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| 1 | Effect of minor content of Gd on the mechanical and degradable properties of as-cast Mg-2Zn-xGd-0.5Zr alloys显示文摘RE-containing Mg alloys used as biodegradable medical implants exhibit good promising application due to their good mechanical properties and degradation resistance. In this work, effect of Gd on the microstructure, mechanical properties and biodegradation of as-cast Mg-2Zn-xGd-0.5Zr alloys was investigated. The results showed that there were mainly α-Mg, I-phase, W-phase and MgZn2 phase in Mg-Zn-Gd-Zr alloys. With increase of the Gd content, the strength of the alloys was enhanced due to the second phase strengthening and grain refinement. The degradation resistance of Mg-2Zn-0.5Zr alloy was increased by adding 0.5%–1% Gd due to the uniformly distributed second phases which acted as a barrier to prevent the pitting corrosion. However, increasing Gd content to 2% reduced the degradation resistance of the alloy due to the galvanic corrosion between the matrix and the second phases.The good degradation resistance and mechanical properties of as-cast Mg-2Zn-1Gd-0.5Zr alloy makes it outstanding for biomaterial application. | Junxiu Chen Lili Tan Xiaoming Yu Ke Yang | 2019 | Journal of Materials Science & Technology2019，35，4： | 13 |
| 2 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 3 | Effect of grain refinement and crystallographic texture produced by friction stir processing on the biodegradation behavior of a Mg-Nd-Zn alloy显示文摘The application of a single pass of friction stir processing(FSP) to Mg-Nd-Zn alloy resulted in grain refinement, texture evolution and redistribution of second phases, which improved corrosion resistance.In this work, an as-rolled Mg-Nd-Zn alloy was subjected to FSP. The microstructure in the processed zone of the FS-400 rpm alloy exhibited refined grains, a more homogenous grain size distribution, less second phases, and stronger basal plane texture. The corrosion behavior assessed using immersion tests and electrochemical tests in Hank’s solution indicated that the FS-400 rpm alloy had a lower corrosion rate, which was attributed to the increase of basal plane intensity and grain refinement. The hardness was lowered slightly and the elongation was increased, which might be attributed to the redistribution of the crushed second phases. | Wen Zhang Lili Tan Dingrui Ni Junxiu Chen Ying-Chao Zhao Long Liu Cijun Shuai Ke Yang Andrej Atrens Ming-Chun Zhao | 2019 | Journal of Materials Science & Technology2019，35，5： | 6 |
| 4 | Effect of heat treatment on mechanical and biodegradable properties of an extruded ZK60 alloy显示文摘ZK60 magnesium alloy possess good mechanical properties and is a potential biodegradable material.But its high degradation rate is not desirable.In this study the effect of heat treatment on the biodegradable property of ZK60 alloy was investigated.T5 treated,T6 treated,as-cast and as-extruded ZK60 alloys were studied.Microstructure characterization,electrochemical measurement and immersion test were carried out.The results showed that both the mechanical properties and degradation behavior were improved after T5 treatment due to the formation of small and uniformly distributed MgZn phases.The as-cast alloys also exhibited good corrosion resistance.However,the as-extruded and T6 treated samples were severely corroded due to the formation of large amounts of second phases accelerating the corrosion rate owing to the galvanic corrosion.The corrosion resistance of ZK60 alloy was as following:T5 treated>as-cast>T6 treated>as-extruded. | Junxiu Chen Lili Tan Ke Yang | 2017 | Bioactive Materials2017，2，1： | 6 |
