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| 1 | Roux-en-Y versus BillrothⅠreconstruction after distal gastrectomy for gastric cancer:A meta-analysis显示文摘AIM:To conduct a meta-analysis to compare Rouxen-Y(R-Y) gastrojejunostomy with gastroduodenal Billroth Ⅰ(B-Ⅰ) anastomosis after distal gastrectomy(DG) for gastric cancer.METHODS:A literature search was performed to identify studies comparing R-Y with B-Ⅰ after DG for gastric cancer from January 1990 to November 2012 in Medline,Embase,Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in The Cochrane Library.Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed or random effects model.Operative outcomes such as operation time,intraoperative blood loss and postoperative outcomes such as anastomotic leakage and stricture,bile reflux,remnant gastritis,reflux esophagitis,dumping symptoms,delayed gastric emptying and hospital stay were the main outcomes assessed.Meta-analyses were performed using RevMan 5.0 software(Cochrane library).RESULTS:Four randomized controlled trials(RCTs) and 9 non-randomized observational clinical studies(OCS) involving 478 and 1402 patients respectively were included.Meta-analysis of RCTs revealed that R-Y reconstruction was associated with a reduced bile reflux(OR 0.04,95%CI:0.01,0.14;P < 0.00 001) and remnant gastritis(OR 0.43,95%CI:0.28,0.66;P = 0.0001),however needing a longer operation time(WMD 40.02,95%CI:13.93,66.11;P = 0.003).Metaanalysis of OCS also revealed R-Y reconstruction had a lower incidence of bile reflux(OR 0.21,95%CI:0.08,0.54;P = 0.001),remnant gastritis(OR 0.18,95%CI:0.11,0.29;P < 0.00 001) and reflux esophagitis(OR 0.48,95%CI:0.26,0.89;P = 0.02).However,this reconstruction method was found to be associated with a longer operation time(WMD 31.30,95%CI:12.99,49.60;P = 0.0008).CONCLUSION:This systematic review point towards some clinical advantages that are rendered by R-Y compared to B-Ⅰ reconstruction post DG.However there is a need for further adequately powered,welldesigned RCTs comparing the same. | Jun-Jie Xiong Kiran Altaf Muhammad A Javed Quentin M Nunes Wei Huang Gang Mai Chun-Lu Tan Rajarshi Mukherjee Robert Sutton Wei-Ming Hu Xu-Bao Liu | 2013 | World Journal of Gastroenterology2013，19，7： | 33 |
| 2 | Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma显示文摘AIM:To conduct a meta-analysis to determine the safety and efficacy of laparoscopic liver resection(LLR) and open liver resection(OLR) for hepatocellular carcinoma(HCC).METHODS:PubMed(Medline),EMBASE and Science Citation Index Expanded and Cochrane Central Register of Controlled Trials in the Cochrane Library were searched systematically to identify relevant comparative studies reporting outcomes for both LLR and OLR for HCC between January 1992 and February 2012.Two authors independently assessed the trials for inclusion and extracted the data.Meta-analysis was performed using Review Manager Version 5.0 software(The Cochrane Collaboration,Oxford,United Kingdom).Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed effects(Mantel-Haenszel method) or random effects models(DerSimonian and Laird method).Evaluated endpoints were operative outcomes(operation time,intraoperative blood loss,blood transfusion requirement),postoperative outcomes(liver failure,cirrhotic decompensation/ascites,bile leakage,postoperative bleeding,pulmonary complications,intraabdominal abscess,mortality,hospital stay and oncologic outcomes(positive resection margins and tumor recurrence).RESULTS:Fifteen eligible non-randomized studies were identified,out of which,9 high-quality studies involving 550 patients were included,with 234 patients in the LLR group and 316 patients in the OLR group.LLR was associated with significantly lower intraoperative blood loss,based on six studies with 333 patients [WMD:-129.48 mL;95%CI:-224.76-(-34.21) mL;P = 0.008].Seven studies involving 416 patients were included to assess blood