|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Study on Mach stems induced by interaction of planar shock waves on two intersecting wedges显示文摘The properties of Mach stems in hypersonic corner flow induced by Mach interaction over 3D intersecting wedges were studied theoretically and numerically.A new method called 'spatial dimension reduction' was used to analyze theoretically the location and Mach number behind Mach stems. By using this approach, the problem of 3D steady shock/shock interaction over 3D intersecting wedges was transformed into a 2D moving one on cross sections, which can be solved by shock-polar theory and shock dynamics theory. The properties of Mach interaction over 3D intersecting wedges can be analyzed with the new method,including pressure, temperature, density in the vicinity of triple points, location, and Mach number behind Mach stems.Theoretical results were compared with numerical results,and good agreement was obtained. Also, the influence of Mach number and wedge angle on the properties of a 3D Mach stem was studied. | Gaoxiang Xiang Chun Wang Honghui Teng Yang Yang Zonglin Jiang | 2016 | Acta Mechanica Sinica2016，32，3： | 6 |
| 2 | Shock/shock interactions between bodies and wings显示文摘This paper examines the Shock/Shock Interactions(SSI)between the body and wing of aircraft in supersonic flows.The body is simplified to a flat wedge and the wing is assumed to be a sharp wing.The theoretical spatial dimension reduction method,which transforms the 3D problem into a 2D one,is used to analyze the SSI between the body and wing.The temperature and pressure behind the Mach stem induced by the wing and body are obtained,and the wave configurations in the corner are determined.Numerical validations are conducted by solving the inviscid Euler equations in 3D with a Non-oscillatory and Non-free-parameters Dissipative(NND)finite difference scheme.Good agreements between the theoretical and numerical results are obtained.Additionally,the effects of the wedge angle and sweep angle on wave configurations and flow field are considered numerically and theoretically.The influences of wedge angle are significant,whereas the effects of sweep angle on wave configurations are negligible.This paper provides useful information for the design and thermal protection of aircraft in supersonic and hypersonic flows. | Gaoxiang XIANG Chun WANG Honghui TENG Zonglin JIANG | 2018 | Chinese Journal of Aeronautics2018，31，2： | 5 |
| 3 | Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19显示文摘The blood and immune system of coronavirus disease 2019(COVID-19)infected patients are dysfunctional,and numerous studies have been conducted to resolve their characteristics and pathogenic mechanisms.Nevertheless,the variations of immune responses along with disease severity have not been comprehensively documented.Here,we profiled the single-cell transcriptomes of 96,313 peripheral blood mononuclear cells(PBMCs)derived from 12 COVID-19 patients(including four moderate,four severe and four critical cases)and three healthy donors.We showed that proliferative CD8 effector T cells with declined immune functions and cytotoxicity accumulated in the critical stage.By contrast,the quantity of natural killer(NK)cells was significantly reduced,while they exhibited enhanced immune activities.Notably,a gradually attenuated responseto COVID-19 along with disease severity was observed in monocytes,in terms of cellular composition,transcriptional discrepancy and transcription factor regulatory network.Furthermore,we identified immune cell-type dependent cytokine signatures distinguishing the severity of COVID-19 patients.In