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| 1 | Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer显示文摘AIM: To clarify alterations of Dickkopfs (Dkks) and Kremen2 (Krm2) in gastrointestinal cancer. METHODS: We investigated the expression profiles and epigenetic alterations of Dkks and Krm2 genes in gastrointestinal cancer using RT-PCR, tissue microarray analysis, and methylation specific PCR (MSP). Cancer cells were treated with the demethylating agent and/or histone deacetylase inhibitor. WST-8 assays and in vitro invasion assays after treatment with specific siRNA for those genes were performed. RESULTS: Dkks and Krm2 expression levels were reduced in a certain subset of the gastrointestinal cancer cell lines and cancer tissues. This was correlated with promoter hypermethylation. There were significant correlations between Dkks over-expression levels and beta-catenin over-expression in colorectal cancer. In colorectal cancers with beta-catenin over-expression, Dkk-1 expression levels were significantly lower in those with lymph node metastases than in those without. Down-regulation of Dkks expression by siRNA resulted in a significant increase in cancer cell growth and invasiveness in vitro.CONCLUSION: Down-regulation of the Dkks associated to promoter hypermethylation appears to be frequently involved in gastrointestinal tumorigenesis. | Tadateru Maehata Hiroaki Taniguchi Hiroyuki Yamamoto Katsuhiko Nosho Yasushi Adachi Nobuki Miyamoto Chie Miyamoto Noriyuki Akutsu Satoshi Yamaoka Fumio Itoh | 2008 | World Journal of Gastroenterology2008，14，17： | 19 |
| 2 | Acute pancreatitis successfully diagnosed by diffusion-weighted imaging: A case report显示文摘Diffusion-weighted imaging (DWI) is an established diagnostic method of acute stroke. The latest advances in magnetic resonance imaging (MRI) technology have greatly expanded the utility of DWI in the examination of various organs. Recent studies have revealed the usefulness of DWI for imaging of the liver, kidney, ovary, and breast. We report a patient with acute pancreatitis detected by DWI and discussed the efficacy of DWI in diagnosing acute pancreatitis. A 50-year old man presented with a primary complaint of abdominal pain. We performed both DWI and computed tomography (CT) for this patient. The signal intensity in a series of DWI was measured and the apparent diffusion coefficient (ADC) values were calculated to differentiate inflammation from normal tissue. Two experienced radiologists evaluated the grade of acute pancreatitis by comparing the CT findings. Initially, the pancreas and multiple ascites around the pancreas produced a bright signal and ADC values were reduced on DWI. As the inflammation decreased, the bright signal faded to an iso-signal and the ADC values returned to their normal level. There was no difference in the abilities of DWI and CT images to detect acute pancreatitis. However, our case indicates that DWI can evaluate the manifestations of acute pancreatitis using no enhancement material andhas the potential to replace CT as a primary diagnostic strategy for acute pancreatitis. | Satoshi Shinya Takamitsu Sasaki Yoshifumi Nakagawa Zhang Guiquing Fumio Yamamoto Yuichi Yamashita | 2008 | World Journal of Gastroenterology2008，14，35： | 16 |
| 3 | Treatment and prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy显示文摘Antiplatelet therapy is the standard of care for the secondary prevention of acute coronary syndrome and ischemic stroke, especially after coronary intervention. However, this therapy is associated with bleeding complications such as gastrointestinal bleeding, which is one of the most common life-threatening complications. Early endoscopy is recommended for most patients with acute upper gastrointestinal bleeding. After successful endoscopic hemostasis, immediate resumption of antiplatelet therapy with proton-pump inhibitors(PPIs) is recommended to prevent further ischemic events. PPI prophylaxis during antiplatelet therapy reduces the risk of upper gastrointestinal bleeding. The potential negative metabolic interaction between PPIs and clopidogrel is still unclear. | Hiroshi Yasuda Yasumasa Matsuo Yoshinori Sato Sun-ichiro Ozawa Shinya Ishigooka Masaki Yamashita Hiroyuki Yamamoto Fumio Itoh | 2015 | World Journal of Critical Care Medicine2015，4，1： | 13 |
