|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019显示文摘Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics.Here,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of PRV.Based on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic.In addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 strains.We also found specific amino-acid changes and positively selected sites,possibly associated with functional changes.This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV. | Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu | 2019 | Virologica Sinica2019，34，6： | 12 |
| 3 | Phylogenetic Analyses Reveal a Unique Species of Elaphe(Serpentes,Colubridae)New to Science显示文摘The snakes comprising the monophyletic group referred to as ratsnakes are found throughout Asia,Europe and the New World.Recently,three snake samples likely belonging to the ratsnakes were collected in Zoige County,Sichuan Province,China.Species identity was difficult to delimit morphologically because the specimens were juveniles and partially damaged.Subsequently,a molecular phylogenetic approach was used.Portions of three mitochondrial genes(cyt b,ND4 and 12S rRNA) were sequenced and analyzed.The results showed that they were sister to the genus Elaphe.Very little genetic variation was found among the three samples.The minimum genetic distances between these samples and those within Elaphe were greater than any currently recognized species within the genus.We conclude that this likely represents a new species within the genus Elaphe.Adult specimens and a morphologic description are needed for further study. | LING Chen LIU Shaoying HUANG Song Frank T.Burbrink GUO Peng SUN Zhiyu ZHAO Jie | 2010 | Asian Herpetological Research2010，1，2： | 4 |
| 4 | Effects of Rat Cytomegalovirus on the Nervous System of the Early Rat Embryo显示文摘The purpose of the study was to investigate the impact of rat cytomegalovirus(RCMV) infection on the development of the nervous system in rat embryos,and to evaluate the involvement of Wnt signaling pathway key molecules and the downstream gene neurogenin 1(Ngn1) in RCMV infected neural stem cells(NSCs).Infection and control groups were established,each containing 20 pregnant Wistar rats.Rats in the infection group were inoculated with RCMV by intraperitoneal injection on the first day of pregnancy.Rat E20 embryos were taken to evaluate the teratogenic rate.NSCs were isolated from E13 embryos,and maintained in vitro.We found:1) Poor fetal development was found in the infection group with low survival and high malformation rates.2) The proliferation and differentiation of NSCs were affected.In the infection group,NSCs proliferated more slowly and had a lower neurosphere formation rate than the control.The differentiation ratio from NSCs to neurons and glial cells was significantly different from that of the control,showed by immunofluorescence staining.3) Ngn1 mRNA expression and the nuclear β-catenin protein level were significantly lower than the control on day 2 when NSCs differentiated.4) The Morris water maze test was performed on 4-week pups,and the infected rats were found worse in learning and memory ability.In a summary,RCMV infection caused abnormalities in the rat embryonic nervous system,significantly inhibited NSC proliferation and differentiation,and inhibited the expression of key molecules in the Wnt/β-catenin signaling pathway so as to affect NSCs differentiation.This may be an important mechanism by which RCMV causes embryonic nervous system abnormalities. | Xiuning Sun YingJun Guan Fengjie Li Xutong Li Xiaowen Wang Zhiyu Guan Kai Sheng Li Yu Zhijun Liu | 2012 | Virologica Sinica2012，27，4： | 4 |