addition,cell interactions between CD8 effector T/NK cells and monocytes mediated by inflammatory cytokines were enhanced in moderate and severe stages,but weakened in critical cases.Collectively,our work uncovers the cellular and molecular players underlying the disordered and heterogeneous immune responses associated with COVID-19 severity,which could provide valuable insights for the treatment of critical COVID-19 patients. | Xiaowei Xie Xuelian Cheng Gaoxiang Wang Biao Zhang Mengyao Liu Liting Chen Hui Cheng Sha Hao Jianfeng Zhou Ping Zhu Tao Cheng | 2021 | Science China(Life Sciences)2021，64，10： | 3 |
| 4 | RhoB regulates the function of macrophages in the hypoxia-induced inflammatory response显示文摘有免疫力的房间,特别地巨噬细胞,在导致组织缺氧的煽动性的反应起关键作用。小 GTPase RhoB 被许多刺激很快通常导致并且被描述了为细胞骨架组织和泡和膜受体 trafficking 的一个重要管理者。然而, RhoB 是否涉及导致组织缺氧的煽动性的反应,是未知的。这里,我们在巨噬细胞在 RhoB 表示的 RhoB 和机制和意义的表示上调查了组织缺氧的效果。我们显著地发现了那组织缺氧 upregulated 在老鼠的 RAW264.7 房间,鼠标腹巨噬细胞,和怒气的 RhoB 的表达式。RhoB 的导致组织缺氧的表示被组织缺氧可诱导的 factor-1 (HIF-1 ) 的一个特定的禁止者显著地堵住, c6 月 N 终端 kinase (JNK ) ,或细胞外信号的调整蛋白质 kinase (英皇家空军之阶级最低之兵) ,显示那激活组织缺氧的 HIF-1, JNK,和英皇家空军之阶级最低之兵被组织缺氧涉及 RhoB 的 upregulation。RhoB 表示击倒不仅 interleukin-1 贝它(IL-1 ) 的显著地压制的基础生产, interleukin 6 (IL-6 ) ,并且在 normoxia 而且更多的肿瘤坏死因素 alpha (TNF-) 显著地减少了这些 cytokines 的刺激组织缺氧的生产。而且,我们证明 RhoB 增加了 NF-B transcriptional 的原子 factor-kappa B (NF-B ) 活动,和抑制活动显著地减少了 IL-1, IL-6,和 TNF- 的增加 RhoB 的 mRNA 层次。最后,我们证明 RhoB 提高了房间粘附并且在 normoxia 和组织缺氧禁止了房间移植。一起拿,这些结果建议 RhoB 在巨噬细胞和煽动性的反应的导致组织缺氧的激活起一个重要作用。 | Gaoxiang Huang Jie Su Mingzhuo Zhang Yiduo Jin Yan Wang Peng Zhou Jian Lu | 2017 | Cellular & Molecular Immunology2017，14，3： | 3 |
| 5 | IntegrinαEβ7^(+)T cells direct intestinal stem cell fate decisions via adhesion signaling显示文摘Intestinal stem cell(ISC)differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying(TA)cells.However,whether and how lymphocyte–stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell–stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrinαEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.BlockingαEβ7−E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7^(+)T cells regulate ISC differentiation at single-cell level through cell–cell contact-mediatedαEβ7−E-cadherin adhesion signaling,highlighting a critical role of the T cell–stem/TA cell contact in maintaining intestinal homeostasis. | Shiyang Chen Yajuan Zheng Xiaojuan Ran Hui Du Hua Feng Lei Yang Yating Wen Changdong Lin Shihui Wang Mengwen Huang Zhanjun Yan Dianqing Wu Hongyan Wang Gaoxiang Ge An Zeng Yi Arial Zeng Jianfeng Chen | 2021 | Cell Research2021，31，12： | 3 |
| 6 | Rice(Oryza sativa L.)seedlings enriched with zinc or manganese:Their impacts on cadmium accumulation and expression of related genes显示文摘Cadmium(Cd)contamination in paddy soils means that the rice produced there may be unsafe for human consumption.A hydroponic study was conducted to enrich rice seedlings with zinc(Zn)or manganese(Mn),and the uptake and transport characteristics of Cd in these Zn-and Mn-rich seedlings were subsequently investigated using a greenhouse pot trial.The results showed that hydroponic cultivation in 10-50μmol L^(-1) Zn(ZnSO_(4)·7 H_(2)O)or50-250μmol L^(-1) Mn(MnSO_(4)·H_(2)O)for 30 d had no significant impact on rice growth,while the accumulation of Zn and Mn was 7.31-18.5 and 25.4-47.7 times higher,respectively,than in the control(no Zn or Mn addition).The accumulation of Cd in the Zn-and Mn-rich rice plants was 26.3%-38.6% and 34.4%-44.5% lower than that in the control,respectively,and the translocation factors of Cd from roots to shoots also decreased by 23.3%-41.3% and 25.3%-37.0%,respectively,after transplanting to Cd-contaminated soils.Furthermore,the