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| 1 | The Impact of the South Asia High Bimodality on the Chemical Composition of the Upper Troposphere and Lower Stratosphere显示文摘The South Asia High (SAH) is the dominant feature of the circulation in the upper troposphere and lower stratosphere (UTLS) during the boreal summer,and the upper tropospheric anticyclonic circulation extends into the lower stratosphere.The preferred locations of the center of the SAH occur in two different regions,and the center can be located over the Iranian Plateau or over the Tibetan Plateau.This bimodality has an impact on the distribution of chemical constituents in the UTLS region.We analyzed water vapor (H 2 O),carbon monoxide (CO),and ozone (O 3) data derived from the Aura Microwave Limb Sounder (MLS) and total column ozone data from the Ozone Monitoring Instrument (OMI).For the Iranian Plateau mode of the SAH,the tropospheric tracers exhib-ited a positive anomaly over the Iranian Plateau and a negative anomaly over the Tibetan Plateau,whereas the stratospheric tracer exhibited a negative and a positive anomaly over the Iranian Plateau and the Tibetan Plateau,respectively.For the Tibetan Plateau mode,however,the distribution of the anomaly was the reverse of that found for the chemical species in the UTLS region.Furthermore,the locations of the extrema within the anomaly seemed to differ across chemical species.The anomaly extrema for H 2 O occurred in the vicinity of the SAH ridgeline,whereas CO and O 3 exhibited a northward shift of 4-8 degrees.These impacts of the variation in the SAH on the chemical constitutes in the UTLS region can be attributed in part to the dynamical structure delineated by the tro-popause field and the temperature field at 100 hPa. | YAN Ren-Chang BIAN Jian-Chun FAN Qiu-Jun | 2011 | Atmospheric and Oceanic Science Letters2011，4，4： | 13 |
| 2 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 3 | Quantification of pancreatic exocrine function of chronic pancreatitis with secretin-enhanced MRCP显示文摘AIM:To obtain reference values for pancreatic flow output rate(PFR)and peak time(PT)in healthy volunteers and chronic pancreatitis(CP);to correlate quantification of secretin enhanced magnetic resonance cholangiopancreatography(SMRCP)of pancreatic fluid output following secretin with fecal elastase-1(FE-1)tests.METHODS:The present study includes 53 subjects comprised of 17 healthy individuals and 36 patients with CP from April 2011 to January 2013.The 36 patients with CP were divided into three groups of mild CP(n=14),moderate CP(n=19)and advanced CP(n=3)by M-ANNHEIM classification for CP..Fifty-three cases underwent FE-1 test and magnetic resonance imaging using 3.0 T-device(Signa EXCITE,GE Healthcare).Coronal T2-weighted single-shot turbo spin-echo,spiratory triggered,covering the papillae,duodenum and small bowel.MRCP was performed with a heavily T2-weighted fat-suppressed long TE HASTE sequence (thick slab 2D MRCP sequence),repeated every 2 min up to 11 min after 0.1 mL/kg secretin injection(Secrelux,Sanochemia,Germany).FE-1 test used sandwich enzyme-linked immunosorbent assay(ELISA)test(ScheBo.Tech,Germany).RESULTS:A good linear correlation showed between the calculated volume and the actual volume by Phantom experiments.Fifty-three paired Quantification of secretin enhanced magnetic resonance cholangiopancreatography(MRCPQ)and FE-1 data sets were analyzed.The mean FE-1 of 53 cases was 525.41±94.44μg/g for 17 healthy volunteers,464.95±136.13μg/g for mild CP,301.55±181.55μg/g for moderate CP,229.30±146.60μg/g for advanced CP.Also,there was statistically significant difference in FE-1(P=0.0001)between health and CP.The mean values of PFR and PT were 8.18±1.11 mL/min,5.76±1.71 min for normal;7.27±2.04 mL/min,7.71±2.55 min for mild CP;4.98±2.57 mL/min,9.10±3.00 min for moderate CP;4.13±1.83 mL/min,12.33±1.55 min for advanced CP.Further,statistically significant difference in PFR(P=0.0001)and PT(P=0.0001)was observed between health and CP.Besides,there was correlation(r=0.79)and consistency(K=0.6)between MRCPQ and ELISA Test.It was related between M-ANNHEIM classification and PFR(r=0.55),FE-1(r=0.57).CONCLUSION:SMRCP can provide a safe,non-invasive and efficient method to evaluate the exocrine function of the pancreas. | Yun Bian Li Wang Chao Chen Jian-Ping Lu Jia-Bao Fan Shi-Yue Chen Bing-Hui Zhao | 2013 | World Journal of Gastroenterology2013，19，41： | 11 |