| 5 | Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors显示文摘Co-delivery of anti-cancer drugs is promising to improve the efficacy of cancer treatment.This study was aiming to investigate the potential of concurrent delivery of resveratrol(RES)and docetaxel(DTX)via polymeric nanocarriers to treat breast cancer.To this end,methoxyl poly(ethylene glycol)-poly(D,L-lactide)copolymer(mPEG-PDLA)was prepared and characterized using FTIR and 1H NMR,and their molecular weights were determined by GPC.Isobologram analysis and combination index calculation were performed to find the optimal ratio between RES and DTX to against human breast adenocarcinoma cell line(MCF-7 cells).Subsequently,RES and DTX were loaded in the mPEG-PDLA micelles simultaneously,and the morphology,particle size distribution,in vitro release,pharmacokinetic profiles,as well as cytotoxicity to the MCF-7 cells were characterized.IC50 of RES and DTX in MCF-7 cells were determined to be 23.0μg/ml and 10.4μg/ml,respectively,while a lower IC50 of 4.8μg/ml of the combination of RES and DTX was obtained.The combination of RES and DTX at a ratio of 1:1(w/w)generated stronger synergistic effect than other ratios in the MCF-7 cells.RES and DTX loaded mPEG-PDLA micelles exhibited prolonged release profiles,and enhanced cytotoxicity in vitro against MCF-7 cells.The AUC(0→t)of DTX and RES in mPEG-PDLA micelles after i.v.administration to rats were 3.0-fold and 1.6-fold higher than that of i.v.injections of the individual drugs.These findings indicated that the co-delivery of RES and DTX using mPEG-PDLA micelles could have better treatment of tumors. | Xiong Guo Zhiyue Zhao Dawei Chen Mingxi Qiao Feng Wan Dongmei Cun Yi Sun Mingshi Yang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 4 |
| 6 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 7 | Parametrization of woods-saxon potential for heavy-ion systems显示文摘Several elastic scattering angular distributions of ^(12)C from target nuclei of A ≥39 are analyzed to extract the Woods-Saxon potential parameters with the fixed imaginary potential and Coulomb radius parameters.Using the best fitted diffuseness parameters,the correlations of the real part parameters with A_1^(1/3)+ A_2^(1/3) and incident energy are revealed, and the systematic Woods-Saxon potential parameters are presented for nucleus-nucleus interaction.The proposed potential parameters can reproduce not only the elastic scattering angular distributions induced by ^(12)C,but also many elastic scattering angular distributions induced by the projectiles other than ^(12)C,thus providing important inputs for the study of nuclear reactions of heavy-ion systems. | Lin Gan ZhiHong Li HuiBin Sun DanYang Pang Bing Guo YunJu Li Jun Su ShengQuan Yan ErTao Li YouBao Wang Gang Lian ZhiYu Han XinYue Li DongHui Li TianLi Ma ChangJin Pei YangPing Shen Yi Su Sheng Zeng Yong Zhou WeiPing Liu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，8： | 2 |
| 8 | Hydrothermal Synthesis and Visible-light Photocatalytic Activities of SnS_2 Nanoflakes显示文摘SnS2 nanoflakes were successfully synthesized via a simple hydrothermal process. The as-prepared SnS2 samples were characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM), nitrogen adsorption-desorption isotherms, and UV-vis diffuse reflectance spectroscopy(DRS). The photocatalytic activities of the as-prepared SnS2 nanoflakes under visible light irradiation(λ>420 nm) were evaluated by the degradation of rhodamine B(Rh B). The effect of hydrothermal temperatures on the photocatalytic efficiency of as-prepared SnS2 nanoflakes was investigated. The experimental result showed that SnS2 nanoflakes synthesized at the temprature of 160 o had higher photocatalytic efficiency and good photocatalytic stability. | 贾铁昆 MIN Zhiyu CAO Jianliang SUN Guang WANG Xiaodong ZHANG Zhanying LI Tingting | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，2： | 2 |