relative expression levels of OsIRT1(Oryza sativa iron-regulated transporter 1)were downregulated by 40.1%-59.3% and 16.0%-25.9%,respectively,in the Zn-and Mn-rich seedling roots.This downregulation may indicate a possible mechanism contributing to the reductions in Cd absorption.Field experiments confirmed that the Zn-and Mn-rich seedlings produced brown rice(unpolished rice grains)with significantly decreased concentrations of Cd(34.2%-44.4%).This study provides an innovative method for reducing the food safety risks from rice grown on slightly to moderately Cd-contaminated paddy soils. | Gaoxiang HUANG Changfeng DING Yibing MA Yurong WANG Zhigao ZHOU Shun'an ZHENG Xingxiang WANG | 2021 | Pedosphere2021，31，6： | 2 |
| 7 | Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers显示文摘Breast cancer is a heterogeneous disease.In particular,triple-negative breast cancer(TNBC)comprises various molecular subgroups with unclear identities and currently has few targeted treatment options.Our previous study identified protein C receptor(Procr)as a surface marker on mammary stem cells(MaSCs)located in the basal layer of the normal mammary gland.Given the possible connection of TNBC with basal layer stem cells,we conducted comparative analyses of Procr in breast cancers of mouse and human origin.In mouse mammary tumors,we showed that Procr+cells are enriched for cancer stem cells(CSCs)in Wnt1 basal-like tumors,but not in Brea basal-like tumors or PyVT luminal tumors.In human cancers,PROCR was robustly expressed in half of TNBC cases.Experiments with patient-derived xenografts(PDXs)revealed that PROCR marks CSCs in this discrete subgroup(referred to as PROCR+TNBC).Interfering with the function of PROCR using an inhibitory nanobody reduced the CSC numbers,arrested tumor growth and prevented rapid tumor recurrence.Our data suggest a key role of MaSC in breast tumorigenesis.Moreover,our work indicates that PROCR can be used as a biomarker to stratify TNBC into clinically relevant subgroups and may provide a novel targeted treatment strategy for this clinically important tumor subtype. | Daisong Wang Xin Hu Chunye Liu Yingying Jia Yiqin Bai Cheguo Cai Jingqiang Wang Lanyue Bai Ruikai Yang ChangDong Lin Yi-Rong Liu Shan Li Feng Qiao Ling Yao Li Chen Gaoxiang Ge Hai Jiang Dianfan Li Lin Li JianFeng Chen Zhi-Ming Shao Yi Arial Zeng | 2019 | Cell Research2019，29，10： | 2 |
| 8 | Multiscale rescaled range analysis of EEG recordings in sevoflurane anesthesia显示文摘 | Zhenhu Liang Duan Li Gaoxiang Ouyang Yinghua Wang Logan J. Voss Jamie W. Sleigh Xiaoli Li | 2011 | Clinical Neurophysiology2011，，4： | 1 |
| 9 | In vitro antifungal activity of baicalin against Candida albicans biofilms via apoptotic induction显示文摘 | TianMing Wang GaoXiang Shi Jing Shao DaQiang Wu YuanYuan Yan MengXiang Zhang YanYan Cui ChangZhong Wang | 2015 | Microbial Pathogenesis2015，，： | 1 |
| 10 | Theoretical solutions to three-dimensional asymmetrical shock/shock interaction显示文摘这份报纸探索理论答案到三维(3D ) 不均匀的交叉压缩在超声的 inviscid 挤的 3D 导致的吃惊 / 吃惊相互作用流动。为马赫相互作用,作为空间尺寸的减小知道的一个分析方法,它转变 3D 的问题稳定的吃惊 / 吃惊相互作用进一二维(2D ) 生气的节上的伪 steady 问题,被用来在马赫茎的附近获得答案。理论答案包括压力,温度,密度,在马赫茎后面的马赫数字,和全部的压力恢复系数。数字模拟被执行验证理论结果。这里, NND 计划被解决 3D inviscid Euler 方程采用,并且好协议被获得。流动特征的不对称现象由楔角度导致了并且扫角度彻底地被讨论。 | XIANG GaoXiang WANG Chun HU ZongMin LI XuDong JIANG ZongLin | 2016 | Science China(Technological Sciences)2016，59，8： | 1 |
| 11 | Genome-wide analysis of long noncoding RNA signature in human colorectal cancer显示文摘 | Yao Xue Gaoxiang Ma Dongying Gu Lingjun Zhu Qiuhan Hua Mulong Du Haiyan Chu Na Tong Jinfei Chen Zhengdong Zhang Meilin Wang | 2014 | Gene2014，，： | 1 |