transfusion requirement between the two groups.The LLR group had lower blood transfusion requirement(OR:0.49;95%CI:0.26-0.91;P = 0.02).While analyzing hospital stay,six studies with 333 patients were included.Patients in the LLR group were found to have shorter hospital stay [WMD:-3.19 d;95%CI:-4.09-(-2.28) d;P < 0.00001] than their OLR counterpart.Seven studies including 416 patients were pooled together to estimate the odds of developing postoperative ascites in the patient groups.The LLR group appeared to have a lower incidence of postoperative ascites(OR:0.32;95%CI:0.16-0.61;P = 0.0006) as compared with OLR patients.Similarly,fewer patients had liver failure in the LLR group than in the OLR group(OR:0.15;95%CI:0.02-0.95;P =0.04).However,no significant differences were found between the two approaches with regards to operation time [WMD:4.69 min;95%CI:-22.62-32 min;P = 0.74],bile leakage(OR:0.55;95%CI:0.10-3.12;P = 0.50),postoperative bleeding(OR:0.54;95%CI:0.20-1.45;P = 0.22),pulmonary complications(OR:0.43;95%CI:0.18-1.04;P = 0.06),intra-abdominal abscesses(OR:0.21;95%CI:0.01-4.53;P = 0.32),mortality(OR:0.46;95%CI:0.14-1.51;P = 0.20),presence of positive resection margins(OR:0.59;95%CI:0.21-1.62;P = 0.31) and tumor recurrence(OR:0.95;95%CI:0.62-1.46;P = 0.81).CONCLUSION:LLR appears to be a safe and feasible option for resection of HCC in selected patients based on current evidence.However,further appropriately designed randomized controlled trials should be undertaken to ascertain these findings. | Jun-Jie Xiong Kiran Altaf Muhammad A Javed Wei Huang Rajarshi Mukherjee Gang Mai Robert Sutton Xu-Bao Liu Wei-Ming Hu | 2012 | World Journal of Gastroenterology2012，18，45： | 25 |
| 3 | Efficacy of Atorvastatin combined with adipose-derived mesenchymal stem cell transplantation on cardiac function in rats with acute myocardial infarction显示文摘间充质的干细胞(MSC ) 广泛地被申请了在尖锐心肌的梗塞(AMI ) 以后的 cardiomyocytes 损失的恢复。然而,在 ischemic 心疾病的 MSC 的最佳的治疗学的功效被他们的差的幸存和低区分的率妨碍了。因此, MSC 幸存的改进和区分的率被保证并且为在 AMI 的 MSC 的功效批评。在这份报纸,从腹股沟的胖纸巾作为脂肪质导出被称为间充质的干细胞(ASC ) 的老鼠孤立的 MSC,和 ASC 的第四个段落被文化 co 在一个 transwell 系统与 cardiomyocytes 预先指定作为 co-ASCs 称为。十四天以后, GATA-4 (一个抄写因素) 和心脏的 troponin -- 我被细胞的 immunofluorescence 检测。Atorvastatin (Ator 组) 或车辆(控制组) 在老鼠在 AMI 生产以后为开始的 24 h 被管理。十四天以后,煽动性的参数和心脏的功能被评估。另外的幸存老鼠与 1 普物敭 ? 潴戠 ? 的一个总数被注射 ? 楤敲瑣琠牡敧 ? 敧敮漠 ? 業??? 祢攠桮湡散 ? 牧敥 ? 汦潵敲 ' 諟?牰瑯楥? 敲潰瑲牥攠灸牥浩湥吗? | Anping Cai Dongdan Zheng Yugang Dong Ruofeng Qiu Yuli Huang Yuanbin Song Zhigao Jiang Shaoqi Rao Xinxue Liao Jian Kuang Gang Dai Weiyi Mai | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 16 |
| 4 | Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis显示文摘瞄准:在尖锐胰腺炎(AP ) 期间在胰腺的微循环上调查硬膜上的麻醉(EA ) 的效果。方法:AP 被牛磺胆酸钠的注射导致进 Sprague-Dawley 老鼠的胰腺的管。认识到 EA,一根导管被介绍进在 T7 和 T9 之间的硬膜外腔, bupivacaine 被注射。Microcirculatory 流动被激光 Doppler flowmetry 测量。动脉的血气体分析被执行。在实验(<or=5 h ) 的结束,胰为组织学被移开。动物被划分成三个组:组织 1 (n=9 ) ,没有 EA 的 AP;组织 2 (n=4 ) ,没有 AP 的 EA;并且组织 3 (n=6 ) , AP 由 EA 对待。结果:在组 1,在 AP 以前的胰腺的微循环流动是 141+/- 39 个灌注单位(PU ) 。在 AP 以后,微循环流动显然减少了到 9+/- 6 PU (P<0.05 ) 。与基础过量开发的新陈代谢的酸中毒()-14+/-3 mmol/L。组织学揭示了广泛的浮肿和织物坏死。在组 2, EA 显著地没修改微循环流动。被仍然是未改变、组织学的分析显示出正常胰腺的织物。在组 3, AP 开始从 155+/-25 在微循环流动引起了重要减少到 11+/-7 PU (P<0.05 ) 。在 EA 的开始以后,微循环流动显然再增加了到 81+/-31 PU (P<0.05 ) 。是 -6+/-4 mmol/L,它与组 1 相比是显著地不同的(P<0.05 ) 。而且,组织学在组 1 在比那的组 3 在胰腺的组织揭示了不太广泛的浮肿和坏死。结论:AP 在胰以内引起了戏剧的微循环变化,与新陈代谢的酸中毒和织物坏死的开发。EA 允许微循环流动的部分恢复并且阻止了织物坏死和全身的复杂并发症的开发。因此, EA 应该被看作治疗学的选择阻止进化水肿到坏死的 AP。 | AlpDemirag CatherineMPastor PhilippeMorel NilgunGüvener GangMai ThierryBerney LeoHBühler CopinJean-Christophe Jean-LouisFrossard Andreas W.Sielenk mper Gang Mai | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 5 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 6 | Pretreatment platelet count improves the prognostic performance of the TNM staging system and aids in planning therapeutic regimens for nasopharyngeal carcinoma:a singleinstitutional study of 2,626 patients显示文摘Introduction:Thrombocytosis has been identified as an unfavorable prognostic factor in several types of cancer.This study aimed to evaluate the prognostic value of pretreatment platelet count in association with the TNM staging system and therapeutic regimens in patients with nasopharyngeal carcinoma(NPC).Methods:A total of 2,626 patients with NPC were retrospectively analyzed.Platelet count >300 × 10~9/L was defined as thrombocytosis.Matched-pair analysis was performed between patients receiving chemoradiotherapy and radiotherapy.Results:Multivariate analysis showed that platelet count was an independent unfavorable prognostic factor for overall survival(OS)[hazard ratio(HR) = 1.810,95%confidence interval(CI) = 1.531-2.140,P < 0.001]and distant metastasis-free survival(DMFS)(HR = 1.873,95%CI = 1.475-2.379,P < 0.001) in the entire patient cohort.Further subgroup analysis revealed that increased platelet count was an independent unfavorable prognostic factor for OS and DMFS in patients with NPC stratified by early and advanced T category,N category,or TNM classification(all P < 0.001).Receiver operating characteristic(ROC) curves verified that the predictive value of TNM classification for OS was improved when combined with pretreatment platelet count(P = 0.030).Matched-pair analysis showed that chemoradiotherapy significantly improved OS only in advanced-stage NPC with thrombocytosis(HR = 0.416,95%CI = 0.226-0.765,P = 0.005).Conclusions:Pretreatment platelet count,when combined with TNM classification,is a useful indicator for metastasis and survival in patients with NPC.It may improve the predictive value of the TNM classification and help to identify patients likely to benefit from more aggressive therapeutic regimens. | Yu-Pei Chen Bing-Cheng Zhao Chen Chen Lu-Jun Shen Jin Gao Zhuo-Yao Mai Meng-Kun Chen Gang Chen Fang Yan Su Liu Yun-Fei Xia | 2015 | Chinese Journal of Cancer2015，34，3： | 10 |
| 7 | Solid pseudopapillary tumor of the pancreas in male patients: Report of 16 cases显示文摘AIM:To investigate the clinical characteristics,surgical strategies and prognosis of solid pseudopapillary tumors(SPTs)of the pancreas in male patients.METHODS:From July 2003 to March 2013,116 patients were diagnosed with SPT of the pancreas in our institution.Of these patients,16 were male.The patients were divided into two groups based on gender:female(group 1)and male(group 2).The groups were compared with regard to demographic characteristics,clinical presentations,surgical strategies,complications and follow-up outcomes.RESULTS:Male patients were older than female patients(43.1±12.3 years vs 33.1±11.5 years,P=0.04).Tumor size,location,and symptoms were comparable between the two groups.All patients,with the exception of one,underwent complete surgical resection.The patients were regularly followed up.Themean follow-up period was 58 mo.Two female patients(1.7%)developed tumor recurrence or metastases and required a second resection,and two female patients(1.7%)died during the follow-up period.CONCLUSION:Male patients with SPT of the pancreas are older than female patients.There are no significant differences between male and female patients regarding surgical strategies and prognosis. | Yun-Qiang Cai Si-Ming Xie Xun Ran Xing Wang Gang Mai Xu-Bao Liu | 2014 | World Journal of Gastroenterology2014，20，22： | 8 |