| 9 | Calibration of Mars Energetic Particle Analyzer (MEPA)显示文摘The first Mars exploration mission of China(Tianwen-1)is scheduled to be launched in 2020;a charged particle telescope,the Mars Energetic Particle Analyzer(MEPA),is carried as one of the payloads on the orbiter.The MEPA is designed to measure solar energetic particles(SEPs)and galactic cosmic rays(GCRs)in the near-Mars space and in the transfer orbit from Earth to Mars.Before the launch,the MEPA was calibrated in ground experiments with radioactive sources,electronic pulses,and accelerator beams.The calibration parameters,such as energy conversion constants,threshold values for the triggers,and particle identification criteria,were determined and have been stored for onboard use.The validity of the calibration parameters has been verified with radioactive sources and beams.The calibration results indicate that the MEPA can measure charged particles reliably,as designed,and that it can satisfy the requirements of the Tianwen-1 mission. | ShuWen Tang Yi Wang HongYun Zhao Fang Fang Yi Qian YongJie Zhang HaiBo Yang CunHui Li Qiang Fu Jie Kong XiangYu Hu Hong Su ZhiYu Sun YuHong Yu BaoMing Zhang Yu Sun ZhiPeng Sun | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 10 | Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating HSP70 in SHSY-5Y cells显示文摘Background:Mesencephalic astrocyte-derived neurotrophic factor(MANF)is a new candidate growth factor for dopaminergic neurons against endoplasmic reticulum stress(ER stress).HSP70 family,a chaperon like heat shock protein family,was proved to be involved in the MANF induced survival pathway in 6-OHDA treated SHSY-5Y cells.However,the ER stress relative transcriptome,in MANF signaling cascades is still investigated.The involvement of HSP70,a 70kd member of HSP70 family,need further to be verified.Methods:The cell apoptosis was assayed by MTT,TUNEL staining and western blot of cleaved Caspase-3.The differentially expressed genes in SHSY-5Y cells under different conditions(control,6-OHDA,6-OHDA+MANF)were investigated by RNA-seq.Expression of HSP70 was further confirmed by real-time PCR.RNAi knockdown for HSP70 was performed to investigate the role of HSP70 in the MANF signaling pathway.Results:MANF inhibits 6-OHDA-induced apoptosis in SHSY-5Y cells.Six ER stress relative genes(HSP70,GRP78,xbp-1,ATF-4,ATF-6,MAPK)were found enriched in 6-OHDA+MANF treatment group.HSP70 was the most significantly up-regulated gene under 6-OHDA+MANF treatment in SHSY-5Y cells.RNAi knockdown for HSP70 inhibits the protective effects of MANF against 6-OHDA toxicity in SHSY-5Y cells.Conclusion:MANF exerts a protective role against 6-OHDA induced apoptosis in SHSY-5Y cells via up-regulating some ER stress genes,including HSP70 family members.The HSP70 expression level plays a key role in MANFmediated survival pathway. | Hui Sun Ming Jiang Xing Fu Qiong Cai Jingxing Zhang Yanxin Yin Jia Guo Lihua Yu Yun Jiang Yigang Liu Liang Feng Zhiyu Nie Jianmin Fang Lingjing Jin | 2017 | Translational Neurodegeneration2017，6，1： | 2 |
| 11 | Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats显示文摘 | Liang Xi Zhiyu Qian Guanglin Xu Shuguo Zheng Sai Sun Na Wen Liang Sheng Yun Shi Yabing Zhang | 2007 | The Journal of Nutritional Biochemistry2007，，1： | 1 |
| 12 | Distributed Stepping Motor Control System显示文摘The beam diagnostic devices used at RIBLL are driven by stepper motors, which are controlled by I/O modules based on ISA-bus in an industrial computer. The disadvantages of such mode are that a large number of long cables are used and one computer to control is unsafe. We have developed a distributed stepping motor control system for the remote, local and centralized control of the stepping motors. RS-485 bus is used for the connection between the remote control unit and the local control units. The con... | Bai Jie, Chen Zhiqiang, Xiao Guoqing, Zhan Wenlong, Guo Zhongyan, Wang Meng, Sun Zhiyu Li Jiaxing, Tian Wendong, Wang Jiansong, Wang Wusheng, Mao Ruishi, Chen Zhiqiang Hu Zhcngguo, Chen Lixin and Li Ch | 2001 | IMP & HIRFL Annual Report2001，，1： | 1 |
| 13 | Switchable multi-wavelength Tm-doped mode-locked fiber laser 显示文摘 | Yan Zhiyu Tang ulong Sun Biao | 2015 | Optics Letters2015，40，9： | 1 |