| 4 | A deep stratospheric intrusion associated with an intense cut-off low event over East Asia显示文摘European Centre for Medium-Range Weather Forecasts Re-Analysis Interim(ERA-Interim)reanalysis data and satellite data,and trajectory model were applied to analyze the dynamical,thermo-dynamical,and chemical structure in the upper troposphere and lower stratosphere(UTLS)of an intense cut-off low(COL)event occurring over East Asia during June 19-23,2010,and to characterize the process and transport pathway of deep stratospheric intrusion.The Atmospheric Infrared Sounder(AIRS)ozone data and the Global Positioning System Ozone(GPSO3)sonde data showed that the air mass originating from the polar formed a region with relatively high values of potential vorticity(PV)and ozone in the center of COL,and a secondary ozone peak appeared in the upper troposphere during mature stage of the COL.Forward trajectory simulation suggested that during the first stage of COL,deep stratospheric intrusion associated with strong northerly wind jet on the west side of the upper-level trough transported ozone-rich air from the polar lower stratosphere into the middle and lower troposphere in the mid-latitude,and increased the ozone concentration there.During the mature stage of the COL,stratospheric air was transported counterclockwise into the troposphere.Backward trajectory model was used to find the source regions of air mass within the COL during its mature stage.Model results show that air masses with high ozone concentration in the center of the COL have two source regions:one is the subpolar vortex which lies in northern part of Center Siberia,where ozone-rich air plays a major role in increasing the ozone concentrations,and the other is the strong shear region which is near by the cyclonic side of the extratropical jet axis(west of 90°E,near 50°N).The air masses with low ozone concentration around the COL also have two source regions:one is the anticyclonic side of the extratropical jet axis,where the air mass with the relatively low ozone concentration at the bottom of the COL is mainly controlled by horizontal movement,and the other is the warm area of the south side of COL,where the air mass on the east and west side of the COL is mainly dominated by upward motion. | LI Dan BIAN JianChun FAN QiuJun | 2015 | Science China Earth Sciences2015，58，1： | 10 |
| 5 | Recent Progress and Development in Extrusion of Rare Earth Free Mg Alloys: A Review显示文摘Mg and its alloys are the lightest structural metals available and are extremely attractive for applications as lightweight components, particularly in the automobile, electronic, and aerospace industries. The global market for wrought Mg alloys has steadily expanded over the past decade. And numerous studies have been carried out to meet this increasing demand of high-performance Mg alloys. However, Mg extrusion alloys have had a very limited usage so far. To overcome existing industrial challenges, one desirable approach is the development of low-cost rare earth(RE) free Mg extrusion alloys with superior mechanical properties. This review will introduce the recent research highlights in the extrusion of Mg alloys, specifi cally focusing on low-cost RE-free Mg alloy. The results from both the literature and our previous study are summarized and critically reviewed. Several aspects of RE-free Mg extrusion alloys are described in detail:(1) novel alloying designs including Mg–Al-, Mg–Zn-, Mg–Ca-, Mg–Sn-, and Mg–Bi-based alloys,(2) advanced extrusion techniques, and(3) extrusion-related severe plastic deformation(SPD) processing. Accordingly, considering the large gap in mechanical properties between the current RE-free Mg alloys and high-performance aluminum alloys, new alloy design, processing route control, and recommendations for future research on RE-free Mg extrusion alloys are also proposed. We hope this review will not only off er insightful information regarding the extrusion of RE-free Mg alloys but also inspire the development of new Mg extrusion technologies. | Shuai-Ju Meng Hui Yu Shao-Da Fan Qi-Zhi Li Sung Hyuk Park Joung Sik Suh Young Min Kim Xiao-Long Nan Ming-Zhe Bian Fu-Xing Yin Wei-Min Zhao Bong Sun You Kwang Seon Shin | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，2： | 6 |
