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| 1 | Hydrate agglomeration modeling and pipeline hydrate slurry flow behavior simulation显示文摘Dynamic modeling and numerical simulation of hydrate slurry flow behavior are of great importance to offshore hydrate management.For this purpose, a dynamic model of hydrate agglomeration was proposed in this paper.Based on population balance equation, the frame of the dynamic model was established first, which took both hydrate agglomeration and hydrate breakage into consideration.Then, the calculating methods of four key parameters involved in the dynamic model were given according to hydrate agglomeration dynamics.The four key parameters are collision frequency, agglomeration efficiency, breakage frequency and the size distribution of sub particles resulting from particle breakage.After the whole dynamic model was built, it was combined with several traditional solid–liquid flow models and then together solved by the CFD software FLUENT 14.5.Finally, using this method, the influences of flow rate and hydrate volume fraction on hydrate particle size distribution, hydrate volume concentration distribution and pipeline pressure drop were simulated and analyzed. | Guangchun Song Yuxing Li Wuchang Wang Kai Jiang Zhengzhuo Shi Shupeng Yao | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 6 |
| 2 | Static three - point bending behavior of alumi- num foam sandwich 显示文摘 | Guoyin Zu Binna Song Zhaoyang Zhong Xiaobing Li Yongliang Mu Guangchun Yah | 2012 | Journal of Alloys and Compounds2012，540，5： | 1 |
| 3 | A review of electrochemical desulfurization technologies tor fi)ssil fuels 显示文摘 | Vincent Lam Guangchun Li Chaojie Song | 2012 | Fuel Process Technol2012，98，： | 1 |
| 4 | Synthesis, characterization and evaluation of unsupported porous NiS 2 sub-micrometer spheres as a potential hydrodesulfurization catalyst显示文摘 | Debajyoti Mondal Gilles Villemure Guangchun Li Chaojie Song Jiujun Zhang Rob Hui Jinwen Chen Craig Fairbridge | 2012 | Applied Catalysis A General2012，，： | 1 |
| 5 | Preparation of aluminum foam sandwich panels by power-filled tube rolling显示文摘 | Song Binna Zu Guoyin Yao Guangchun | 2011 | Journal of Northeastern University2011，32，2： | 1 |
| 6 | HDS of dibenzothiophenes and hydrogenation of tetralin over a SiO2 supported Ni-Mo-S catalyst显示文摘一出一步舞综合了在 SiO 2 上支持的 Ni-Mo-S 催化剂被准备并且为 dibenzothiophene (DBT ) 的 hydrodesulphurization (HDS ) 使用了,并且 4,6-dimethyl-dibenzothiophene (4,6-DMDBT ) ,并且为 tetralin 的加氢。催化剂在 280 祮漠桴牥愠敲獡的温度与 DBT 和 4,6-DMDBT 的完全的变换显示出相对高的 HDS | Qiang Wei Jinwen Chen Chaojie Song Guangchun Li | 2015 | Frontiers of Chemical Science and Engineering2015，9，3： | 1 |
| 7 | Investigation on hydrate growth at the oil–water interface:In the presence of asphaltene显示文摘Natural gas hydrates can readily form in deep-water oil production processes and pose a great threat to the oil industry.Moreover,the coexistence of hydrate and asphaltene can result in more severe challenges to subsea flow assurance.In order to study the effects of asphaltene on hydrate growth at the oil-water interface,a series of micro-experiments were conducted in a self-made reactor,where hydrates nucleated and grew on the surface of a water droplet immersed in asphaltene-containing oil.Based on the micro-observations,the shape and growth rate of the hydrate shell formed at the oil-water interface were mainly investigated and the effects of asphaltene on hydrate growth were analyzed.According to the experimental results,the shape of the water droplet and the interfacial area changed significantly after the formation of the hydrate shell when the asphaltene concentration was higher than a certain value.A mechanism related to the reduction of the interfacial tension caused by the absorption of asphaltenes on the interface was proposed for illustration.Moreover,the growth rate of the hydrate shell decreased significantly with the increasing asphaltene concentration under experimental conditions.The conclusions of this paper could provide preliminary insight how asphaltene affect hydrate growth at the oil-water interface. | Guangchun Song Yuanxing Ning Yuxing Li Wuchang Wang | 2022 | Chinese Journal of Chemical Engineering2022，35，5： | 1 |
