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| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Corrigendum to “Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis” [Cancer Lett. 328 (2) (2012) 212–221]显示文摘 | Angela L. McCleary-Wheeler Gwen A. Lomberk Frank U. Weiss Günter Schneider Muller Fabbri Tara L. Poshusta Nelson J. Dusetti Sandra Baumgart Juan L. Iovanna Volker Ellenrieder Raul Urrutia Martin E. Fernandez-Zapico | 2013 | Cancer Letters2013，，1： | 2 |
| 3 | Fluvoxamine and Sleep Disturbances in Posttraumatic Stress Disorder显示文摘 | Thomas C. Neylan Thomas J. Metzler Frank B. Schoenfeld Daniel S. Weiss Maryann Lenoci Suzanne R. Best Tami L. Lipsey Charles R. Marmar | 2001 | Journal of Traumatic Stress2001，，3： | 1 |
| 4 | Response to Pacing at Sites of Isolated Diastolic Potentials During Ventricular Tachycardia in Patients With Previous Myocardial Infarction显示文摘 | Frank Bogun Marwan Bahu Bradley P Knight Raul Weiss Rajiva Goyal Emile Daoud K.Ching Man S.Adam Strickberger Fred Morady | 1997 | Journal of the American College of Cardiology1997，，： | 1 |
| 5 | BIM在2020年的发展趋势显示文摘2020年,开放、中立和合作将仍是建筑行业的主旋律。建筑行业应像其他行业一样,充分重视数据的存在,并做好发挥数据作用的准备。建筑信息模型(BIM)在2019年经历了某种程度上的复兴与变革,这并不是说BIM已经过时,而是大家对它的理解和讨论在去年有了很大的进展。我们看到,业内很多企业为了解决当前面临的问题和挑战,已经开展了许多关于BIM的应用和研究。这也让2020年BIM领域的发展显现出更多乐观势态。 | Frank Weiss | 2020 | 中国建设信息化2020，，8： | 1 |
| 6 | Incisionless revision of post-Roux-en- Y bypass stomal and pouch dilation: multicenter registry results显示文摘 | Santiago Horgan Garth Jacobsen G. Derek Weiss John S. Oldham Peter M. Denk Frank Borao Steven Gorcey Brad Watkins John Mobley Kari Thompson Adam Spivack Dave Voellinger Chris Thompson Lee Swanstrom Paresh Shah Greg Haber Matthew Brengman Gregory Schroder | 2010 | Surgery for Obesity and Related Diseases2010，，3： | 1 |
| 7 | The TERE1 protein interacts with mitochondrial TBL2: Regulation of trans‐membrane potential, ROS/RNS and SXR target genes显示文摘 | William J. Fredericks Terry McGarvey Huiyi Wang Yongmu Zheng Nathaniel J. Fredericks Hankun Yin Li‐Ping Wang Wayland Hsiao Rob Lee Jayne S. Weiss Michael L. Nickerson Howard S. Kruth Frank J. RauscherIII S. Bruce Malkowicz | 2013 | J Cell Biochem2013，，9： | 1 |
| 8 | Methylprednisolone Therapy in Deceased Donors Reduces Inflammation in the Donor Liver and Improves Outcome After Liver Transplantation: A Prospective Randomized Controlled Trial显示文摘 | Katja Kotsch Frank Ulrich Anja Reutzel-Selke Andreas Pascher W Faber P Warnick S Hoffman M Francuski C Kunert O Kuecuek G Schumacher C Wesslau A Lun S Kohler S Weiss S G. Tullius P Neuhaus Johann Pratschke | 2008 | Annals of Surgery2008，，6： | 1 |
| 9 | Electrospun protein fibers as matrices for tissue engineering显示文摘 | Mengyan Li Mark J. Mondrinos Milind R. Gandhi Frank K. Ko Anthony S. Weiss Peter I. Lelkes | 2005 | Biomaterials2005，，30： | 1 |
| 10 | Crystallite growth:width and thickness study related to possible presence of octacalcium phosphate during ameiogenesis显示文摘 | WEISS M P VOLGEL J C FRANK R M | 1981 | J Ultrastruct Res1981，76，： | 1 |
| 11 | Pharmacological Suppression of Hepcidin Increases Macrophage Cholesterol Efflux and Reduces Foam Cell Formation and Atherosclerosis显示文摘 | Omar Saeed Fumiyuki Otsuka Rohini Polavarapu Vinit Karmali Daiana Weiss Talina Davis Brad Rostad Kimberly Pachura Lila Adams John Elliott W. Robert Taylor Jagat Narula Frank Kolodgie Renu Virmani Charles C. Hong Aloke V. Finn | 2012 | Arteriosclerosis Thrombosis and Vascular Biology2012，，2： | 1 |