| 6 | ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer显示文摘The Serine-Glycien-One-Carbon(SGOC)pathway is pivotal in multiple anabolic processes.Expression levels of SGOC genes are deregulated under tumoeigenic condltions,suggesting panicipation of oncogenes in deregulating the SGOC biosynthetic pathway.However,the underlying mechanism remains elusive.Here,we identifed that Interleukin enfiarccer-binding factor 3(ILF3)is overexpressed in primary CRC patient specimens and correlates with poor progroosis.ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes,thereby increasing SGOC genes expression and facilitating tumor growth.Mehhanktic studies showed that the EGF-MIEK-ERK pathway nnediates ILF3 phosphorylation,which hin ders E3 ligase speckle-type POZ protein(SPOP)-mediated poly-ubiquitination and degradation of ILF3.Sign iftca ntly,combination of SGOC inhibitor and the anti-EGFR monoclonal antibody cetuximab can hinder the growth of patient-derived xenografts that sustain high ERK-ILF3 levels.Taken together,deregutation of ILF3 via the EGF-ERK signaling plays an important role in systemic serine metabolic reprogramming and confers a predilection toward CRC development.Our findings indicate that clinical evaluation of SCOC inhibitor is warranted for CRC patients with ILF3 overexpression. | Kai Li Jian-lin Wu Baifu Qin Zongmin Fan Qin Tang Weisi Lu Haipeng Zhang Fan Xing Manqi Meng Shaomin Zou Wenxia Wei Honglei Chen Jian Cai Huaiming Wang Hui Zhang Jiayue Cai Ling Fang Xiqing Bian Chuangqi Chen Ping Lan Bart Ghesquiere Lekun Fang Mong-Hong Lee | 2020 | Cell Research2020，30，2： | 6 |
| 7 | MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing显示文摘Wound healing is a complex physiological process that involves coordinated phases such as inflammation and neovascularization.Attempts to promote the healing process tend to construct an effective delivery system based on different drugs and materials.In this paper,we propose novel MXene-integrated microneedle patches with adenosine encapsulation for wound healing.Owing to the dynamic covalent bonding capacity of boronate molecules with adenosine,3-(acrylamido)phenylboronic acid-(PBA-)integrated polyethylene glycol diacrylate(PEGDA)hydrogel is utilized as the host material of microneedle patches.Benefitting from photothermal conversion capacity of MXene,the release of loaded adenosine could be accelerated under NIR irradiation for maintaining the activation signal around injury site.In vitro cell experiments proved the effect of MXene-integrated microneedle patches with adenosine encapsulation in enhancing angiogenesis.When applied for treating animal models,it is demonstrated that the microneedle patches efficiently promote angiogenesis,which is conductive to wound healing.These features make the proposed microneedle patch potential for finding applications in wound healing and other biomedical fields. | Lingyu Sun Lu Fan Feika Bian Guopu Chen Yuetong Wang Yuanjin Zhao | 2021 | Research2021，，1： | 6 |
| 8 | Isolation of egg yolk IgY from hens immunized with S.mutans B29-33 and S.sobrinus 6715显示文摘目的 :从鸡蛋中提取特异性抗体 ,鉴定抗体性质并分析其蛋白质含量 ,以探索一种制备被动免疫防龋抗体的制备方法。方法 :变形链球菌GTF高表达株S .mutansB2 9- 33及茸毛链球菌S .sobrinus 6 715免疫母鸡 ,采用硫酸铵沉淀法提取鸡蛋黄抗体 ,SDS -PAGE凝胶扫描鉴定抗体性质 ,分析其纯度并用分光光度法测蛋白质含量。结果 :用硫酸铵沉淀法可提取出鸡蛋黄抗体 ,其性质为IgG ,蛋白质含量约为 7.0 0mg/ml。结论 :鸡蛋黄抗体含量高 ,作为被动免疫抗体的载体有较好的应用前景。 | FAN Ming-wen, JIANG Qian-zhou, BIAN Zhuan, ZHANG Ping, LIU Ning-hui, LIU Jian.College of Stomatology, Wuhan University, Wuhan 430079 | 2000 | 口腔医学纵横2000，16，3： | 6 |
| 9 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 10 | Inhibition factors and Kinetic model for ammonium inhibition on the anammox process of the SNAD biofilm显示文摘The aim of the present work was to evaluate the anaerobic ammonium oxidation(anammox) activity of simultaneous partial nitrification, anammox and denitrification(SNAD) biofilm with different substrate concentrations and p H values. Kaldnes rings taken from the SNAD biofilm reactor were incubated in batch tests to determine the anammox activity. Haldane model was applied to investigate the ammonium inhibition on anammox process. As for nitrite inhibition, the NH_(4^-)^+N removal rate of anammox process remained 87.4% of the maximum rate with the NO_(2^-)^-N concentration of 100 mg/L. Based on the results of Haldane model, no obvious difference in kinetic coefficients was observed under high or low free ammonia(FA) conditions, indicating that ammonium rather than FA was the true inhibitor for anammox process of SNAD biofilm. With the p H value of 7.0, the r max, Ks and K_I of ammonium were 0.209 kg NO_(2^-)^-N/kg VSS/day, 9.5 mg/L and 422 mg/L, respectively. The suitable p H ranges for anammox process were 5.0 to 9.0. These results indicate that the SNAD biofilm performs excellent tolerance to adverse conditions. | Zhaoming Zheng Jun Li Jing Ma Jia Du Fan Wang Wei Bian Yanzhuo Zhang Baihang Zhao | 2017 | Journal of Environmental Sciences2017，29，3： | 5 |