| 12 | Existence of limit cycles of equation显示文摘 | WANG GAOXIANG | 1986 | Acta Sci Nat Sunyatseni1986，1，： | 1 |
| 13 | Algorithms for determination of land surface temperatures and emissivities from satellite radiative measurements显示文摘Deriving LST from satellite radiative measurements is desirable, but the accurate determination of LST is very difficult, whcih is related to the atmospheric effect, the nonuniformity of land surface and the coupling between surface temperature and emissivity. In particular, the coupling between the land surface temperature and emissivity constructs a severe obstacle for the accurate determination of LST, because at present, the knowledge about global and surface emissivity is still very deficient. Based on the assumption that the change of emissivity is normally negligible in a short period of time a two_channel method is proposed to determine LSTs and emissivities, simultaneously, in which a set of measurement data of two channels made at two different time, day and night or two continuous days or nights, are used. If there are emissivity variations in two time measurements, with the relative changes of emissivities for different channels being the same, then a three_channel method can be used to determine land surface temperautre and emssivity simultaneously. | Gaoxiang Zhao Hongqi Wang | 1998 | Chinese Science Bulletin1998，43，15： | 1 |
| 14 | Parameterization of longwave optical properties for water cloud显示文摘 | Wang Hongqi Zhao Gaoxiang | 2002 | Adv Atmos Sci2002，19，1： | 1 |
| 15 | Parameterization for narrow band shortwave optical properties of water clouds显示文摘Based on the drop size distribution models built from the observational data of microphysical properties of water clouds, the relationships between the optical properties and microphysical characteristics of water clouds have been investigated, and some different parameterization schemes of cloud optical properties have been analyzed. It is found that with the parameterization scheme, in addition to the equivalent radius, also including the mean radius of cloud droplet size distribution, the role of small cloud drops might be able to be considered more properly and better accuracies of parameterization calculation of cloud optical properties can be obtained, compared with that of using only the equivalent radius as parameter. | Hongqi Wang Gaoxiang Zhao | 1999 | Chinese Science Bulletin1999，44，3： | 0 |
| 16 | Characteristics and formation mechanism of siltstone-mudstone rhythmic sedimentary sections in the Lower Silurian Longmaxi Formation in the Changning area,South Sichuan Basin,southwest China显示文摘The Lower Member of the Longrnaxi Forma-tion is generally dominated by siliceous shale,but recently we found some siltstone-mudstone rhythm sections developed in the Lower Member of the Longmaxi Formation.The study of formation mechanism of siltstone-mudstone rhythmic sedimentary sections may provide new insights into the shale sedimentary environ-ment.Therefore,we studied the characteristics and formation mechanism of siltstone-mudstone rhythmic sedimentary sections in the Lower Member of the Long-maxi Formation in the Changning area based on core observation,thin section identification,major elements and trace elements analysis.The results show the following:1)Two siltstone-mudstone rhythmic sedimentary sections are characterized by frequent interbed between black or gray-black shale and light gray siltstone,abundant argillaceous laminas and silty laminas,with obvious lithological boundaries having developed.Horizontal laminas and rhythmic laminas are well-developed in the shale layer,while the wavy laminas are well-developed in the siltstone layer.2)The