| 14 | Effect of thinning intensity on understory herbaceous diversity and biomass in mixed coniferous and broad-leaved forests of Changbai Mountain显示文摘Background:Herbs are an important part of the forest ecosystem,and their diversity and biomass can reflect the restoration of vegetation after forest thinning disturbances.Based on the near-mature secondary coniferous and broad-leaved mixed forest in Jilin Province Forestry Experimental Zone,this study analyzed seasonal changes of species diversity and biomass of the understory herb layer after different intensities of thinning.Results:The results showed that although the composition of herbaceous species and the ranking of importance values were affected by thinning intensity,they were mainly determined by seasonal changes.Across the entire growing season,the species with the highest importance values in thinning treatments included Carex pilosa,Aegopodium alpestre,Meehania urticifolia,and Filipendula palmata,which dominated the herb layer of the coniferous and broad-leaved mixed forest.The number of species,Margalef index,Shannon-Wiener index and Simpson index all had their highest values in May,and gradually decreased with months.Pielou index was roughly inverted“N”throughout the growing season.Thinning did not increase the species diversity.Thinning can promote the total biomass,above-and below-ground biomass.The number of plants per unit area and coverage were related to the total biomass,above-and below-ground biomass.The average height had a significantly positive correlation with herb biomass in May but not in July.However,it exerted a significantly negative correlation with herb biomass in September.The biomass in the same month increased with increasing thinning intensity.Total herb biomass,above-and below-ground biomass showed positive correlations with Shannon-Winner index,Simpson index and Pielou evenness index in May.Conclusions:Thinning mainly changed the light environment in the forest,which would improve the plant diversity and biomass of herb layer in a short time.And different thinning intensity had different effects on the diversity of understory herb layer.The findings provide theoretical basis and reference for reasonable thinning and tending in coniferous and broad-leaved mixed forests. | Gerong Wang Yue Sun Mo Zhou Naiqian Guan Yuwen Wang Runhua Jiang Zhiyu Liu Mengjia Wu Fucai Xia | 2021 | Forest Ecosystems2021，8，4： | 1 |
| 15 | Carbon-incorporated TiO 2 microspheres: Facile flame assisted hydrolysis of tetrabutyl orthotitanate and photocatalytic hydrogen production显示文摘 | Xiaoyan Zhang Yujun Sun Xiaoli Cui Zhiyu Jiang | 2011 | International Journal of Hydrogen Energy2011，，2： | 1 |
| 16 | Electrical and γ-ray energy spectrum response properties of PbI<SUB>2</SUB> crystal grown by physical vapor transport显示文摘 | Sun Hui Zhu Xinghua Yang Dingyu He Zhiyu Zhu Shifu Zhao Beijun | 2012 | Journal of Semiconductors2012，，5： | 1 |
| 17 | Effects of microstructure characteristics on the tensile properties and fracture toughness of TA15 alloy fabricated by hot isostatic pressing显示文摘Powder hot isostatic pressing(HIP) is an effective method to achieve near-net-shape manufacturing of high-quality complex thinwalled titanium alloy parts, and it has received extensive attention in recent years. However, there are few reports about the microstructure characteristics on the strengthening and toughening mechanisms of powder hot isostatic pressed(HIPed) titanium alloys. Therefore, TA15powder was prepared into alloy by HIP approach, which was used to explore the microstructure characteristics at different HIP temperatures and the corresponding tensile properties and fracture toughness. Results show that the fabricated alloy has a “basket-like structure” when the HIP temperature is below 950℃, consisting of lath clusters and surrounding small equiaxed grains belts. When the HIP temperature is higher than 950℃, the microstructure gradually transforms into the Widmanstatten structure, accompanied by a significant increase in grain size. The tensile strength and elongation are reduced from 948 MPa and 17.3% for the 910℃ specimen to 861 MPa and 10% for the 970℃ specimen.The corresponding tensile fracture mode changes from transcrystalline plastic fracture to mixed fracture including