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| 1 | Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription显示文摘为 histone crotonylation 的酶和读者蛋白质上的最近的研究在抄写支持 histone crotonylation 的功能。然而,为 histone decrotonylation (HDCR ) 负责的酶仍然保持糟糕定义。而且,如果 histone crotonylation 从生理地重要、机能上地不同或对 histone acetylation 冗余,它尚待坚定。这里我们一级 histone deacetylases (HDAC ) 而非 sirtuin 家庭 deacetylases (SIRT ) 是主要 histone decrotonylases 的现在的证据,和那 histone crotonylation 象在哺乳动物的房间的 histone acetylation 一样动态。尤其是,我们与损害 HDAC 产生了新奇 HDAC1 和 HDAC3 异种但是未经触动的 HDCR 活动。用这些异种,我们证明在哺乳动物的房间的选择 HDCR 与宽广 transcriptional 压抑和 crotonylation 然而并非 acetylation 读者蛋白质的减少的倡导者协会相关。而且,我们证明那 histone crotonylation 被充实在并且为老鼠的自强要求了胚胎的干细胞。 | Wei Wei Xiaoguang Liu Jiwei Chen Shennan Gao Lu Lu Huifang Zhang Guangjin Ding Zhiqiang Wang Zhongzhou Chen Tieliu Shi Jiwen Li Jianjun Yu Jiemin Wong | 2017 | Cell Research2017，27，7： | 18 |
| 2 | Structural insights into a novel histone demethylase PHF8显示文摘histone methylation/demethylation 的动态规定在开发期间起一个重要作用。在人的植物 homeodomain (哲学博士) 的变化和截断摸蛋白质 8 (PHF8 ) 与 X 连接智力迟钝和面部异例被联系,例如一张长脸,宽广鼻音尖端,劈开 lip/cleft 腭和大手,然而,它的分子的功能和结构的基础仍然保持不清楚。这里,我们在高分辨率报导 PHF8 的催化核心的水晶结构与或没有伪 - ketoglutarate (伪 - KG ) 。生物化学、结构的研究表明 PHF8 是为甲醇化物 di 、单音甲醇化物的 histone H3 离氨酸 9,然而并非为 H3K9me3 特定的新奇 histone demethylase (H3K9me2/1 ) 。我们的分析也揭示人的 PHF8 怎么在 methylation 状态之间区别并且为 methylated H3K9 完成顺序特性。在里面 vitro demethylation 试金也证明在临床的病人观察的 F279S 异种不拥有 demethylation 活动,建议酶的活动的那损失为 PHF8 病人的致病是关键的。一起拿,这些结果将使位于联系 PHF8 的发展、神经病学的疾病下面的分子的机制清楚些。 | Lin Yu Yang wang Shuo Huang Jianjun Wang Zengqin Deng Qi Zhang Wei Wu Xingliang Zhang Zhao Liu Weimin Gong Zhongzhou Chen | 2010 | Cell Research2010，20，2： | 11 |
| 3 | Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1显示文摘Dear Editor,DNA N^6-methyladenine(6mA)modification is common in prokaryotes1 and eukaryotes,2 involving in gene regulation,transposon,stem cell differentiation,and human tumors.At present,it has been confirmed that 6mA is ubiquitous in the human genome,and[G/C]AGG[C/T]is the most prominent motif for 6mA modification.3 Human ALKBH1(hALKBH1),one of the nine human homologs of the AlkB family,is an Fe(Ⅱ)and aketoglutarate(α-KG)-dependent dioxygenase and highly conserved in mammals.AlkB family proteins can repair damaged DNA/RNA or other lesions. | Li-Fei Tian Yan-Ping Liu Lianqi Chen Qun Tang Wei Wu Wei Sun Zhongzhou Chen Xiao-Xue Yan | 2020 | Cell Research2020，30，3： | 7 |
| 4 | Symmetry Reduction and Exact Solutions of a Hyperbolic Monge-Ampère Equation显示文摘By means of the classical symmetry method,a hyperbolic Monge-Ampère equation is investigated.The symmetry group is studied and its corresponding group invariant solutions are constructed.Based on the associated vector of the obtained symmetry,the authors construct the group-invariant optimal system of the hyperbolic Monge-Ampère equation,from which two interesting classes of solutions to the hyperbolic Monge-Ampère equation are obtained successfully. | Zhongzhou DONG Yong CHEN Dexing KONG Zenggui WANG | 2012 | Chinese Annals of Mathematics,Series B2012，33，2： | 4 |
| 5 | Orientation of the peptide formation of N-phosphoryl amino acids in solution显示文摘The peptide formation of N-phosphoryl aminoacids with amino acids proceeds in aqueous solution withoutany coupling reagents. After being separated in sephadex gelcolumn, the phosphoryl dipeptides were analyzed by theelectrospray ionization tandem mass spectrometry (ESIMS/MS). The result demonstrates that phosphoryl dipeptideswere datected in all the reaction systems. It is found tkat theformation of N-phosphoryl dipeptides is oriented: theN-terminal amino acid residues of the N-phosphoryl dipep-tides are from N-phosphoryl amino acids, and the peptideelongation happened at