| 4 | An updated review of gastric cancer in the next-generation sequencing era:Insights from bench to bedside and vice versa显示文摘Gastric cancer(GC)is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide.There is an increasing understanding of the roles that genetic and epigenetic alterations play in GCs.Recent studies using nextgeneration sequencing(NGS)have revealed a number of potential cancer-driving genes in GC.Whole-exome sequencing of GC has identified recurrent somatic mutations in the chromatin remodeling gene ARID1A and alterations in the cell adhesion gene FAT4,a member of the cadherin gene family.Mutations in chromatin remodeling genes(ARID1A,MLL3 and MLL)have been found in 47%of GCs.Whole-genome sequencing and whole-transcriptome sequencing analyses have also discovered novel alterations in GC.Recent studies of cancer epigenetics have revealed widespread alterations in genes involved in the epigenetic machinery,such as DNA methylation,histone modifications,nucleosome positioning,noncoding RNAs and microRNAs.Recent advances in molecular research on GC have resulted in the introduction of new diagnostic and therapeutic strategies into clinical settings.The antihuman epidermal growth receptor 2(HER2)antibody trastuzumab has led to an era of personalized therapy in GC.In addition,ramucirumab,a monoclonal antibody targeting vascular endothelial growth factor receptor(VEGFR)-2,is the first biological treatment that showed survival benefits as a single-agent therapy in patients with advanced GC who progressed after firstline chemotherapy.Using NGS to systematically identify gene alterations in GC is a promising approach with remarkable potential for investigating the pathogenesis of GC and identifying novel therapeutic targets,as well as useful biomarkers.In this review,we will summarize the recent advances in the understanding of the molecular pathogenesis of GC,focusing on the potential use of these genetic and epigenetic alterations as diagnostic biomarkers and novel therapeutic targets. | Hiroyuki Yamamoto Yoshiyuki Watanabe Tadateru Maehata Ryo Morita Yoshihito Yoshida Ritsuko Oikawa Shinya Ishigooka Shun-ichiro Ozawa Yasumasa Matsuo Kosuke Hosoya Masaki Yamashita Hiroaki Taniguchi Katsuhiko Nosho Hiromu Suzuki Hiroshi Yasuda Yasuhisa Shinomura Fumio Itoh | 2014 | World Journal of Gastroenterology2014，20，14： | 12 |
| 5 | Tubulopapillary adenoma of the gallbladder accompanied by bile duct tumor thrombus显示文摘Intraductal papillary mucinous neoplasm of the bile duct(IPNB)is recognized as a precancerous lesion;however,both its pathogenesis and progression remain unclear.We present here a case of IPNB arising from the gallbladder accompanied by bile duct tumor thrombus in a 79-year-old female.The resected specimen revealed a tubulopapillary adenoma with no malignant cells.This case suggests that even in the absence of malignant cells,these tumors can behave as malignant tumors requiring aggressive treatment.Even if no malignant cells are present,intraepithelial neoplasms occurring in the ampullopancreatobiliary tract can behave as malignant tumors. | Kentaroh Yamamoto Fumio Yamamoto Atsuhiro Maeda Hirotsune Igimi Mami Yamamoto Ryosuke Yamaguchi Yuichi Yamashita | 2014 | World Journal of Gastroenterology2014，20，26： | 3 |
| 6 | Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment显示文摘 | Satoshi Kondo Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Kazuhiro Tsukada Masato Nagino Junji Furuse Hiroya Saito Toshio Tsuyuguchi Masakazu Yamamoto Masato Kayahara Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Satoshi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 2 |