| 11 | Circulating-free DNA Mutation Associated with Response of Targeted Therapy in Human Epidermal Growth Factor Receptor 2-positive Metastatic Breast Cancer显示文摘 | Qing Ye Fan Qi Li Bian Shao-Hua Zhang Tao Wang Ze-Fei Jiang | 2017 | Chinese Medical Journal2017，，5： | 4 |
| 12 | The mutation network for the hemagglutinin gene from the novel influenza A (H1N1) virus显示文摘A mutation network for the hemagglutinin gene(HA) of the novel type A(H1N1) influenza virus was constructed.Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic.Based on the 658A and 1408T mutations in HA,the viruses evolving into this epidemic were divided into three categories,the Mexico,the transitional and the New York type.The three groups of viruses presented distinctive clustering features in their geographic distributions. | HE YunGang DING GuoHui BIAN Chao HUANG Zhong LAN Ke SUN Bing WANG XueCai LI YiXue WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang JIN WeiRong XIONG Hui DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenAn ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN Li | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 13 | Monochromatic green light stimulation during incubation shortened the hatching time via pineal function in White Leghorn eggs显示文摘Background:Effect of monochromatic green light illumination on embryo development has been reported in chickens.The avian pineal gland is an important photo-endocrine organ formed by a mediodorsal protrusion during embryonic development.However,the involvement of pineal gland in the light transduction process remains to be elucidated.In the present study,we investigated the influence of monochromatic green light on hatching time and explored the possible mechanism via pineal function.Results:A total of 600 eggs of White Leghorn(Shaver strain)were incubated under photoperiods of either 12 h of light and 12 h of darkness using monochromatic green light(12L:12D group)or 24 h of darkness(0L:24D group)for 18 d.Compared to 0L:24D group,the green light stimulation shortened the hatching time without extending the hatch window or impairing hatchability.The liver of embryos incubated in the 12L:12D light condition was heavier than those of the 0L:24D group on d 21 post incubation which may be linked to the observed increase in the serum concentration of insulin-like growth factor 1(IGF-1);primary secretion of the liver.Histological structure analysis of pineal gland demonstrated that the light stimulation increased follicle area,wall thickness and lumen area on d 10 and d 12 post incubation.Rhythmic function analysis demonstrated that three clock related genes(brain and muscle ARNT-like-1,BMAL1;circadian locomotor output cycles kaput,CLOCK;and cryptochrome-1,CRY1)and a melatonin rate-limiting enzyme related gene(arylalkylamine N-acetyltransferase,AANAT)were rhythmically expressed in the pineal gland of the 12L:12D group,but not in the 0L:24D group.Simultaneously,the light stimulation also increased the concentration of melatonin(MT),which was linked to hepatocyte proliferation and IGF-1 secretion in previous studies.Conclusions:The 12L:12D monochromatic green light stimulation during incubation shortened hatching time without impairing hatching performance.Pineal gland’s early histological development and maturation of its rhythmic function were accelerated by the light stimulation.It may be the key organ in the photo-endocrine axis that regulates embryo development,and the potential mechanism could be through enhanced secretion of MT in the 12L:12D group which promotes the secretion of IGF-1. | Panlin Wang Yanyan Sun Yunlei Li Jing Fan Yunhe Zong Adamu Mani Isa Lei Shi Yuanmei Wang Aixin Ni Pingzhuang Ge Linlin Jiang Shixiong Bian Hui Ma Zhengdong Yuan Xiaolin Liu Jilan Chen | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 3 |
| 14 | Stratospheric entry point for upper-tropospheric air within the Asian summer monsoon anticyclone显示文摘The Asian summer monsoon(ASM) anticyclone isolates upper-tropospheric air within the interior of the anticyclone from the outside. Forward trajectory simulations in previous studies have shown that much of the air within the ASM anticyclone can be trapped for up to two or three weeks, not only laterally but also vertically. Here, we investigate the locations of exit points for upper-tropospheric air trapped within the ASM anticyclone, especially the preferred tropopause-crossing locations, using a 3-dimensional trajectory model. Forward trajectory calculations show two-thirds of the air crosses the tropopause at the southern part of the anticyclone via upward diabatic transport. Furthermore, some air crosses at northern and eastern parts via isentropic shedding, but air crosses rarely through the center of the anticyclone. However, calculations also show that many stratospheric parcels within the anticyclone are traceable from the upper-tropospheric anticyclone. This implies they cannot break through the tropopause directly overhead but instead enter the stratosphere via other entry points. | FAN QiuJun BIAN JianChun Laura L.PAN | 2017 | Science China Earth Sciences2017，60，9： | 2 |