the C-terminal. Only adipeptide, noβ-dipeptide, is formed in the N-phosphoryl dipeptides,showing that α-carboxylic group is activated selectively byN-pbosphorylation. Theoretical calculation shows that thepeptide formation of N-phosphoryl amino acids might hap-pen through a pentu-coordinate carboxylic-phosphoric in-termediate in solution. These results might give some clues tothe stlidy on the origin of proteins and protein | CHEN Zhongzhou TONG Yufeng CHEN Shuibing LI Yanmei CHEN YI ZHAO Yufen WANG Jinfeng | 2002 | Chinese Science Bulletin2002，47，22： | 2 |
| 6 | Structure and Function of N-Terminal Zinc Finger Domain of SARS-CoV-2 NSP2显示文摘SARS-CoV-2 has become a global pandemic threatening human health and safety.It is urgent to find effective therapeutic agents and targets with the continuous emergence of novel mutant strains.The knowledge of the molecular basis and pathogenesis of SARS-CoV-2 in host cells requires to be understood comprehensively.The unknown structure and function of nsp2 have hindered our understanding of its role in SARS-CoV-2 infection.Here,we report the crystal structure of the N-terminal of SARS-CoV-2 nsp2 to a high resolution of 1.96?.This novel structure contains three zinc fingers,belonging to the C2 H2,C4,and C2 HC types,respectively.Structure analysis suggests that nsp2 may be involved in binding nucleic acids and regulating intracellular signaling pathways.The binding to single or double-stranded nucleic acids was mainly through the large positively charged region on the surface of nsp2,and K111,K112,K113 were key residues.Our findings lay the foundation for a better understanding of the relationship between structure and function for nsp2.It is helpful to make full use of nsp2 as further research and development of antiviral targets and drug design. | Jun Ma Yiyun Chen Wei Wu Zhongzhou Chen | 2021 | Virologica Sinica2021，36，5： | 2 |
| 7 | Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOFI/KDMlb显示文摘 | Qi Zhang Shankang Qi Mingchu Xu Lin Yu Ye Tao Zengqin Deng Wei Wu Jiwen Li Zhongzhou Chen Jiemin Wong | 2013 | Cell Research2013，23，2： | 2 |
| 8 | A practical approach to disturbance decoupling control显示文摘 | Qing Zheng Zhongzhou Chen Zhiqiang Gao | 2009 | Control Engineering Practice2009，，9： | 1 |
| 9 | A practical ap- proach to disturbance decoupling control 显示文摘 | Zheng Qing Chen Zhongzhou Gao Zhiqiang | 2009 | ControlEngineering Practice2009，17，9： | 1 |
| 10 | New isotope 265Bh显示文摘 | Z. G. Gan J. S. Guo X. L. Wu Z. Qin H. M. Fan X. G. Lei H. Y. Liu B. Guo H. G. Xu R. F. Chen C. F. Dong F. M. Zhang H. L. Wang C. Y. Xie Z. Q. Feng Y. Zhen L. T. Song P. Luo H. S. Xu X. H. Zhou G. M. Jin Zhongzhou Ren | 2004 | The European Physical Journal A2004，，3： | 1 |
| 11 | The basis of a more contagious 501Y.V1 variant of SARS-CoV-2显示文摘Dear Editor,The SARS-CoV-2 virus has infected over one hundred million people(COVID-19 patients)and caused more than two million deaths to date.The number of infected people continues to grow quickly,emphasizing the need for rapid use of effective vaccines.Although two mRNA vaccines based on Spike protein(produced by Pfizer-BioNTech and MODERNA)have been approved for emergency use in the US,1,2 the increasing Spike variants that have appeared around the world raise concerns about the continued efficacy of the vaccines.3 Monoclonal antibodies,developed by Regeneron and Eli Lilly,specifically targeting the native form of Spike have been approved by the FDA for emergency use.4,5 An N501Y variant(Y501)of the Spike protein of SARS-CoV-2(B.1.1.7,20I/501Y.V1),first emerged in UK and has now spread to the rest of the world.This variant appears to be much more contagious than the original N501 version.3 