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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation显示文摘 | Vidisha Tripathi Jonathan D. Ellis Zhen Shen David Y. Song Qun Pan Andrew T. Watt Susan M. Freier C. Frank Bennett Alok Sharma Paula A. Bubulya Benjamin J. Blencowe Supriya G. Prasanth Kannanganattu V. Prasanth | 2010 | Molecular Cell2010，，6： | 4 |
| 3 | Phylogenetic Analyses Reveal a Unique Species of Elaphe(Serpentes,Colubridae)New to Science显示文摘The snakes comprising the monophyletic group referred to as ratsnakes are found throughout Asia,Europe and the New World.Recently,three snake samples likely belonging to the ratsnakes were collected in Zoige County,Sichuan Province,China.Species identity was difficult to delimit morphologically because the specimens were juveniles and partially damaged.Subsequently,a molecular phylogenetic approach was used.Portions of three mitochondrial genes(cyt b,ND4 and 12S rRNA) were sequenced and analyzed.The results showed that they were sister to the genus Elaphe.Very little genetic variation was found among the three samples.The minimum genetic distances between these samples and those within Elaphe were greater than any currently recognized species within the genus.We conclude that this likely represents a new species within the genus Elaphe.Adult specimens and a morphologic description are needed for further study. | LING Chen LIU Shaoying HUANG Song Frank T.Burbrink GUO Peng SUN Zhiyu ZHAO Jie | 2010 | Asian Herpetological Research2010，1，2： | 4 |
| 4 | Ultrathin wavy Rh nanowires as highly effective electrocatalysts for methanol oxidation reaction with ultrahigh ECSA显示文摘Direct methanol fuel cells (DMFCs) have received tremendous research interests because of the facile storage of liquid methanol vs.hydrogen.However,the DMFC today is severely plagued by the poor kinetics and rather high overpotential in methanol oxidation reaction (MOR).Here we report the investigation of the ultrathin Rh wavy nanowires as a highly effective MOR electrocatalyst.We show that ultrathin wavy Rh nanowires can be robustly synthesized with 2-3 nm diameters.Electrochemical studies show a current peak at the potential of 0.61 V vs.reversible hydrogen electrode (RHE),considerably lower than that of Pt based catalysts (~ 0.8-0.9 V vs.RHE).Importantly,with ultrathin diameters and favorable charge transport,the Rh nanowires catalysts exhibit an ultrahigh electrochemically active surface area determined from CO-stripping (ECSAco) of 144.2 m2/g,far exceeding that of the commercial Rh black samples (20 m2/g).Together,the Rh nanowire catalysts deliver a mass activity of 722 mA/mg at 0.61 V,considerably higher than many previously reported electrocatalysts at the same potential.The chronoamperometry studies also demonstrate good stability and CO-tolerance compared with the Rh black control sample,making ultrathin Rh wavy nanowires an attractive electrocatalyst for MOR. | Xiaoyang Fu Zipeng Zhao Chengzhang Wan Yiliu Wang Zheng Fan Frank Song Bocheng Cao Mufan Li Wang Xue Yu Huang Xiangfeng Duan | 2019 | Nano Research2019，12，1： | 3 |
| 5 | Cardiomyocyte peroxisome proliferator-activated receptorαis essential for energy metabolism and extracellular matrix homeostasis during pressure overload-induced cardiac remodeling显示文摘Peroxisome proliferator-activated receptorα(PPARα),a ligand-activated nuclear receptor critical for systemic lipid homeostasis,has been shown closely related to cardiac remodeling.However,the roles of cardiomyocyte PPARαin pressure overload-induced cardiac remodeling remains unclear because of lacking a cardiomyocyte-specific Ppara-deficient(Ppara^(ΔCM))mouse model.This study