| 5 | Shumian capsule(舒眠胶囊) improves symptoms of sleep mood disorder in convalescent patients of Corona Virus Disease 2019显示文摘OBJECTIVE:To evaluate the clinical effectiveness of Shumian capsule(舒眠胶囊)in improving the symptoms of insomnia,anxiety,depression,and other symptoms of convalescent patients of COVID-19.METHODS:Totally 200 patients were collected and randomly divided into experiment group(n=100)and control group(n=100).The control group was treated with Shumian capsule simulator,and the experiment group was treated with Shumian capsule.The improvement of TCM symptom score,the total effective rate and symptom disappearance rate of TCM symptoms in the two groups before and after treatment were observed,and the clinical effect was evaluated.RESULTS:One week after treatment,the scores of anxiety symptoms in the experiment group were significantly different from those in the control group(P<0.05),but there was no significant difference in the scores of insomnia and depression between the experiment group and the control group(P>0.05).There was no significant difference in the total effective rate and disappearance rate of TCM symptoms of insomnia,anxiety and depression between the experiment group and the control group(P>0.05).After 2 weeks of treatment,the scores of insomnia,anxiety,depression and the total effective rate of TCM symptoms in the experiment group were significantly different from those in the control group(P<0.05).There was no significant difference in the disappearance rate of insomnia,anxiety and depression between the experiment group and the control group(P>0.05).There were no significant differences in heart rate,respiration,systolic blood pressure and diastolic blood pressure between the experiment group and the control group(P>0.05).CONCLUSION:Shumian capsule can significantly improve the symptoms of insomnia,anxiety and depression in COVID-19’s convalescent patients with sleep and mood disorders. | LI Li AN Xuedong ZHANG Qing TAO Junxiu HE Jing CHEN Yun LI Kejian LIU Ru GUO Juan ZHANG Hao TONG Xiaolin BA Yuanming | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 4 |
| 6 | In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect显示文摘In the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank’s solution. In vitro cytotoxicity test showed that Mg69Zn27Ca4 metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original φ6 mm to φ3.35 ± 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. | Junxiu Chen Jiahui Dong Huameng Fu Haifeng Zhang Lili Tan Dewei Zhao Ke Yang | 2019 | Journal of Materials Science & Technology2019，35，10： | 4 |
| 7 | SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer显示文摘Alternative splicing is a critical process to generate protein diversity.However,whether and how alternative splicing regulates autophagy remains largely elusive.Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor.Specifically,SRSF1 inhibits autophagosome formation by reducing the accumulation of LC3-ⅡI and numbers of autophagosomes in different cell lines.Mechanistically,SRSF1 promotes the splicing of the long isoform of Bcl-x that interacts with Beclinl,thereby dissociating the Beclin1-PIK3C3 complex.In addition,SRSF1 also directly interacts with PIK3C3 to disrupt the interaction between Beclinl and PIK3C3.Consequently,the decrease of SRSF1 stabilizes the Beclinl and PIK3C3 complex and activates autophagy.Interestingly,SRSF1 can be degraded by starvation-and oxidative stresses-induced autophagy through interacting with LC3-Ⅱ,whereas reduced SRSF1 further promotes autophagy.This positive feedback is critical to inhibiting Gefitinib-resistant cancer cell progression both in vitro and in vivo.Consistently,the expression level of SRSF1 is inversely correlated to LC3 level in clinical cancer samples.Our study not only provides mechanistic insights of alternative splicing in autophagy regulation but also discovers a new regulatory role of SRSF1 in tumorigenesis,thereby offering a novel avenue for potential cancer therapeutics. | Yuesheng Lv Wenjing Zhang Jinyao Zhao Bing Sun Yangfan Qi Haoyu Ji Chaoqun Chen Jinrui Zhang Junxiu Sheng Taishu Wang Daniel Dominguez Han Liu Quentin Liu Songshu Meng Xiaoling Li