| 8 | Influence of chronic HBV infection on superimposed acute hepatitis E显示文摘AIM:To investigate the influence of chronic hepatitis B virus(HBV)infection[based on the status of hepatitis B e antigen(HBeAg),HBV DNA,and cirrhosis]on superimposed acute hepatitis E.METHODS:A total of 294 patients were recruited from the Department of Infectious Diseases of the Third Affiliated Hospital,Sun Yat-sen University,from January 2003 to January 2012.The patients were classified into two groups:an HBV+hepatitis E virus(HEV)group(a group with chronic HBV infection that was superinfected with acute hepatitis E,n=118)and an HEV group(a group with acute hepatitis E,n=176).We retrospectively analyzed and compared the clinical features of the two groups.Statistical analyses were performed using theχ2test or Fisher’s exact test for categorical variables and the Student’s t test forcontinuous variables.A P value<0.05 was considered statistically significant.RESULTS:The peak values of prothrombin time,serum total bilirubin,and Model for End-Stage Liver Disease scores were significantly higher in the HBV+HEV group.More patients in the HBV+HEV group had complications(39.8%vs 16.5%,P=0.000)and developed liver failure(35.6%vs 8.5%,P=0.000).Additionally,the mortality of the HBV+HEV group was significantly higher(20.3%vs 7.4%,P=0.002).Further analysis of the HBV+HEV group showed that there were no significant differences in complication occurrence,liver failure incidence,or mortality between patients with different HBeAg and HBV DNA statuses.However,in patients with underlying cirrhosis,complication occurrence and liver failure incidence significantly increased.In total,12.7%of the patients in the HBV+HEV group received anti-HBV treatment,but this therapy failed to reduce mortality in patients who developed liver failure.CONCLUSION:The presence of underlying cirrhosis in chronic HBV infection results in more severe clinical outcomes with superimposed acute hepatitis E.AntiHBV treatment cannot improve the prognosis of liver failure caused by HBV-HEV superinfection. | Si-Hong Cheng Li Mai Feng-Qin Zhu Xing-Fei Pan Hai-Xia Sun Hong Cao Xin Shu Wei-Min Ke Gang Li Qi-Huan Xu | 2013 | World Journal of Gastroenterology2013，19，35： | 8 |
| 9 | HIV Prevention and Health Poverty Alleviation-Liangshan Prefecture,Sichuan Province,China,2017-2020显示文摘BACKGROUND Liangshan,officially the Liangshan Yi Autonomous Prefecture,is an autonomous prefecture occupying much of the southern portion of Sichuan Province.It has been a remote and deeply impoverished area and also has the largest population of ethnic Yi people in China(1).For many years,due to geographical environment conditions,traffic conditions,and other historic restrictions,the human immunodeficiency virus(HIV)epidemic in Liangshan Prefecture has become the focus of HIV prevention and control in China since the first acquired immunodeficiency syndrome(AIDS)case was reported in this area in 1995(2-3). | Zhongfu Liu Xuefeng Tang Yufen Liu Linglin Zhang Yihui Yang Yongli Zheng Weixin Liu Chunnong Jike Hong Mai Heying Fan Gang Yu Mengjie Han George F.Gao | 2021 | China CDC weekly2021，3，48： | 4 |
| 10 | Clinical impact of preoperative acute pancreatitis in patients who undergo pancreaticoduodenectomy for periampullary tumors显示文摘AIM: To investigate the impact of preoperative acute pancreatitis(PAP) on the surgical management of periampullary tumors.METHODS: Fifty-eight patients with periampullary tumors and PAP were retrospectively analyzed. Thirtyfour patients who underwent pancreaticoduodenectomy(PD) and 4 patients who underwent total pancreatectomy were compared with a control group of 145 patients without PAP during the same period.RESULTS: The preoperative waiting time was significantly shorter for the concomitant PAP patients who underwent a resection(22.4 d vs 54.6 d, p < 0.001)compared to those who did not. The presence of PAP significantly increased the rate of severe complications(Clavien grade 3 or higher)(17.6% vs 4.8%, p = 0.019)and lengthened the hospital stay(19.5 d vs 14.5 d,p = 0.006). A multivariate logistic regression analysis revealed that PAP was an independent risk factor for postoperative pancreatic fistula(OR = 2.91; 95%CI:1.10-7.68; p = 0.032) and severe complications(OR =4.70; 95%CI: 1.48-14.96; p = 0.009) after PD. There was no perioperative mortality.CONCLUSION: PAP significantly increases the incidence of severe complications and lengthens thehospital stay following PD. PD could be safely performed in highly selective patients with PAP. | Yong-Hua Chen Si-Ming Xie Hao Zhang Chun-Lu Tan Neng-Wen Ke Gang Mai Xu-Bao Liu | 2015 | World Journal of Gastroenterology2015，21，22： | 4 |