| 15 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 16 | Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates显示文摘Emerging SARS-CoV-2 variants and the gradually decreasing neutralizing antibodies over time post vaccination have led to an increase in incidents of breakthrough infection across the world.To investigate the potential protective effect of the recombinant protein subunit COVID-19 vaccine targeting receptor-binding domain(RBD)(PS-RBD)and whole inactivated virus particle vaccine(IV)against the variant strains,in this study,rhesus macaques were immunized with PS-RBD or IV vaccine,followed by a Beta variant(B.1.351)challenge.Although neutralizing activity against the Beta variant was reduced compared with that against the prototype,the decreased viral load in both upper and lower respiratory tracts,milder pathological changes,and downregulated inflammatory cytokine levels in lung tissues after challenge demonstrated that PS-RBD and IV still provided effective protection against the Beta variant in the macaque model.Furthermore,PS-RBD-induced macaque sera possessed general binding and neutralizing activity to Alpha,Beta,Delta,and Omicron variants in our study,though the neutralizing antibody(NAb)titers declined by varying degrees,demonstrating potential protection of PS-RBD against current circulating variants of concern(VOCs).Interestingly,although the IV vaccine-induced extremely low neutralizing antibody titers against the Beta variant,it still showed reduction for viral load and significantly alleviated pathological change.Other correlates of vaccine-induced protection(CoP)like antibody-dependent cellular cytotoxicity(ADCC)and immune memory were both confirmed to be existing in IV vaccinated group and possibly be involved in the protective mechanism. | Qian He Qunying Mao Xiaozhong Peng Zhanlong He Shuaiyao Lu Jialu Zhang Fan Gao Lianlian Bian Chaoqiang An Wenhai Yu Fengmei Yang Yanan Zhou Yun Yang Yanyan Li Yadi Yuan Xujia Yan Jinghuan Yang Xing Wu Weijin Huang Changgui Li Junzhi Wang Zhenglun Liang Miao Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 17 | Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions显示文摘Rhesus monkey neural stem cells are capable of differentiating into neurons and glial cells.Therefore,neural stem cell transplantation can be used to promote functional recovery of the nervous system.Rhesus monkey neural stem cells(1×105 cells/μL) were injected into bilateral hippocampi of rats with hippocampal lesions.Confocal laser scanning microscopy demonstrated that green fluorescent protein-labeled transplanted cells survived and grew well.Transplanted cells were detected at the lesion site,but also in the nerve fiber-rich region of the cerebral cortex and corpus callosum.Some transplanted cells differentiated into neurons and glial cells clustering along the ventricular wall,and integrated into the recipient brain.Behavioral tests revealed that spatial learning and memory ability improved,indicating that rhesus monkey neural stem cells noticeably improve spatial learning and memory abilities in rats with hippocampal lesions. | Li-juan Ye Hui Bian Yao-dong Fan Zheng-bo Wang Hua-lin Yu Yuan-ye Ma Feng Chen | 2016 | Neural Regeneration Research2016，11，9： | 2 |
| 18 | A hybrid brain-computer interface control strategy in a virtual environment显示文摘This paper presents a hybrid brain-computer interface (BCI) control strategy,the goal of which is to expand control functions of a conventional motor imagery or a P300 potential based BCI in a virtual environment.The hybrid control strategy utilizes P300 potential to control virtual devices and motor imagery related sensorimotor rhythms to navigate in the virtual world.The two electroencephalography (EEG) patterns serve as source signals for different control functions in their corresponding system states,and state switch is achieved in a sequential manner.In the current system,imagination of left/right hand movement was translated into turning left/right in the virtual apartment continuously,while P300 potentials were mapped to discrete virtual device control commands using a five-oddball paradigm.The combination of motor imagery and P300 patterns in one BCI system for virtual environment control was tested and the results were compared with those of a single motor imagery or P300-based BCI.Subjects obtained similar performances in the hybrid and single control tasks,which indicates the hybrid control strategy works well in the virtual environment. | Yu SU | 2011 | Journal of Zhejiang University-Science C(Computers and Electronics)2011，12，5： | 2 |