Yang Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 8 | Shugan Jieyu capsule(舒肝解郁胶囊) improve sleep and emotional disorder in coronavirus disease 2019 convalescence patients: a randomized, double-blind, placebo-controlled trial显示文摘OBJECTIVE: To evaluate the efficacy of the Shugan Jieyu capsule(舒肝解郁胶囊) on improving sleep and emotional disorder during Coronavirus disease 2019(COVID-19) convalescence. METHODS: We conducted a randomized, double-blind, placebo-controlled trial, and recruit 200 COVID-19 convalescence patients and then divide the subjects into two groups respectively: the experimental group(n = 100) and the control group(n = 100). Patients in the control group were given doses as a placebo, while those in the experimental group were given Shugan Jieyu capsule.The investigators mainly observed the differences between the two groups before and after treatment in terms of the rate of reduction and the rate of efficiency in Hamilton Depression Scale(HAMD-17) total scores from baseline, and recorded the scores of Hamilton Anxiety Scale(HAMA), Patient Health Questionnaire-15(PHQ-15), Insomnia Severity Index(ISI) and Treatment Emergent Symptom Scale at 2 week, the 4 week and the 6 week respectively after treatment, and compared the differences between the groups. And the occurrence of adverse events was recorded. RESULTS: After 6-week treatment, there were statistically significant differences in the rate of reduction as well as efficiency in HAMD-17 scores, HAMA Total Scores, PHQ-15 Score, ISI Score from baseline in the experimental group and control group(P < 0.05). There were 4 adverse events in the experimental group and 1 in the control group. CONCLUSION: Shugan Jieyu capsule could significantly improve sleep and emotional disorder in patients during COVID-19 convalescence. | AN Xuedong ZHANG Qing TAO Junxiu LI Li CHEN Yun LI Kejian HE Jing LIU Ru GUO Juan ZHANG Jia ZHU Hui LIAN Fengmei LI Xiaodong | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 2 |
| 9 | Preparation of Gu nanoparticles from water - in - Oil microemulsions显示文摘 | Qiu Sunqing Dong Junxiu Chen Guoxu | 1999 | Journal of Colloid and Interface Science1999，216，： | 1 |
| 10 | Tribological properties of CeF3 nanoparticles as additives in lubricating oils显示文摘 | Dong Junxiu Chen Guoxu | 1999 | Wear1999，230，： | 1 |
| 11 | Tribological properties of CeF3 nanoparticles as additives in lubricating oils显示文摘 | Qiu Sunqing Dong Junxiu Chen Guoxu | 1999 | Wear1999，230，： | 1 |
| 12 | Wear and Friction Behaviour of CaCO3 Nanopaticles Used as Additives in Lubricating Oils显示文摘 | Qiu SunQing Dong JunXiu Chen GuoXu | 2000 | Lubrication Science2000，12，2： | 1 |
| 13 | Synthesis of CeF3 nanoparticles from water-in-oil microemulsions 显示文摘 | Qiu Sunqing Dong Junxiu Chen Guoxu | 2000 | Powder Technology2000，113，12： | 1 |
| 14 | Effects of chitosan coating on quality and shelf life of silver carp during frozen storage显示文摘 | Wenjiao Fan Junxiu Sun Yunchuan Chen Jian Qiu Yan Zhang Yuanlong Chi | 2008 | Food Chemistry2008，，1： | 1 |
| 15 | Tribological proper ties of CeF3 nanoparticles as additives in lubricating oils显示文摘 | Oiu Sunqing Dong Junxiu Chen Guoxu | 1999 | Wear1999，230，1： | 1 |
| 16 | Powder Technology显示文摘 | Qiu Sunqing Dong Junxiu Chen Guoxu | 2000 | 113:9-132000，113，： | 1 |
| 17 | 显示文摘 | Qiu Sunqing Dong Junxiu Chen Guoxu | 1999 | Wear1999，230，1： | 1 |
| 18 | Tribological properties of CeF3 nanoparticles as additives in lubricating oils显示文摘 | Qiu Sunqing Dong Junxiu Chen Guoxu | 1999 | Wear1999，230，： | 1 |
| 19 | A review of ultra- fine particles as antiwear additives and friction modiers in lubricating oils显示文摘 | Qiu Sunqing Dong Junxiu Chen Guoxu | 1999 | Lubrieation Science1999，11，3： | 1 |
| 20 | Preparation and tri- bology of aerogel silica and alumina-silica as lubricant oil addi- tives 显示文摘 | Dong Junxiu Hu Zexiang Chen Guoxu | 1999 | Lubrication Science1999，11，3： | 1 |
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