| 7 | Transmesosigmoid Hernia: Report of a Case显示文摘 | Takamitsu Sasaki Koutaro Sakai Daisuke Fukumori Masayuki Sato Hitoshi Ohmori Fumio Yamamoto | 2002 | Surgery Today2002，，12： | 1 |
| 8 | Overcoming hybrid lethality in a cross between Japanese pear and apple using gamma irradiation and confirmation of hybrid status using flow cytometry and SSR markers显示文摘 | Takeru Gonai Toru Manabe Eiichi Inoue Mikio Hayashi Toshiya Yamamoto Tateki Hayashi Fumio Sakuma Masakazu Kasumi | 2006 | Scientia Horticulturae2006，，1： | 1 |
| 9 | Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer显示文摘 | Ken-ichi Fujita Yuichi Ando Fumio Nagashima Wataru Yamamoto Hisashi Eodo Kazuhiro Araki Keiji Kodama Toshimichi Miya Masaru Narabayashi Yasutsuna Sasaki | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 10 | Classification of Barrett’s epithelium by magnifying endoscopy显示文摘 | Takao Endo Teruhito Awakawa Hiroaki Takahashi Yoshiaki Arimura Fumio Itoh Kentaro Yamashita Sigeru Sasaki Hiroyuki Yamamoto Xiufen Tang Kohzoh Imai | 2002 | Gastrointestinal Endoscopy2002，，6： | 1 |
| 11 | Mode of onset of ventricular fibrillation in patients with Brugada syndrome detected by implantable cardioverter defibrillator therapy显示文摘 | Mikio Kakishita Takashi Kurita Kiyotaka Matsuo Atsushi Taguchi Kazuhiro Suyama Wataru Shimizu Naohiko Aihara Shiro Kamakura Fumio Yamamoto Junjiro Kobayashi Yoshio Kosakai Tohru Ohe | 2000 | Journal of the American College of Cardiology2000，，5： | 1 |
| 12 | Preparation of microcapsules by electrostatic atomization显示文摘 | Eri Sasaki Fumio Kurayama Jun-ichi Ida Tatsushi Matsuyama Hideo Yamamoto | 2008 | Journal of Electrostatics2008，，5： | 1 |
| 13 | Short-Term Surgical Outcomes From a Randomized Controlled Trial to Evaluate Laparoscopic and Open D3 Dissection for Stage II/III Colon Cancer: Japan Clinical Oncology Group Study JCOG 0404显示文摘 | Seiichiro Yamamoto Masafumi Inomata Hiroshi Katayama Junki Mizusawa Tsuyoshi Etoh Fumio Konishi Kenichi Sugihara Masahiko Watanabe Yoshihiro Moriya Seigo Kitano | 2014 | Annals of Surgery2014，，1： | 1 |
| 14 | Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer显示文摘 | Ken-ichi Fujita Yuichi Ando Fumio Nagashima Wataru Yamamoto Hisashi Eodo Kazuhiro Araki Keiji Kodama Toshimichi Miya Masaru Narabayashi Yasutsuna Sasaki | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 15 | Small Bowel Obstruction Caused by Anisakiasis of the Small Intestine: Report of a Case显示文摘 | Takamitsu Sasaki Daisuke Fukumori Hisanobu Matsumoto Hitoshi Ohmori Fumio Yamamoto | 2003 | Surgery Today2003，，2： | 1 |
| 16 | Classification of Barrett’s epithelium by magnifying endoscopy显示文摘 | Takao Endo Teruhito Awakawa Hiroaki Takahashi Yoshiaki Arimura Fumio Itoh Kentaro Yamashita Sigeru Sasaki Hiroyuki Yamamoto Xiufen Tang Kohzoh Imai | 2002 | Gastrointestinal Endoscopy2002，，6： | 1 |
| 17 | The effects of Na movement on surgical myocardial protection: The role of the Na^+ - H^+ exchange system and Na-Channel in the development of ischemia and reperfusion injury显示文摘 | Ke-Xiang Liu Fumio Yamamoto Hiroshi Yamamoto | 2007 | Ann Thorae Cardiovasc Surg2007，13，5： | 1 |
| 18 | Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment显示文摘 | Satoshi Kondo Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Kazuhiro Tsukada Masato Nagino Junji Furuse Hiroya Saito Toshio Tsuyuguchi Masakazu Yamamoto Masato Kayahara Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Satoshi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 1 |
| 19 | Salivary gland progenitor cells induced by duct ligation differentiate into hepatic and pancreatic lineages显示文摘 | Kenji Okumura Kimitoshi Nakamura Yuichiro Hisatomi Koji Nagano Yasuhiko Tanaka Kunihiko Terada Toshihiro Sugiyama Kazuhiro Umeyama Kozo Matsumoto Tetsuro Yamamoto Fumio Endo | 2003 | Hepatology2003，，1： | 1 |
| 20 | Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features显示文摘 | Hiroyuki Yamamoto Javier Perez–Piteira Teruhiko Yoshida Masaaki Terada Fumio Itoh Kohzoh Imai Manuel Perucho | 1999 | Gastroenterology1999，，6： | 1 |
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