| 11 | Recurrence and survival after surgery for pancreatic cancer with or without acute pancreatitis显示文摘BACKGROUND In pancreatic cancer,acute pancreatitis(AP)is a serious morbidity,but its negative effect on long-term outcomes remains to be elucidated.AIM To investigate the effects of AP on the tumor recurrence pattern of pancreatic ductal adenocarcinoma(PDAC)and tumor-specific survival.METHODS The medical records of 219 patients with curative pancreatectomy for pancreatic cancer at the Pancreatic Surgery Center of West China Hospital from July 2012 to December 2016 were analyzed retrospectively.The severity of acute pancreatitis was classified according to the Atlanta classification of AP.The patient demographics and tumor characteristics were assessed.Early recurrence was defined as a relapse within 12 mo after surgery.Overall and disease-free survival and recurrence patterns were analyzed.Mild acute pancreatitis was excluded because its negative effects can be negligible.RESULTS Early recurrence in AP group was significantly higher than in non-AP group(71.4%vs 41.2%;P=0.009).Multivariate analysis of postoperative early recurrence showed that moderate or severe AP was an independent risk factor for an early recurrence[odds ratio(OR):4.13;95%confidence interval(CI):1.41-12.10;P=0.01].The median time to recurrence was shorter in patients with AP than in those without(8.4 vs 12.8 mo;P=0.003).Multivariate analysis identified AP as an independent prognostic factor for overall survival[relative risk(RR):2.35;95%CI:1.45-3.83]and disease-free survival(RR:2.24;95%CI:1.31-3.85)in patients with PDAC.CONCLUSION Patients with moderate or severe acute pancreatitis developed recurrences earlier than those without.Moderate or severe AP is associated with shorter overall and disease-free survival of patients with PDAC. | Qian Feng Cheng Li Sheng Zhang Chun-Lu Tan Gang Mai Xu-Bao Liu Yong-Hua Chen | 2019 | World Journal of Gastroenterology2019，25，39： | 4 |
| 12 | Arabidopsis ENOR3 regulates RNAi-mediated antiviral defense显示文摘Viruses can infect host plants to cause severe diseases and substantial agricultural loss, while plants have evolved RNA interference(RNAi) strategy to defend against viral infection. Despite enormous efforts, only a few host proteins in RNAi pathway were shown to mediate antiviral defense, including RNA-dependent RNA polymerase 1(RDR1), RDR6, DICER-LIKE 2(DCL2) and DCL4. In this study, we carried out a genetic screen for antiviral factors of RNAi pathway in Arabidopsis rdr6 background via inoculation with a 2 bdeficient Cucumber Mosaic Virus(CMV-D2b). We identified a mutant susceptible to CMV-D2b, referred to as enhancer of rdr6(enor) 3-1 rdr6, and found that ENOR3 encodes a functionally unknown protein with high homology to the mammalian Non Imprinted in Prader-Willi/Angelman(NIPA) magnesium transporters. ENOR3 inhibits accumulation of CMV-D2b and acts additively with RDR1, RDR6, DCL2 and DCL4 in antiviral defense. These results uncover that ENOR3 is a key component in antiviral RNAi pathway, and provide new insights into antiviral immunity. | Hua Gao Mai Yang Haitao Yang Yue Qin Biyun Zhu Gang Xu Chengyuan Xie Dewei Wu Xiaolin Zhang Wanxiang Li Jianbin Yan Susheng Song Tiancong Qi Shou-Wei Ding Daoxin Xie | 2018 | Journal of Genetics and Genomics2018，45，1： | 2 |