| 8 | Migration to gliomas of bone mesenchymal stem cells transfected with cytosine deaminase gene following transplantation in vivo显示文摘This experiment sought to observe the migration and distribution of bone mesenchymal stem cells transfected with the cytosine deaminase gene (BMSCs-CD/eGFP) after transplantation in vivo through three pathways. In addition, we examined the tropism of these cells to glioma. Intracranial C6 glioma models were established in Sprague-Dawley rats using an intracranial stereotactic inoculation method. When tumors were 7 days old, rats were inoculated with 1×106 BMSCs-CD/eGFP cells via the tumor-bearing internal carotid artery, the contralateral hemisphere and the tumor-bearing glioma. Fluorescence microscopy revealed that BMSCs-CD/eGFP exhibited a strong capacity for migration to tumors. BMSCs-CD/eGFP transplanted via the tumor-bearing internal carotid artery were observed to distribute in glioma tissues. BMSCs-CD/eGFP inoculated via the ipsilateral glioma mainly located within and at the edge of glioma tissues. BMSCs-CD/eGFP inoculated via the contralateral hemisphere mainly distributed at the proximal end of the tumor at the incubation site. | Guangchun Ji Fei Song Qi Xing Jian Liu Kedong Song Daqing Zhang Zihan Wang | 2011 | Neural Regeneration Research2011，6，19： | 0 |
| 9 | STRUCTURE OF LIQUID Al-Si ALLOYS显示文摘In the light of DSC,electronic microprobe and X-ray diffration analyses of the melt-spin-ning ribbons and the structures of liquid hypoeutectic Al-7%Si,eutectic Al-12.7%Si andhypereutectic Al-18%Si alloys have been investigated.The results show that theAl-Si clusters in liquid hypoeutectic Al-Si alloy,the Si-Si clusters in liquid eutectic andhypereutectic Al-Si alloys exist at low temperatures,however,the size of clusters de-creases gradurally with increasing temperature.This process in which inhomogeneous liquidturns into homogeneous one happens in a range of temperatures. | GUI Manchang, JIA Jun, SONG Guangchun, LI Peiyong, LI QingchunHarbin Institute of Technology, Harbin, China | 1994 | Acta Metallurgica Sinica(English Letters)1994，7，1： | 0 |
| 10 | Single-Atom Ce-N_(4)-C-(OH)_(2)Nanozyme-Catalyzed Cascade Reaction to Alleviate Hyperglycemia显示文摘The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor treatment.However,research on alleviating metabolic diseases,such as hyperglycemia,has not been reported.Herein,we found that the single-atom Ce-N_(4)-C-(OH)_(2)(SACe-N_(4)-C-(OH)_(2))nanozyme promoted glucose absorption in lysosomes,resulting in increased reactive oxygen species production in HepG2 cells.Furthermore,the SACe-N_(4)-C-(OH)_(2)nanozyme initiated a cascade reaction involving superoxide dismutase-,oxidase-,catalase-,and peroxidase-like activity to overcome the limitations associated with the substrate and produce•OH,thus improving glucose intolerance and insulin resistance by increasing the phosphorylation of protein kinase B and glycogen synthase kinase 3β,and the expression of glycogen synthase,promoting glycogen synthesis to improve glucose intolerance and insulin resistance in high-fat diet-induced hyperglycemic mice.Altogether,these results demonstrated that the novel nanozyme SACeN_(4)-C-(OH)_(2)alleviated the effects of hyperglycemia without evident toxicity,demonstrating its excellent clinical application potential. | Guangchun Song Jia Xu Hong Zhong Qi Zhang Xin Wang Yitong Lin Scott PBeckman Yunbo Luo Xiaoyun He Jin-Cheng Li Kunlun Huang Nan Cheng | 2023 | Research2023，，4： | 0 |
| 11 | Web Resources for Stem Cell Research显示文摘In this short review, we have presented a brief overview on major web resources relevant to stem cell research. To facilitate more efficient use of these resources, we have provided a preliminary rating based on our own user experience of the overall quality for each resource. We plan to update the information on an annual basis. | Ting Wei Xing Peng Lili Ye Jiajia Wang Fuhai Song Zhouxian Bai Guangchun Han Fengmin Ji Hongxing Lei | 2015 | Genomics, Proteomics & Bioinformatics2015，13，1： | 0 |
