联系的一个复杂条件。然而,很少有希望的处理为催促存在。在现在的学习,中央目的是识别覆有毛的鹿角多肽(奶头) 的治疗学的效果在上在老鼠催促。Sprague-Dawley (SD ) 老鼠(14 天旧) 被使用并且把组划分了成三包括控制组, hypoxic 局部缺血(嗨) 组和奶头组。在 21 天处理以后,运动活动在对待奶头的老鼠被改进,大脑萎缩被减少,服的浮肿被减轻到某程度。实时量的聚合酶链反应(RT-qPCR ) 分析显示奶头管理减少了在马头鱼尾的怪兽的煽动性的 cytokines 和 apoptosis 基因的表情与相比嗨组。而且,与神经营养的因素有关的基因的 mRNA 表情显著地在马头鱼尾的怪兽被增加。另外,氧化压力标记的表情都在奶头管理以后是下面调整的。而且,奶头起来调整 mRNA 和 SDF1 和 CXCR4 的蛋白质层次,它可以激活 SDF1/CXCR4 轴到节制大脑损害。这些结果建议那个奶头可以潜在地在处理被使用催促。 | Tao Wu Luna Yang Yan Chen Yinhua Ni Jianguo Jiang Wanjing Zhang Qianchen Zhou Xiaojun Zheng Qi Wang Zhengwei Fu Haifeng Li | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 3 |
| 19 | Correlation Between Dynamic Compressive Strength and Fracture Behaviors of Bulk Metallic Glasses显示文摘The mechanical behaviors of Zr43.5Cu43.5Ni4Al8Nb1,Zr55.4Cu31.6Ni4Al8Nb1,Ti32.8Zr30.2Ni5.3Cu9Be22.7(at.%)metallic glass at different strain rates were studied.For all the present alloys,the dispersion over 700 MPa was observed on the strength in the repeated dynamic compressions,which was much stronger than that of the quasi-static compressive strength.Such the dispersion of the dynamic compressive strength was well correlated with the corresponding fracture behaviors.The area of fracture surface was calculated and also showed a strong dispersion for all the fractured specimens tested at the strain rate of 500 s^-1 and 1000 s^-1.All the specimens showed a linear relationship between the square of dynamic compressive strength and the area of fracture surface in the dynamic compression tests.This phenomenon was mainly thought to be related to the difference of mean initial free volume concentration of different samples,stress concentration caused by the split Hopkinson pressure bar experimental setup and high sensitivity of defects under dynamic deformation.These findings were beneficial to deeply understand the effect of strain rate on the mechanical properties of the metallic glass. | Wenqing Li Zhengwang Zhu Guojie Li Long Zhang Zhengkun Li Huameng Fu Hongwei Zhang Hong Li Aimin Wang Haifeng Zhang | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，10： | 2 |
| 20 | Co_(78)Si_(8)B_(14)metallic glass:A highly efficient and ultra-sustainable Fenton-like catalyst in degrading wastewater under universal pH conditions显示文摘Overcoming the pH limitation and increasing the catalyst reusability remain pressing demands for metal-lic glass(MG)in wastewater remediation.Herein,Co_(78)Si_(8)B_(14)MG ribbons are used to degrade dye wastew-ater by activating hydrogen peroxide(H_(2)O_(2))as Fenton-like catalysts.The Co-based MG catalysts exhibit high degradation efficiency under both acidic and alkaline conditions,and the kinetic reaction rate at pH 10(0.176 min^(−1)) and pH 4(0.089 min^(−1)) is 5.9 and 1.2 times higher than that of the extensively studied Fe-based MG catalysts,respectively.Impressively,the Co-based MG catalysts can be reused up to 20-60 times at universal pH conditions,demonstrating fairly good reusability.The newly discovered Co-based MG catalysts do not follow the classical Fenton reactions with H_(2)O^(2) the way Fe-based MGs do.In an acid environment,hydroxyl radicals play a dominant role in the degradation,while in an alkaline environ-ment,the effect of hydroxyl radicals is weakened,and Co^(3+) ions exert a relatively major function on the degradation.The excellent performance in catalytic activity and reusability at universal pH conditions of the Co-based MGs will inspire the development of MGs in wastewater treatment. | Xindong Qin Jiliang Xu Zhengwang Zhu Zhengkun Li Dawei Fang Huameng Fu Shiming Zhang Haifeng Zhang | 2022 | Journal of Materials Science & Technology2022，，18： | 2 |
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