| 13 | Helioscopianoids A–Q,bioactive jatrophane diterpenoid esters from Euphorbia helioscopia显示文摘The EtOH extracts of the whole plants of Euphorbia helioscopia afforded 17 new jatrophane diterpenoid esters, helioscopianoids A–Q(1–17), along with eight known compounds(18–25). Their structures were elucidated by extensive spectroscopic methods and Mo_2(OAc)_4-induced ECD analysis,and the structures of compounds 1, 2, and 7 were confirmed by X-ray crystallography. Compounds 1–17 were evaluated for inhibitory effects on P-glycoprotein(P-gp) in an adriamycin(ADM)-resistant human breast adenocarcinoma cell line(MCF-7/ADR) and neuroprotective effects against serum deprivationinduced and rotenone-induced PC12 cell damage. Compounds 8 and 16 increased the accumulation of ADM in MCF-7/ADR cells by approximately 3-fold at a concentration of 20 μmol/L. Compound 8 could attenuate rotenone-induced PC12 cell damage, and compounds 2, 8, and 12 showed neuroprotective activities against serum deprivation-induced PC12 cell damage. | Zhenpeng Mai Gang Ni Yanfei Liu Zhao Zhang Li Li Naihong Chen Dequan Yu | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 2 |
| 14 | A systematic review and meta‐analysis of studies comparing laparoscopic and open distal pancreatectomy显示文摘 | Tao Jin Kiran Altaf Jun J. Xiong Wei Huang Muhammad A. Javed Gang Mai Xu B. Liu Wei M. Hu Qing Xia | 2012 | HPB2012，，11： | 2 |
| 15 | A simple kinetic analysis to determine the intrinsic reactivity of coal chars显示文摘 | Sima-Ella Edwige Yuan Gang Mays Tim | 2005 | Fuel2005，84，： | 1 |
| 16 | A Simple Kinetic Analy- sis to Determine the Intrinsic Reactivity of Coal Chars显示文摘 | Edwige Sima-Ella Gang Yuan Tim Mays | 2003 | Thermo- ehimica Aeta2003，404，： | 1 |
| 17 | Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold显示文摘 | GuoGang Tu ShaoHua Li HuiMing Huang Gang Li Fang Xiong Xi Mai HuaWei Zhu BinHai Kuang Wen Fang Xu | 2008 | Bioorganic & Medicinal Chemistry2008，，14： | 1 |
| 18 | An altered CD8^(+) T cell epitope of insulin prevents type 1 diabetes in humanized NOD mice显示文摘Autoreactive CD8^(+)T cells,which play an indispensable role inβcell destruction,represent an emerging target for the prevention of type 1 diabetes(T1D).Altered peptide ligands(APLs)can efficiently induce antigen-specific T cells anergy,apoptosis or shifts in the immune response.Here,we found that HLA-A*0201-restricted CD8^(+)T cell responses against a primaryβ-cell autoantigen insulin epitope InsB15–14 were present in both NOD.β2m null.HHD NOD mice and T1D patients.We generated several APL candidates for InsB15–14 by residue substitution at the p6 position.Only H6F exhibited an inhibitory effect on mInsB1_(5–14)-specific CD8^(+)T cell responses in vitro.H6F treatment significantly reduced the T1D incidence,which was accompanied by diminished autoreactive CD8^(+)T cell responses to mInsB15-14,inhibited infiltration of CD8^(+)and CD4^(+)T cells in the pancreas and reduced pro-inflammatory cytokine production in pancreatic and splenic T cells in NOD.β2m^(null).HHD mice.Mechanistically,H6F treatment significantly augmented a tiny portion of CD8^(+)CD25^(+)Foxp3^(+)T cells in the spleen and especially in the pancreas.This subset exhibited typical Treg phenotypes and required peptide-specific restimulation to exert immunosuppressive activity.Therefore,this APL H6F may be a promising candidate with potential clinical application value for antigen-specific prevention of T1D. | Mengjun Zhang Shufeng Wang Binbin Guo Gang Meng Chi Shu Wenli Mai Qian Zheng Xiaoling Chen Yuzhang Wu Li Wang | 2019 | Cellular & Molecular Immunology2019，16，6： | 1 |
| 19 | A systematic review and meta‐analysis of studies comparing laparoscopic and open distal pancreatectomy显示文摘 | Tao Jin Kiran Altaf Jun J. Xiong Wei Huang Muhammad A. Javed Gang Mai Xu B. Liu Wei M. Hu Qing Xia | 2012 | HPB2012，，11： | 1 |
| 20 | Malrotation causing duodenal chronic obstruction in an adult显示文摘Congenital duodenal obstruction is rare in adulthood. An unusual presentation of this condition has led to difficult preoperative diagnosis.We present a case of proximal jejunal obstruction by a congenital band in an adult and review the literature. | Jun Gong Zhen-Jiang Zheng Gang Mai Xu-Bao Liu | 2009 | World Journal of Gastroenterology2009，15，9： | 1 |
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