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| 1 | An updated review of gastric cancer in the next-generation sequencing era:Insights from bench to bedside and vice versa显示文摘Gastric cancer(GC)is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide.There is an increasing understanding of the roles that genetic and epigenetic alterations play in GCs.Recent studies using nextgeneration sequencing(NGS)have revealed a number of potential cancer-driving genes in GC.Whole-exome sequencing of GC has identified recurrent somatic mutations in the chromatin remodeling gene ARID1A and alterations in the cell adhesion gene FAT4,a member of the cadherin gene family.Mutations in chromatin remodeling genes(ARID1A,MLL3 and MLL)have been found in 47%of GCs.Whole-genome sequencing and whole-transcriptome sequencing analyses have also discovered novel alterations in GC.Recent studies of cancer epigenetics have revealed widespread alterations in genes involved in the epigenetic machinery,such as DNA methylation,histone modifications,nucleosome positioning,noncoding RNAs and microRNAs.Recent advances in molecular research on GC have resulted in the introduction of new diagnostic and therapeutic strategies into clinical settings.The antihuman epidermal growth receptor 2(HER2)antibody trastuzumab has led to an era of personalized therapy in GC.In addition,ramucirumab,a monoclonal antibody targeting vascular endothelial growth factor receptor(VEGFR)-2,is the first biological treatment that showed survival benefits as a single-agent therapy in patients with advanced GC who progressed after firstline chemotherapy.Using NGS to systematically identify gene alterations in GC is a promising approach with remarkable potential for investigating the pathogenesis of GC and identifying novel therapeutic targets,as well as useful biomarkers.In this review,we will summarize the recent advances in the understanding of the molecular pathogenesis of GC,focusing on the potential use of these genetic and epigenetic alterations as diagnostic biomarkers and novel therapeutic targets. | Hiroyuki Yamamoto Yoshiyuki Watanabe Tadateru Maehata Ryo Morita Yoshihito Yoshida Ritsuko Oikawa Shinya Ishigooka Shun-ichiro Ozawa Yasumasa Matsuo Kosuke Hosoya Masaki Yamashita Hiroaki Taniguchi Katsuhiko Nosho Hiromu Suzuki Hiroshi Yasuda Yasuhisa Shinomura Fumio Itoh | 2014 | World Journal of Gastroenterology2014，20，14： | 12 |
| 2 | Crowned dens syndrome developed after an endoscopic retrograde cholangiopancreatography procedure显示文摘We present a unique case of crowned dens syndrome(CDS) that developed after endoscopic retrograde cholangiopancreatography(ERCP) in a patient who presented with fever and neck pain. Administration of non-steroidal anti-inflammatory drugs was extremely effective for relieving fever and neck pain, and in the improvement of inflammatory markers. To the best of our knowledge, this is the first case report of CDS caused by an ERCP procedure. In a patient with fever and neck pain after an ERCP procedure, CDS should be considered in the differential diagnosis. | Hiroyasu Nakano Kazunari Nakahara Yosuke Michikawa Keigo Suetani Ryo Morita Nobuyuki Matsumoto Fumio Itoh | 2016 | World Journal of Gastroenterology2016，22，39： | 5 |
| 3 | Thrombomodulin in the management of acute cholangitisinduced disseminated intravascular coagulation显示文摘AIM: To evaluate the need for thrombomodulin(r TM) therapy for disseminated intravascular coagulation(DIC) in patients with acute cholangitis(AC)-induced DIC. METHODS: Sixty-six patients who were diagnosedwith AC-induced DIC and who were treated at our hospital were enrolled in this study. The diagnoses of AC and DIC were made based on the 2013 Tokyo Guidelines and the DIC diagnostic criteria as defined by the Japanese Association for Acute Medicine, respectively. Thirty consecutive patients who were treated with r TM between April 2010 and September 2013(r TM group) were compared to 36 patients who were treated without r TM(before the introduction of r TM therapy at our hospital) between January 2005 and January 2010(control group). The two groups were compared in terms of patient characteristics at the time of DIC diagnosis(including age, sex, primary disease, severity of cholangitis, DIC score, biliary drainage, and anti-DIC drugs), the DIC resolution rate, DIC score, the systemic inflammatory response syndrome(SIRS) score, hematological values, and outcomes. Using logistic regression analysis based on multivariate analyses, we also examined factors that contributed to persistent DIC. RESULTS: There were no differences between the r TM group and the control group in terms of the patients' backgrounds other than administration. DIC resolution rates on day 9 were higher in the r TM group than in the control group(83.3% vs 52.8%, P < 0.01). The mean DIC scores on day 7 were lower in the r TM group than in the control group(2.1 ± 2.1 vs 3.5 ± 2.3, P = 0.02). The mean SIRS scores on day 3 were significantly lower in the r TM group than in the control group(1.1 ± 1.1 vs 1.8 ± 1.1, P = 0.03). Mortality on day 28 was 13.3% in the r TM group and 27.8% in the control group; these rates were not significantly different(P = 0.26). Multivariate analysis identified only the absence of biliary drainage as significantly associated with persistent DIC(P < 0.01, OR = 12, 95%CI: 2.3-60). Although the difference did not reach statistical significance, primary diseases(malignancies)(P = 0.055, OR = 3.9, 95%CI: 0.97-16) and the non-use of r TM had a tendency to be associated with persistent DIC(P = 0.08, OR = 4.3, 95%CI: 0.84-22).CONCLUSION: The add-on effects of r TM are anticipated in the treatment of AC-induced DIC, although biliary drainage for AC remains crucial. | Keigo Suetani Chiaki Okuse Kazunari Nakahara Yosuke Michikawa Yohei Noguchi Midori Suzuki Ryo Morita Nozomi Sato Masaki Kato Fumio Itoh | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