| 12 | The application of Runge-Kutta schemes to singular initial value problems显示文摘 | de Hoog Frank Weiss Richard | 1985 | Math Comput1985，44，： | 1 |
| 13 | Direct and Indirect Measurement of Patient Radiation Exposure during Endovascular Aortic Aneurysm Repair显示文摘 | Dustin J. Weiss Iraklis I. Pipinos G. Mathew Longo Thomas G. Lynch Frank J. Rutar Jason M. Johanning | 2008 | Annals of Vascular Surgery2008，，6： | 1 |
| 14 | Noninvasive Measurement of Shortening in the Fiber and Cross-Fiber Directions in the Normal Human Left Ventricle and in Idiopathic Dilated Cardiomyopathy显示文摘 | Guy A. MacGowan Edward P. Shapiro Haim Azhari Cynthia O. Siu Paul S. Hees Grover M. Hutchins James L. Weiss Frank E. Rademakers | 1997 | Circulation1997，，2： | 1 |
| 15 | 柴油机用高性能铸铝活塞显示文摘本文介绍了一种用于铸造活塞的全新的过共品铝合金,改进的活塞铸造工艺以及先进的金属重熔技术。 | Simon Reichstein Rainer Weiss Scott Kenningley Klaus Lades Frank Doernenburg | 2011 | 汽车制造业2011，，11： | 0 |
| 16 | 2020年建筑与工程领域科技趋势预测显示文摘2020年伊始,甲骨文针对新兴科技对建筑与工程行业的影响预测了四大趋势。四大趋势分别如下所示:数字孪生:BIM技术将在数据的基础上持续演进,而不只是建筑设计。为了进一步促进BIM技术的发展,最为基本的因素是建立标准,这主要体现在鼓励整个项目供应链对建筑信息建模进行更广泛的应用,从而有效提高生产力和创造力。这样的技术演进只有当信息向项目的所有相关方开放,不再由单一实体掌控时,才有可能真正实现。其中的关键在于数据,而不只是建筑设计。 | Frank Weiss Burcin Kaplanoglu | 2020 | 软件和集成电路2020，，1： | 0 |
| 17 | BIM在2020年的发展趋势显示文摘在2020年,业界在使用BIM的过程中必须继续保持协作、开放和中立的态度。同时,我们也应像其他行业一样,充分重视数据的存在,并做好发挥数据作用的准备。建筑信息模型(BIM)在2019年经历了某种程度上的复兴与变革。并不是说BIM已经过时,而是大家对它的理解和讨论在去年有了很大的进展。我们看到,业内很多企业为了解决当前面临的问题和挑战,已经开展了许多关于BIM的合作。这也让2020年BIM领域的发展显现出更多乐观势态。 | Frank Weiss Léon Van Berlo | 2020 | 软件和集成电路2020，，4： | 0 |
| 18 | Occult celiac disease prevents penetrance of hemochromatosis显示文摘AIM: To report a patient with C282Y homozygocity, depleted body iron and intestinal atrophy caused by celiac disease (CD) who experienced resolution of the enteropathy with subsequent normalization of iron metabolism upon glutenfree diet.METHODS: To obtain information on the tissue distribution and quantitative expression of proteins involved in duodenal iron trafficking, we determined the expression of divalent-metal transporter 1 (DMT1), ferroportin 1 (FP1) and transferrin receptor (TfR1) by means of immunohistochemistry and real-time PCR in duodenal biopsies of this patient.RESULTS: Whereas in hereditary hemochromatosis patients without CD, DMT1 expression was up-regulated leading to excessive uptake of iron, we identified a significant reduction in protein and mRNA expression of DMT1 as acompensatory mechanism in this patient with HH and CD.CONCLUSION: Occult CD may compensate tot increased DMT1 expression in a specific subset of individuals withhomozygous C282Y mutations in the hemochromatosis(HFE) gene, thus contributing to the low penetrance of HH. | Andreas Geier Carsten Gartung Igor Theurl Guenter Weiss Frank Lammert Christoph G.Dietrich Ralf Weiskirchen Heinz Zoller Benita Hermanns Siegfried Matern | 2005 | World Journal of Gastroenterology2005，11，21： | 0 |
| 19 | 高能视频系统实现精细检验显示文摘在 Nürnberg 市 Inter Control 公司中,利用100%高暖量的图像处理技术负责控翩产品的高质量,最终也成为对生产基地的贡献。图像处理系统基于一种由高能视频系统和软件与程序管理模块组成的结构,因此可以完成对大约150种产品的一系列标识进行检验的复杂要求。 | FRANK NEUMANN KAMILLO WEISS | 2008 | 现代制造2008，，45： | 0 |
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