intercrystalline cleavage.The fracture toughness of the specimens increases from 82.64 MPa·m^(1/2)for the 910℃ specimen to 140.18 MPa·m^(1/2)for the 970℃ specimen.Specimens below 950℃ tend to form holes due to the prior particle boundaries(PPBs), which is not conducive to toughening. Specimens above 950℃ have high fracture toughness due to the crack deflection, crack branching, and shear plastic deformation of the Widmanstatten structure. This study provides a valid reference for the development of powder HIPed titanium alloy. | Langping Zhu Yu Pan Yanjun Liu Zhiyu Sun Xiangning Wang Hai Nan Muhammad-Arif Mughal Dong Lu Xin Lu | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，4： | 1 |
| 18 | 5 - 17 Power Control System of RIBLL显示文摘 | Zhang Xueheng Bai Zhen Shangguan Jingbin Sun Zhiyu Wang Jiansong | 2010 | IMP & HIRFL Annual Report2010，，1： | 1 |
| 19 | High-Resolution Projections of Mean and Extreme Precipitation over China by Two Regional Climate Models显示文摘In this study, we employ two regional climate models(RCMs or RegCMs), which are RegCM4 and PRECIS(Providing Regional Climates for Impact Studies), with a horizontal grid spacing of 25 km, to simulate the precipitation dynamics across China for the baseline climate of 1981–2010 and two future climates of 2031–2060 and 2061–2090. The global climate model(GCM)—Hadley Centre Global Environment Model version 2-Earth Systems(HadGEM2-ES) is used to drive the two RCMs. The results of baseline simulations show that the two RCMs can correct the obvious underestimation of light rain below 5 mm day^-1 and the overestimation of precipitation above 5 mm day^-1 in Northwest China and the Qinghai–Tibetan Plateau, as being produced by the driving GCM. While PRECIS outperforms RegCM4 in simulating annual precipitation and wet days in several sub-regions of Northwest China, its underperformance shows up in eastern China. For extreme precipitation, the two RCMs provide a more accurate simulation of continuous wet days(CWD) with reduced biases and more realistic spatial patterns compared to their driving GCM. For other extreme precipitation indices, the RCM simulations show limited benefit except for an improved performance in some localized regions. The future projections of the two RCMs show an increase in the annual precipitation amount and the intensity of extreme precipitation events in most regions. Most areas of Southeast China will experience fewer number of wet days, especially in summer, but more precipitation per wet day(≥ 30 mm day^-1). By contrast, number of wet days will increase in the Qinghai–Tibetan Plateau and some areas of northern China. The increase in both the maximum precipitation for five consecutive days and the regional extreme precipitation will lead to a higher risk of increased flooding. The findings of this study can facilitate the efforts of climate service institutions and government agencies to improve climate services and to make climate-smart decisions. | Zhiyu JIANG Zhan TIAN Guangtao DONG Laixiang SUN Peiqun ZHANG Erasmo BUONOMO Dongli FAN | 2020 | Journal of Meteorological Research2020，34，5： | 1 |
| 20 | Isolation and Identification of a Cellulose-degrading Bac- terium from Paddy Soils in Chengdu City显示文摘In this study,a cellulose-degrading bacterium was isolated from paddy soils in Chengdu City.After 2 d of culture,the average diameter of hydrolytic circles on CMC-Congo red medium was 26-30 mm.Single colonies on LB plates were white and wrinkled.The isolated strain was identified as a Gram-negative bacterium by Gram staining,which could produce short rod-like spores.Colony PCR was performed using the bacterial 16S rDNA universal primers.A 1 429 kb DNA fragment was amplified.Based on sequence homology analysis and comprehensive analysis,the isolated strain was identified as Bacillus velezensis,which was named CDBV62 according to the origin. | Yulong CHEN Zhiyu SUN Jintao LI Ling SHEN Ruling HONG | 2016 | Agricultural Biotechnology2016，5，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员