| 19 | Theoretical analysis of non-probabilistic reliability based on interval model显示文摘The aim of this paper is to propose a theoretical approach for performing the nonprobabilistic reliability analysis of structure.Due to a great deal of uncertainties and limited measured data in engineering practice,the structural uncertain parameters were described as interval variables.The theoretical analysis model was developed by starting from the 2-D plane and 3-D space.In order to avoid the loss of probable failure points,the 2-D plane and 3-D space were respectively divided into two parts and three parts for further analysis.The study pointed out that the probable failure points only existed among extreme points and root points of the limit state function.Furthermore,the low-dimensional analytical scheme was extended to the high-dimensional case.Using the proposed approach,it is easy to find the most probable failure point and to acquire the reliability index through simple comparison directly.A number of equations used for calculating the extreme points and root points were also evaluated.This result was useful to avoid the loss of probable failure points and meaningful for optimizing searches in the research field.Finally,two kinds of examples were presented and compared with the existing computation.The good agreements show that the proposed theoretical analysis approach in the paper is correct.The efforts were conducted to improve the optimization method,to indicate the search direction and path,and to avoid only searching the local optimal solution which would result in missed probable failure points. | Xu-Yong Chen Jian-Ping Fan Xiao-Ya Bian | 2017 | Acta Mechanica Solida Sinica2017，30，6： | 2 |
| 20 | Assessing the genetic diversity of the critically endangered Chinese sturgeon Acipenser sinensis using mitochondrial markers and genome-wide single-nucleotide polymorphisms from RAD-seq显示文摘As a living fossil, the endangered Chinese sturgeon(Acipenser sinensis) has been considered a national treasure in China. Here,the famous Gezhouba Dam and Three Gorges Dam on the Yangtze River were built in 1988 and 2006, for economic purposes.The natural population of Chinese sturgeon has declined since then, as these dams block its migratory route to the original spawning grounds in the middle reaches of the Yangtze River. In 2013 and 2014, there was an absence of spawning where it typically happened near the Gezhouba Dam. Nevertheless, from April to June in 2015, over 1,000 larvae with different body lengths(10–35 cm) were detected along the Shanghai Yangtze Estuary; but only little is currently known about the population genetic structure of the Chinese sturgeon. Herein, we inferred population genetic parameters from 462 available Chinese sturgeon specimens based on a 421-bp fragment of the mitochondrial DNA(mtDNA) D-loop region and 1,481,620 SNPs(singlenucleotide polymorphisms) generated by restriction site-associated DNA sequencing(RAD-seq). For the D-loop dataset, 15 haplotypes were determined. Randomly picked 23 individuals, representing the 15 D-loop haplotype groups, were subsequently used for further RAD-seq validation. The average nucleotide diversity calculated from the mtDNA and RAD datasets was 0.0086 and 0.000478, respectively. The overall effective female population size was calculated to be 1,255 to 2,607, and the long-term effective population size was estimated to range from 11,950 to 119,500. We observed that the genetic variability and the effective female population size of the current population in the Yangtze River are severely low, which are similar to the data reported over 10 years ago. The deduced relatively small effective population of female fish, limiting the genetic connectivity among Chinese sturgeon, should be considered a serious threat to this endangered species. | Jian Liu Xinxin You Pao Xu Ping Zhuang Yueping Zheng Kai Zhang Min Wang Yunyun Lv Gangchun Xu Feng Zhao Jianhui Wu Houyong Fan Jianan Xu Zhiqiang Ruan Chao Bian Kai Liu Dongpo Xu Jinhui Chen Junmin Xu Qiong Shi | 2018 | Science China(Life Sciences)2018，61，9： | 2 |
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