aimed to determine the specific role of cardiomyocyte PPARαin transverse aortic constriction(TAC)-induced cardiac remodeling using an inducible Ppara^(ΔCM) mouse model.Ppara^(ΔCM) and Pparafl/fl mice were randomly subjected to sham or TAC for 2 weeks.Cardiomyocyte PPARαdeficiency accelerated TAC-induced cardiac hypertrophy and fibrosis.Transcriptome analysis showed that genes related to fatty acid metabolism were dramatically downregulated,but genes critical for glycolysis were markedly upregulated in Ppara^(ΔCM) hearts.Moreover,the hypertrophy-related genes,including genes involved in extracellular matrix(ECM)remodeling,cell adhesion,and cell migration,were upregulated in hypertrophic Ppara^(ΔCM) hearts.Western blot analyses demonstrated an increased HIF1αprotein level in hypertrophic Ppara^(ΔCM) hearts.PET/CT analyses showed an enhanced glucose uptake in hypertrophic Ppara^(ΔCM) hearts.Bioenergetic analyses further revealed that both basal and maximal oxygen consumption rates and ATP production were significantly increased in hypertrophic Pparafl/fl hearts;however,these increases were markedly blunted in Ppara^(ΔCM) hearts.In contrast,hypertrophic Ppara^(ΔCM) hearts exhibited enhanced extracellular acidification rate(ECAR)capacity,as reflected by increased basal ECAR and glycolysis but decreased glycolytic reserve.These results suggest that cardiomyocyte PPARαis crucial for the homeostasis of both energy metabolism and ECM during TAC-induced cardiac remodeling,thus providing new insights into potential therapeutics of cardiac remodeling-related diseases. | Xia Wang Xin-xin Zhu Shi-yu Jiao Dan Qi Bao-qi Yu Guo-min Xie Ye Liu Yan-ting Song Qing Xu Qing-bo Xu Frank JGonzalez Jie Du Xiao-min Wang Ai-juan Qu | 2022 | Acta Pharmacologica Sinica2022，43，5： | 3 |
| 6 | An Early Warning System for Curved Road Based on OV7670 Image Acquisition and STM32显示文摘Nowadays,the number of vehicles in China has increased significantly.The increase of the number of vehicles has also led to the increasingly complex traffic situation and the urgent safety measures in need.However,the existing early warning devices such as geomagnetic,ultrasonic and infrared detection have some shortcomings like difficult installation and maintenance.In addition,geomagnetic detection will damage the road surface,while ultrasonic and infrared detection will be greatly affected by the environment.Considering the shortcomings of the existing solutions,this paper puts forward a solution of early warning for vehicle turning meeting based on image acquisition and microcontrollers.This solution combines image acquisition and processing technology,which uses image sensor to perceive traffic condition and image data analysis algorithm to process perceived image,and then utilize LED display screen to issue an early warning. | Xiaoliang Wang Wenhua Song Bowei Zhang Brandon Mausler Frank Jiang | 2019 | Computers, Materials & Continua2019，，4： | 2 |
| 7 | Preliminary study of microstructure, mechanical properties and corrosion resistance of antibacterial Ti-15Zr-xCu alloy for dental application显示文摘Ti-15 Zr-xCu(3≤x≤7,wt.%) novel antibacterial and antibiofilm alloys with competitive mechanical properties,biological responses and corrosion resistance were designed and fabricated.Annealing heat treatment on Ti-15 Zr-7 Cu(TZC-7 A),after holding for 2 h at slightly above their beta transus temperature(BTT) ensured their tensile strength(UTS),yield strength(YS) and hardness(HRV) were improved by31.2%,20% and 12.3% respectively compared to the control without Cu,Ti-15 Zr(T-15 ZA).Although the3 wt.