| 12 | Towards Personalized Intervention for Alzheimer's Disease显示文摘Alzheimer's disease(AD) remains to be a grand challenge for the international community despite over a century of exploration. A key factor likely accounting for such a situation is the vast heterogeneity in the disease etiology, which involves very complex and divergent pathways.Therefore, intervention strategies shall be tailored for subgroups of AD patients. Both demographic and in-depth information is needed for patient stratification. The demographic information includes primarily APOE genotype, age, gender, education, environmental exposure, life style, and medical history, whereas in-depth information stems from genome sequencing, brain imaging, peripheral biomarkers, and even functional assays on neurons derived from patient-specific induced pluripotent cells(i PSCs). Comprehensive information collection, better understanding of the disease mechanisms, and diversified strategies of drug development would help with more effective intervention in the foreseeable future. | Xing Peng Peiqi Xing Xiuhui Li Ying Qian Fuhai Song Zhouxian Bai Guangchun Han Hongxing Lei | 2016 | Genomics, Proteomics & Bioinformatics2016，14，5： | 0 |
| 13 | Genomics in Neurological Disorders显示文摘Neurological disorders comprise a variety of complex diseases in the central nervous system, which can be roughly classified as neurodegenerative diseases and psychiatric disorders.The basic and translational research of neurological disorders has been hindered by the difficulty in accessing the pathological center(i.e., the brain) in live patients. The rapid advancement of sequencing and array technologies has made it possible to investigate the disease mechanism and biomarkers from a systems perspective. In this review, recent progresses in the discovery of novel risk genes, treatment targets and peripheral biomarkers employing genomic technologies will be discussed. Our major focus will be on two of the most heavily investigated neurological disorders,namely Alzheimer's disease and autism spectrum disorder. | Guangchun Han Jiya Sun Jiajia Wang Zhouxian Bai Fuhai Song Hongxing Lei | 2014 | Genomics, Proteomics & Bioinformatics2014，12，4： | 0 |
| 14 | A GPU accelerated Boussinesq-type model for coastal waves显示文摘This study presents an efficient Boussinesq-type wave model accelerated by a single Graphics Processing Unit(GPU).The model uses the hybrid finite volume and finite difference method to solve weakly dispersive and nonlinear Boussinesq equations in the horizontal plane,enabling the model to have the shock-capturing ability to deal with breaking waves and moving shoreline properly.The code is written in CUDA C.To achieve better performance,the model uses cyclic reduction technique to solve massive tridiagonal linear systems and overlapped tiling/shared memory to reduce global memory access and enhance data reuse.Four numerical tests are conducted to validate the GPU implementation.The performance of the GPU model is evaluated by running a series of numerical simulations on two GPU platforms with different hardware configurations.Compared with the CPU version,the maximum speedup ratios for single-precision and double-precision calculations are 55.56 and 32.57,respectively. | Kezhao Fang Jiawen Sun Guangchun Song Gang Wang Hao Wu Zhongbo Liu | 2022 | Acta Oceanologica Sinica2022，41，9： | 0 |
| 15 | Inhibitory effects of cytosine deaminase gene-transfected bone marrow mesenchymal stem cells on glioma cell proliferation显示文摘Bone marrow mesenchymal stem cells were isolated from C57BL mice,transfected with the cytosine deaminase(CD) gene using a lentivirus vector and co-cultured with C6 glioma cells to verify anti-tumor effects of bone marrow mesenchymal stem cells carrying CD genes.C57MSC-CD/eGFP cells converted 5-fluorocytosine to 5-fluorouracil and exhibited significant inhibition of proliferation and apoptosis in C6 glioma cells.C57MSC-CD/eGFP cells were then implanted into rat models of brain C6 glioma.Rats were also intraperitoneally injected with 5-fluorocytosine after 7 days.MSC-CD/eGFP cells were irregularly distributed at the margin of the glioma,as well as encased and reduced the volume of the glioma.CD-transfected bone marrow mesenchymal stem cells inhibit the in vivo growth and in vitro proliferation of glioma. | Fei Song Qi Xing Kedong Song Jian Liu Guangchun Ji Yufang Ma Tianqing Liu Minghai Wei Xuehu Ma | 2011 | Neural Regeneration Research2011，6，16： | 0 |
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