Furthermore,Y501 mutation is also found in a variant(B.1.351,20H/501Y.V2)from South Africa and a variant(P1,20J/501Y.V3)from Brazil.3 Unfortunately,this mutation is located at the interaction surface between the RBD and human Angiotensin Converting Enzyme 2(ACE2).6 Thus,the Y501 variation present in B.1.1.7,20I/501Y.V1 might affect the binding ability of the RBD to bind ACE2.We therefore compared the binding affinity of N501 and Y501 RBD for ACE2,uncovering that the affinity for ACE2 of the Y501-RBD was~10 fold higher than that of the N501 version.This may account,at least in part,for the greater infectivity of SARS-CoV-2 with this mutation.Structural modeling data showed that Y501-RBD can form an additional aromatic ring–ring interaction and an additional hydrogen bond with ACE2 by comparison with the RBD of the wild type.In spite of this,sera from individuals immunized with the Pfizer-BioNTech vaccine still efficiently block ACE2 binding to Y501-RBD.Furthermore,Bamlanivimab,the recently FDA approved therapeutic antibody drug for treatment of COVID-19 patients4 still binds the variant Y501-RBD as efficiently as it binds the N501-RBD,giving hope that treatment with the existing monoclonal antibodies may still help COVID-19 patients. | Haolin Liu Qianqian Zhang Pengcheng Wei Zhongzhou Chen Katja Aviszus John Yang Walter Downing Chengyu Jiang Bo Liang Lyndon Reynoso Gregory PDowney Stephen KFrankel John Kappler Philippa Marrack Gongyi Zhang | 2021 | Cell Research2021，31，6： | 1 |
| 12 | Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation显示文摘co 翻译的指向或插入能分泌并且膜蛋白质进 endoplasmic 蜂窝胃(嗯) 一个关键生物过程被信号识别粒子(SRP ) 调停。在优核质, SRP68-SRP72 (SRP68/72 ) heterodimer 在蛋白质 translocation 起一个必要作用。然而,二最大的 SRP 蛋白质, SRP68 和 SRP72 的结构的信息,被限制,特别关于他们的相互作用。此处,我们在 2.91 点报导人的 apo-SRP72 和 SRP68/72 建筑群的第一水晶结构吗?并且 1.7?分辨率分别地。SRP72 的 SRP68 有约束力的领域包含四次不正常的 tetratricopeptide 重复(TPR ) 和一顶灵活 C 终端帽子。Apo-SRP72 在答案主要作为 dimers 存在。为了绑在 SRP68, SRP72 homodimer disassociates,和不可缺少的 C 终端帽子,经历一个显著 conformational 变化帮助 SRP68/72 heterodimer 的形成。SRP68 的 A 23 残余多肽为到通过它的不平常地恐水病、扩大的表面的 SRP72 的紧密的绑定是足够的。结构,生物物理,并且 mutagenesis 分析表明联系癌症的变化破坏 SRP68-SRP72 相互作用和他们的合作本地化与嗯在哺乳动物的房间。结果在调停 SRP 的蛋白质 translocation 加亮 SRP68-SRP72 相互作用的必要角色并且为疾病诊断, pathophysiology,和药设计提供一个结构的基础。 | Yina Gao Qi Zhang Yue Lang Yang Liu Xiaofei Dong Zhenhang Chen Wenli Tian Jun Tang Wei Wu Yufeng Tong Zhongzhou Chen | 2017 | Journal of Molecular Cell Biology2017，9，3： | 1 |
| 13 | A practical approach to disturbance decoupling control显示文摘 | ZHENG Qing CHEN Zhongzhou GAO Zhiqiang | | 0，，09： | 1 |
| 14 | Apractical approach to disturbance decoupling control显示文摘 | Zheng Qing Chen Zhongzhou Gao Zhiqiang | 2006 | Control Engineering Practice2006，17，3： | 1 |
| 15 | A practical approach to disturbance decoupling control显示文摘 | Qing Zheng Zhongzhou Chen Zhiqiang Gao | 2009 | Control Engineering Practice2009，，9： | 1 |
| 16 | A Pratical Approach to Disturbance Decoupling Control显示文摘 | Zheng Qing Chen Zhongzhou Gao Zhiqiang | 2009 | Control Engineering Prac- tice2009，17，9： | 1 |
| 17 | A practical approach to disturbance decoupling control 显示文摘 | Zheng Qing Chen Zhongzhou Gao Zhiqiang | 2006 | Control Engineering Practice2006，17，3： | 1 |
| 18 | A practical approach to disturbance dccoupling control显示文摘 | Zheng Qing Chen Zhongzhou Gao Zhiqiang | 2009 | Control Engineering Practice2009，17，9： | 1 |
| 19 | Systematic Calculations of the Ground State Properties of Superheavy Nuclei显示文摘 | Ren Zhongzhou Tai Fei Chen Ding-han | 2002 | Phys Rev2002，66，06： | 1 |
| 20 | A practical approach to disturbance decoupling control显示文摘 | Qing Zheng Zhongzhou Chen Zhiqiang Gao | 2009 | Control Engineering Practice2009，，9： | 1 |
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