% Cu alloy displayed the highest elongation(26%),the TZC-7 A alloy also possessed a good ductility.Presence of evenly dispersed Ti2 Cu and Zr2 Cu Cu-rich intermetallic phases formed as interwoven and alternating lamellae within the α+β matrix as a result of Cu addition,as revealed by X-ray diffraction(XRD),scanning electron microscopy(SEM) and transmission electron microscopy(TEM).These greatly contributed to their strengthening and bactericidal properties.Over 98% antibacterial effect against E.coli and S.aureus have been imparted,coupled with excellent biofilm inhibition.Potentiodynamic polarization curves showed that the TZC-7 A alloy possessed higher corrosion resistance than commercially pure titanium,cp-Ti;contact angle test revealed enhanced hydrophilicity;while confocal laser scanning microscopy(CLSM) and cell counting kit(CCK-8) assays also displayed drastically lowered bacterial adhesion rate with comparatively no cytotoxicity.Cell attachment on all alloys was similar but the best spread was obtained on TZC-7 A after 24 h.The developed alloy has good potential as an antibacterial implant material with combination of optimized properties. | Sharafadeen Kunle Kolawole Wang Hai Shuyuan Zhang Ziqing Sun Muhammad Ali Siddiqui Ihsan Ullah Wei Song Frank Witte Ke Yang | 2020 | Journal of Materials Science & Technology2020，47，15： | 2 |
| 8 | Property rights protection and corporate R&D: Evidence from China显示文摘 | Chen Lin Ping Lin Frank Song | 2009 | Journal of Development Economics2009，，1： | 2 |
| 9 | Intraday periodicity, long memory volatility, and macroeconomic announcement effects in the US Treasury bond market显示文摘 | Jun Cai Frank M Song | 2000 | Journal of Empirical Finance2000，，7： | 1 |
| 10 | Overview of three-dimensional shape measurement using optical methods显示文摘 | Frank Chert Gordon M Brown Mumin Song | 2000 | Optical Engineering2000，39，1： | 1 |
| 11 | Property Rights Protection and Corporate R&D:Evidence from China 显示文摘 | Chen Lin Ping Lin Frank Song | 2010 | Journal of Devel- opment Economics2010，，93： | 1 |
| 12 | Managerial incentives, CEO characteristics and corporate innovation in China’s private sector显示文摘 | Chen Lin Ping Lin Frank M. Song Chuntao Li | 2010 | Journal of Comparative Economics2010，，2： | 1 |
| 13 | Comparison and Conversion of AVHRR GIMMS and SPOT VEGETATION NDVI Data in China显示文摘 | Song Y Ma M G Frank V | 2010 | International Journal of Remote Sensing2010，31，9： | 1 |
| 14 | Over- view of three-dimensional shape measurement using optical methods显示文摘 | Frank Chen Gordon M Brown Mumin Song | 2000 | Opt Eng2000，39，1： | 1 |
| 15 | Managerial incentives, CEO characteristics and corporate innovation in China’s private sector显示文摘 | Chen Lin Ping Lin Frank M. Song Chuntao Li | 2010 | Journal of Comparative Economics2010，，2： | 1 |
| 16 | Social Diversity and Construction Era of Neighborhoods with Traditional Design Features: Portland and Atlanta Compared显示文摘 | Miles P~ Song Y Frank L | 2010 | Journal of Urbanism2010，3，1： | 1 |
| 17 | Corporate governance and market valuation in China显示文摘 | Chong-En Bai Qiao Liu Joe Lu Frank M. Song Junxi Zhang | 2004 | Journal of Comparative Economics2004，，4： | 1 |
| 18 | E- lasticity of the living abdominal wall in laparoscopicsurgery显示文摘 | Song C Aliiani A Frank T Hanna G Cuschieri A | 2006 | J Biomech2006，39，： | 1 |
| 19 | Mechanical properties of the human abdominal wall measured in vivo during insufflation for laparoscopic surgery显示文摘 | Song C Alijani A Frank T Hanna G B Cuschieri A | 2006 | Surg Endosc2006，20，： | 1 |
| 20 | Overview of three dimensional shape measurement using optical methods 显示文摘 | Frank Chen Gordon M Brown Mumin Song | 2000 | Opt Eng2000，39，1： | 1 |
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