| 4 | Rare earth elements(REEs) in naturally grown plants in relation to their variation in soils 显示文摘 | Hideyoshi Morita Ryo Tatsukawa | 1992 | Environmental Pollution1992，76，： | 1 |
| 5 | Usefulness of magnetic resonance imaging for diagnosing deep anorectal abscesses显示文摘 | Ryo Maruyama Tsuyoshi Noguchi Masahiro Takano Koichi Takagi Norikazu Morita Ryuichi Kikuchi Yuzo Uchida | 2000 | Diseases of the Colon & Rectum2000，，： | 1 |
| 6 | Rare earth elements (REEs) in naturally grown plants in relation to their variation in soils显示文摘 | Hideki Ichihashi Hideyoshi Morita Ryo Tatsukawa | 1992 | Environmental Pollution1992，76，： | 1 |
| 7 | Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer显示文摘 | Manabu Muto Hironaga Satake Tomonori Yano Keiko Minashi Ryuichi Hayashi Satoshi Fujii Atsushi Ochiai Atsushi Ohtsu Shuko Morita Takahiro Horimatsu Yasumasa Ezoe Shinichi Miyamoto Ryo Asato Ichiro Tateya Akihiko Yoshizawa Tsutomu Chiba | 2011 | Gastrointestinal Endoscopy2011，，3： | 1 |
| 8 | Rapid quantitative screening assay for SARS-CoV-2 neutralizing antibodies using HiBiT-tagged virus-like particles显示文摘Due to the unavailability of any specific countermeasure,the constantly spreading C0VID-19 pandemic could only be partially and temporarily slowed down by implementing regional lockdowns that force people to stay at home and prevent their movement.With the progression of the pandemic,a considerable subset of the population would have acquired post-infection immunity and the tests that reveal the postinfection immune status of individuals are the need of the hour. | Kei Miyakawa Sundararaj Stanleyraj Jeremiah Norihisa Ohtake Satoko Matsunaga Yutaro Yamaoka Mayuko Nishi Takeshi Morita Ryo Saji Mototsugu Nishii Hirokazu Kimura Hideki Hasegawa Ichiro Takeuchi Akihide Ryo | 2020 | Journal of Molecular Cell Biology2020，12，12： | 1 |
| 9 | Surgical outcomes of laparoscopy-assisted gastrectomy versus open gastrectomy for gastric cancer: a case-control study显示文摘 | Chikara Kunisaki Hirochika Makino Takashi Kosaka Takashi Oshima Shoichi Fujii Ryo Takagawa Jun Kimura Hidetaka A. Ono Hirotoshi Akiyama Masataka Taguri Satoshi Morita Itaru Endo | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 10 | Enteral metallic stenting by balloon enteroscopy for obstruction of surgically reconstructed intestine显示文摘We present three cases of self-expandable metallic stent(SEMS) placement using a balloon enteroscope(BE) and its overtube(OT) for malignant obstruction of surgically reconstructed intestine. A BE is effective for the insertion of an endoscope into the deep bowel. However, SEMS placement is impossible through the working channel, because the working channel of BE is too small and too long for the stent device. Therefore, we used a technique in which the BE is inserted as far as the stenotic area; thereafter, the BE is removed, leaving only the OT, and then the stent is placed by inserting the stent device through the OT. In the present three cases, a modification of this technique resulted in the successful placement of the SEMS for obstruction of surgically reconstructed intestine, and the procedures were performed without serious complications. We consider that the present procedure is extremely effective as a palliative treatment for distal bowel stenosis, such as in the surgically reconstructed intestine. | Kazunari Nakahara Chiaki Okuse Nobuyuki Matsumoto Keigo Suetani Ryo Morita Yosuke Michikawa Shun-ichiro Ozawa Kosuke Hosoya Shinjiro Kobayashi Takehito Otsubo Fumio Itoh | 2015 | World Journal of Gastroenterology2015，21，24： | 1 |
| 11 | Gene expression of sex-determining factors and steroidogenic enzymes in the chicken embryo: influence of xenoestrogens显示文摘 | Ryo Kamata Shinji Takahashi Masatoshi Morita | 2004 | General and Comparative Endocrinology2004，，2： | 1 |
| 12 | Surgical outcomes of laparoscopy-assisted gastrectomy versus open gastrectomy for gastric cancer: a case-control study显示文摘 | Chikara Kunisaki Hirochika Makino Takashi Kosaka Takashi Oshima Shoichi Fujii Ryo Takagawa Jun Kimura Hidetaka A. Ono Hirotoshi Akiyama Masataka Taguri Satoshi Morita Itaru Endo | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 13 | CFD simulations and experiments of flow fluetuations around a steam control valve显示文摘 | RYO Morita FUMIO Inada MIEHITSUGU Mori | 2007 | ASME Journal of Fluids Engineering2007，129，1： | 1 |
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