major compositional elements are SiO2,Al2O3 and CaO,followed by Fe_(2)O_(3),MgO,K_(2)O and Na_(2)O.3)Compared with the world average shale,these siltstone-mudstone rhythmic sedimentary sections are rich in Mo,U and Ba,but less in V,Co,Ni,Cu.Compared with the shale layer,the siltstone layer has lower contents of V,Co and Ni.4).The geochemical redox indices,Mo-U and CIA values suggest the formation of the siltstone-mudstone rhythmic sedimentary sections are related to influences from bottom currents in an oxic condition with a warm and humid paleoclimate. | Gaoxiang WANG Lei CHEN Yang YANG Cui JING Man CHEN Xiucheng TAN Xin CHEN Di CAO Zibo WEI Minglong LI Dong HUANG | 2021 | Frontiers of Earth Science2021，15，4： | 0 |
| 17 | Purification of the Beonite from Shangtianti, Henan Province, China显示文摘Bentonites consisting mainly of montmorillonite are widely utilized in various applications. However, natural bentonites contain many kinds of impurities such as quartz, cristobalite, feldspar, zeolite, calcite etc., which can decrease the performance of bentonite. Furthermore, quartz and cristobalite are carcinogenic. Therefore purification of bentonite is critical to its applications. Among the impurities in bentonite, cristobalite is the most difficult one to get rid of because of its tiny particle size and aggregation state. | LIAO Libing WANG Mingjun DU Gaoxiang GONG Zhijin L Guocheng | 2013 | 矿物学报2013，33，S1： | 0 |
| 18 | Scoring cytokine storm by the levels of MCP-3 and IL-8 accurately distinguished COVID-19 patients with high mortality显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a global-spread infectious disease caused by a novel coronavirus,SARS-CoV-2.1 COVID-19 causes heterogeneous disease phenotype,of which most patients exhibit mild to moderate symptoms,and~15%progress to severe pneumonia,5%of whom were eventually admitted to the intensive care unit(ICU)due to acute respiratory distress syndrome(ARDS),septic shock and/or multiple organ failure,and exhibit a high mortality rate.Two major obstacles to the improvement of the clinical outcomes in these patients are inadequate identification of the determinant cytokines correlated with fatal outcomes,and an inability to determine whether an individual patient has high risks of ICU admission and fatality. | Liting Chen Gaoxiang Wang Jiaqi Tan Yang Cao Xiaolu Long Hui Luo Qing Tang Tiebin Jiang Wei Wang Jianfeng Zhou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 19 | Voltage Breakdown of Ag Thin Film Deposited on Fractal Surface显示文摘A new type of inhomogeneous system was constructed by depositing Ag thin films on fractal surfaces.The I-V characteristics of such samples exhibit a non-linear effect in air and a voltage breakdown effect in vacuum.Based on the special structure geometry of the samples,these unusual phenomena can be explained by the random tunnelling junction model under different environment. | WANG Jinsong YE Gaoxiang XU Yuqing ZHANG Qirui | 1994 | Chinese Physics Letters1994，11，1： | 0 |
| 20 | Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2显示文摘Dear Editor,T-cell infection by SARS-CoV-2 and associated immune responses are correlated with disease severity and prognosis of COVID-19.Lymphopenia is associated with increased disease severity in COVID-19.Significantly lower circulating T and B cell counts were observed in patients who died from COVID-19 compared with survivors.Moreover,SARS-CoV-2 infection causes aberrant lymphocyte activation and dysfunction. | Mengwen Huang Xingchao Pan Xinling Wang Qingfei Ren Bei Tong Xianchi Dong Gaoxiang Ge Lu Lu Shibo Jiang Jianfeng Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员